메뉴 건너뛰기




Volumn 17, Issue 31, 2011, Pages 3413-3417

Microtubules (tau) as an emerging therapeutic target: Nap (davunetide)

Author keywords

Activity dependent neuroprotective protein (adnp); Alzheimer's disease; Behavior; Cognition; Davunetide; Developmental disorders; Drug discovery and development; Frontotemporal dementia; Microtubules; Nap; Neurodegeneration; Neuroprotection; Parkinson disease; Progressive supranuclear palsy (psp); Schizophrenia; Tau; Tauopathy; Tubulin

Indexed keywords

ACTIVITY DEPENDENT NEUROPROTECTIVE PROTEIN; DAVUNETIDE; HETEROCHROMATIN PROTEIN 1; HETEROCHROMATIN PROTEIN 1ALPHA; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROTROPHIC FACTOR; NOCODAZOLE; PROTEIN; SYNAPTOPHYSIN; TAU PROTEIN; UNCLASSIFIED DRUG; ZINC;

EID: 80055108264     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211798072553     Document Type: Article
Times cited : (41)

References (62)
  • 1
    • 0029883129 scopus 로고    scopus 로고
    • A femtomolar-acting neuroprotective peptide
    • Brenneman DE, Gozes I. A femtomolar-acting neuroprotective peptide. J Clin Invest 1996; 97: 2299-307.
    • (1996) J Clin Invest , vol.97 , pp. 2299-2307
    • Brenneman, D.E.1    Gozes, I.2
  • 2
    • 0030340539 scopus 로고    scopus 로고
    • Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?
    • Gozes I, Brenneman DE. Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin? J Mol Neurosci 1996; 7: 235-44.
    • (1996) J Mol Neurosci , vol.7 , pp. 235-244
    • Gozes, I.1    Brenneman, D.E.2
  • 3
    • 0030901579 scopus 로고    scopus 로고
    • Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: Immunological and biological specificity
    • Gozes I, Davidson A, Gozes Y, et al. Antiserum to activity-dependent neurotrophic factor produces neuronal cell death in CNS cultures: immunological and biological specificity. Brain Res Dev Brain Res 1997; 99: 167-75.
    • (1997) Brain Res Dev Brain Res , vol.99 , pp. 167-175
    • Gozes, I.1    Davidson, A.2    Gozes, Y.3
  • 4
    • 0034329281 scopus 로고    scopus 로고
    • A glia-derived signal regulating neuronal differentiation
    • Blondel O, Collin C, McCarran WJ, et al. A glia-derived signal regulating neuronal differentiation. J Neurosci 2000; 20: 8012-20.
    • (2000) J Neurosci , vol.20 , pp. 8012-8020
    • Blondel, O.1    Collin, C.2    McCarran, W.J.3
  • 5
    • 0033049956 scopus 로고    scopus 로고
    • Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide
    • Bassan M, Zamostiano R, Davidson A, et al. Complete sequence of a novel protein containing a femtomolar-activity-dependent neuroprotective peptide. J Neurochem 1999; 72: 1283-93.
    • (1999) J Neurochem , vol.72 , pp. 1283-1293
    • Bassan, M.1    Zamostiano, R.2    Davidson, A.3
  • 6
    • 7044260591 scopus 로고    scopus 로고
    • Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP
    • Zusev M, Gozes I. Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP. Regul Pept 2004; 123: 33-41.
    • (2004) Regul Pept , vol.123 , pp. 33-41
    • Zusev, M.1    Gozes, I.2
  • 7
    • 78349312687 scopus 로고    scopus 로고
    • Tau pathology and future therapeutics
    • Gozes I. Tau pathology and future therapeutics. Curr Alzheimer Res 2010; 7: 685-96.
    • (2010) Curr Alzheimer Res , vol.7 , pp. 685-696
    • Gozes, I.1
  • 9
    • 0042347559 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein: A novel gene essential for brain formation
    • Pinhasov A, Mandel S, Torchinsky A, et al. Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Brain Res Dev Brain Res 2003; 144: 83-90.
    • (2003) Brain Res Dev Brain Res , vol.144 , pp. 83-90
    • Pinhasov, A.1    Mandel, S.2    Torchinsky, A.3
  • 10
    • 33847364781 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis
    • Mandel S, Rechavi G, Gozes I. Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol 2007; 303: 814-24.
    • (2007) Dev Biol , vol.303 , pp. 814-824
    • Mandel, S.1    Rechavi, G.2    Gozes, I.3
  • 11
    • 36348968997 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex
    • Mandel S, Gozes I. Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex. J Biol Chem 2007; 282: 34448-56.
    • (2007) J Biol Chem , vol.282 , pp. 34448-56
    • Mandel, S.1    Gozes, I.2
  • 12
    • 79251580715 scopus 로고    scopus 로고
    • HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats
    • Mosch K, Franz H, Soeroes S, Singh PB, Fischle W. HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats. PLoS One 2011; 6: e15894.
    • (2011) PLoS One , vol.e15894 , pp. 6
    • Mosch, K.1    Franz, H.2    Soeroes, S.3    Singh, P.B.4    Fischle, W.5
  • 14
    • 20844438514 scopus 로고    scopus 로고
    • The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury
    • Gozes I, Zaltzman R, Hauser J, Brenneman DE, Shohami E, Hill JM. The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury. Curr Alzheimer Res 2005; 2: 149-53.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 149-153
    • Gozes, I.1    Zaltzman, R.2    Hauser, J.3    Brenneman, D.E.4    Shohami, E.5    Hill, J.M.6
  • 15
    • 77950187707 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease
    • Fernandez-Montesinos R, Torres M, Baglietto-Vargas D, et al. Activity-dependent neuroprotective protein (ADNP) expression in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer's disease. J Mol Neurosci 2010; 41: 114-20.
    • (2010) J Mol Neurosci , vol.41 , pp. 114-120
    • Fernandez-Montesinos, R.1    Torres, M.2    Baglietto-Vargas, D.3
  • 16
    • 33745223638 scopus 로고    scopus 로고
    • Recombinant activity-dependent neuroprotective protein protects cells against oxidative stress
    • Steingart RA, Gozes I. Recombinant activity-dependent neuroprotective protein protects cells against oxidative stress. Mol Cell Endocrinol 2006; 252: 148-53.
    • (2006) Mol Cell Endocrinol , vol.252 , pp. 148-153
    • Steingart, R.A.1    Gozes, I.2
  • 17
    • 0035808175 scopus 로고    scopus 로고
    • Cloning and characterization of the human activity-dependent neuroprotective protein
    • Zamostiano R, Pinhasov A, Gelber E, et al. Cloning and characterization of the human activity-dependent neuroprotective protein. J Biol Chem 2001; 276: 708-14.
    • (2001) J Biol Chem , vol.276 , pp. 708-714
    • Zamostiano, R.1    Pinhasov, A.2    Gelber, E.3
  • 18
    • 0141748174 scopus 로고    scopus 로고
    • The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome
    • Poggi SH, Goodwin K, Hill JM, et al. The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome. Am J Obstet Gynecol 2003; 189: 790-3.
    • (2003) Am J Obstet Gynecol , vol.189 , pp. 790-793
    • Poggi, S.H.1    Goodwin, K.2    Hill, J.M.3
  • 19
    • 34848928509 scopus 로고    scopus 로고
    • The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways, and protects neurons co-cultured with astrocytes damaged by ethanol
    • Pascual M, Guerri C. The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways, and protects neurons co-cultured with astrocytes damaged by ethanol. J Neurochem 2007; 103: 557-68.
    • (2007) J Neurochem , vol.103 , pp. 557-568
    • Pascual, M.1    Guerri, C.2
  • 21
    • 34548259237 scopus 로고    scopus 로고
    • Multigene deletions on chromosome 20q13.13-q13.2 including SALL4 result in an expanded phenotype of Okihiro syndrome plus developmental delay
    • Borozdin W, Graham JM, Jr., Bohm D, et al. Multigene deletions on chromosome 20q13.13-q13.2 including SALL4 result in an expanded phenotype of Okihiro syndrome plus developmental delay. Hum Mutat 2007; 28: 830.
    • (2007) Hum Mutat , vol.28 , pp. 830
    • Borozdin, W.1    Graham Jr., J.M.2    Bohm, D.3
  • 22
    • 43649084518 scopus 로고    scopus 로고
    • Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure
    • Cosgrave AS, McKay JS, Bubb V, Morris R, Quinn JP, Thippeswamy T. Regulation of activity-dependent neuroprotective protein (ADNP) by the NO-cGMP pathway in the hippocampus during kainic acid-induced seizure. Neurobiol Dis 2008; 30: 281-292.
    • (2008) Neurobiol Dis , vol.30 , pp. 281-292
    • Cosgrave, A.S.1    McKay, J.S.2    Bubb, V.3    Morris, R.4    Quinn, J.P.5    Thippeswamy, T.6
  • 23
    • 70449650452 scopus 로고    scopus 로고
    • Expression of Activity- Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis
    • Braitch M, Kawabe K, Nyirenda M, et al. Expression of Activity- Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis. Neuroimmunomodulation 2009; 17: 120-5.
    • (2009) Neuroimmunomodulation , vol.17 , pp. 120-125
    • Braitch, M.1    Kawabe, K.2    Nyirenda, M.3
  • 24
    • 79953746464 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia
    • Dresner E, Agam G, Gozes I. Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia. Eur Neuropsychopharmacol 2011; 21: 355-61.
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 355-361
    • Dresner, E.1    Agam, G.2    Gozes, I.3
  • 25
    • 45849101215 scopus 로고    scopus 로고
    • Xenon induces transcription of ADNP in neonatal rat brain
    • Cattano D, Valleggi S, Ma D, et al. Xenon induces transcription of ADNP in neonatal rat brain. Neurosci Lett 2008; 440: 217-21.
    • (2008) Neurosci Lett , vol.440 , pp. 217-221
    • Cattano, D.1    Valleggi, S.2    Ma, D.3
  • 26
    • 41749116612 scopus 로고    scopus 로고
    • Silencing of the ADNP- family member, ADNP2, results in changes in cellular viability under oxidative stress
    • Kushnir M, Dresner E, Mandel S, Gozes I. Silencing of the ADNP- family member, ADNP2, results in changes in cellular viability under oxidative stress. J Neurochem 2008; 105: 537-45.
    • (2008) J Neurochem , vol.105 , pp. 537-545
    • Kushnir, M.1    Dresner, E.2    Mandel, S.3    Gozes, I.4
  • 27
    • 35548974346 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model
    • Vulih-Shultzman I, Pinhasov A, Mandel S, Grigoriadis N, Touloumi O, Pittel Z, et al. Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model. J Pharmacol Exp Ther 2007; 323: 438-49.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 438-449
    • Vulih-Shultzman, I.1    Pinhasov, A.2    Mandel, S.3    Grigoriadis, N.4    Touloumi, O.5    Pittel, Z.6
  • 28
    • 8844269512 scopus 로고    scopus 로고
    • Sexual dimorphism of activity- dependent neuroprotective protein in the mouse arcuate nucleus
    • Furman S, Hill JM, Vulih I, et al. Sexual dimorphism of activity- dependent neuroprotective protein in the mouse arcuate nucleus. Neurosci Lett 2005; 373: 73-8.
    • (2005) Neurosci Lett , vol.373 , pp. 73-78
    • Furman, S.1    Hill, J.M.2    Vulih, I.3
  • 29
    • 84863987458 scopus 로고    scopus 로고
    • Expression of activity-dependent neuroprotective protein in the brain of adult rats
    • Gennet N, Herden C, Bubb VJ, Quinn JP, Kipar A. Expression of activity-dependent neuroprotective protein in the brain of adult rats. Histol Histopathol 2008; 23: 309-17.
    • (2008) Histol Histopathol , vol.23 , pp. 309-317
    • Gennet, N.1    Herden, C.2    Bubb, V.J.3    Quinn, J.P.4    Kipar, A.5
  • 30
    • 49849083741 scopus 로고    scopus 로고
    • ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance
    • Mandel S, Spivak-Pohis I, Gozes I. ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance. J Mol Neurosci 2008; 35: 127-41.
    • (2008) J Mol Neurosci , vol.35 , pp. 127-141
    • Mandel, S.1    Spivak-Pohis, I.2    Gozes, I.3
  • 31
    • 20844437391 scopus 로고    scopus 로고
    • Subcellular localization and secretion of activity- Illana Gozes dependent neuroprotective protein in astrocytes
    • Furman S, Steingart RA, Mandel S, Hauser JM, Brenneman DE, Gozes I. Subcellular localization and secretion of activity- Illana Gozes dependent neuroprotective protein in astrocytes. Neuron Glia Biol 2004; 1: 193-9.
    • (2004) Neuron Glia Biol , vol.1 , pp. 193-199
    • Furman, S.1    Steingart, R.A.2    Mandel, S.3    Hauser, J.M.4    Brenneman, D.E.5    Gozes, I.6
  • 32
    • 0034704078 scopus 로고    scopus 로고
    • Novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1
    • Underhill C, Qutob MS, Yee SP, Torchia J. A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1. J Biol Chem 2000; 275: 40463-70.
    • (2000) J Biol Chem , vol.275 , pp. 40463-70
    • Underhill, C.1    Qutob, M.S.2    Yee, S.P.3    Torchia, J.A.4
  • 33
    • 0036297928 scopus 로고    scopus 로고
    • Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes
    • Dellaire G, Makarov EM, Cowger JJ, et al. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol Cell Biol 2002; 22: 5141-56.
    • (2002) Mol Cell Biol , vol.22 , pp. 5141-5156
    • Dellaire, G.1    Makarov, E.M.2    Cowger, J.J.3
  • 34
    • 77952945262 scopus 로고    scopus 로고
    • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron- specific gene repression
    • de Barreda EG, Dawson HN, Vitek MP, Avila J. Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron- specific gene repression. FEBS Lett 2010; 584: 2265-70.
    • (2010) FEBS Lett , vol.584 , pp. 2265-2270
    • de Barreda, E.G.1    Dawson, H.N.2    Vitek, M.P.3    Avila, J.4
  • 35
    • 0031596284 scopus 로고    scopus 로고
    • Evolution of neuronal changes in the course of Alzheimer's disease
    • Braak H, Braak E. Evolution of neuronal changes in the course of Alzheimer's disease. J Neural Transm Suppl 1998; 53: 127-40.
    • (1998) J Neural Transm Suppl , vol.53 , pp. 127-140
    • Braak, H.1    Braak, E.2
  • 36
    • 79958132423 scopus 로고    scopus 로고
    • Davunetide (NAP) pharmacology: Neuroprotection and tau
    • In: Martinez A, editor, Cambridge: Royal Society of Chemistry
    • Gozes I. Davunetide (NAP) pharmacology: Neuroprotection and tau. In: Martinez A, editor. Emerging Drugs and Targets for Alzheimer's Disease. 1st ed. Cambridge: Royal Society of Chemistry, 2010: 108-28.
    • (2010) Emerging Drugs and Targets For Alzheimer's Disease. 1st Ed , pp. 108-128
    • Gozes, I.1
  • 37
    • 3142582005 scopus 로고    scopus 로고
    • A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication
    • Divinski I, Mittelman L, Gozes I. A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication. J Biol Chem 2004; 279: 28531-8.
    • (2004) J Biol Chem , vol.279 , pp. 28531-28538
    • Divinski, I.1    Mittelman, L.2    Gozes, I.3
  • 39
    • 37049015188 scopus 로고    scopus 로고
    • NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell
    • Gozes I, Divinski I. NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell. Curr Alzheimer Res 2007; 4: 507-9.
    • (2007) Curr Alzheimer Res , vol.4 , pp. 507-509
    • Gozes, I.1    Divinski, I.2
  • 40
    • 68949176990 scopus 로고    scopus 로고
    • NAP protects against cytochrome c release: Inhibition of the initiation of apoptosis
    • Zemlyak I, Sapolsky R, Gozes I. NAP protects against cytochrome c release: inhibition of the initiation of apoptosis. Eur J Pharmacol 2009; 618: 9-14.
    • (2009) Eur J Pharmacol , vol.618 , pp. 9-14
    • Zemlyak, I.1    Sapolsky, R.2    Gozes, I.3
  • 41
    • 70449535759 scopus 로고    scopus 로고
    • NAP protects against cyanide- related microtubule destruction
    • Zemlyak I, Sapolsky R, Gozes I. NAP protects against cyanide- related microtubule destruction. J Neural Transm 2009; 116: 1411-1416.
    • (2009) J Neural Transm , vol.116 , pp. 1411-1416
    • Zemlyak, I.1    Sapolsky, R.2    Gozes, I.3
  • 42
    • 79958124972 scopus 로고    scopus 로고
    • Protection against tauopathy by the drug candidates NAP (Davunetide) and D-SAL: Biochemical, cellular and behavioral aspects
    • In Press
    • Shiryaev N, Pickman R, Giladi E, Gozes I. Protection against tauopathy by the drug candidates NAP (Davunetide) and D-SAL: Biochemical, cellular and behavioral aspects. Curr Pharm Design 2011; In Press.
    • (2011) Curr Pharm Design
    • Shiryaev, N.1    Pickman, R.2    Giladi, E.3    Gozes, I.4
  • 43
    • 78751685767 scopus 로고    scopus 로고
    • Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases
    • Sudo H, Baas PW. Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases. Hum Mol Genet 2011; 20: 763-78.
    • (2011) Hum Mol Genet , vol.20 , pp. 763-778
    • Sudo, H.1    Baas, P.W.2
  • 44
    • 23744506898 scopus 로고    scopus 로고
    • PolyADP- ribosylation is involved in neurotrophic activity
    • Visochek L, Steingart RA, Vulih-Shultzman I, et al. PolyADP- ribosylation is involved in neurotrophic activity. J Neurosci 2005; 25: 7420-8.
    • (2005) J Neurosci , vol.25 , pp. 7420-7428
    • Visochek, L.1    Steingart, R.A.2    Vulih-Shultzman, I.3
  • 45
    • 16244393723 scopus 로고    scopus 로고
    • The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro
    • Lagreze WA, Pielen A, Steingart R, et al. The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro. Invest Ophthalmol Vis Sci 2005; 46: 933-8.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 933-938
    • Lagreze, W.A.1    Pielen, A.2    Steingart, R.3
  • 46
    • 33745685544 scopus 로고    scopus 로고
    • Spivak-Pohis I. Neurotrophic effects of the peptide NAP: A novel neuroprotective drug candidate
    • Gozes I, Spivak-Pohis I. Neurotrophic effects of the peptide NAP: A novel neuroprotective drug candidate. Curr Alzheimer Res 2006; 3: 197-9.
    • (2006) Curr Alzheimer Res , vol.3 , pp. 197-199
    • Gozes, I.1
  • 47
    • 22244491345 scopus 로고    scopus 로고
    • Activity-Dependent Neurotrophic Factor-9 and NAP Promote Neurite Outgrowth in Rat Hippocampal and Cortical Cultures
    • Smith-Swintosky VL, Gozes I, Brenneman DE, D'Andrea MR, Plata-Salaman CR. Activity-Dependent Neurotrophic Factor-9 and NAP Promote Neurite Outgrowth in Rat Hippocampal and Cortical Cultures. J Mol Neurosci 2005; 25: 225-38.
    • (2005) J Mol Neurosci , vol.25 , pp. 225-238
    • Smith-Swintosky, V.L.1    Gozes, I.2    Brenneman, D.E.3    D'andrea, M.R.4    Plata-Salaman, C.R.5
  • 48
    • 13444287985 scopus 로고    scopus 로고
    • The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection
    • Gozes I, Divinski I. The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection. J Alzheimers Dis 2004; 6: S37-41.
    • (2004) J Alzheimers Dis , vol.6 , pp. 37-41
    • Gozes, I.1    Divinski, I.2
  • 50
    • 34248354279 scopus 로고    scopus 로고
    • Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
    • Matsuoka Y, Gray A, Hirata-Fukae C, Sakura Minami S, Graeme Waterhouse E, Mattson MP, et al. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci 2007; 31: 165-170.
    • (2007) J Mol Neurosci , vol.31 , pp. 165-170
    • Matsuoka, Y.1    Gray, A.2    Hirata-Fukae, C.3    Sakura Minami, S.4    Graeme Waterhouse, E.5    Mattson, M.P.6    Et al.7
  • 51
    • 41149175575 scopus 로고    scopus 로고
    • A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
    • Matsuoka Y, Jouroukhin Y, Gray AJ, et al. A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther 2008; 325: 146-53.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 146-153
    • Matsuoka, Y.1    Jouroukhin, Y.2    Gray, A.J.3
  • 52
    • 77952632665 scopus 로고    scopus 로고
    • NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophrenia
    • Merenlender-Wagner A, Pikman R, Giladi E, Andrieux A, Gozes I. NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophrenia. Peptides 2010; 31: 1368-73.
    • (2010) Peptides , vol.31 , pp. 1368-1373
    • Merenlender-Wagner, A.1    Pikman, R.2    Giladi, E.3    Andrieux, A.4    Gozes, I.5
  • 53
    • 78751646734 scopus 로고    scopus 로고
    • Microtubules, schizophrenia and cognitive behavior: Preclinical development of davunetide (NAP) as a peptide-drug candidate
    • Gozes I. Microtubules, schizophrenia and cognitive behavior: Preclinical development of davunetide (NAP) as a peptide-drug candidate. Peptides 2011; 32: 428-31.
    • (2011) Peptides , vol.32 , pp. 428-431
    • Microtubules Gozes, I.1
  • 54
    • 70350757663 scopus 로고    scopus 로고
    • The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy
    • Zemlyak I, Manley N, Vulih-Shultzman I, Cutler AB, Graber K, Sapolsky RM, et al. The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. J Neurochem 2009; 111: 1252-63.
    • (2009) J Neurochem , vol.111 , pp. 1252-1263
    • Zemlyak, I.1    Manley, N.2    Vulih-Shultzman, I.3    Cutler, A.B.4    Graber, K.5    Sapolsky, R.M.6
  • 55
    • 79958170189 scopus 로고    scopus 로고
    • A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
    • Fleming SM, Mulligan CK, Richter F, et al. A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions. Mol Cell Neurosci 2010.
    • (2010) Mol Cell Neurosci
    • Fleming, S.M.1    Mulligan, C.K.2    Richter, F.3
  • 56
    • 78650679439 scopus 로고    scopus 로고
    • Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: Implications for cerebral palsy
    • Sokolowska P, Passemard S, Mok A, Schwendimann L, Gozes I, Gressens P. Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: implications for cerebral palsy. Neuroscience 2011; 173: 156-68.
    • (2011) Neuroscience , vol.173 , pp. 156-168
    • Sokolowska, P.1    Passemard, S.2    Mok, A.3    Schwendimann, L.4    Gozes, I.5    Gressens, P.6
  • 58
    • 79958010798 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP)- derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain
    • Sharma NK, Sethy NK, Meena RN, Ilavazhagan G, Das M, Bhargava K. Activity-dependent neuroprotective protein (ADNP)- derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain. Peptides 2011.
    • (2011) Peptides
    • Sharma, N.K.1    Sethy, N.K.2    Meena, R.N.3    Ilavazhagan, G.4    Das, M.5    Bhargava, K.6
  • 59
    • 33646595648 scopus 로고    scopus 로고
    • NAP: Research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP)
    • Gozes I, Morimoto BH, Tiong J, et al. NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS Drug Rev 2005; 11: 353-68.
    • (2005) CNS Drug Rev , vol.11 , pp. 353-368
    • Gozes, I.1    Morimoto, B.H.2    Tiong, J.3
  • 61
    • 78349313639 scopus 로고    scopus 로고
    • Effects of intranasal AL-108 (davunetide) on neurocognition and functional outcome in schizopherenia
    • Javitt DC. Effects of intranasal AL-108 (davunetide) on neurocognition and functional outcome in schizopherenia. Schizophrenia Research 2010; 117: 118-9.
    • (2010) Schizophrenia Research , vol.117 , pp. 118-119
    • Javitt, D.C.1
  • 62
    • 70350338273 scopus 로고    scopus 로고
    • Davunetide: Pharmacokinetics and distribution to brain after intravenous or intranasal administration to rat
    • Morimoto BH, de Lannoy I, Fox AW, Gozes I, Stewart AJ. Davunetide: Pharmacokinetics and distribution to brain after intravenous or intranasal administration to rat. chimica Oggi/CHEMISTRY today 2009; 27: 16-20.
    • (2009) Chimica Oggi/CHEMISTRY Today , vol.27 , pp. 16-20
    • Morimoto, B.H.1    de Lannoy, I.2    Fox, A.W.3    Gozes, I.4    Stewart, A.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.