Microtubule-stabilizing marine metabolite laulimalide and its derivatives: Synthetic approaches and antitumor activity

Chemical Reviews

Volumn 103, Issue 9, 2003, Pages 3753-3786

  Mulzer, Johann ^a   Öhler, Elisabeth ^a  

^a INSTITUT FÜR ORGANISCHE CHEMIE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUMOR ACTIVITY; EPOXIDES; MACROCYCLIZATION; MARINE METABOLITE LAULIMALIDE; OLEFINATION;

ALKYLATION; CELLS; CHEMICAL BONDS; DERIVATIVES; ISOMERIZATION; ISOMERS; KETONES; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL); TUMORS;

METABOLITES;

ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; LAULIMALIDE; PACLITAXEL; TAXOID;

ADENOCARCINOMA; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; FEMALE; HUMAN; MICROTUBULE; MULTIDRUG RESISTANCE; OVARY TUMOR; REVIEW; SYNTHESIS;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MICROTUBULES; OVARIAN NEOPLASMS; PACLITAXEL; TAXOIDS;

EID: 0141508044     PISSN: 00092665     EISSN: None     Source Type: Journal    
DOI: 10.1021/cr940368c     Document Type: Article

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209. 16b
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242. For an analogous approach in Crimmins' total synthesis, see: Scheme 35.