Metabolic profiling of cell growth and death in cancer: Applications in drug discovery

Drug Discovery Today

Volumn 7, Issue 6, 2002, Pages 364-372

  Boros, László G ^a   Cascante, Marta ^b   Paul Lee, Wai Nang ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AVEMAR; CARBON 13; DEOXYRIBOSE; FLUORODEOXYGLUCOSE F 18; GENISTEIN; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; IMATINIB; ISOENZYME; ISOFENPHOS; ORGANOPHOSPHATE INSECTICIDE; OXYTHIAMINE; PRASTERONE SULFATE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; PYRUVATE KINASE; RIBOSE; TRANSFORMING GROWTH FACTOR BETA2; TRANSKETOLASE; RADIOPHARMACEUTICAL AGENT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL DEATH; CELL PROLIFERATION; CELL TRANSFORMATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; FATTY ACID SYNTHESIS; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOLYSIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; ISOTOPE TRACING; NUCLEIC ACID SYNTHESIS; ONCOGENE; PENTOSE PHOSPHATE CYCLE; REVIEW; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; CELL DIVISION; CELL FUNCTION; METABOLISM; METHODOLOGY; NEOPLASM; PATHOLOGY; PHARMACOLOGY; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; CELL DEATH; CELL DIVISION; CELL PHYSIOLOGY; HUMAN; METABOLISM; NEOPLASMS; PHARMACOLOGY; RADIOPHARMACEUTICALS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS;

EID: 0037085584     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(02)02179-7     Document Type: Review

References (31)

1. Constitutive uncoupling of the controls for growth and differentiation in myeloid leukemia and the development of cancer
2. Reciprocal alterations of enzymic phenotype of purine and pyrimidine metabolism in induced differentiation of leukemia cells
3. Glucose transport and apoptosis
4. Positron emission tomography with 2-[18F]-fluoro-2-deoxy-D-glucose in oncology. Part IIIb: Therapy response monitoring in colorectal and lung tumours, head and neck cancer, hepatocellular carcinoma and sarcoma
5. The rate-limiting step for tumor [18F] fluoro-2-deoxy-D-glucose (FDG) incorporation
6. 2] glucose
7. Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes
8. Complete mass spectra of N-TAB esters of amino acids
9. Isotopomer study of lipogenesis in human hepatoma cells in culture: Contribution of carbon and hydrogen atoms from glucose
10. Cyclosporine induces cancer progression by a cell-autonomous mechanism
11. 2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells
12. Isofenphos induced metabolic changes in K562 myeloid blast cells
13. 2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein
14. 2-PK) as a tumor marker for renal carcinoma
15. 2-pyruvate kinase in plasma of patients with lung cancer in comparison to other lung diseases
16. 2-pyruvate kinase: A promising tumor marker in the diagnosis of gastro-intestinal cancer
17. 2 pyruvate kinase expression in advanced breast cancer
18. Chronic myeloid leukemia with an unusual simple variant translocation: t(22;22)(q13;q11)
19. Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model
20. Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow towards nucleic acid and fatty acid synthesis in myeloid tumor cells
21. Genistein inhibits nonoxidative ribose synthesis in MIA pancreatic adenocarcinoma cells: A new mechanism of controlling tumor growth
22. Wheat germ extract decreases glucose uptake and rna ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells
23. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
24. The leukemic effect of anticholinesterases
25. Ageing of clones of mammalian cells
26. Importance of glucose-6-phosphate dehydrogenase activity in cell death
27. Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation
28. Detection of elementary flux modes in biochemical networks: A promising tool for pathway analysis and metabolic engineering
29. The effect of thiamine supplementation on tumor proliferation: A metabolic control analysis study
30. Metabolic control analysis in biotechnology and medicine
31. Oxythiamine and dehydroepiandrosterone induce a G1 phase cycle arrest in Ehrlich's tumor cells through inhibition of the pentose cycle