Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules

Journal of the American Chemical Society

Volumn 119, Issue 37, 1997, Pages 8744-8745

  Lindel, Thomas ^a   Jensen, Paul R ^a   Fenical, William ^a   Long, Byron H ^b   Casazza, Anna Maria ^b   Carboni, Joan ^b   Fairchild, Craig R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; ELEUTHEROBIN A; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CYTOTOXICITY; DRUG IDENTIFICATION; DRUG ISOLATION; HUMAN; HUMAN CELL; MICROTUBULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

EID: 0030984058     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9717828     Document Type: Article

References (14)

1. Soft corals of the genus Eleutherobia (Alcyonacea, Octocorallia) are rare, but they have been reported from a variety of locales worldwide. We thank Dr. Phil Alderslade, Northern Territory Museum of Arts and Sciences, Darwin, Australia, for identifying this animal.
2. The cytotoxic properties of eleutherobin, but not its tubulin stabilizing properties, were described in U.S. Letters Patent # 5,473,057 issued 5 December, 1995.
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5. 3): δ 34.3 (CH, C-1), 137.4 (CH, C-2), 132.8 (C, C-3), 115.9 (C, C-4), 131.0 (CH, C-5), 133.7 (CH, C-6), 89.9 (C, C-7), 81.5 (CH, C-8), 31.5 (CH2, C-9), 38.7 (CH, C-10), 134.2 (C, C-11), 121.3 (CH, C-12), 24.5 (CH2, C-13), 42.4 (CH, C-14), 69.1 (CH2, C-15), 24.3 (CH3, C-16), 21.9 (CH3, C-17), 29.1 (CH, C-18), 20.5 (CH3, C-19), 22.2 (CH3, C-20), 49.6 (CH3, C-21), 166.7 (C, C-1′), 115.9 (CH, C-2′), 136.4 (CH, C-3′), 138.4 (C, C-4′), 122.9 (CH, C-5′), 139.5 (CH, C-7′), 33.6 (CH3, C-9′), 93.4 (CH, C-1″), 71.8 (CH, C-2″), 68.1 (CH, C-3″), 69.5 (CH, C-4″), 62.1 (CH2, C-5″), 171.4 (C, C-1‴), 21.0 (CH3, C-2‴).
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