Overcoming the Blood-Brain Barrier to Taxane Delivery for Neurodegenerative Diseases and Brain Tumors

Journal of Molecular Neuroscience

Volumn 20, Issue 3, 2003, Pages 339-343

  Rice, Antonie ^a   Michaelis, Mary L ^a   Georg, Gunda ^a   Liu, Yanbin ^a   Turunen, Brandon ^a   Audus, Kenneth L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Blood brain barrier; Brain microcapillary endothelial cells; CNS drug permeation; Microtubule stabilizing drugs; Neurofibrillary pathology; Taxol

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; PACLITAXEL DERIVATIVE; RHODAMINE; STABILIZING AGENT; SUCCINIC ACID; TAXANE DERIVATIVE; TX 67; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; DRUG DERIVATIVE; PACLITAXEL; RHODAMINE 123; TAXOID;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TUMOR; CELL LINE; CENTRAL NERVOUS SYSTEM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG INDICATION; DRUG PENETRATION; DRUG POTENCY; DRUG PROTEIN BINDING; EXPERIMENTAL MODEL; IN VITRO STUDY; MALE; MICROTUBULE; NONHUMAN; PROTEIN INTERACTION; RAT; ANIMAL; BINDING SITE; CELL CULTURE; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG DESIGN; DRUG EFFECT; ENDOTHELIUM CELL; METABOLISM; METHODOLOGY; NEUROFIBRILLARY TANGLE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; BINDING SITES; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG DESIGN; ENDOTHELIAL CELLS; MALE; MICROTUBULES; MOLECULAR CONFORMATION; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; P-GLYCOPROTEIN; PACLITAXEL; RATS; RATS, SPRAGUE-DAWLEY; RHODAMINE 123; SUCCINIC ACID; TAXOIDS;

EID: 0642309504     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:20:3:339     Document Type: Article

References (22)

1. Audus K. L. and Borchardt R. T. (1987) Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier. Ann. NY Acad. Sci. 507, 9-18.
2. Audus K. L., Ng L., Wang W., and Borchardt R. T. (1996) Brain microvessel endothelial cell culture systems. Pharm. Biotechnol. 8, 239-258.
3. Brouty-Boye D., Kolonias D., Wu C. J., Savaraj N., and Lampidis T. J. (1995) Relationship of multidrug resistance to rhodamine-123 selectivity between carcinoma and normal epithelial cells: taxol and vinblastine modulate drug efflux. Cancer Res. 55, 1633-1638.
4. Cahan M. A., Walter K. A., Colvin O. M., and Brem H. (1994) Cytotoxicity of taxol in vitro against human and rat malignant brain tumors. Cancer Chemother. Pharmacol. 33, 441-444.
5. Cordon-Cardo C., O'Brien J. P., Casals D., Rittman-Grauer L., Biedler J. L., Melamed M. R., and Bertino J. R. (1989) Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 86, 695-698.
6. Desnottes J. F. (1996) New targets and strategies for the development of antibacterial agents. Trends Biotechnol. 14, 134-140.
7. Fellner S., Bauer B., Miller D.S., Schaffrik M., Franhanel M., Spruss T., et al. (2002) Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J. Clin. Invest. 110, 1309-1318.
8. Gottesman M. M., Pastan I., and Ambudkar S. V. (1996) P-glycoprotein and multidrug resistance. Curr. Opin. Genet. Dev. 6, 610-617.
9. Greig N. H., Soncrant T. T., Shetty H. U., Momma S., Smith Q. R., and Rapoport S. I. (1990) Brain uptake and anti-cancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother. Pharmacol. 26, 263-268.
10. Lovich M. A., Creel C., Hong K., Hwang C. W., and Edelman E. R. (2001) Carrier proteins determine local pharmacokinetics and arterial distribution of paclitaxel. J. Pharm. Sci. 90, 1324-1335.
11. Mann H., Ladenheim B., Hirata H., Moran T. H., and Cadet J. L. (1997) Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug resistant (mdr1a) knockout mice. Brain Res. 769, 340-346.
12. Michaelis M. L., Chen Y., Hill S., Reiff E., Georg G., Rice A., and Audus K. L. (2002) Amyloid peptide toxicity and microtubule-stabilizing drugs. J. Mol. Neurosci. 19, 101-105.
13. Michaelis M. L., Ranciat N., Chen Y., Bechtel M., Ragan R., Hepperle M., et al. (1998) Protection against β-amyloid toxicity in primary neurons by paclitaxel (Taxol). J. Neurochem. 70, 1623-1627.
14. Ojima I. and Slater J. C. (1997) Synthesis of novel 3′- trifluoromethyl taxoids through effective kinetic resolution of racemic 4-CF3-beta-lactams with baccatins. Chirality 9, 487-494.
15. Ojima I., Slater J. C., Michaud E., Kuduk S. D., Bounaud P. Y., Vrignaud P., et al. (1996) Syntheses and structure-activity relationships of the second-generation antitumor taxoids: exceptional activity against drug-resistant cancer cells. J. Med. Chem. 39, 3889-3896.
16. Pardridge W. M. (2002) Targeting neurotherapeutic agents through the blood-brain barrier. Arch. Neurol. 59, 35-40.
17. Rose J. M., Peckham S. L., Scism J. L., and Audus K. L. (1998) Evaluation of the role of P-glycoprotein in ivermectin uptake by primary cultures of bovine brain microvessel endothelial cells. Neurochem. Res. 23, 203-209.
18. Schinkel A. H. (1999) P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36, 179-194.
19. Siegal T. and Zylber-Katz E. (2002) Strategies for increasing drug delivery to the brain: focus on brain lymphoma. Clin. Pharmacokinet. 41, 171-186.
20. Smith Q. (1996) Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. Pharm. Biotechnol. 8, 285-307.
21. Taylor E. M. (2002) The impact of efflux transporters in the brain on the development of drugs for CNS disorders. Clin. Pharmacokinet. 41, 81-92.
22. Tsuji A., Terasaki T., Takabatake Y., Tenda Y., Tamai I., Yamashima T., et al. (1992) P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51, 1427-1437.