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Volumn 45, Issue 47, 2006, Pages 7942-7948

Total synthesis and antitumor activity of ZK-EPO: The first fully synthetic epothilone in clinical development

Author keywords

Clinical development; Epothilones; Natural products; Total synthesis

Indexed keywords

CONVERGENCE OF NUMERICAL METHODS; DATA REDUCTION; MEDICAL APPLICATIONS; SYNTHESIS (CHEMICAL); TUMORS;

EID: 33845486692     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200602785     Document Type: Article
Times cited : (113)

References (44)
  • 22
    • 33845505434 scopus 로고    scopus 로고
    • note
    • Since the IUPAC nomenclature of epothilone D is completely different from epothilone B we prefer to use the numbering depicted in Scheme 2 throughout the following discussions.
  • 24
    • 33845492303 scopus 로고    scopus 로고
    • note
    • Compounds that inhibit the proliferation of tumor cells by 50% at concentrations below 100 nM are defined as active.
  • 25
    • 33845505949 scopus 로고    scopus 로고
    • note
    • Three other epothilones have been investigated in early clinical studies (phase I): Kos-1584 (Kosan/Roche), ABJ879 (Novartis), BMS 310705 (BMS).
  • 31
    • 33845479202 scopus 로고    scopus 로고
    • note
    • Only stereochemically homogeneous material obtained from the direct crystallization was used in the calculation. Additional product can be obtained from the mother liquor.
  • 38
    • 33845503838 scopus 로고    scopus 로고
    • note
    • See supporting information.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.