Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry for metabolic flux analyses using isotope-labeled ethanol

Rapid Communications in Mass Spectrometry

Volumn 21, Issue 3, 2007, Pages 336-342

  Hollemeyer, Klaus ^a   Velagapudi, Vidya R ^a,b   Wittmann, Christoph ^a   Heinzle, Elmar ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; AMINO ACIDS; DESORPTION; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; YEAST;

13-C LABELING; CULTURE SUPERNATANT; DINITROPHENYLHYDRAZINE; HIGH-THROUGHPUT; LABELINGS; MATRIX-ASSISTED LASER DESORPTION/IONIZATION-TIME-OF-FLIGHT MASS SPECTROMETRY; METABOLIC FLUX ANALYSIS; NOVEL METHODS; PARALLEL SAMPLES; SAMPLE PREPARATION;

ETHANOL;

EID: 33846799483     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2840     Document Type: Article

References (26)

1. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, El Bakkoury M, Foury F, Friend SH, Gentalen E, Giaever G, Hegemann JH, Jones T, Laub M, Liao H, Liebundguth N, Lockhart DJ, Lucau-Danila A, Lussier M, M'Rabet N, Menard P, Mittmann M, Pai C, Rebischung C, Revuelta JL, Riles L, Roberts CJ, Ross-MacDonald P, Scherens B, Snyder M, Sookhai-Mahadeo S, Storms RK, Veronneau S, Voet M, Volckaert G, Ward TR, Wysocki R, Yen GS, Yu K, Zimmermann K, Philippsen P, Johnston M, Davis RW. Science 1999; 285: 901.
2. Que QQ, Winzeler EA. Funct. Integr. Genomics 2002; 2: 193.
3. Giaever G, Chu AM, Ni L, Connelly C, Riles L, Veronneau S, Dow S, Lucau-Danila A, Anderson K, Andre B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, Brachat S, Campanaro S, Curtiss M, Davis K, Deutschbauer A, Entian KD, Flaherty P, Foury F, Garfinkel DJ, Gerstein M, Gotte D, Guldener U, Hegemann JH, Hempel S, Herman Z, Jaramillo DF, Kelly DE, Kelly SL, Kotter P, LaBonte D, Lamb DC, Lan N, Liang H, Liao H, Liu L, Luo C, Lussier M, Mao R, Menard P, Ooi SL, Revuelta JL, Roberts CJ, Rose M, Ross-Macdonald P, Scherens B, Schimmack G, Shafer B, Shoemaker DD, Sookhai-Mahadeo S, Storms RK, Strathern JN, Valle G, Voet M, Volckaert G, Wang CY, Ward TR, Wilhelmy J, Winzeler EA, Yang Y, Yen G, Youngman E, Yu K, Bussey H, Boeke JD, Snyder M, Philippsen P, Davis RW, Johnston M. Nature 2002; 418: 387.
4. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P, Boeke JD. Yeast 1998; 14: 115.
5. Wittmann C, Heinzle E. Biotechnol. Bioeng. 1999; 62: 739.
6. Wittmann C, Heinzle E. Eur. J. Biochem. 2001; 268: 2441.
7. Wittmann C, Heinzle E. Biotechnol. Bioeng. 2001; 72: 642.
8. Wittmann C, Heinzle E. Metabol. Eng. 2001; 3: 173.
9. Wittmann C, Kim HM, Heinzle E. Biotechnol Bioeng. 2004; 87: 1.
10. Fischer E, Zamboni N, Sauer U. Anal. Biochem. 2004; 325: 308.
11. Tangerman A. Clin. Chem. 1997; 43: 1003.
12. Siebert TE, Smyth HE, Capone DL, Neuwohner C, Pardon KH, Skouroumounis GK, Herderich MJ, Sefton MA, Pollnitz AP. Anal. Bioanal. Chem. 2005; 381: 937.
13. Doizaki WM, Lewitt MD. J. Chromatogr. 1983; 276: 11.
14. Watts MT, McDonnald OL. Am. J. Clin. Pathol. 1987; 87: 79.
15. Knapp DR. In Handbook of Analytical Derivatization Reactions, John Wiley: New York, 1979; 26.
16. Dong JZ, Moldoveanu SC. J. Chromatogr. A 2004; 1027: 25.
17. Wittmann C, Heinzle E. Appl. Environ. Microbiol. 2002; 68: 5843.
18. 13C flux analysis. PhD thesis, Saarland University, 2006.
19. Wiechert W, Möllney M, Petersen S, de Graaf AA. Metab. Eng. 2001; 3: 265.
20. Wittmann C. Adv. Biochem. Eng. Biotechnol. 2002; 74: 39.
21. Christensen B, Nielsen J. Biotechnol. Bioeng. 2000; 68: 652.
22. van Winden WA, van Dam JC, Ras C, Kleijn RJ, Vinke JL, van Gulik WM, Heijnen JJ. FEMS Yeast Res. 2005; 5: 559.
23. Frick O, Wittmann C. Microb. Cell. Factories 2005; 4: 30.
24. Kleijn RJ, van Winden WA, Ras C, van Gulik WM, Schipper D, Heijnen JJ. Appl. Environ. Microbiol. 2006; 72: 4743.
25. Park H, Girdaukas GG, Northrop DB. J. Am. Chem. Soc. 2006; 128: 1868.
26. Baer E, Stanacev NZ. J. Am. Chem. Soc. 1964; 87: 679.