The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide

Angewandte Chemie - International Edition

Volumn 45, Issue 44, 2006, Pages 7388-7394

  Sánchez Pedregal, Víctor M ^a,d   Kubicek, Karel ^a   Meiler, Jens ^b   Lyothier, Isabelle ^c   Paterson, Ian ^c   Carlomagno, Teresa ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Conformation analysis; Discodermolide; NMR spectroscopy; Structure activity relationships; Tubulin

Indexed keywords

CONFORMATIONS; MATHEMATICAL MODELS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

CONFORMATION ANALYSIS; DISCODERMOLIDE; STRUCTURE-ACTIVITY RELATIONSHIPS; TUBULIN;

MOLECULAR STRUCTURE;

ALKANE; CARBAMIC ACID DERIVATIVE; DISCODERMOLIDE; EPOTHILONE DERIVATIVE; LACTONE; PYRONE DERIVATIVE; TUBULIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; SOLUTION AND SOLUBILITY;

ALKANES; CARBAMATES; EPOTHILONES; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PYRONES; SOLUTIONS; TUBULIN;

EID: 33751204460     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200602793     Document Type: Article

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