Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicity

Chemistry and Biology

Volumn 12, Issue 12, 2005, Pages 1269-1279

  Buey, Rubén M ^a   Barasoain, Isabel ^a   Jackson, Evelyn ^b   Meyer, Arndt ^c   Giannakakou, Paraskevi ^d   Paterson, Ian ^c   Mooberry, Susan ^b   Andreu, José M ^a   Díaz, J Fernando ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; LIGAND; PACLITAXEL; TUBULIN; TUBULIN MODULATOR;

ARTICLE; BINDING COMPETITION; CELL CULTURE; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; HUMAN; METABOLISM; MICROTUBULE; PREDICTION AND FORECASTING; PROTEIN BINDING; THERMODYNAMICS;

ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL CYCLE; DRUG DESIGN; HUMANS; LIGANDS; MICROTUBULES; MOLECULAR STRUCTURE; PACLITAXEL; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; THERMODYNAMICS; TUBULIN; TUBULIN MODULATORS; TUMOR CELLS, CULTURED;

EID: 28844499921     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2005.09.010     Document Type: Article

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