The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 4, 2009, Pages 681-689

  Beyer, Carl F ^a   Zhang, Nan ^a   Hernandez, Richard ^a   Vitale, Danielle ^a   Nguyen, Thai ^a   Ayral Kaloustian, Semiramis ^a   Gibbons, James J ^a  

^a WYETH RESEARCH   (United States)

Author keywords

Antitumor agent; Cevipabulin; Microtubule; TTI 237; Tubulin; Tubulin polymerizer

Indexed keywords

ANTINEOPLASTIC AGENT; CALCIUM ION; CELL PROTEIN; COLCHICINE; DOCETAXEL; HETERODIMER; MICROTUBULE PROTEIN; NUCLEOTIDE; PACLITAXEL; PHOSPHOPROTEIN; TTI 237; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ANTIBODY SPECIFICITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; KINETICS; LOW TEMPERATURE; MICROTUBULE; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TURBIDIMETRY;

ANTINEOPLASTIC AGENTS; BIOPOLYMERS; COLD TEMPERATURE; FLOW CYTOMETRY; GUANOSINE TRIPHOSPHATE; HELA CELLS; HUMANS; HYDROCARBONS, HALOGENATED; MICROTUBULES; PACLITAXEL; RADIOLIGAND ASSAY; TRIAZOLES; TUBULIN; VINCRISTINE;

EID: 68149136588     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0916-2     Document Type: Article

References (25)

1. N Zhang S Ayral-Kaloustian T Nguyen J Afragola R Hernandez J Lucas 2007 Synthesis and SAR of [1, 2, 4]triazolo[1, 5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition J Med Chem 50 319 327
2. CF Beyer N Zhang R Hernandez D Vitale J Lucas T Nguyen 2008 TTI-237: a novel microtubule-active compound with in vivo antitumor activity Cancer Res 68 2292 2300
3. E Hamel 1996 Antimitotic natural products and their interactions with tubulin Med Res Rev 16 207 231
4. PO Krutzik GP Nolan 2003 Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events Cytometry Part A 55A 61 70
5. JM Irish R Hovland PO Krutzik OD Perez O Bruserud BT Gjertsen 2004 Single cell profiling of potentiated phospho-protein networks in cancer cells Cell 118 217 228
6. S Lobert B Vulevic JJ Correia 1996 Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine Biochem 35 6806 6814
7. PB Schiff J Fant SB Horwitz 1979 Promotion of microtubule assembly in vitro by taxol Nature 277 665 667
8. DA Dabydeen JC Burnett R Bai P Verdier-Pinard SJH Hickford GR Pettit 2006 Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin Mol Pharmacol 70 1866 1875
9. MV Blagosklonny T Fojo 1999 Molecular effects of paclitaxel: myths and reality Int J Cancer 83 151 156
10. Sackett DL, Fojo T (1999) Taxanes and other microtubule stabilizing agents. In: Pinedo HM, Longo DL, Chabner BA (eds) Cancer Chemotherapy and biological response modifiers annual 18. Elsevier Science BV, New York, pp 59-80
11. JG Chen C-PH Yang M Cammer SB Horwitz 2003 Gene expression and mitotic exit induced by microtubule-stabilizing drugs Cancer Res 63 7891 7899
12. DT Bergstralh JP-Y Ting 2006 Microtubule stabilizing agents: their molecular signaling consequences and the potential for enhancement by drug combinations Cancer Treat Rev 32 166 179
13. L Wilson MA Jordan A Morse RL Margolis 1982 Interaction of vinblastine with steady-state microtubules in vitro J Mol Biol 159 125 149
14. RI Dhamodharan MA Jordan D Thrower L Wilson P Wadsworth 1995 Vinblastine suppresses dynamics of individual microtubules in living cells Mol Biol Cell 6 1215 1229
15. MA Jordan K Kamath 2007 How do microtubule-targeted drugs work? An overview Curr Cancer Drug Targets 7 730 742
16. B Vitre FM Coquelle C Heichette C Garnier D Chretien I Arnal 2008 EB1 regulates microtubule dynamics and tubulin sheet closure in vitro Nature Cell Biol 10 415 421
17. glued Biochem 47 779 786
18. A Akhmanova MO Steinmetz 2008 Tracking the ends: a dynamic protein network controls the fate of microtubule tips Nat Rev Mol Cell Biol 9 309 322
19. R Bai NA Durso DL Sackett E Hamel 1999 Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1 Biochemistry 38 14302 14310
20. JJ Correia S Lobert 2001 Physiochemical aspects of tubulin-interacting antimitotic drugs Curr Pharm Des 7 1213 1228
21. A Mitra D Sept 2004 Localization of the antimitotic peptide and depsipeptide binding site on β-tubulin Biochemistry 43 13955 13962
22. B Gigant C Wang RBG Ravelli F Roussi MO Steinmetz PA Curmi 2005 Structural basis for the regulation of tubulin by vinblastine Nature 435 519 522
23. JG Chen SB Horwitz 2002 Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs Cancer Res 62 1935 1938
24. N Zhang S Ayral-Kaloustian T Nguyen R Hernandez C Beyer 2007 2-Cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization Bioorg Med Chem Let 17 3003 3005
25. T Fojo 2008 Commentary: novel therapies for cancer: why dirty might be better Oncologist 13 277 283