The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells

Molecular Pharmacology

Volumn 52, Issue 4, 1997, Pages 613-622

  Kowalski, Richard J ^a   Giannakakou, Paraskevi ^b   Gunasekera, Sarath P ^c   Longley, Ross E ^c   Day, Billy W ^d   Hamel, Ernest ^a,e  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Oceanographic Institute   (United States)

^d UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISCODERMOLIDE; GLYCOPROTEIN P; GUANOSINE TRIPHOSPHATE; MICROTUBULE ASSOCIATED PROTEIN; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL GROWTH; COLON CARCINOMA; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SENSITIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; MULTIDRUG RESISTANCE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN BINDING;

EID: 0030761586     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.4.613     Document Type: Article

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