The relationship between Taxol and (+)-discodermolide: Synthetic analogs and modeling studies

Chemistry and Biology

Volumn 8, Issue 9, 2001, Pages 843-855

  Martello, Laura A ^a   LaMarche, Matthew J ^b   He, Lifeng ^a   Beauchamp, Thomas J ^b   Smith III, Amos B ^b   Horwitz, Susan Band ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Discodermolide; Microtubule; Pharmacophore; Taxol

Indexed keywords

ALKANE; ANTINEOPLASTIC AGENT; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; LACTONE; PACLITAXEL; PYRONE DERIVATIVE; TUBULIN;

ARTICLE; BINDING COMPETITION; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; ELECTRON MICROSCOPY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; IC 50; MICROTUBULE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ALKANES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BINDING, COMPETITIVE; CARBAMATES; FLOW CYTOMETRY; HUMANS; INHIBITORY CONCENTRATION 50; LACTONES; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MICROTUBULES; MODELS, MOLECULAR; PACLITAXEL; PYRONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUMOR CELLS, CULTURED;

EID: 0034826406     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(01)00055-2     Document Type: Article

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