Stable isotope-resolved metabolomics and applications for drug development

Pharmacology and Therapeutics

Volumn 133, Issue 3, 2012, Pages 366-391

  Fan, Teresa W M ^a   Lorkiewicz, Pawel K ^a   Sellers, Katherine ^a   Moseley, Hunter N B ^a   Higashi, Richard M ^a   Lane, Andrew N ^a,b  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b University of Louisville School of Medicine   (United States)

Author keywords

Drug discovery; Metabolic compartmentation and regulation; Metabolomics; Pathway reconstruction; Stable isotope tracing; Systems biochemistry

Indexed keywords

CARBON 11; CARBON 13; CISPLATIN; CYCLOPHOSPHAMIDE; DOXYCYCLINE; ETOPOSIDE; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; FLUOROURACIL; ISOCITRATE DEHYDROGENASE; LACTATE DEHYDROGENASE; METHYLSELENINIC ACID; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; NITROGEN 13; NITROGEN 15; OXYGEN 15; PACLITAXEL; PHOSPHORUS 31; PYRUVATE CARBOXYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SELENIUM DERIVATIVE; SPHINGOMYELIN; STABLE ISOTOPE; TAMOXIFEN; TEMOZOLOMIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; VALPROIC ACID; VERAPAMIL;

BIOINFORMATICS; BREAST CANCER; CANCER CELL; CARCINOGENESIS; CENTRAL NERVOUS SYSTEM; CITRIC ACID CYCLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG RESEARCH; DRUG SYNTHESIS; DRUG TARGETING; FEEDBACK SYSTEM; FLUORESCENCE IMAGING; FLUORESCENCE RESONANCE ENERGY TRANSFER; FOURIER TRANSFORM MASS SPECTROMETRY; FUNCTIONAL GENOMICS; GEL CHROMATOGRAPHY; HEAD AND NECK CANCER; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOMEOSTASIS; HUMAN; HYPERPOLARIZATION; IN VIVO STUDY; ION CYCLOTRON RESONANCE MASS SPECTROMETRY; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; LYMPHOMA; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLISM; METABOLOME; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEOMICS; REVIEW; SIGNAL TRANSDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; X RAY DIFFRACTION;

ANIMALS; DIAGNOSTIC IMAGING; DRUG DESIGN; HUMANS; ISOTOPE LABELING; MAGNETIC RESONANCE SPECTROSCOPY; METABOLOMICS;

EID: 84856426996     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.12.007     Document Type: Review

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