메뉴 건너뛰기




Volumn 178, Issue 1, 2007, Pages 93-105

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; GLUTAMINE; MYC PROTEIN;

EID: 34347402459     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200703099     Document Type: Article
Times cited : (576)

References (71)
  • 1
    • 23144464363 scopus 로고    scopus 로고
    • Transcriptional regulation and transformation by Myc proteins
    • Adhikary, S., and M. Eilers. 2005. Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6:635-645.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 635-645
    • Adhikary, S.1    Eilers, M.2
  • 2
    • 0025232412 scopus 로고
    • Metabolism and action of amino acid analog anti-cancer agents
    • Ahluwalia, G.S., J.L. Grem, Z. Hao, and D.A. Cooney. 1990. Metabolism and action of amino acid analog anti-cancer agents. Pharmacol. Ther. 46:243-271.
    • (1990) Pharmacol. Ther , vol.46 , pp. 243-271
    • Ahluwalia, G.S.1    Grem, J.L.2    Hao, Z.3    Cooney, D.A.4
  • 4
    • 0031427398 scopus 로고    scopus 로고
    • Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines
    • Anderson, C.P., J. Tsai, W. Chan, C.K. Park, L. Tian, R.M. Lui, H.J. Forman, and C.P. Reynolds. 1997. Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines. Eur. J. Cancer. 33:2016-2019.
    • (1997) Eur. J. Cancer , vol.33 , pp. 2016-2019
    • Anderson, C.P.1    Tsai, J.2    Chan, W.3    Park, C.K.4    Tian, L.5    Lui, R.M.6    Forman, H.J.7    Reynolds, C.P.8
  • 5
    • 0026619273 scopus 로고
    • Deviant energetic metabolism of glycolytic cancer cells
    • Baggetto, L.G. 1992. Deviant energetic metabolism of glycolytic cancer cells. Biochimie. 74:959-974.
    • (1992) Biochimie , vol.74 , pp. 959-974
    • Baggetto, L.G.1
  • 7
    • 0000416021 scopus 로고
    • Lactate dehydrogenase assay with pyruvate and NADH
    • H.U. Bergmeyer, editor. Academic Press, New York. pp
    • Bergmeyer, H.U. 1974. Lactate dehydrogenase assay with pyruvate and NADH. In Methods of Enzymatic Analysis. Vol. 2. H.U. Bergmeyer, editor. Academic Press, New York. pp. 574-579.
    • (1974) Methods of Enzymatic Analysis , vol.2 , pp. 574-579
    • Bergmeyer, H.U.1
  • 12
    • 0024396222 scopus 로고
    • Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells
    • Eilers, M., D. Picard, K.R. Yamamoto, and J.M. Bishop. 1989. Chimaeras of myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature. 340:66-68.
    • (1989) Nature , vol.340 , pp. 66-68
    • Eilers, M.1    Picard, D.2    Yamamoto, K.R.3    Bishop, J.M.4
  • 13
    • 0029022365 scopus 로고
    • Involvement of an ICE-like protease in Fas-mediated apoptosis
    • Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature. 375:78-81.
    • (1995) Nature , vol.375 , pp. 78-81
    • Enari, M.1    Hug, H.2    Nagata, S.3
  • 14
    • 0034722379 scopus 로고    scopus 로고
    • Caspases disrupt the nuclear-cytoplasmic barrier
    • Faleiro, L., and Y. Lazebnik. 2000. Caspases disrupt the nuclear-cytoplasmic barrier. J. Cell Biol. 151:951-959.
    • (2000) J. Cell Biol , vol.151 , pp. 951-959
    • Faleiro, L.1    Lazebnik, Y.2
  • 16
    • 32444440620 scopus 로고    scopus 로고
    • Stressing out over survival: Glutamine as an apoptotic modulator
    • Fuchs, B.C., and B.P. Bode. 2006. Stressing out over survival: glutamine as an apoptotic modulator. J. Surg. Res. 131:26-40.
    • (2006) J. Surg. Res , vol.131 , pp. 26-40
    • Fuchs, B.C.1    Bode, B.P.2
  • 17
    • 34147172349 scopus 로고    scopus 로고
    • HIF-1-regulated glucose metabolism: A key to apoptosis resistance?
    • Fulda, S., and K.M. Debatin. 2007. HIF-1-regulated glucose metabolism: a key to apoptosis resistance? Cell Cycle. 6:790-792.
    • (2007) Cell Cycle , vol.6 , pp. 790-792
    • Fulda, S.1    Debatin, K.M.2
  • 18
    • 33744969828 scopus 로고    scopus 로고
    • Energy deregulation: Licensing tumors to grow
    • Garber, K. 2006. Energy deregulation: licensing tumors to grow. Science. 312:1158-1159.
    • (2006) Science , vol.312 , pp. 1158-1159
    • Garber, K.1
  • 19
    • 3442886811 scopus 로고    scopus 로고
    • The pathophysiology of mitochondrial cell death
    • Green, D.R., and G. Kroemer. 2004. The pathophysiology of mitochondrial cell death. Science. 305:626-629.
    • (2004) Science , vol.305 , pp. 626-629
    • Green, D.R.1    Kroemer, G.2
  • 20
    • 0018666729 scopus 로고
    • Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
    • Griffith, O.W., and A. Meister. 1979. Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J. Biol. Chem. 254:7558-7560.
    • (1979) J. Biol. Chem , vol.254 , pp. 7558-7560
    • Griffith, O.W.1    Meister, A.2
  • 21
    • 33645855889 scopus 로고    scopus 로고
    • Oxidative stress is not required for the induction of apoptosis upon glutamine starvation of Sp2/0-Ag14 hybridoma cells
    • Guerin, P.J., T. Furtak, K. Eng, and E.R. Gauthier. 2006. Oxidative stress is not required for the induction of apoptosis upon glutamine starvation of Sp2/0-Ag14 hybridoma cells. Eur. J. Cell Biol. 85:355-365.
    • (2006) Eur. J. Cell Biol , vol.85 , pp. 355-365
    • Guerin, P.J.1    Furtak, T.2    Eng, K.3    Gauthier, E.R.4
  • 22
    • 6344243173 scopus 로고    scopus 로고
    • Beginnings of a signal-transduction pathway for bioenergetic control of cell survival
    • Hammerman, P.S., C.J. Fox, and C.B. Thompson. 2004. Beginnings of a signal-transduction pathway for bioenergetic control of cell survival. Trends Biochem. Sci. 29:586-592.
    • (2004) Trends Biochem. Sci , vol.29 , pp. 586-592
    • Hammerman, P.S.1    Fox, C.J.2    Thompson, C.B.3
  • 24
    • 17144424622 scopus 로고    scopus 로고
    • Translational control in stress and apoptosis
    • Holcik, M., and N. Sonenberg. 2005. Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 6:318-327.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 318-327
    • Holcik, M.1    Sonenberg, N.2
  • 27
    • 0014481891 scopus 로고
    • The proportionality of glutaminase content to growth rate and morphology of rat neoplasms
    • Knox, W.E., M.L. Horowitz, and G.H. Friedell. 1969. The proportionality of glutaminase content to growth rate and morphology of rat neoplasms. Cancer Res. 29:669-680.
    • (1969) Cancer Res , vol.29 , pp. 669-680
    • Knox, W.E.1    Horowitz, M.L.2    Friedell, G.H.3
  • 28
    • 0015507567 scopus 로고
    • Possibility for the transfer of reducing equivalents from the cytosol to the mitochondrial compartment in Ehrlich ascites tumor cells by the malate-aspartate shuttle
    • Kovacevic, Z. 1972. Possibility for the transfer of reducing equivalents from the cytosol to the mitochondrial compartment in Ehrlich ascites tumor cells by the malate-aspartate shuttle. Eur. J. Biochem. 25:372-378.
    • (1972) Eur. J. Biochem , vol.25 , pp. 372-378
    • Kovacevic, Z.1
  • 29
    • 0026060803 scopus 로고
    • Control and function of the transamination pathways of glutamine oxidation in tumour cells
    • Kovacevic, Z., O. Brkljac, and K. Bajin. 1991. Control and function of the transamination pathways of glutamine oxidation in tumour cells. Biochem. J. 273:271-275.
    • (1991) Biochem. J , vol.273 , pp. 271-275
    • Kovacevic, Z.1    Brkljac, O.2    Bajin, K.3
  • 30
    • 33749052511 scopus 로고    scopus 로고
    • Rheostat control of gene expression by metabolites
    • Ladurner, A.G. 2006. Rheostat control of gene expression by metabolites. Mol. Cell. 24:1-11.
    • (2006) Mol. Cell , vol.24 , pp. 1-11
    • Ladurner, A.G.1
  • 31
    • 0036182507 scopus 로고    scopus 로고
    • A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy
    • Le Belle, J.E., N.G. Harris, S.R. Williams, and K.K. Bhakoo. 2002. A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy. NMR Biomed. 15:37-44.
    • (2002) NMR Biomed , vol.15 , pp. 37-44
    • Le Belle, J.E.1    Harris, N.G.2    Williams, S.R.3    Bhakoo, K.K.4
  • 33
    • 0014524860 scopus 로고
    • Glutaminase activities and growth rates of rat hepatomas
    • Linder-Horowitz, M., W.E. Knox, and H.P. Morris. 1969. Glutaminase activities and growth rates of rat hepatomas. Cancer Res. 29:1195-1199.
    • (1969) Cancer Res , vol.29 , pp. 1195-1199
    • Linder-Horowitz, M.1    Knox, W.E.2    Morris, H.P.3
  • 34
    • 0021958778 scopus 로고    scopus 로고
    • Linker, W., M. Loffler, and F. Schneider. 1985. Uridine, but not cytidine can sustain growth of Ehrlich ascites tumor cells in glucose-deprived medium with altered proliferation kinetics. Eur. J. Cell Biol. 36:176-181.
    • Linker, W., M. Loffler, and F. Schneider. 1985. Uridine, but not cytidine can sustain growth of Ehrlich ascites tumor cells in glucose-deprived medium with altered proliferation kinetics. Eur. J. Cell Biol. 36:176-181.
  • 35
    • 0029002136 scopus 로고
    • A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
    • Littlewood, T.D., D.C. Hancock, P.S. Danielian, M.G. Parker, and G.I. Evan. 1995. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23:1686-1690.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1686-1690
    • Littlewood, T.D.1    Hancock, D.C.2    Danielian, P.S.3    Parker, M.G.4    Evan, G.I.5
  • 36
    • 73049133557 scopus 로고
    • The measurement of pyridine nucleotides by enzymatic cycling
    • Lowry, O.H., J.V. Passonneau, D.W. Schulz, and M.K. Rock. 1961. The measurement of pyridine nucleotides by enzymatic cycling. J. Biol. Chem. 236:2746-2755.
    • (1961) J. Biol. Chem , vol.236 , pp. 2746-2755
    • Lowry, O.H.1    Passonneau, J.V.2    Schulz, D.W.3    Rock, M.K.4
  • 38
    • 0034856827 scopus 로고    scopus 로고
    • Glutamine and cancer
    • discussion 2550S-1S
    • Medina, M.A. 2001. Glutamine and cancer. J. Nutr. 131:2539S-2542S (discussion 2550S-1S).
    • (2001) J. Nutr , vol.131
    • Medina, M.A.1
  • 39
    • 0021248051 scopus 로고
    • The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme
    • Moreadith, R.W., and A.L. Lehninger. 1984. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme. J. Biol. Chem. 259:6215-6221.
    • (1984) J. Biol. Chem , vol.259 , pp. 6215-6221
    • Moreadith, R.W.1    Lehninger, A.L.2
  • 40
    • 0037439054 scopus 로고    scopus 로고
    • c-MYC apoptotic function is mediated by NRF-1 target genes
    • Morrish, F., C. Giedt, and D. Hockenbery. 2003. c-MYC apoptotic function is mediated by NRF-1 target genes. Genes Dev. 17:240-255.
    • (2003) Genes Dev , vol.17 , pp. 240-255
    • Morrish, F.1    Giedt, C.2    Hockenbery, D.3
  • 41
    • 0028850950 scopus 로고
    • alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity
    • Nath, K.A., E.O. Ngo, R.P. Hebbel, A.J. Croatt, B. Zhou, and L.M. Nutter. 1995. alpha-Ketoacids scavenge H2O2 in vitro and in vivo and reduce menadione-induced DNA injury and cytotoxicity. Am. J. Physiol. 268:C227-C236.
    • (1995) Am. J. Physiol , vol.268
    • Nath, K.A.1    Ngo, E.O.2    Hebbel, R.P.3    Croatt, A.J.4    Zhou, B.5    Nutter, L.M.6
  • 42
    • 0033551374 scopus 로고    scopus 로고
    • MYC oncogenes and human neoplastic disease
    • Nesbit, C.E., J.M. Tersak, and E.V. Prochownik. 1999. MYC oncogenes and human neoplastic disease. Oncogene. 18:3004-3016.
    • (1999) Oncogene , vol.18 , pp. 3004-3016
    • Nesbit, C.E.1    Tersak, J.M.2    Prochownik, E.V.3
  • 43
    • 0021792065 scopus 로고
    • The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
    • Newsholme, E.A., B. Crabtree, and M.S. Ardawi. 1985. The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci. Rep. 5:393-400.
    • (1985) Biosci. Rep , vol.5 , pp. 393-400
    • Newsholme, E.A.1    Crabtree, B.2    Ardawi, M.S.3
  • 50
    • 0028077867 scopus 로고
    • Profile of energy metabolism in a murine hybridoma: Glucose and glutamine utilization
    • Petch, D., and M. Butler. 1994. Profile of energy metabolism in a murine hybridoma: glucose and glutamine utilization. J. Cell. Physiol. 161:71-76.
    • (1994) J. Cell. Physiol , vol.161 , pp. 71-76
    • Petch, D.1    Butler, M.2
  • 51
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • Ramanathan, A., C. Wang, and S.L. Schreiber. 2005. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc. Natl. Acad. Sci. USA. 102:5992-5997.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5992-5997
    • Ramanathan, A.1    Wang, C.2    Schreiber, S.L.3
  • 52
    • 0018386209 scopus 로고
    • Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells
    • Reitzer, L.J., B.M. Wice, and D. Kennell. 1979. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J. Biol. Chem. 254:2669-2676.
    • (1979) J. Biol. Chem , vol.254 , pp. 2669-2676
    • Reitzer, L.J.1    Wice, B.M.2    Kennell, D.3
  • 53
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E.P., D.R. Pilch, A.H. Orr, V.S. Ivanova, and W.M. Bonner. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273:5858-5868.
    • (1998) J. Biol. Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 54
    • 2142641665 scopus 로고    scopus 로고
    • Clinical applications of PET in oncology
    • Rohren, E.M., T.G. Turkington, and R.E. Coleman. 2004. Clinical applications of PET in oncology. Radiology. 231:305-332.
    • (2004) Radiology , vol.231 , pp. 305-332
    • Rohren, E.M.1    Turkington, T.G.2    Coleman, R.E.3
  • 55
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • Sabatini, D.M. 2006. mTOR and cancer: insights into a complex relationship. Nat. Rev. Cancer. 6:729-734.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 57
    • 0031790243 scopus 로고    scopus 로고
    • Flow cytometric determination of cellular thiols
    • Sen, C.K., S. Roy, and L. Packer. 1999. Flow cytometric determination of cellular thiols. Methods Enzymol. 299:247-258.
    • (1999) Methods Enzymol , vol.299 , pp. 247-258
    • Sen, C.K.1    Roy, S.2    Packer, L.3
  • 58
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw, R.J., and L.C. Cantley. 2006. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 60
    • 0032539534 scopus 로고    scopus 로고
    • A unique glucose-dependent apoptotic pathway induced by c-Myc
    • Shim, H., Y.S. Chun, B.C. Lewis, and C.V. Dang. 1998. A unique glucose-dependent apoptotic pathway induced by c-Myc. Proc. Natl. Acad. Sci. USA. 95:1511-1516.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1511-1516
    • Shim, H.1    Chun, Y.S.2    Lewis, B.C.3    Dang, C.V.4
  • 61
    • 0242569355 scopus 로고    scopus 로고
    • Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
    • Soga, T., Y. Ohashi, Y. Ueno, H. Naraoka, M. Tomita, and T. Nishioka. 2003. Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. J. Proteome Res. 2:488-494.
    • (2003) J. Proteome Res , vol.2 , pp. 488-494
    • Soga, T.1    Ohashi, Y.2    Ueno, Y.3    Naraoka, H.4    Tomita, M.5    Nishioka, T.6
  • 64
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability
    • Vafa, O., M. Wade, S. Kern, M. Beeche, T.K. Pandita, G.M. Hampton, and G.M. Wahl. 2002. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol. Cell. 9:1031-1044.
    • (2002) Mol. Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6    Wahl, G.M.7
  • 65
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. 1956. On the origin of cancer cells. Science. 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 66
    • 0019849530 scopus 로고
    • The continuous growth of vertebrate cells in the absence of sugar
    • Wice, B.M., L.J. Reitzer, and D. Kennell. 1981. The continuous growth of vertebrate cells in the absence of sugar. J. Biol. Chem. 256:7812-7819.
    • (1981) J. Biol. Chem , vol.256 , pp. 7812-7819
    • Wice, B.M.1    Reitzer, L.J.2    Kennell, D.3
  • 67
    • 0037098941 scopus 로고    scopus 로고
    • A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP
    • Yang, N.C., W.M. Ho, Y.H. Chen, and M.L. Hu. 2002. A convenient one-step extraction of cellular ATP using boiling water for the luciferin-luciferase assay of ATP. Anal. Biochem. 306:323-327.
    • (2002) Anal. Biochem , vol.306 , pp. 323-327
    • Yang, N.C.1    Ho, W.M.2    Chen, Y.H.3    Hu, M.L.4
  • 70
    • 0021366190 scopus 로고
    • Glutamine: A major energy source for cultured mammalian cells
    • Zielke, H.R., C.L. Zielke, and P.T. Ozand. 1984. Glutamine: a major energy source for cultured mammalian cells. Fed. Proc. 43:121-125.
    • (1984) Fed. Proc , vol.43 , pp. 121-125
    • Zielke, H.R.1    Zielke, C.L.2    Ozand, P.T.3
  • 71
    • 0347694776 scopus 로고    scopus 로고
    • Cancer metabolism: Facts, fantasy, and fiction
    • Zu, X.L., and M. Guppy. 2004. Cancer metabolism: facts, fantasy, and fiction. Biochem. Biophys. Res. Commun. 313:459-465.
    • (2004) Biochem. Biophys. Res. Commun , vol.313 , pp. 459-465
    • Zu, X.L.1    Guppy, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.