-
1
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O (1956) On the origin of cancer cells. Science 123:309-314
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
2
-
-
60249085118
-
Mitochondria in cancer: Not just innocent bystanders
-
Frezza C, Gottlieb E (2009) Mitochondria in cancer: Not just innocent bystanders. Semin Cancer Biol 19:4-11
-
(2009)
Semin Cancer Biol
, vol.19
, pp. 4-11
-
-
Frezza, C.1
Gottlieb, E.2
-
3
-
-
77949967131
-
Targeting metabolic transformation for cancer therapy
-
Tennant DA, Duran RV, Gottlieb E (2010) Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 10:267-277
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 267-277
-
-
Tennant, D.A.1
Duran, R.V.2
Gottlieb, E.3
-
4
-
-
69249247037
-
SDH5 mutations and familial paraganglioma: Somewhere Warburg is smiling
-
Kaelin WG Jr (2009) SDH5 mutations and familial paraganglioma: Somewhere Warburg is smiling. Cancer Cell 16:180-182
-
(2009)
Cancer Cell
, vol.16
, pp. 180-182
-
-
Kaelin Jr., W.G.1
-
5
-
-
73649145880
-
IDH1 mutations in gliomas: When an enzyme loses its grip
-
Frezza C, Tennant DA, Gottlieb E (2010) IDH1 mutations in gliomas: When an enzyme loses its grip. Cancer Cell 17:7-9
-
(2010)
Cancer Cell
, vol.17
, pp. 7-9
-
-
Frezza, C.1
Tennant, D.A.2
Gottlieb, E.3
-
6
-
-
0034602950
-
Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
-
DOI 10.1126/science.287.5454.848
-
Baysal BE, Ferrell RE, Willett-Brozick JE, Lawrence EC, Myssiorek D, Bosch A, van der Mey A, Taschner PE, Rubinstein WS, Myers EN, Richard CW 3rd, Cornelisse CJ, Devilee P, Devlin B (2000) Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848-851 (Pubitemid 30084326)
-
(2000)
Science
, vol.287
, Issue.5454
, pp. 848-851
-
-
Baysal, B.E.1
Ferrell, R.E.2
Willett-Brozick, J.E.3
Lawrence, E.C.4
Myssiorek, D.5
Bosch, A.6
Van Der Mey, A.7
Taschner, P.E.M.8
Rubinstein, W.S.9
Myers, E.N.10
Richard III, C.W.11
Cornelisse, C.J.12
Devilee, P.13
Devlin, B.14
-
7
-
-
0033767445
-
Mutations in SDHC cause autosomal dominant paraganglioma, type 3
-
Niemann S, Muller U (2000) Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Nat Genet 26:268-270
-
(2000)
Nat Genet
, vol.26
, pp. 268-270
-
-
Niemann, S.1
Muller, U.2
-
8
-
-
0034964421
-
Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
-
DOI 10.1086/321282
-
Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Skoldberg F, Husebye ES, Eng C, Maher ER (2001) Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. Am J Hum Genet 69:49-54 (Pubitemid 32614017)
-
(2001)
American Journal of Human Genetics
, vol.69
, Issue.1
, pp. 49-54
-
-
Astuti, D.1
Latif, F.2
Dallol, A.3
Dahia, P.L.M.4
Douglas, F.5
George, E.6
Skoldberg, F.7
Husebye, E.S.8
Eng, C.9
Maher, E.R.10
-
9
-
-
69549088424
-
SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma
-
Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J (2009) SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 325:1139-1142
-
(2009)
Science
, vol.325
, pp. 1139-1142
-
-
Hao, H.X.1
Khalimonchuk, O.2
Schraders, M.3
Dephoure, N.4
Bayley, J.P.5
Kunst, H.6
Devilee, P.7
Cremers, C.W.8
Schiffman, J.D.9
Bentz, B.G.10
Gygi, S.P.11
Winge, D.R.12
Kremer, H.13
Rutter, J.14
-
10
-
-
77950342008
-
SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma
-
Bayley JP, Kunst HP, Cascon A, Sampietro ML, Gaal J, Korpershoek E, Hinojar-Gutierrez A, Timmers HJ, Hoefsloot LH, Hermsen MA, Suarez C, Hussain AK, Vriends AH, Hes FJ, Jansen JC, Tops CM, Corssmit EP, de Knijff P, Lenders JW, Cremers CW, Devilee P, Dinjens WN, de Krijger RR, Robledo M (2010) SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma. Lancet Oncol 11:366-372
-
(2010)
Lancet Oncol
, vol.11
, pp. 366-372
-
-
Bayley, J.P.1
Kunst, H.P.2
Cascon, A.3
Sampietro, M.L.4
Gaal, J.5
Korpershoek, E.6
Hinojar-Gutierrez, A.7
Timmers, H.J.8
Hoefsloot, L.H.9
Hermsen, M.A.10
Suarez, C.11
Hussain, A.K.12
Vriends, A.H.13
Hes, F.J.14
Jansen, J.C.15
Tops, C.M.16
Corssmit, E.P.17
De Knijff, P.18
Lenders, J.W.19
Cremers, C.W.20
Devilee, P.21
Dinjens, W.N.22
De Krijger, R.R.23
Robledo, M.24
more..
-
11
-
-
77958164441
-
SDHA is a tumor suppressor gene causing paraganglioma
-
Burnichon N, Briere JJ, Libe R, Vescovo L, Riviere J, Tissier F, Jouanno E, Jeunemaitre X, Benit P, Tzagoloff A, Rustin P, Bertherat J, Favier J, Gimenez-Roqueplo AP (2010) SDHA is a tumor suppressor gene causing paraganglioma. Hum Mol Genet 19:3011-3020
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3011-3020
-
-
Burnichon, N.1
Briere, J.J.2
Libe, R.3
Vescovo, L.4
Riviere, J.5
Tissier, F.6
Jouanno, E.7
Jeunemaitre, X.8
Benit, P.9
Tzagoloff, A.10
Rustin, P.11
Bertherat, J.12
Favier, J.13
Gimenez-Roqueplo, A.P.14
-
12
-
-
77449097012
-
Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene
-
Housley SL, Lindsay RS, Young B, McConachie M, Mechan D, Baty D, Christie L, Rahilly M, Qureshi K, Fleming S (2010) Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene. Histopathology 56:405-408
-
(2010)
Histopathology
, vol.56
, pp. 405-408
-
-
Housley, S.L.1
Lindsay, R.S.2
Young, B.3
McConachie, M.4
Mechan, D.5
Baty, D.6
Christie, L.7
Rahilly, M.8
Qureshi, K.9
Fleming, S.10
-
13
-
-
51749113159
-
Germline SDHB mutations and familial renal cell carcinoma
-
Ricketts C, Woodward ER, Killick P, Morris MR, Astuti D, Latif F, Maher ER (2008) Germline SDHB mutations and familial renal cell carcinoma. J Natl Cancer Inst 100:1260-1262
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1260-1262
-
-
Ricketts, C.1
Woodward, E.R.2
Killick, P.3
Morris, M.R.4
Astuti, D.5
Latif, F.6
Maher, E.R.7
-
14
-
-
68449085905
-
SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis
-
Henderson A, Douglas F, Perros P, Morgan C, Maher ER (2009) SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis. Fam Can 8:257-260
-
(2009)
Fam Can
, vol.8
, pp. 257-260
-
-
Henderson, A.1
Douglas, F.2
Perros, P.3
Morgan, C.4
Maher, E.R.5
-
15
-
-
28544446058
-
Mitochondrial tumour suppressors: A genetic and biochemical update
-
DOI 10.1038/nrc1737
-
Gottlieb E, Tomlinson IP (2005) Mitochondrial tumour suppressors: A genetic and biochemical update. Nat Rev Cancer 5:857-866 (Pubitemid 41746030)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.11
, pp. 857-866
-
-
Gottlieb, E.1
Tomlinson, I.P.M.2
-
16
-
-
34447520170
-
Somatic SDHB mutation in an extraadrenal pheochromocytoma [12]
-
DOI 10.1056/NEJMc070010
-
van Nederveen FH, Korpershoek E, Lenders JW, de Krijger RR, Dinjens WN (2007) Somatic SDHB mutation in an extraadrenal pheochromocytoma. N Engl J Med 357:306-308 (Pubitemid 47080409)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.3
, pp. 306-308
-
-
Van Nederveen, F.H.1
Korpershoek, E.2
Lenders, J.W.M.3
De Krijger, R.R.4
Dinjens, W.N.M.5
-
17
-
-
66849135214
-
The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): Molecular genetics and clinical implications
-
Stratakis CA, Carney JA (2009) The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): Molecular genetics and clinical implications. J Intern Med 266:43-52
-
(2009)
J Intern Med
, vol.266
, pp. 43-52
-
-
Stratakis, C.A.1
Carney, J.A.2
-
18
-
-
0035853166
-
Inherited susceptibility to uterine leiomyomas and renal cell cancer
-
DOI 10.1073/pnas.051633798
-
Launonen V, Vierimaa O, Kiuru M, Isola J, Roth S, Pukkala E, Sistonen P, Herva R, Aaltonen LA (2001) Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci USA 98:3387-3392 (Pubitemid 32220855)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3387-3392
-
-
Launonen, V.1
Vierimaa, O.2
Kiuru, M.3
Isola, J.4
Roth, S.5
Pukkala, E.6
Sistonen, P.7
Herva, R.8
Aaltonen, L.A.9
-
19
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, Leigh I, Gorman P, Lamlum H, Rahman S, Roylance RR, Olpin S, Bevan S, Barker K, Hearle N, Houlston RS, Kiuru M, Lehtonen R, Karhu A, Vilkki S, Laiho P, Eklund C, Vierimaa O, Aittomaki K, Hietala M, Sistonen P, Paetau A, Salovaara R, Herva R, Launonen V, Aaltonen LA (2002) Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 30:406-410
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.5
Kelsell, D.6
Leigh, I.7
Gorman, P.8
Lamlum, H.9
Rahman, S.10
Roylance, R.R.11
Olpin, S.12
Bevan, S.13
Barker, K.14
Hearle, N.15
Houlston, R.S.16
Kiuru, M.17
Lehtonen, R.18
Karhu, A.19
Vilkki, S.20
Laiho, P.21
Eklund, C.22
Vierimaa, O.23
Aittomaki, K.24
Hietala, M.25
Sistonen, P.26
Paetau, A.27
Salovaara, R.28
Herva, R.29
Launonen, V.30
Aaltonen, L.A.31
more..
-
20
-
-
33747696434
-
Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations
-
DOI 10.1210/jc.2006-0183
-
Carvajal-Carmona LG, Alam NA, Pollard PJ, Jones AM, Barclay E, Wortham N, Pignatelli M, Freeman A, Pomplun S, Ellis I, Poulsom R, El-Bahrawy MA, Berney DM, Tomlinson IP (2006) Adult leydig cell tumors of the testis caused by germline fumarate hydratase mutations. J Clin Endocrinol Metab 91:3071-3075 (Pubitemid 44271757)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.8
, pp. 3071-3075
-
-
Carvajal-Carmona, L.G.1
Alam, N.A.2
Pollard, P.J.3
Jones, A.M.4
Barclay, E.5
Wortham, N.6
Pignatelli, M.7
Freeman, A.8
Pomplun, S.9
Ellis, I.10
Poulsom, R.11
El-Bahrawy, M.A.12
Berney, D.M.13
Tomlinson, I.P.M.14
-
21
-
-
33745234207
-
Increased risk of cancer in patients with fumarate hydratase germline mutation
-
DOI 10.1136/jmg.2005.036400
-
Lehtonen HJ, Kiuru M, Ylisaukko-Oja SK, Salovaara R, Herva R, Koivisto PA, Vierimaa O, Aittomaki K, Pukkala E, Launonen V, Aaltonen LA (2006) Increased risk of cancer in patients with fumarate hydratase germline mutation. J Med Genet 43:523-526 (Pubitemid 43927328)
-
(2006)
Journal of Medical Genetics
, vol.43
, Issue.6
, pp. 523-526
-
-
Lehtonen, H.J.1
Kiuru, M.2
Ylisaukko-Oja, S.K.3
Salovaara, R.4
Herva, R.5
Koivisto, P.A.6
Vierimaa, O.7
Aittomaki, K.8
Pukkala, E.9
Launonen, V.10
Aaltonen, L.A.11
-
22
-
-
77952536841
-
IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
-
Marcucci G, Maharry K, Wu YZ, Radmacher MD, Mrozek K, Margeson D, Holland KB, Whitman SP, Becker H, Schwind S, Metzeler KH, Powell BL, Carter TH, Kolitz JE, Wetzler M, Carroll AJ, Baer MR, Caligiuri MA, Larson RA, Bloomfield CD (2010) IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study. J Clin Oncol 28:2348-2355
-
(2010)
J Clin Oncol
, vol.28
, pp. 2348-2355
-
-
Marcucci, G.1
Maharry, K.2
Wu, Y.Z.3
Radmacher, M.D.4
Mrozek, K.5
Margeson, D.6
Holland, K.B.7
Whitman, S.P.8
Becker, H.9
Schwind, S.10
Metzeler, K.H.11
Powell, B.L.12
Carter, T.H.13
Kolitz, J.E.14
Wetzler, M.15
Carroll, A.J.16
Baer, M.R.17
Caligiuri, M.A.18
Larson, R.A.19
Bloomfield, C.D.20
more..
-
23
-
-
56749156414
-
Analysis of the IDH1 codon 132 mutation in brain tumors
-
Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, von Deimling A (2008) Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol 116:597-602
-
(2008)
Acta Neuropathol
, vol.116
, pp. 597-602
-
-
Balss, J.1
Meyer, J.2
Mueller, W.3
Korshunov, A.4
Hartmann, C.5
Von Deimling, A.6
-
24
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW (2008) An integrated genomic analysis of human glioblastoma multiforme. Science 321:1807-1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
Olivi, A.11
McLendon, R.12
Rasheed, B.A.13
Keir, S.14
Nikolskaya, T.15
Nikolsky, Y.16
Busam, D.A.17
Tekleab, H.18
Diaz Jr., L.A.19
Hartigan, J.20
Smith, D.R.21
Strausberg, R.L.22
Marie, S.K.23
Shinjo, S.M.24
Yan, H.25
Riggins, G.J.26
Bigner, D.D.27
Karchin, R.28
Papadopoulos, N.29
Parmigiani, G.30
Vogelstein, B.31
Velculescu, V.E.32
Kinzler, K.W.33
more..
-
25
-
-
58349111311
-
R132) occur frequently in high-grade gliomas but not in other solid tumors
-
R132) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat 30:7-11
-
(2009)
Hum Mutat
, vol.30
, pp. 7-11
-
-
Bleeker, F.E.1
Lamba, S.2
Leenstra, S.3
Troost, D.4
Hulsebos, T.5
Vandertop, W.P.6
Frattini, M.7
Molinari, F.8
Knowles, M.9
Cerrato, A.10
Rodolfo, M.11
Scarpa, A.12
Felicioni, L.13
Buttitta, F.14
Malatesta, S.15
Marchetti, A.16
Bardelli, A.17
-
26
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765-773
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
Kos, I.7
Batinic-Haberle, I.8
Jones, S.9
Riggins, G.J.10
Friedman, H.11
Friedman, A.12
Reardon, D.13
Herndon, J.14
Kinzler, K.W.15
Velculescu, V.E.16
Vogelstein, B.17
Bigner, D.D.18
-
27
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739-744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
Bennett, B.D.4
Bittinger, M.A.5
Driggers, E.M.6
Fantin, V.R.7
Jang, H.G.8
Jin, S.9
Keenan, M.C.10
Marks, K.M.11
Prins, R.M.12
Ward, P.S.13
Yen, K.E.14
Liau, L.M.15
Rabinowitz, J.D.16
Cantley, L.C.17
Thompson, C.B.18
Vander Heiden, M.G.19
Su, S.M.20
more..
-
28
-
-
0035213138
-
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway
-
DOI 10.1086/324413
-
Gimenez-Roqueplo AP, Favier J, Rustin P, Mourad JJ, Plouin PF, Corvol P, Rotig A, Jeunemaitre X (2001) The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am J Hum Genet 69:1186-1197 (Pubitemid 33124200)
-
(2001)
American Journal of Human Genetics
, vol.69
, Issue.6
, pp. 1186-1197
-
-
Gimenez-Roqueplo, A.-P.1
Favier, J.2
Rustin, P.3
Mourad, J.-J.4
Plouin, P.-F.5
Corvol, P.6
Rotig, A.7
Jeunemaitre, X.8
-
29
-
-
77955594623
-
A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas
-
Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nose V, Li C, Stiles CD (2005) A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet 1:72-80
-
(2005)
PLoS Genet
, vol.1
, pp. 72-80
-
-
Dahia, P.L.1
Ross, K.N.2
Wright, M.E.3
Hayashida, C.Y.4
Santagata, S.5
Barontini, M.6
Kung, A.L.7
Sanso, G.8
Powers, J.F.9
Tischler, A.S.10
Hodin, R.11
Heitritter, S.12
Moore, F.13
Dluhy, R.14
Sosa, J.A.15
Ocal, I.T.16
Benn, D.E.17
Marsh, D.J.18
Robinson, B.G.19
Schneider, K.20
Garber, J.21
Arum, S.M.22
Korbonits, M.23
Grossman, A.24
Pigny, P.25
Toledo, S.P.26
Nose, V.27
Li, C.28
Stiles, C.D.29
more..
-
30
-
-
29644433861
-
Distinct expression profile in fumarate-hydratase-deficient uterine fibroids
-
DOI 10.1093/hmg/ddi431
-
Vanharanta S, Pollard PJ, Lehtonen HJ, Laiho P, Sjoberg J, Leminen A, Aittomaki K, Arola J, Kruhoffer M, Orntoft TF, Tomlinson IP, Kiuru M, Arango D, Aaltonen LA (2006) Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Hum Mol Genet 15:97-103 (Pubitemid 43020108)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.1
, pp. 97-103
-
-
Vanharanta, S.1
Pollard, P.J.2
Lehtonen, H.J.3
Laiho, P.4
Sjoberg, J.5
Leminen, A.6
Aittomaki, K.7
Arola, J.8
Kruhoffer, M.9
Orntoft, T.F.10
Tomlinson, I.P.11
Kiuru, M.12
Arango, D.13
Aaltonen, L.A.14
-
31
-
-
49249127688
-
Cells silenced for SDHB expression display characteristic features of the tumor phenotype
-
Cervera AM, Apostolova N, Crespo FL, Mata M, McCreath KJ (2008) Cells silenced for SDHB expression display characteristic features of the tumor phenotype. Cancer Res 68:4058-4067
-
(2008)
Cancer Res
, vol.68
, pp. 4058-4067
-
-
Cervera, A.M.1
Apostolova, N.2
Crespo, F.L.3
Mata, M.4
McCreath, K.J.5
-
32
-
-
78549275858
-
Expression profiling in progressive stages of fumarate-hydratase deficiency: The contribution of metabolic changes to tumorigenesis
-
Ashrafian H, O'Flaherty L, Adam J, Steeples V, Chung YL, East P, Vanharanta S, Lehtonen H, Nye E, Hatipoglu E, Miranda M, Howarth K, Shukla D, Troy H, Griffiths J, Spencer-Dene B, Yusuf M, Volpi E, Maxwell PH, Stamp G, Poulsom R, Pugh CW, Costa B, Bardella C, Di Renzo MF, Kotlikoff MI, Launonen V, Aaltonen L, El-Bahrawy M, Tomlinson I, Pollard PJ (2010) Expression profiling in progressive stages of fumarate-hydratase deficiency: The contribution of metabolic changes to tumorigenesis. Cancer Res 70:9153-9165
-
(2010)
Cancer Res
, vol.70
, pp. 9153-9165
-
-
Ashrafian, H.1
O'Flaherty, L.2
Adam, J.3
Steeples, V.4
Chung, Y.L.5
East, P.6
Vanharanta, S.7
Lehtonen, H.8
Nye, E.9
Hatipoglu, E.10
Miranda, M.11
Howarth, K.12
Shukla, D.13
Troy, H.14
Griffiths, J.15
Spencer-Dene, B.16
Yusuf, M.17
Volpi, E.18
Maxwell, P.H.19
Stamp, G.20
Poulsom, R.21
Pugh, C.W.22
Costa, B.23
Bardella, C.24
Di Renzo, M.F.25
Kotlikoff, M.I.26
Launonen, V.27
Aaltonen, L.28
El-Bahrawy, M.29
Tomlinson, I.30
Pollard, P.J.31
more..
-
33
-
-
19944433653
-
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
-
DOI 10.1016/j.ccr.2004.11.022, PII S153561080400368X
-
Selak MA, Armour SM, MacKenzie ED, Boulahbel H, Watson DG, Mansfield KD, Pan Y, Simon MC, Thompson CB, Gottlieb E (2005) Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase. Cancer Cell 7:77-85 (Pubitemid 40126384)
-
(2005)
Cancer Cell
, vol.7
, Issue.1
, pp. 77-85
-
-
Selak, M.A.1
Armour, S.M.2
MacKenzie, E.D.3
Boulahbel, H.4
Watson, D.G.5
Mansfield, K.D.6
Pan, Y.7
Simon, M.C.8
Thompson, C.B.9
Gottlieb, E.10
-
34
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
DOI 10.1016/j.ccr.2005.06.017, PII S1535610805002266
-
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L (2005) HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability. Cancer Cell 8:143-153 (Pubitemid 41132743)
-
(2005)
Cancer Cell
, vol.8
, Issue.2
, pp. 143-153
-
-
Isaacs, J.S.1
Yun, J.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.-L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
Ratcliffe, P.J.11
Linehan, W.M.12
Neckers, L.13
-
35
-
-
26444570010
-
Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations
-
DOI 10.1093/hmg/ddi227
-
Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, Wortham NC, Hunt T, Mitchell M, Olpin S, Moat SJ, Hargreaves IP, Heales SJ, Chung YL, Griffiths JR, Dalgleish A, McGrath JA, Gleeson MJ, Hodgson SV, Poulsom R, Rustin P, Tomlinson IP (2005) Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 14:2231-2239 (Pubitemid 41418022)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.15
, pp. 2231-2239
-
-
Pollard, P.J.1
Briere, J.J.2
Alam, N.A.3
Barwell, J.4
Barclay, E.5
Wortham, N.C.6
Hunt, T.7
Mitchell, M.8
Olpin, S.9
Moat, S.J.10
Hargreaves, I.P.11
Heales, S.J.12
Chung, Y.L.13
Griffiths, J.R.14
Dalgleish, A.15
McGrath, J.A.16
Gleeson, M.J.17
Hodgson, S.V.18
Poulsom, R.19
Rustin, P.20
Tomlinson, I.P.M.21
more..
-
36
-
-
34047255064
-
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates
-
DOI 10.1074/jbc.M608337200
-
Hewitson KS, Lienard BM, McDonough MA, Clifton IJ, Butler D, Soares AS, Oldham NJ, McNeill LA, Schofield CJ (2007) Structural and mechanistic studies on the inhibition of the hypoxiainducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem 282:3293-3301 (Pubitemid 47084322)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.5
, pp. 3293-3301
-
-
Hewitson, K.S.1
Lienard, B.M.R.2
McDonough, M.A.3
Clifton, I.J.4
Butler, D.5
Soares, A.S.6
Oldham, N.J.7
McNeill, L.A.8
Schofield, C.J.9
-
37
-
-
34247553146
-
Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
-
DOI 10.1128/MCB.01927-06
-
MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E (2007) Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol 27:3282-3289 (Pubitemid 46685207)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.9
, pp. 3282-3289
-
-
MacKenzie, E.D.1
Selak, M.A.2
Tennant, D.A.3
Payne, L.J.4
Crosby, S.5
Frederiksen, C.M.6
Watson, D.G.7
Gottlieb, E.8
-
38
-
-
77950679964
-
The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization
-
Porcelli AM, Ghelli A, Ceccarelli C, Lang M, Cenacchi G, Capristo M, Pennisi LF, Morra I, Ciccarelli E, Melcarne A, Bartoletti-Stella A, Salfi N, Tallini G, Martinuzzi A, Carelli V, AttimonelliM, RugoloM, Romeo G, Gasparre G (2010) The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization. Hum Mol Genet 19:1019-1032
-
(2010)
Hum Mol Genet
, vol.19
, pp. 1019-1032
-
-
Porcelli, A.M.1
Ghelli, A.2
Ceccarelli, C.3
Lang, M.4
Cenacchi, G.5
Capristo, M.6
Pennisi, L.F.7
Morra, I.8
Ciccarelli, E.9
Melcarne, A.10
Bartoletti-Stella, A.11
Salfi, N.12
Tallini, G.13
Martinuzzi, A.14
Carelli, V.15
Attimonelli, M.16
Rugolo, M.17
Romeo, G.18
Gasparre, G.19
-
39
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
DOI 10.1016/j.cmet.2005.05.001, PII S1550413105001397
-
Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab 1:401-408 (Pubitemid 43960623)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
Chen, H.4
Liu, L.5
Mansfield, K.D.6
Simon, M.C.7
Hammerling, U.8
Schumacker, P.T.9
-
40
-
-
24144447915
-
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
-
DOI 10.1016/j.cmet.2005.05.003, PII S1550413105001415
-
Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab 1:393-399 (Pubitemid 43960625)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 393-399
-
-
Mansfield, K.D.1
Guzy, R.D.2
Pan, Y.3
Young, R.M.4
Cash, T.P.5
Schumacker, P.T.6
Simon, M.C.7
-
41
-
-
37849022071
-
Loss of the SdhB, but not the SdhA, subunit of complex II triggers ROS-dependent HIF activation and tumorigenesis
-
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT (2008) Loss of the SdhB, but not the SdhA, subunit of complex II triggers ROS-dependent HIF activation and tumorigenesis. Mol Cell Biol 28:718-731
-
(2008)
Mol Cell Biol
, vol.28
, pp. 718-731
-
-
Guzy, R.D.1
Sharma, B.2
Bell, E.3
Chandel, N.S.4
Schumacker, P.T.5
-
42
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L (2009) Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 29:4080-4090
-
(2009)
Mol Cell Biol
, vol.29
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Valera Romero, V.A.5
Yang, Y.6
Galindo, C.7
Mollapour, M.8
Scroggins, B.9
Goode, N.10
Lee, M.J.11
Gourlay, C.W.12
Trepel, J.13
Linehan, W.M.14
Neckers, L.15
-
43
-
-
33745591371
-
Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells
-
DOI 10.1016/j.bbabio.2006.05.015, PII S0005272806001411
-
Selak MA, Duran RV, Gottlieb E (2006) Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells. Biochim Biophys Acta 1757:567-572 (Pubitemid 43993873)
-
(2006)
Biochimica et Biophysica Acta - Bioenergetics
, vol.1757
, Issue.5-6
, pp. 567-572
-
-
Selak, M.A.1
Duran, R.V.2
Gottlieb, E.3
-
44
-
-
77956503391
-
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
-
O'Flaherty L, Adam J, Heather LC, Zhdanov AV, Chung YL, Miranda MX, Croft J, Olpin S, Clarke K, Pugh CW, Griffiths J, Papkovsky D, Ashrafian H, Ratcliffe PJ, Pollard PJ (2010) Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum Mol Genet 19:3844-3851
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3844-3851
-
-
O'Flaherty, L.1
Adam, J.2
Heather, L.C.3
Zhdanov, A.V.4
Chung, Y.L.5
Miranda, M.X.6
Croft, J.7
Olpin, S.8
Clarke, K.9
Pugh, C.W.10
Griffiths, J.11
Papkovsky, D.12
Ashrafian, H.13
Ratcliffe, P.J.14
Pollard, P.J.15
-
45
-
-
79951678403
-
MiR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity
-
(in press)
-
Puissegur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouyssegur J, Gounon P, Hofman P, Barbry P, Mari B (2011) miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity. Cell Death Differ (in press)
-
(2011)
Cell Death Differ
-
-
Puissegur, M.P.1
Mazure, N.M.2
Bertero, T.3
Pradelli, L.4
Grosso, S.5
Robbe-Sermesant, K.6
Maurin, T.7
Lebrigand, K.8
Cardinaud, B.9
Hofman, V.10
Fourre, S.11
Magnone, V.12
Ricci, J.E.13
Pouyssegur, J.14
Gounon, P.15
Hofman, P.16
Barbry, P.17
Mari, B.18
-
46
-
-
23644436667
-
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
-
DOI 10.1016/j.ccr.2005.06.015, PII S1535610805002242
-
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG Jr, Schlisio S (2005) Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer. Cancer Cell 8:155-167 (Pubitemid 41132744)
-
(2005)
Cancer Cell
, vol.8
, Issue.2
, pp. 155-167
-
-
Lee, S.1
Nakamura, E.2
Yang, H.3
Wei, W.4
Linggi, M.S.5
Sajan, M.P.6
Farese, R.V.7
Freeman, R.S.8
Carter, B.D.9
Kaelin Jr., W.G.10
Schlisio, S.11
-
47
-
-
41649116940
-
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
-
DOI 10.1101/gad.1648608
-
Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr (2008) The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev 22:884-893 (Pubitemid 351482842)
-
(2008)
Genes and Development
, vol.22
, Issue.7
, pp. 884-893
-
-
Schlisio, S.1
Kenchappa, R.S.2
Vredeveld, L.C.W.3
George, R.E.4
Stewart, R.5
Greulich, H.6
Shahriari, K.7
Nguyen, N.V.8
Pigny, P.9
Dahia, P.L.10
Pomeroy, S.L.11
Maris, J.M.12
Look, A.T.13
Meyerson, M.14
Peeper, D.S.15
Carter, B.D.16
Kaelin Jr., W.G.17
-
48
-
-
62049083152
-
Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas
-
Raimundo N, Vanharanta S, Aaltonen LA, Hovatta I, Suomalainen A (2009) Downregulation of SRF-FOS-JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas. Oncogene 28:1261-1273
-
(2009)
Oncogene
, vol.28
, pp. 1261-1273
-
-
Raimundo, N.1
Vanharanta, S.2
Aaltonen, L.A.3
Hovatta, I.4
Suomalainen, A.5
-
50
-
-
70450239624
-
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
-
Cervera AM, Bayley JP, Devilee P, McCreath KJ (2009) Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells. Mol Cancer 8:89
-
(2009)
Mol Cancer
, vol.8
, pp. 89
-
-
Cervera, A.M.1
Bayley, J.P.2
Devilee, P.3
McCreath, K.J.4
-
51
-
-
36249005491
-
Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
-
DOI 10.1093/hmg/ddm275
-
Smith EH, Janknecht R, Maher LJ 3rd (2007) Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet 16:3136-3148 (Pubitemid 350131331)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.24
, pp. 3136-3148
-
-
Smith, E.H.1
Janknecht, R.2
Maher III, J.L.3
-
52
-
-
77957666255
-
Histone methyl transferases and demethylases; can they link metabolism and transcription?
-
Teperino R, Schoonjans K, Auwerx J (2010) Histone methyl transferases and demethylases; can they link metabolism and transcription? Cell Metab 12:321-327
-
(2010)
Cell Metab
, vol.12
, pp. 321-327
-
-
Teperino, R.1
Schoonjans, K.2
Auwerx, J.3
-
53
-
-
58949097017
-
Regulation of Jumonji-domaincontaining histone demethylases by hypoxia-inducible factor (HIF)-1alpha
-
Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ, Ratcliffe PJ (2008) Regulation of Jumonji-domaincontaining histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J 416:387-394
-
(2008)
Biochem J
, vol.416
, pp. 387-394
-
-
Pollard, P.J.1
Loenarz, C.2
Mole, D.R.3
McDonough, M.A.4
Gleadle, J.M.5
Schofield, C.J.6
Ratcliffe, P.J.7
-
54
-
-
61349088682
-
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF
-
Beyer S, Kristensen MM, Jensen KS, Johansen JV, Staller P (2008) The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem 283:36542-36552
-
(2008)
J Biol Chem
, vol.283
, pp. 36542-36552
-
-
Beyer, S.1
Kristensen, M.M.2
Jensen, K.S.3
Johansen, J.V.4
Staller, P.5
-
55
-
-
77955757491
-
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth
-
Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL (2010) The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res 70:6456-6466
-
(2010)
Cancer Res
, vol.70
, pp. 6456-6466
-
-
Yang, J.1
Jubb, A.M.2
Pike, L.3
Buffa, F.M.4
Turley, H.5
Baban, D.6
Leek, R.7
Gatter, K.C.8
Ragoussis, J.9
Harris, A.L.10
-
56
-
-
2442649129
-
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors
-
DOI 10.1038/nature02488
-
He W, Miao FJ, Lin DC, Schwandner RT, Wang Z, Gao J, Chen JL, Tian H, Ling L (2004) Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. Nature 429:188-193 (Pubitemid 38656195)
-
(2004)
Nature
, vol.429
, Issue.6988
, pp. 188-193
-
-
He, W.1
Miao, F.J.-P.2
Lin, D.C.-H.3
Schwandner, R.T.4
Wang, Z.5
Gao, J.6
Chen, J.-L.7
Tlan, H.8
Ling, L.9
-
57
-
-
78649662102
-
High glucose and renin release: The role of succinate and GPR91
-
Peti-Peterdi J (2010) High glucose and renin release: The role of succinate and GPR91. Kidney Int 78:1214-1217
-
(2010)
Kidney Int
, vol.78
, pp. 1214-1217
-
-
Peti-Peterdi, J.1
-
58
-
-
53549118277
-
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
-
Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, Cho JH, Honore JC, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Beausejour C, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S (2008) The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med 14:1067-1076
-
(2008)
Nat Med
, vol.14
, pp. 1067-1076
-
-
Sapieha, P.1
Sirinyan, M.2
Hamel, D.3
Zaniolo, K.4
Joyal, J.S.5
Cho, J.H.6
Honore, J.C.7
Kermorvant-Duchemin, E.8
Varma, D.R.9
Tremblay, S.10
Leduc, M.11
Rihakova, L.12
Hardy, P.13
Klein, W.H.14
Mu, X.15
Mamer, O.16
Lachapelle, P.17
Di Polo, A.18
Beausejour, C.19
Andelfinger, G.20
Mitchell, G.21
Sennlaub, F.22
Chemtob, S.23
more..
-
59
-
-
68549122792
-
Novel role of fumarate metabolism in dahl-salt sensitive hypertension
-
Tian Z, Liu Y, Usa K, Mladinov D, Fang Y, Ding X, Greene AS, Cowley AW Jr, Liang M (2009) Novel role of fumarate metabolism in dahl-salt sensitive hypertension. Hypertension 54:255-260
-
(2009)
Hypertension
, vol.54
, pp. 255-260
-
-
Tian, Z.1
Liu, Y.2
Usa, K.3
Mladinov, D.4
Fang, Y.5
Ding, X.6
Greene, A.S.7
Cowley III, A.W.8
Liang, M.9
-
60
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, Reed JS, Robinson JS, Wylie T, Smith SM, Carmichael L, Eldred JM, Harris CC, Walker J, Peck JB, Du F, Dukes AF, Sanderson GE, Brummett AM, Clark E, McMichael JF, Meyer RJ, Schindler JK, Pohl CS, Wallis JW, Shi X, Lin L, Schmidt H, Tang Y, Haipek C, Wiechert ME, Ivy JV, Kalicki J, Elliott G, Ries RE, Payton JE, Westervelt P, Tomasson MH, Watson MA, Baty J, Heath S, Shannon WD, Nagarajan R, Link DC, Walter MJ, Graubert TA, DiPersio JF, Wilson RK, Ley TJ (2009) Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med 361:1058-1066
-
(2009)
N Engl J Med
, vol.361
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
Larson, D.E.4
McLellan, M.D.5
Chen, K.6
Koboldt, D.C.7
Fulton, R.S.8
Delehaunty, K.D.9
McGrath, S.D.10
Fulton, L.A.11
Locke, D.P.12
Magrini, V.J.13
Abbott, R.M.14
Vickery, T.L.15
Reed, J.S.16
Robinson, J.S.17
Wylie, T.18
Smith, S.M.19
Carmichael, L.20
Eldred, J.M.21
Harris, C.C.22
Walker, J.23
Peck, J.B.24
Du, F.25
Dukes, A.F.26
Sanderson, G.E.27
Brummett, A.M.28
Clark, E.29
McMichael, J.F.30
Meyer, R.J.31
Schindler, J.K.32
Pohl, C.S.33
Wallis, J.W.34
Shi, X.35
Lin, L.36
Schmidt, H.37
Tang, Y.38
Haipek, C.39
Wiechert, M.E.40
Ivy, J.V.41
Kalicki, J.42
Elliott, G.43
Ries, R.E.44
Payton, J.E.45
Westervelt, P.46
Tomasson, M.H.47
Watson, M.A.48
Baty, J.49
Heath, S.50
Shannon, W.D.51
Nagarajan, R.52
Link, D.C.53
Walter, M.J.54
Graubert, T.A.55
DiPersio, J.F.56
Wilson, R.K.57
Ley, T.J.58
more..
-
61
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, Sasaki M, Jin S, Schenkein DP, Su SM, Dang L, Fantin VR, Mak TW (2010) Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med 207:339-344
-
(2010)
J Exp Med
, vol.207
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
Sasaki, M.7
Jin, S.8
Schenkein, D.P.9
Su, S.M.10
Dang, L.11
Fantin, V.R.12
Mak, T.W.13
-
62
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB (2010) The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alphaketoglutarate to 2-hydroxyglutarate. Cancer Cell 17:225-234
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
Cross, J.R.7
Fantin, V.R.8
Hedvat, C.V.9
Perl, A.E.10
Rabinowitz, J.D.11
Carroll, M.12
Su, S.M.13
Sharp, K.A.14
Levine, R.L.15
Thompson, C.B.16
-
63
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao S, Lin Y, XuW, JiangW, Zha Z,Wang P, YuW, Li Z, Gong L, Peng Y, Ding J, Lei Q, Guan KL, Xiong Y (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324:261-265
-
(2009)
Science
, vol.324
, pp. 261-265
-
-
Zhao, S.1
Lin, Y.2
Xu, W.3
Jiang, W.4
Zha, Z.5
Wang, P.6
Yu, W.7
Li, Z.8
Gong, L.9
Peng, Y.10
Ding, J.11
Lei, Q.12
Guan, K.L.13
Xiong, Y.14
-
64
-
-
64849087954
-
Cancer. Puzzling patterns of predisposition
-
Pollard PJ, Ratcliffe PJ (2009) Cancer. Puzzling patterns of predisposition. Science 324:192-194
-
(2009)
Science
, vol.324
, pp. 192-194
-
-
Pollard, P.J.1
Ratcliffe, P.J.2
-
65
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, Li Y, Bhagwat N, Vasanthakumar A, Fernandez HF, Tallman MS, Sun Z, Wolniak K, Peeters JK, Liu W, Choe SE, Fantin VR, Paietta E, Lowenberg B, Licht JD, Godley LA, Delwel R, Valk PJ, Thompson CB, Levine RL, Melnick A (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18:553-567
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
Li, Y.7
Bhagwat, N.8
Vasanthakumar, A.9
Fernandez, H.F.10
Tallman, M.S.11
Sun, Z.12
Wolniak, K.13
Peeters, J.K.14
Liu, W.15
Choe, S.E.16
Fantin, V.R.17
Paietta, E.18
Lowenberg, B.19
Licht, J.D.20
Godley, L.A.21
Delwel, R.22
Valk, P.J.23
Thompson, C.B.24
Levine, R.L.25
Melnick, A.26
more..
-
66
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A (2010) Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468:839-843
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
Pape, U.J.4
Tahiliani, M.5
Bandukwala, H.S.6
An, J.7
Lamperti, E.D.8
Koh, K.P.9
Ganetzky, R.10
Liu, X.S.11
Aravind, L.12
Agarwal, S.13
Maciejewski, J.P.14
Rao, A.15
|