Towards single-molecule nanomechanical mass spectrometry

Nature Nanotechnology

Volumn 4, Issue 7, 2009, Pages 445-450

  Naik, A K ^a   Hanay, M S ^a   Hiebert, W K ^a,b   Feng, X L ^a   Roukes, M L ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MOLECULES; NEMS; PROTEINS; REAL TIME SYSTEMS;

BIOLOGICAL ANALYSIS; BIOLOGICAL MOLECULE; ELECTROSPRAY INJECTIONS; NANO-ELECTROMECHANICAL; NANOELECTROMECHANICAL RESONATOR; QUANTITATIVE IDENTIFICATION; SPECTROMETRY SYSTEMS; ULTRA-HIGH FREQUENCY;

MASS SPECTROMETRY;

NANOPARTICLE;

ADSORPTION; ARTICLE; CONTROLLED STUDY; ELECTROSPRAY; ENVIRONMENTAL TEMPERATURE; MASS SPECTROMETRY; MOLECULAR MECHANICS; MOLECULE; NANOELECTROMECHANICAL SYSTEM; OPTICS; PHASE TRANSITION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; VACUUM;

EID: 67651202346     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2009.152     Document Type: Article

References (34)

1. Roukes, M. L. Nanoelectromechanical systems face the future. Phys. World 14, 25-31 (February 2001).
2. Naik, A. et al. Cooling a nanomechanical resonator with quantum back-action. Nature 443, 193-196 (2006).
3. Burg, T. P. & Manalis, S. R. Suspended microchannel resonators for biomolecular detection. Appl. Phys. Lett. 83, 2698-2700 (2003).
4. LaHaye, M. D., Buu, O., Camarota, B. & Schwab, K. C. Approaching the quantum limit of a nanomechanical resonator. Science 304, 74-77 (2004).
5. Thompson, J. D. et al. Strong dispersive coupling of a high-finesse cavity to a micromechanical membrane. Nature 452, 72-75 (2008).
6. Rugar, D., Budakian, R., Mamin, H. J. & Chui, B. W. Single spin detection by magnetic resonance force microscopy. Nature 430, 329-332 (2004).
7. Schwab, K., Henriksen, E. A., Worlock, J. M. & Roukes, M. L. Measurement of the quantum of thermal conductance. Nature 404, 974-977 (2000).
8. Burg, T. P. et al. Weighing of biomolecules, single cells and single nanoparticles in fluid. Nature 446, 1066-1069 (2007).
9. Ilic, B., Yang, Y. & Craighead, H. G. Virus detection using nanoelectromechanical devices. Appl. Phys. Lett. 85, 2604-2606 (2004).
10. Domon, B. & Aebersold, R. Mass spectrometry and protein analysis. Science 312, 212-217 (2006).
11. Aebersold, R. & Mann, M. Mass spectrometry-based proteomics. Nature 422, 198-207 (2003).
12. Yu, J., Xiao, J., Ren, X., Lao, K. & Xie, X. S. Probing gene expression in live cells, one protein molecule at a time. Science 311, 1600-1603 (2006).
13. Cai, L., Friedman, N. & Xie, X. S. Stochastic protein expression in individual cells at the single molecule level. Nature 440, 358-362 (2006).
14. Ekinci, K. L., Huang, X. M. H. & Roukes, M. L. Ultrasensitive nanoelectromechanical mass detection. Appl. Phys. Lett. 84, 4469-4471 (2004).
15. Yang, Y. T., Callegari, C., Feng, X. L., Ekinci, K. L. & Roukes, M. L. Zeptogramscale nanomechanical mass sensing. Nano Lett. 6, 583-586 (2006).
16. Feng, X. L., White, C. J., Hajimiri, A. & Roukes, M. L. A self-sustaining ultrahigh-frequency nanoelectromechanical oscillator. Nature Nanotech. 3, 342-346 (2008).
17. Feng, X. L. Ultra high frequency nanoelectromechanical systems with low noise technologies for single molecule mass sensing. PhD. thesis, California Institute of Technology (2006).
18. Roukes, M. L. & Ekinci, K. L. Apparatus and method for ultrasensitive nanoelectromechanical mass detection. US patent 6,722,200 (2004).
19. Cleland, A. N. Thermomechanical noise limits on parametric sensing with nanomechanical resonators. New J. Phys. 7, 235 (2005).
20. Ekinci, K. L., Yang, Y. T. & Roukes, M. L. Ultimate limits to inertial mass sensing based upon nanoelectromechanical systems. J. Appl. Phys. 95, 2682-2689 (2004).
21. Lassagne, B., Garcia-Sanchez, D., Aguasca, A. & Bachtold, A. Ultrasensitive mass sensing with a nanotube electromechanical resonator. Nano Lett. 8, 3735-3738 (2008).
22. Jensen, K., Kim, K. & Zettl, A. An atomic-resolution nanomechanical mass sensor. Nature Nanotech. 3, 533-537 (2008).
23. Chiu, H.-Y., Hung, P., Postma, H. W. C. & Bockrath, M. Atomic-scale mass sensing using carbon nanotube resonators. Nano Lett. 8, 4342-4346 (2008).
24. Blain, M. G. et al. Towards the hand-held mass spectrometer: design considerations, simulation and fabrication of micrometer-scaled cylindrical ion traps. Int. J. Mass Spectrom. 236, 91-104 (2004).
25. Xie, J., Miao, Y., Shih, J., Tai, Y. C. & Lee, T. D. Microfluidic platform for liquid chromatography-tandem mass spectrometry analyses of complex peptide mixtures. Anal. Chem. 77, 6947-6953 (2005).
26. Yamashita, M. & Fenn, J. B. Electrospray ion source. Another variation on the free-jet theme. J. Phys. Chem. 88, 4451-4459 (1984).
27. Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F. & Whitehouse, C. M. Electrospray ionization for mass spectrometry of large biomolecules. Science 246, 64-71 (1989).
28. Dieter, G. Inhomogeneous RF fields: A versatile tool for the study of processes with slow ions, in Advances in Chemical Physics: State-Selected and State-To-State Ion-Molecule Reaction Dynamics (eds Ng, C. Y., Baer, M., Prigogine, I. & Rice, S. A.) 1-176 (Wiley, 2007).
29. Heck, A. J. & van den Heuvel, R. H. H. Investigation of intact protein complexes by mass spectrometry. Mass Spectrom. Rev. 23, 368-389 (2004).
30. van Berkel, W. J., van den Heuvel, R. H., Versluis, C. & Heck, A. J. Detection of intact megadalton protein assemblies of vanillyl-alcohol oxidase by mass spectrometry. Protein Sci. 9, 435-439 (2000).
31. Dohn, S., Svendsen, W., Boisen, A. & Hansen, O. Mass and position determination of attached particles on cantilever based mass sensors. Rev. Sci. Instrum. 78, 103303 (2007).
32. Hanay, M. S. & Roukes, M. L. Multimode detection schemes for NEMS-based mass spectrometry. US patent CIT-4423-P (2005).
33. El-Faramawy, A., Siu, K. W. M. & Thomson, B. A. Efficiency of nano-electrospray ionization. J. Am. Soc. Mass. Spectrom. 16, 1702-1707 (2005).
34. http://www.nanovlsi.org.