Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis

International Immunopharmacology

Volumn 4, Issue 12, 2004, Pages 1499-1514

  Verhoeckx, Kitty C M ^a,b   Bijlsma, Sabina ^a   Jespersen, Sonja ^c   Ramaker, Raymond ^a   Verheij, Elwin R ^a,b   Witkamp, Renger F ^a   Van Der Greef, Jan ^a,b   Rodenburg, Richard J T ^d  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c Ferring Pharmaceuticals AS   (Denmark)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

2 D gel electrophoresis; Anti inflammatory drugs; Metabolomics; Micro array; Multivariate data analysis; Principal component discriminant analysis

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLENBUTEROL; DEXAMETHASONE; FORMOTEROL; LIPOPOLYSACCHARIDE; SALBUTAMOL; UNCLASSIFIED DRUG; ZILPATEROL;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DNA MICROARRAY; DRUG DETERMINATION; GEL ELECTROPHORESIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LIPOGENESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOLECULE; MONOCYTE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEOMICS;

ADRENERGIC BETA-AGONISTS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIPIDS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MULTIVARIATE ANALYSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME; RECEPTORS, ADRENERGIC, BETA-2; RNA, MESSENGER;

EID: 4444363957     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2004.07.008     Document Type: Article

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