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Volumn 41, Issue 29, 2002, Pages 9109-9115

The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity

(12) Pryor, Donald E a O'Brate, Aurora b Bilcer, Geoffrey c Díaz, J Fernando d Wang, Yuefang b Wang, Yong c Kabaki, Mikio c Jung, M Katherine a Andreu, José M d Ghosh, Arun K c Giannakakou, Paraskevi b Hamel, Ernest a

a NATIONAL CANCER INSTITUTE (United States)

b EMORY UNIVERSITY SCHOOL OF MEDICINE (United States)

c UNIVERSITY OF ILLINOIS AT CHICAGO (United States)

d CENTRO DE INVESTIGACIONES BIOLÓGICAS (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULES;

CELLS; DRUG DOSAGE; ORGANIC COMPOUNDS;

BIOCHEMISTRY;

7 O [N (2,7 DIFLUORO 4' FLUORESCEINCARBONYL)ALANYL]PACLITAXEL; BETA TUBULIN; EPOTHILONE A; EPOXIDE; GLYCOPROTEIN P; ISOLAULIMALIDE; LAULIMALIDE; PACLITAXEL; PACLITAXEL DERIVATIVE; POLYMER; TAXOID; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE MUTATION; MICROTUBULE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN STABILITY;

BINDING SITES; DRUG RESISTANCE, NEOPLASM; EPOXY COMPOUNDS; FLUORESCENCE POLARIZATION; MICROTUBULES; MODELS, MOLECULAR; PACLITAXEL; TAXOIDS; TRITIUM;

EID: 18444400213 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi020211b Document Type: Article

Times cited : (233)

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