A common pharmacophore for epothilone and taxanes: Molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 6, 2000, Pages 2904-2909

  Giannakakou, Paraskevi ^a   Gussio, Rick ^c   Nogales, Eva ^e   Downing, Kenneth H ^e   Zaharevitz, Daniel ^c   Bollbuck, Birgit ^f   Poy, George ^b   Sackett, Dan ^d   Nicolaou, K C ^f   Fojo, Tito ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMITOTIC AGENT; BETA TUBULIN; DOCETAXEL; EPOTHILONE A; EPOTHILONE B; PACLITAXEL; SARCODICTYIN; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CONFORMATION; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR MODEL; OVARY CARCINOMA; PEPTIDE MAPPING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN POLYMERIZATION; STRUCTURE ANALYSIS;

ALKALOIDS; ANTINEOPLASTIC AGENTS; BRIDGED COMPOUNDS; DITERPENES; DRUG RESISTANCE, NEOPLASM; EPOTHILONES; EPOXY COMPOUNDS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; PACLITAXEL; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TAXOIDS; THIAZOLES; TUBULIN; TUMOR CELLS, CULTURED;

EID: 12944277104     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.040546297     Document Type: Article

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