Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site

Biochemistry

Volumn 44, Issue 34, 2005, Pages 11525-11538

  Edler, Michael C ^a   Buey, Rubén M ^b   Gussio, Rick ^a   Marcus, Adam I ^c   Vanderwal, Christopher D ^d   Sorensen, Erik J ^d,e   Díaz, J Fernando ^b   Giannakakou, Paraskevi ^c   Hamel, Ernest ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENTHALPY; HYDROGEN BONDS; TUMORS;

ANTITUMOR ACTIVITIES; CANCER CELLS; CYCLOSTREPTIN; MOLECULAR MODELING;

PROTEINS;

CYCLOSTREPTIN; DOCETAXEL; EPOTHILONE A; FR 182877; GUANOSINE TRIPHOSPHATE; MICROTUBULE ASSOCIATED PROTEIN; NATURAL PRODUCT; PACLITAXEL; POLYMER; SARCODICTYIN A; SARCODICTYIN B; TAXOID; TERPENOID; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN MCF 7; COMPETITIVE INHIBITION; DRUG BINDING; DRUG MECHANISM; DRUG STRUCTURE; ENTHALPY; HUMAN; HUMAN CELL; HYDROGEN BOND; ISOTOPE LABELING; LOW TEMPERATURE; MICROTUBULE ASSEMBLY; MICROTUBULE ORGANIZING CENTER; MOLECULAR MODEL; PHARMACOPHORE; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TURBIDIMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CATTLE; CELL LINE, TUMOR; FEMALE; HUMANS; KINETICS; LIGANDS; MICROTUBULES; MODELS, MOLECULAR; OVARIAN NEOPLASMS; PACLITAXEL; POLYCYCLIC COMPOUNDS; PROTEIN CONFORMATION; TAXOIDS; THERMODYNAMICS; TUBULIN;

MINK CELL FOCUS-FORMING VIRUS;

EID: 23944524786     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi050660m     Document Type: Article

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