Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo

Cancer Chemotherapy and Pharmacology

Volumn 62, Issue 6, 2008, Pages 1045-1054

  O'Reilly, Terence ^a   Wartmann, Markus ^a   Brueggen, Joseph ^a   Allegrini, Peter R ^a   Floersheimer, Andreas ^a   Maira, Michel ^a   McSheehy, Paul M J ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Colon cancer; P glycoprotein; Patupilone; Pharmacokinetics; Tumor vasculature

Indexed keywords

EPOTHILONE B; GLYCOPROTEIN P; IXABEPILONE; MICROTUBULE STABILIZER; PACLITAXEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; COLON CARCINOMA; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG POTENCY; DRUG RETENTION; DRUG SCREENING; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROTUBULE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUDE MOUSE; NUDE RAT; PHARMACOKINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; TUMOR BLOOD FLOW; TUMOR MODEL; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; COLONIC NEOPLASMS; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; EPOTHILONES; FEMALE; GLIOMA; MAGNETIC RESONANCE IMAGING; MICE; MICE, NUDE; MICROTUBULES; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PACLITAXEL; PANCREATIC NEOPLASMS; RATS; RATS, INBRED LEW; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 51849114328     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0695-9     Document Type: Article

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