Impact of high glucose/high insulin and dichloroacetate treatment on carbohydrate oxidation and functional recovery after low-flow ischemia and reperfusion in the isolated perfused rat heart

Circulation

Volumn 111, Issue 16, 2005, Pages 2066-2072

  Wang, Peipei ^a   Lloyd, Steven G ^a   Chatham, John C ^a,b,c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Fatty acids; Glucose; Ischemia; Metabolism; Reperfusion

Indexed keywords

CARBOHYDRATE; CARBON 13; DICHLOROACETIC ACID; FATTY ACID; GLUCOSE; INSULIN; LACTIC ACID; PALMITIC ACID; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; HEART MUSCLE REPERFUSION; ISCHEMIA; MALE; MEASUREMENT; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANIMALS; CARBOHYDRATE METABOLISM; CARBON RADIOISOTOPES; DICHLOROACETATE; GLUCOSE; GLUTAMIC ACID; INSULIN; MAGNETIC RESONANCE IMAGING; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 17744399714     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000162466.06150.D4     Document Type: Article

References (38)

1. Sodi-Pallares D, Testelli M, Fishleder F. Effects of intravenous infusion of a potassium-insulin-glucose solution on the electrographic signs of myocardial infarction. Am J Cardiol. 1962;9:166-181.
2. van der Horst JC, Zijlstra F, van't Hof AW, Doggen CJ, de Boer MJ, Suryapranata H, Hoorntje JC, Dambrink JH, Gans RO, Bilo HJ. Glucose-insulin- potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: the Glucose-Insulin-Potassium Study: a randomized trial. J Am Coll Cardiol. 2003;42:784-791.
3. Pache J, Kastrati A, Mehilli J, Bollwein H, Ndrepepa G, Schuhlen H, Martinoff S, Seyfarth M, Nekolla S, Dirschinger J, Schwaiger M, Schomig A. A randomized evaluation of the effects of glucose-insulin-potassium infusion on myocardial salvage in patients with acute myocardial infarction treated with reperfusion therapy. Am Heart J. 2004;148:e3.
4. Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation. 1997;96:1152-1156.
5. Diaz R, Paolasso EA, Piegas LS, Tajer CD, Moreno MG, Corvalan R, Isea JE, Romero G. Metabolic modulation of acute myocardial infarction: the ECLA (Estudios Cardiologicos Latinoamerica) Collaborative Group. Circulation. 1998;98:2227-2234.
6. Stanley WC, Lopaschuk GD, Hall JL, McCormack JG. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions: potential for pharmacological interventions. Cardiovasc Res. 1997;33:243-257.
7. Chaitman BR, Pepine CJ, Parker JO, Skopal J, Chumakova G, Kuch J, Wang W, Skettino SL, Wolff AA. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004;291:309-316.
8. Fragasso G, Piatti PM, Monti L, Palloshi A, Lu C, Valsecchi G, Setola E, Calori G, Pozza G, Margonato A, Chierchia S. Acute effects of heparin administration on the ischemic threshold of patients, with coronary artery disease: evaluation of the protective role of the metabolic modulator trimetazidine. J Am Coll Cardiol. 2002;39:413-419.
9. Opie LH. Heart: Physiology: From Cell to Circulation. 4th ed. Philadelphia, Pa: Lippincott. Williams and Wilkins; 2004.
10. Lopaschuk GD, Wambolt RB, Barr RL. An imbalance between glycolysis and glucose oxidation is a possible explanation for the detrimental effects of high levels of fatty acids during aerobic reperfusion of ischemic hearts. J Pharmacol Exp Ther. 1993;264:135-144.
11. Liu Q, Docherty JC, Rendell JC, Clanachan AS, Lopaschuk GD. High levels of fatty acids delay the recovery of intracellular pH and cardiac efficiency in post-ischemic hearts by inhibiting glucose oxidation. J Am Coll Cardiol. 2002;39:718-725.
12. Lloyd S, Brocks C, Chatham JC. Differential modulation of glucose, lactate and pyruvate oxidation by insulin and dichloroacetate in the isolated perfused rat heart. Am J Physiol Heart Circ Physiol. 2003;285: H163-H172.
13. Lloyd SG, Wang PP, Zeng H, Chatham JC. The impact of low flow ischemia on substrate oxidation and glycolysis in the isolated perfused rat heart. Am J Physiol Heart Circ Physiol. 2004;287:351-362.
14. 13C-substratcs and ex vivo perfusion in the working mode. Mol Cell Biochem. 2003;242:89-99.
15. Wang P, Chatham JC. The onset of diabetes in Zucker diabetic fatty (ZDF) rats leads to improved recovery of function following ischemia in the isolated perfused heart. Am J Physiol Endocrinol Metab. 2004;286: E725-E736.
16. Hinkle PC, Kumar MA, Resetar A, Harris DL. Mechanistic stoichiometry of mitochondrial oxidative phosphorylation. Biochemistry. 1991;30:3576-3582.
17. Young LH, Zaret BL, Barrett EJ. Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metabolism. 1989;38:1115-1119.
18. Bartelds B, Knoester H, Beaufort-Krol GCM, Smid GB, Takens J, Zijlstra WG, Heymans HSA, Kuipers JRG. Myocardial lactate metabolism in fetal and newborn lambs. Circulation, 1999;99:1892-1897.
19. Chatham JC, Des Rosiers C, Forder JR. Evidence of separate pathways for lactate uptake and release by the perfused rat heart. Am J Physiol Endocrinol Metab. 2001;281:E794-E802.
20. Stanley WC, Hall JL, Hacker TA, Hernandez LA, Whitesell LF. Decreased myocardial glucose uptake during ischemia in diabetic swine. Metabolism. 1997;46:168-172.
21. Burkhoff D, Weiss RG, Schulman SP, Kalil-Filho R, Wannenburg T, Gerstenblith G. Influence of metabolic substrate on rat heart function and metabolism at different coronary flows. Am J Physiol. 1991;261: H741-H750.
22. Hatherill M, McIntyre AG, Wattie M, Murdoch IA. Early hyperlactataemia in critically ill children. Intensive Care Med. 2000;26:314-318.
23. Kemppainen J, Fujimoto T, Kalliokoski KK, Viljanen T, Nuutila P, Knuuti J. Myocardial and skeletal muscle glucose uptake during exercise. J Physiol. 2002;542:403-412.
24. Cross HR, Opie LH, Radda GK, Clarke K. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved. Circ Res. 1996;78;482-491.
25. Jeremy RW, Ambrosio G, Pike MM, Jacobus WE, Becker LC. The functional recovery of post-ischemic myocardium requires glycolysis during early reperfusion. J Mol Cell Cardiol. 1993;25:261-276.
26. Dizon J, Burkhoff D, Tauskela J, Whang J, Cannon P, Katz J. Metabolic inhibition in the perfused rat heart: evidence for glycolytic requirement for normal sodium homeostasis. Am J Physiol. 1998;274:H1082-H1089.
27. Weiss J, Hiltbrand B. Functional compartmentation of glycolytic versus oxidative metabolism in isolated rabbit heart. J Clin Invest. 1985;75:436-447.
28. 2+ transport. Circ Res. 1995;77:88-97.
29. 31P-NMR study of isolated rat hearts. Am J Physiol Heart Circ Physiol. 1991;261:H469-H478.
30. Kolocassides KG, Seymour AM, Galinanes M, Hearse DJ. Paradoxical effect of ischemic preconditioning on ischemic contracture? NMR studies of energy metabolism and intracellular pH in the rat heart. J Mol Cell Cardiol. 1996;28:1045-1057.
31. Stacpoole PW. The pharmacology of dichloroacetate. Metabolism. 1989;38:1124-1144.
32. Beauloye C, Bertrand L, Krause U, Marsin AS, Dresselaers T, Vanstapel F, Vanoverschelde JL, Hue L. No-flow ischemia inhibits insulin signaling in heart by decreasing intracellular pH. Circ Res. 2001;88:513-519.
33. Jonassen AK, Sack MN, Mjos OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res. 2001;89:1191-1198.
34. King LM, Sidell RJ, Wilding JR, Radda GK, Clarke K. Free fatty acids, but not ketone hodies, protect diabetic rat hearts during low-flow ischemia. Am J Physiol Heart Circ Physiol. 2001;280:H1173-H1181.
35. Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell LR, Kaul S. An association between collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med. 1992;327:1825-1831.
36. Christian TF, O'Connor MK, Schwartz RS, Gibbons RJ, Ritman EL. Technetium-99m M1B1 to assess coronary collateral flow during acute myocardial infarction in two closed-chest animal models. J Nucl Med. 1997;38:1840-1846.
37. Force T, Hibberd P, Weeks G, Kemper AJ, Bloomfield P, Tow D, Josa M, Khuri S, Parisi AF. Perioperative myocardial infarction after coronary artery bypass surgery: clinical significance and approach to risk stratification. Circulation. 1990;82:903-912.
38. Mangano DT, Layug EL, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery: Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med. 1996;335:1713-1720.