Synthesis of B-ring homologated estradiol analogues that modulate tubulin polymerization and microtubule stability

Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2000, Pages 2419-2429

  Wang, Zhiqiang ^a   Yang, Donglai ^a   Mohanakrishnan, Arasambattu K ^a   Fanwick, Phillip E ^b   Nampoothiri, Priya ^c   Hamel, Ernest ^c   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; ACETIC ACID; B HOMO 17BETA O ACETYL 2 ETHOXY 3 HYDROXYESTRA 6 KETOESTRADIOL; B HOMO 3,17BETA DI O ACETYL 2 ETHOXY 6 OXOESTRADIOL; COLCHICINE; ESTRADIOL DERIVATIVE; PACLITAXEL; TUBULIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATTLE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROTUBULE; MICROTUBULE ASSEMBLY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; POLYMERIZATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; DRUG SCREENING ASSAYS, ANTITUMOR; ESTRADIOL; HUMANS; MICROTUBULES; PACLITAXEL; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0033918981     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0001119     Document Type: Article

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