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Volumn 6, Issue 6, 2004, Pages 584-592

The promise of metabolomics in cancer molecular therapeutics

Author keywords

Chemoinformatics; Flux; Isotopomers; Mass spectrometry; Metabolomics; Nuclear magnetic resonance

Indexed keywords

ANALYTIC METHOD; CANCER CELL; CANCER THERAPY; CELL FUNCTION; CONTROLLED STUDY; GENE EXPRESSION; GENOMICS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INSTRUMENTATION; MASS SPECTROMETRY; METABOLISM; METABOLOMICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN FUNCTION; PROTEOMICS; REVIEW;

EID: 11344272281     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (50)

References (54)
  • 1
    • 84957940642 scopus 로고    scopus 로고
    • (Ed): John Wiley & Sons, New York, NY, USA
    • Karp G (Ed): Cancer. John Wiley & Sons, New York, NY, USA (2002).
    • (2002) Cancer
    • Karp, G.1
  • 2
    • 0034009502 scopus 로고    scopus 로고
    • Structural analysis of α-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene
    • Subramanian A, Miller DM: Structural analysis of α-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem (2000) 275 8):5958-5965.
    • (2000) J. Biol. Chem. , vol.275 , Issue.8 , pp. 5958-5965
    • Subramanian, A.1    Miller, D.M.2
  • 4
    • 0025946128 scopus 로고
    • Human eosinophil cytotoxicity-enhancing factor II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin adult T cell leukemia-derived factor
    • Balcewicz-Sablinska MK, Wollman EE, Gortl R, Silberstein DS: Human eosinophil cytotoxicity-enhancing factor II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin adult T cell leukemia-derived factor. J Immunol (1991) 147 7):2170-2174.
    • (1991) J. Immunol. , vol.147 , Issue.7 , pp. 2170-2174
    • Balcewicz-Sablinska, M.K.1    Wollman, E.E.2    Gortl, R.3    Silberstein, D.S.4
  • 6
    • 0037561649 scopus 로고    scopus 로고
    • The tumor metabolome
    • Mazurek S, Eigenbrodt E: The tumor metabolome. Anticancer Res (2003) 23(2A):1149-1154.
    • (2003) Anticancer Res. , vol.23 , Issue.2 A , pp. 1149-1154
    • Mazurek, S.1    Eigenbrodt, E.2
  • 7
    • 0035816464 scopus 로고    scopus 로고
    • Transcriptome meets metabolome: Hierarchical and metabolic regulation of the glycolytic pathway
    • ter Kuile BH, Westerhoff HV: Transcriptome meets metabolome: Hierarchical and metabolic regulation of the glycolytic pathway. Febs Lett (2001) 500(3):169-171.
    • (2001) Febs. Lett. , vol.500 , Issue.3 , pp. 169-171
    • Ter Kuile, B.H.1    Westerhoff, H.V.2
  • 8
    • 0001413420 scopus 로고    scopus 로고
    • Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures
    • Fan TWM: Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures. Prog NMR Spectrosc (1996) 28:161-219.
    • (1996) Prog. NMR Spectrosc. , vol.28 , pp. 161-219
    • Fan, T.W.M.1
  • 9
    • 0000324202 scopus 로고    scopus 로고
    • Recent advancement in profiling plant metabolites by multinuclear and multi-dimensional NMR
    • Shachar-Hill Y, Pfeffer PE (Eds), American Society of Plant Physiologists, Rockville, MD, USA
    • Fan TWM: Recent advancement in profiling plant metabolites by multinuclear and multi-dimensional NMR. In: Nuclear Magnetic Resonance in Plant Biology. Shachar-Hill Y, Pfeffer PE (Eds), American Society of Plant Physiologists, Rockville, MD, USA (1996 ):181-254.
    • (1996) Nuclear Magnetic Resonance in Plant Biology , pp. 181-254
    • Fan, T.W.M.1
  • 12
    • 3542995149 scopus 로고    scopus 로고
    • In Vivo and in vitro metabolomic analysis of anaerobic rice colleoptiles revealed unexpected pathways
    • Fan TWM, Lane AN, Higashi RM: In Vivo and in vitro metabolomic analysis of anaerobic rice colleoptiles revealed unexpected pathways. Russian J Plant Physiol (2003) 50 6):787-793.
    • (2003) Russian J. Plant Physiol. , vol.50 , Issue.6 , pp. 787-793
    • Fan, T.W.M.1    Lane, A.N.2    Higashi, R.M.3
  • 14
    • 0035232521 scopus 로고    scopus 로고
    • Metabolic engineering for L-lysine production by Corynebacterium glutamicum
    • de Graaf AA, Eggeling L, Sahm H: Metabolic engineering for L-lysine production by Corynebacterium glutamicum. Adv Biochem Eng Biotechnol (2001) 73:9-29.
    • (2001) Adv. Biochem. Eng. Biotechnol. , vol.73 , pp. 9-29
    • De Graaf, A.A.1    Eggeling, L.2    Sahm, H.3
  • 16
    • 0030656343 scopus 로고    scopus 로고
    • Anaerobic nitrate and ammonium metabolism in flood-tolerant rice coleoptiles
    • Fan TWM, Higashi RM, Frenkiel TA, Lane AN: Anaerobic nitrate and ammonium metabolism in flood-tolerant rice coleoptiles. J Exp Botany (1997) 48(314):1655-1666.
    • (1997) J. Exp. Botany , vol.48 , Issue.314 , pp. 1655-1666
    • Fan, T.W.M.1    Higashi, R.M.2    Frenkiel, T.A.3    Lane, A.N.4
  • 19
    • 0037447583 scopus 로고    scopus 로고
    • Polycyclic aromatic hydrocarbons disrupt axial development in sea urchin embryos through a β-catenin dependent pathway
    • Pillai MC, Vines CA, Wikramanayake AH, Cherr GN: Polycyclic aromatic hydrocarbons disrupt axial development in sea urchin embryos through a β-catenin dependent pathway. Toxicology (2003) 186(1-2):93-108.
    • (2003) Toxicology , vol.186 , Issue.1-2 , pp. 93-108
    • Pillai, M.C.1    Vines, C.A.2    Wikramanayake, A.H.3    Cherr, G.N.4
  • 20
    • 0642379467 scopus 로고    scopus 로고
    • Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid
    • Olivo M, Lau W, Manivasager V, Hoon TP, Christopher C: Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid. Int J Oncol (2003) 22 3):523-528.
    • (2003) Int. J. Oncol. , vol.22 , Issue.3 , pp. 523-528
    • Olivo, M.1    Lau, W.2    Manivasager, V.3    Hoon, T.P.4    Christopher, C.5
  • 21
    • 0033089192 scopus 로고    scopus 로고
    • Dependence of fibroblast autofluorescence properties on normal and transformed conditions. Role of the metabolic activity
    • Croce AC, Spano A, Locatelli D, Barni S, Sciola L, Bottiroli G: Dependence of fibroblast autofluorescence properties on normal and transformed conditions. Role of the metabolic activity. Photochem Photobiol (1999) 69(3):364-374.
    • (1999) Photochem. Photobiol. , vol.69 , Issue.3 , pp. 364-374
    • Croce, A.C.1    Spano, A.2    Locatelli, D.3    Barni, S.4    Sciola, L.5    Bottiroli, G.6
  • 23
    • 0028181705 scopus 로고
    • Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry
    • Strickland PT, Kang D, Bowman ED, Fitzwilliam A, Downing TE, Rothman N, Groopman JD, Weston A: Identification of 1-hydroxypyrene glucuronide as a major pyrene metabolite in human urine by synchronous fluorescence spectroscopy and gas chromatography-mass spectrometry. Carcinogenesis (1994) 15(3):483-487.
    • (1994) Carcinogenesis , vol.15 , Issue.3 , pp. 483-487
    • Strickland, P.T.1    Kang, D.2    Bowman, E.D.3    Fitzwilliam, A.4    Downing, T.E.5    Rothman, N.6    Groopman, J.D.7    Weston, A.8
  • 24
    • 0003489517 scopus 로고    scopus 로고
    • Protein NMR Spectroscopy: Principles and Practice
    • Academic Press, San Diego, CA, USA
    • Cavanagh J, Fairbrother WJ, Palmer AG, Skelton AG: Protein NMR Spectroscopy: Principles and Practice. Academic Press, San Diego, CA, USA (1996).
    • (1996)
    • Cavanagh, J.1    Fairbrother, W.J.2    Palmer, A.G.3    Skelton, A.G.4
  • 25
    • 0013671718 scopus 로고
    • 13C NMR spectroscopy
    • Levy GC (Ed), Wiley Interscience, New York, NY, USA
    • 13C NMR Spectroscopy. Levy GC (Ed), Wiley Interscience, New York, NY, USA (1984):197-238.
    • (1984) 13C NMR Spectroscopy , pp. 197-238
    • Bax, A.1
  • 27
    • 0035858482 scopus 로고    scopus 로고
    • Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS
    • Fan TWM, Lane AN, Shenker M, Bartley JP, Crowley D, Higashi RM: Comprehensive chemical profiling of gramineous plant root exudates using high-resolution NMR and MS. Phytochemistry (2001) 57 2):209-221.
    • (2001) Phytochemistry , vol.57 , Issue.2 , pp. 209-221
    • Fan, T.W.M.1    Lane, A.N.2    Shenker, M.3    Bartley, J.P.4    Crowley, D.5    Higashi, R.M.6
  • 33
    • 0035543716 scopus 로고    scopus 로고
    • Speciation of selenoamino acids, selenonium ions and inorganic selenium by ion exchange HPLC with mass spectrometric detection and its application to yeast and algae
    • Larsen EH, Hansen M, Fan T, Vahl M: Speciation of selenoamino acids, selenonium ions and inorganic selenium by ion exchange HPLC with mass spectrometric detection and its application to yeast and algae. J Anal Atomic Spectrom (2001) 16(12):1403-1408.
    • (2001) J. Anal. Atomic Spectrom. , vol.16 , Issue.12 , pp. 1403-1408
    • Larsen, E.H.1    Hansen, M.2    Fan, T.3    Vahl, M.4
  • 36
    • 0032532093 scopus 로고    scopus 로고
    • 31P NMR heteronuclear total correlation spectroscopy (heteroTOCSY)
    • 31P NMR heteronuclear total correlation spectroscopy (heteroTOCSY). Anal Biochem (1998) 263(2 ):139-149.
    • (1998) Anal. Biochem. , vol.263 , Issue.2 , pp. 139-149
    • Gradwell, M.J.1    Fan, T.W.M.2    Lane, A.N.3
  • 37
    • 0028174166 scopus 로고
    • 13C NMR analysis of acyl chain composition and organization of perirenal triacylglycerides in rats fed vegetable and fish oils
    • 13C NMR analysis of acyl chain composition and organization of perirenal triacylglycerides in rats fed vegetable and fish oils. J Lipid Res (1994) 35(4):678-689.
    • (1994) J. Lipid Res. , vol.35 , Issue.4 , pp. 678-689
    • Fan, T.W.1    Clifford, A.J.2    Higashi, R.M.3
  • 38
    • 0032532491 scopus 로고    scopus 로고
    • Biotransformations of selenium oxyanion by filamentous cyanophyte-dominated mat cultured from agricultural drainage waters
    • Fan TWM, Higashi RM, Lane AN: Biotransformations of selenium oxyanion by filamentous cyanophyte-dominated mat cultured from agricultural drainage waters. Environ Sci Technol (1998) 32 20):3185-3193.
    • (1998) Environ. Sci. Technol. , vol.32 , Issue.20 , pp. 3185-3193
    • Fan, T.W.M.1    Higashi, R.M.2    Lane, A.N.3
  • 40
    • 0021668048 scopus 로고
    • Application of in vivo NMR spectroscopy to cancer
    • Evanochko WT, Ng TC, Glickson JD: Application of in vivo NMR spectroscopy to cancer. Magn Reson Med (1984) 1 4):508-534.
    • (1984) Magn. Reson. Med. , vol.1 , Issue.4 , pp. 508-534
    • Evanochko, W.T.1    Ng, T.C.2    Glickson, J.D.3
  • 43
    • 0021671006 scopus 로고
    • High-resolution proton nuclear magnetic resonance analysis of metastatic cancer-cells
    • Mountford CE, Wright LC, Holmes KT, Mackinnon WB, Gregory P, Fox RM: High-resolution proton nuclear magnetic resonance analysis of metastatic cancer-cells. Science (1984) 226 4681):1415-1418.
    • (1984) Science , vol.226 , Issue.4681 , pp. 1415-1418
    • Mountford, C.E.1    Wright, L.C.2    Holmes, K.T.3    Mackinnon, W.B.4    Gregory, P.5    Fox, R.M.6
  • 45
    • 0034808594 scopus 로고    scopus 로고
    • The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy
    • Cecil KM, Schnall MD, Siegelman ES, Lenkinski RE: The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy. Breast Cancer Res Treat (2001) 68(1):45-54.
    • (2001) Breast Cancer Res. Treat. , vol.68 , Issue.1 , pp. 45-54
    • Cecil, K.M.1    Schnall, M.D.2    Siegelman, E.S.3    Lenkinski, R.E.4
  • 46
    • 0036798674 scopus 로고    scopus 로고
    • Pathology of hepatocellular carcinoma and its precursors using proton magnetic resonance spectroscopy and a statistical classification strategy
    • Soper R, Himmelreich U, Painter D, Somorjai RL, Lean CL, Dolenko B, Mountford CE, Russell P: Pathology of hepatocellular carcinoma and its precursors using proton magnetic resonance spectroscopy and a statistical classification strategy. Pathology (2002) 34(5):417-422.
    • (2002) Pathology , vol.34 , Issue.5 , pp. 417-422
    • Soper, R.1    Himmelreich, U.2    Painter, D.3    Somorjai, R.L.4    Lean, C.L.5    Dolenko, B.6    Mountford, C.E.7    Russell, P.8
  • 48
    • 0036377347 scopus 로고    scopus 로고
    • Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy
    • Brindle KM: Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy. Adv Enzyme Regul (2002) 42:101-112.
    • (2002) Adv. Enzyme Regul. , vol.42 , pp. 101-112
    • Brindle, K.M.1
  • 50
    • 0036200834 scopus 로고    scopus 로고
    • Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS
    • Beauregard DA, Pedley RB, Hill SA, Brindle KM: Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS. NMR Biomed (2002) 15(2):99-105.
    • (2002) NMR Biomed. , vol.15 , Issue.2 , pp. 99-105
    • Beauregard, D.A.1    Pedley, R.B.2    Hill, S.A.3    Brindle, K.M.4
  • 51
    • 0037363443 scopus 로고    scopus 로고
    • Increased tumour extracellular pH induced by bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics
    • McSheehy PMJ, Troy H, Kelland LR, Judson IR, Leach MO, Griffiths JR: Increased tumour extracellular pH induced by bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics. Eur J Cancer (2003) 39 4):532-540.
    • (2003) Eur. J. Cancer , vol.39 , Issue.4 , pp. 532-540
    • McSheehy, P.M.J.1    Troy, H.2    Kelland, L.R.3    Judson, I.R.4    Leach, M.O.5    Griffiths, J.R.6
  • 53
    • 0036468251 scopus 로고    scopus 로고
    • Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wildtype tumors and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway
    • Griffiths JR, McSheehy PM, Robinson SP, Troy H, Chung YL, Leek RD, Williams KJ, Stratford IJ, Harris AL, Stubbs M: Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wildtype tumors and tumors deficient in hypoxia-inducible factor-1β (HIF-1β): Evidence of an anabolic role for the HIF-1 pathway. Cancer Res (2002) 62(3):688-695.
    • (2002) Cancer Res. , vol.62 , Issue.3 , pp. 688-695
    • Griffiths, J.R.1    McSheehy, P.M.2    Robinson, S.P.3    Troy, H.4    Chung, Y.L.5    Leek, R.D.6    Williams, K.J.7    Stratford, I.J.8    Harris, A.L.9    Stubbs, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.