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Volumn 133, Issue 47, 2011, Pages 19064-19067
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Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers
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Author keywords
[No Author keywords available]
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Indexed keywords
ANTI-CANCER AGENTS;
ANTI-PROLIFERATIVE;
ANTI-TUMOR ACTIVITIES;
BINDING MODES;
BIOLOGICAL ACTIVITIES;
CANCER CELLS;
CELLULAR EFFECTS;
DIRECT INTERACTIONS;
ETHANOL EXTRACT;
IN-VIVO;
KINETIC PROFILES;
MICROTUBULE STABILIZERS;
MICROTUBULES;
PACLITAXEL;
SEMISYNTHESIS;
SPECTROSCOPIC METHOD;
STABILIZING AGENTS;
STRUCTURE ACTIVITY RELATIONSHIPS;
TUBULIN POLYMERIZATION;
BINDING ENERGY;
EPOXIDATION;
ETHANOL;
SPECTROSCOPIC ANALYSIS;
POLYMERIZATION;
ALCOHOL;
MICROTUBULE PROTEIN;
PACLITAXEL;
PLANT EXTRACT;
TACCALONIDE B;
TACCALONOLIDE DERIVATIVE;
TACCALONOLIDE DERIVATIVE AC;
TACCALONOLIDE DERIVATIVE AD;
TACCALONOLIDE DERIVATIVE AE;
TACCALONOLIDE DERIVATIVE AF;
TACCALONOLIDE DERIVATIVE AJ;
TACCALONOLIDE DERIVATIVE H2;
TUBULIN;
UNCLASSIFIED DRUG;
ANTIANGIOGENIC ACTIVITY;
ARTICLE;
BINDING KINETICS;
BINDING SITE;
BIOLOGICAL ACTIVITY;
CANCER CELL;
CELL FUNCTION;
DRUG ISOLATION;
DRUG POTENCY;
DRUG SYNTHESIS;
ELECTROSPRAY MASS SPECTROMETRY;
EPOXIDATION;
HUMAN;
HUMAN CELL;
IC 50;
MEDICINAL PLANT;
NUCLEAR MAGNETIC RESONANCE;
POLYMERIZATION;
STRUCTURE ACTIVITY RELATION;
TACCA PLANTAGINEA;
BINDING SITES;
CELL CYCLE;
CELL PROLIFERATION;
DOSE-RESPONSE RELATIONSHIP, DRUG;
HELA CELLS;
HUMANS;
MICROTUBULES;
MOLECULAR CONFORMATION;
STEREOISOMERISM;
STEROIDS;
STRUCTURE-ACTIVITY RELATIONSHIP;
TUBULIN;
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EID: 81855199852
PISSN: 00027863
EISSN: 15205126
Source Type: Journal
DOI: 10.1021/ja209045k Document Type: Article |
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Times cited : (49)
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References (14)
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