Modeling O2 transport within engineered hepatic devices

Biotechnology and Bioengineering

Volumn 82, Issue 1, 2003, Pages 12-27

  McClelland, Randall E ^a   MacDonald, Jeffrey M ^b   Coger, Robin N ^a  

^a University of North Carolina at Charlotte   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Bioartificial liver (BAL); Computational modeling; Diffusive and dispersive flows; Oxygen transport

Indexed keywords

ARTIFICIAL ORGANS; COLLAGEN; COMPUTATIONAL METHODS; FIBERS; OXYGEN;

BIOARTIFICIAL LIVER (BAL);

BIOTECHNOLOGY;

COLLAGEN; OXYGEN;

ARTICLE; ARTIFICIAL LIVER; BIOARTIFICIAL ORGAN; BIOENGINEERING; BIOLOGICAL MODEL; CELL VIABILITY; CHEMICAL MODIFICATION; COMPUTER MODEL; LIVER CELL; LIVER FUNCTION; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; POROSITY; PREDICTION; ANIMAL; ARTIFICIAL MEMBRANE; COMPARATIVE STUDY; COMPUTER SIMULATION; CULTURE TECHNIQUE; DIFFUSION; EQUIPMENT; EVALUATION; EXTRACELLULAR MATRIX; FLOW KINETICS; HUMAN; INSTRUMENTATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TISSUE ENGINEERING; TRANSPORT AT THE CELLULAR LEVEL; VALIDATION STUDY;

ANIMALS; BIOLOGICAL TRANSPORT; COLLAGEN; COMPUTER SIMULATION; CULTURE TECHNIQUES; DIFFUSION; EQUIPMENT FAILURE ANALYSIS; EXTRACELLULAR MATRIX; HEPATOCYTES; HUMANS; LIVER, ARTIFICIAL; MEMBRANES, ARTIFICIAL; MODELS, BIOLOGICAL; OXYGEN; OXYGEN CONSUMPTION; REPRODUCIBILITY OF RESULTS; RHEOLOGY; SENSITIVITY AND SPECIFICITY; TISSUE ENGINEERING;

EID: 0037420407     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/bit.10531     Document Type: Article

References (44)

1. Bader A, Knop E, Fruhauf N, Crome O, Boker K, Christians U, Oldhafer K, Ringe B, Pichlmayr R, Sewing K. 1995. Reconstruction of liver tissue in vitro: Geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artif Org 19:941-950.
2. Bhatia S, Yarmush M, Toner M. 1996. Controlling cell interactions by micropatterning in co-cultures: Hepatocytes and 3T3 fibroblasts. J Biomed Mater Res 32:1-11.
3. Bhatia S, Balis U, Yarmush M, Toner M. 1999. Effect of cell-cell interactions in preservation of cellular phenotype: Cocultivation of hepatocytes and nonparenchymal cells. FASEB J 13:1883-1900.
4. Brusse B, Gerlach J. 1999. Bioreactors for hybrid liver support: Historical aspects and novel designs. Ann NY Acad Sci 875:326-339.
5. Catapano G, DeBartolo L, Lombardi C, Drioli E. 1996. the effect of oxygen transport resistances on the viability and functions of isolated rat hepatocytes. Int J Artif Org 19:61-71.
6. Cussler EL. 1997. Diffusion mass transfer in fluid systems. New York: Cambridge University Press.
7. Davies M. 1999. Liquid ventilation. J Pediatr Child Health 35:434-437.
8. DeWiest J. 1969. Flow through porous materials. New York: Academic Press.
9. Dixit V. 1995. Transplantation of isolated hepatocytes and their role in extrahepatic life support systems. Scand J Gastroenterol 30:101-110.
10. Dixit V, Gitnick G. 1996. Artificial liver support: State of the art. Scand J Gastroenterol 31:101-114.
11. Dunn J, Yarmush M, Koebe H, Tompkins R. 1989, Hepatocyte function and extracellular matrix geometry: Long-term culture in a sandwich configuration. FASEB J 3:174-177.
12. Dunn J, Tompkins R, Yarmush M. 1991. Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Progr 7:237-245.
13. Geankoplis C, 1972. Mass transport phenomena, New York: Holt, Rinehart and Winston.
14. Glacken M, Fleischaker R, Sinskey A. 1983. Ann NY Acad Sci 413:355.
15. Hay P, Veitch A, Smith M, Cousins R, Gaylor J. 2000. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Org 24: 278-288.
16. Hughes R, Williams R. 1996. Use of bioartificial and artificial liver support devices. Semin Liver Dis 16:435-443.
17. Ijima H, Matsushita T, Nakazawa K, Fujii Y, Funatsu K. 1998. Hepatocyte spheroids in polyurethane foams: Functional analysis and application for a hybrid artificial liver. Tissue Eng 2:213-226.
18. Incropera F, DeWitt D. 1996a. Fundamentals of heat and mass transfer. New York: John Wiley & Sons.
19. Incropera F, DeWitt D. 1996b. Introduction to heat transfer. New York: John Wiley & Sons.
20. Kreyszig E. 1993. Advanced engineering mathematics. New York: John Wiley & Sons.
21. Ledezma G, Folch A, Bhatia S, Balis U, Yarmush M, Toner M. 1999. Numerical model of fluid flow and oxygen transport in a radial-flow microchannel containing hepatocytes. J Biomech Eng 121:58-64.
22. Leithold L. 1986. The calculus with analytic geometry. New York: Harper & Row.
23. Lide D. 1997. Handbook of chemistry and physics. Boca Raton, FL: CRC Press.
24. MacDonald J, Grillo M, Schmidlin O, Tajiri D, James T. 1998. NMR spectroscopy and MRI investigation of a potential bioartificial liver. NMR Biomed 11:55-66.
25. Macdonald J, Griffin J, Kubota H, Griffith L, Fair J, Reid L. 1999. Bioartificial livers. Boston: Birkhauser.
26. Martin, D. 1999. All you really need to know to interpret arterial blood gases. Philadelphia: Lippincott Williams and Wilkins.
27. McClelland R, Coger R. 2000. Use of micropathways to improve oxygen transport in a hepatic system. J Biomech Eng 122:268-273.
28. 2 transport within bioartificial liver devices. Proceedings of Summer Bioengineering Conference of the ASME. BED-50:547-548.
29. Mills A. 1999. Basic heat and mass transfer. Upper Saddle River, NJ: Prentice Hall.
30. Nyberg S, Shatford R, Peshwa M, White J, Cerra F, Hu W. 1993. Evaluation of a hepatocyte-entrapment hollow fiber bioreactor: A potential bioartificial liver. Biotechnol Bioeng 41:194-203.
31. Ozisik M. 1993. Heat conduction. New York: John Wiley & Sons.
32. Rotem A, Toner M, Tompkins R, Yarmush M. 1992. Oxygen uptake rates in cultured rat hepatocytes. Biotechnol Bioeng 40:1286-1291.
33. Sakai Y, Naruse K, Nagashima I, Muto T, Suzuki M. 1996. In vitro function of porcine hepatocyte spheroids in 100% human plasma. Cell Transplant 5(suppl):S41-S43.
34. Scheidegger A. 1958. Typical solutions of the differential equations of statistical theories of flow through porous media. Am Geophys Union Trans 39:929-932.
35. Schick M. 1999. In: Jsu J, editor. Surfactant science. New York: Marcel Dekker. p 1-10.
36. Simpson E. 1962. Transverse dispersion in liquid flow through porous media. Washington, DC: United States Department of Interior. p C1-C30.
37. Skibitzke H. 1964. Extending Darcy's concept of ground water motion. Washington, DC: United States Department of Interior. p F1-F6.
38. Stallman R. 1964. Multiphase fluids in porous media - a review of theories pertinent to hydrologic studies. Washington, DC: United States Department of the Interior. p E1-E17.
39. Sulieman S, Stevens J. 1987. The effect of oxygen tension on rat hepatocytes in short-term culture. In Vitro Cell Dev Biol 23:332-338.
40. Taguchi K, Matsushita M, Takahashi M, Uchino J. 1996. Development of a bioartificial liver with sandwiched-cultured hepatocytes between two collagen gel layers. Artif Org 20:178-185.
41. Tharakan J, Chau P. 1986. A radial flow hollow fiber bioreactor for the large-scale culture of mammalian cells. Biotechnol Bioeng 18: 329-342.
42. VanOss C. 1994. Interfacial forces in aqueous media. New York: Marcel Dekker.
43. Wolfe S, Hsu E, Reid L, MacDonald J. 2002. A novel multicoaxal hollow fiber bioreactor for adherent cell types. Part I: Hydrodynamic studies. Biotechnol Bioeng 77:83-90.
44. 2 distribution maps. Am J Physiol 270:1390-1397.