The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C

Anti-Cancer Drug Design

Volumn 16, Issue 2-3, 2001, Pages 155-166

  Hood, Kylie A ^a   Bäckström, B Thomas ^a   West, Lyndon M ^a   Northcote, Peter T ^a   Berridge, Michael V ^a   Miller, John H ^a  

^a VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

Author keywords

Apoptosis; Bryostatin; Calcium ionophore; IL 2; Peloruside; Protein kinase C; Sponge toxin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTINEOPLASTIC AGENT; BRYOSTATIN 1; CALCIUM IONOPHORE; INTERLEUKIN 2; IONOMYCIN; LIPOCORTIN 5; PELORUSIDE A; PROPIDIUM IODIDE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; SODIUM BOROHYDRIDE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL ADHESION; CELL PROLIFERATION; CELL VACUOLE; CYTOTOXICITY; DRUG MECHANISM; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; LYMPHOCYTE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPONGE (PORIFERA); T LYMPHOCYTE;

ANIMALS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DNA; ELECTROPHORESIS, AGAR GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; HL-60 CELLS; HUMANS; INTERLEUKIN-2; IONOPHORES; LACTONES; MACROLIDES; OXIDATION-REDUCTION; PORIFERA; PROTEIN KINASE C; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TETRAZOLIUM SALTS; THIAZOLES;

ANIMALIA; MAMMALIA; MURINAE; MYCALE; PORIFERA;

EID: 0035727024     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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