(+)-Discodermolide binds to microtubules in stoichiometric ratio to tubulin dimers, blocks taxol binding and results in mitotic arrest

Chemistry and Biology

Volumn 3, Issue 4, 1996, Pages 287-293

  Hung, Deborah T ^a   Chen, Jie ^a   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

Cell cycle arrest; Discodermolide; Microtubules; Mitotic spindles; Taxol

Indexed keywords

MURINAE;

ALKANE; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; LACTONE; PACLITAXEL; PYRONE DERIVATIVE;

ANIMAL; ARTICLE; BINDING SITE; CELL LINE; CELL STRAIN 3T3; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; MICROTUBULE; MITOSIS; MOUSE;

3T3 CELLS; ALKANES; ANIMALS; BINDING SITES; CARBAMATES; CELL LINE; HUMANS; LACTONES; MICE; MICROTUBULES; MITOSIS; PACLITAXEL; PYRONES;

EID: 0030113284     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(96)90108-8     Document Type: Article

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