The binding mode of epothilone A on α,β-tubulin by electron crystallography

Science

Volumn 305, Issue 5685, 2004, Pages 866-869

  Nettles, James H ^a   Li, Huilin ^b   Cornett, Ben ^a   Krahn, Joseph M ^c   Snyder, James P ^a   Downing, Kenneth H ^d  

^a EMORY UNIVERSITY   (United States)

^b BROOKHAVEN NATIONAL LABORATORY   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEXATION; CONFORMATIONS; CRYSTALLOGRAPHY; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PROTEINS;

ELECTRON CRYSTALLOGRAPHY; LIGANDS; MUTATIONAL RESISTANCE PROFILE; TUBULIN-BINDING POCKET;

DRUG PRODUCTS;

ALPHA TUBULIN; BETA TUBULIN; EPOTHILONE A; LIGAND; PACLITAXEL; ZINC;

BIOLOGY;

ARTICLE; CRYSTALLOGRAPHY; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; HYDROGEN BOND; MUTATIONAL ANALYSIS; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY; CRYSTALLOGRAPHY, X-RAY; EPOTHILONES; HYDROGEN BONDING; HYDROPHOBICITY; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PACLITAXEL; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 3843053396     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099190     Document Type: Article

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34. Supported in part by NIH and the Department of Energy. J.N., B.C., and J.P.S. thank D. Liotta (Emory University) for encouragement, discussion, and support during the course of the work. We thank P. Giannakakou, J. Gallivan, and D. Lynn (Emory University) for helpful discussions. Structure has been deposited in the Protein Data Bank under accession number 1TVK.