-
1
-
-
33847735549
-
Moving in the right direction - nanoimaging in cancer cell motility and metastasis
-
Soon, L., Braet, F. & Condeelis, J. Moving in the right direction - nanoimaging in cancer cell motility and metastasis. Microsc. Res. Tech. 70, 252-257 (2007).
-
(2007)
Microsc. Res. Tech
, vol.70
, pp. 252-257
-
-
Soon, L.1
Braet, F.2
Condeelis, J.3
-
2
-
-
33749848951
-
Next-generation optical technologies for illuminating genetically targeted brain circuits
-
Deisseroth, K. et al. Next-generation optical technologies for illuminating genetically targeted brain circuits. J. Neurosci. 26, 10380-10386 (2006).
-
(2006)
J. Neurosci
, vol.26
, pp. 10380-10386
-
-
Deisseroth, K.1
-
3
-
-
38549166422
-
New approaches for imaging tumour responses to treatment
-
Brindle, K. M. New approaches for imaging tumour responses to treatment. Nature Rev. Cancer 8, 94-107 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 94-107
-
-
Brindle, K.M.1
-
4
-
-
15544383053
-
FDG-PET and beyond: Molecular breast cancer imaging
-
Quon, A. & Gambhir, S. S. FDG-PET and beyond: molecular breast cancer imaging. J. Clin. Oncol. 23, 1664-1673 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 1664-1673
-
-
Quon, A.1
Gambhir, S.S.2
-
5
-
-
33847267302
-
Assessing responses to cancer therapy using molecular imaging
-
Neves, A. A. & Brindle, K. M. Assessing responses to cancer therapy using molecular imaging. Biochim. Biophys. Acta 1766, 242-261 (2006).
-
(2006)
Biochim. Biophys. Acta
, vol.1766
, pp. 242-261
-
-
Neves, A.A.1
Brindle, K.M.2
-
6
-
-
0000627767
-
Étude sur les aspects offerts par des tumeurs expérimentales examinées à la lumière de Wood.
-
Policard, A. Étude sur les aspects offerts par des tumeurs expérimentales examinées à la lumière de Wood. C. R. Séances Soc. Biol. Fil. 91, 1423-1424 (1924).
-
(1924)
C. R. Séances Soc. Biol. Fil
, vol.91
, pp. 1423-1424
-
-
Policard, A.1
-
7
-
-
34347199634
-
Untersuchungen ueber die Rolle der Porphyrine bei geschwulstranken Menschen und Tieren.
-
Auler, H. & Banzer, G. Untersuchungen ueber die Rolle der Porphyrine bei geschwulstranken Menschen und Tieren. Z. Krebsforsch. 53, 65-68 (1942).
-
(1942)
Z. Krebsforsch
, vol.53
, pp. 65-68
-
-
Auler, H.1
Banzer, G.2
-
8
-
-
0000554464
-
The clinical use of fluorescein in neurosurgery. The localization of brain tumors
-
Moore, G. E., Peyton, W. T. & French, L. A. The clinical use of fluorescein in neurosurgery. The localization of brain tumors. J. Neurosurg. 5, 392-398 (1948).
-
(1948)
J. Neurosurg
, vol.5
, pp. 392-398
-
-
Moore, G.E.1
Peyton, W.T.2
French, L.A.3
-
10
-
-
0017571334
-
Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters
-
Jobsis, F. F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 198, 1264-1267 (1977).
-
(1977)
Science
, vol.198
, pp. 1264-1267
-
-
Jobsis, F.F.1
-
11
-
-
0024382958
-
Diagnosis of gastric cancers with fluorescein-labeled monoclonal antibodies to carcinoembryonic antigen
-
Tatsuta, M. et al. Diagnosis of gastric cancers with fluorescein-labeled monoclonal antibodies to carcinoembryonic antigen. Lasers Surg. Med. 9, 422-426 (1989).
-
(1989)
Lasers Surg. Med
, vol.9
, pp. 422-426
-
-
Tatsuta, M.1
-
12
-
-
0026686543
-
Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen
-
Folli, S. et al. Immunophotodiagnosis of colon carcinomas in patients injected with fluoresceinated chimeric antibodies against carcinoembryonic antigen. Proc. Natl Acad. Sci. USA 89, 7973-7977 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 7973-7977
-
-
Folli, S.1
-
13
-
-
0025827360
-
Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice
-
Pelegrin, A. et al. Antibody-fluorescein conjugates for photoimmunodiagnosis of human colon carcinoma in nude mice. Cancer 67, 2529-2537 (1991).
-
(1991)
Cancer
, vol.67
, pp. 2529-2537
-
-
Pelegrin, A.1
-
15
-
-
28444434798
-
In vivo imaging of lymphocyte trafficking
-
Halin, C., Rodrigo Mora, J., Sumen, C. & von Andrian, U. H. In vivo imaging of lymphocyte trafficking. Annu. Rev. Cell Dev. Biol. 21, 581-603 (2005).
-
(2005)
Annu. Rev. Cell Dev. Biol
, vol.21
, pp. 581-603
-
-
Halin, C.1
Rodrigo Mora, J.2
Sumen, C.3
von Andrian, U.H.4
-
16
-
-
30944448496
-
Fiber-optic fluorescence imaging
-
Flusberg, B. A. et al. Fiber-optic fluorescence imaging. Nature Methods 2, 941-950 (2005).
-
(2005)
Nature Methods
, vol.2
, pp. 941-950
-
-
Flusberg, B.A.1
-
17
-
-
34548553154
-
Confocal laser endoscopy for in vivo diagnosis of colorectal cancer
-
Kiesslich, R., Goetz, M., Vieth, M., Galle, P. R. & Neurath, M. F. Confocal laser endoscopy for in vivo diagnosis of colorectal cancer. Nature Clin. Pract. Oncol. 4, 480-490 (2007).
-
(2007)
Nature Clin. Pract. Oncol
, vol.4
, pp. 480-490
-
-
Kiesslich, R.1
Goetz, M.2
Vieth, M.3
Galle, P.R.4
Neurath, M.F.5
-
18
-
-
33750347349
-
Three-dimensional miniature endoscopy
-
Yelin, D. et al. Three-dimensional miniature endoscopy. Nature 443, 765 (2006).
-
(2006)
Nature
, vol.443
, pp. 765
-
-
Yelin, D.1
-
19
-
-
21444441373
-
Looking and listening to light: The evolution of whole-body photonic imaging
-
Ntziachristos, V., Ripoll, J., Wang, L. V. & Weissleder, R. Looking and listening to light: the evolution of whole-body photonic imaging. Nature Biotechnol. 23, 313-320 (2005).
-
(2005)
Nature Biotechnol
, vol.23
, pp. 313-320
-
-
Ntziachristos, V.1
Ripoll, J.2
Wang, L.V.3
Weissleder, R.4
-
20
-
-
26444615380
-
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
-
Grimm, J. et al. Use of gene expression profiling to direct in vivo molecular imaging of lung cancer. Proc. Natl Acad. Sci. USA 102, 14404-14409 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 14404-14409
-
-
Grimm, J.1
-
21
-
-
29444437303
-
Volumetric tomography of fluorescent proteins through small animals in vivo
-
Zacharakis, G. et al. Volumetric tomography of fluorescent proteins through small animals in vivo. Proc. Natl Acad. Sci. USA 102, 18252-18257 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 18252-18257
-
-
Zacharakis, G.1
-
22
-
-
33845514512
-
Comprehensive volumetric optical microscopy in vivo
-
This paper describes the development of a fibre-optic imaging technique that is useful for diagnostic imaging of epithelial disease
-
Yun, S. H. et al. Comprehensive volumetric optical microscopy in vivo. Nature Med. 12, 1429-1433 (2006). This paper describes the development of a fibre-optic imaging technique that is useful for diagnostic imaging of epithelial disease.
-
(2006)
Nature Med
, vol.12
, pp. 1429-1433
-
-
Yun, S.H.1
-
23
-
-
33746152397
-
Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
-
Zhang, H. F., Maslov, K., Stoica, G. & Wang, L. V. Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging. Nature Biotechnol. 24, 848-851 (2006).
-
(2006)
Nature Biotechnol
, vol.24
, pp. 848-851
-
-
Zhang, H.F.1
Maslov, K.2
Stoica, G.3
Wang, L.V.4
-
24
-
-
34547691201
-
Optical markers in duodenal mucosa predict the presence of pancreatic cancer
-
Liu, Y. et al. Optical markers in duodenal mucosa predict the presence of pancreatic cancer. Clin. Cancer Res. 13, 4392-4399 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 4392-4399
-
-
Liu, Y.1
-
25
-
-
28044449944
-
Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy
-
Evans, C. L. et al. Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy. Proc. Natl Acad. Sci. USA 102, 16807-16812 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 16807-16812
-
-
Evans, C.L.1
-
26
-
-
12344300543
-
Spying on cancer: Molecular imaging in vivo with genetically encoded reporters
-
Gross, S. & Piwnica-Worms, D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 7, 5-15 (2005).
-
(2005)
Cancer Cell
, vol.7
, pp. 5-15
-
-
Gross, S.1
Piwnica-Worms, D.2
-
27
-
-
33645798851
-
The fluorescent toolbox for assessing protein location and function
-
Giepmans, B. N., Adams, S. R., Ellisman, M. H. & Tsien, R. Y. The fluorescent toolbox for assessing protein location and function. Science 312, 217-224 (2006).
-
(2006)
Science
, vol.312
, pp. 217-224
-
-
Giepmans, B.N.1
Adams, S.R.2
Ellisman, M.H.3
Tsien, R.Y.4
-
28
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665 (2007).
-
(2007)
Nature
, vol.445
, pp. 661-665
-
-
Ventura, A.1
-
29
-
-
33748331308
-
The mighty mouse: Genetically engineered mouse models in cancer drug development
-
Sharpless, N. E. & Depinho, R. A. The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Rev. Drug Discov. 5, 741-754 (2006).
-
(2006)
Nature Rev. Drug Discov
, vol.5
, pp. 741-754
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
30
-
-
0037022597
-
Noninvasive quantitative imaging of protein-protein interactions in living subjects
-
Ray, P. et al. Noninvasive quantitative imaging of protein-protein interactions in living subjects. Proc. Natl Acad. Sci. USA 99, 3105-3110 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 3105-3110
-
-
Ray, P.1
-
31
-
-
12344276574
-
Real-time monitoring of ubiquitination in living cells by BRET
-
Perroy, J., Pontier, S., Charest, P. G., Aubry, M. & Bouvier, M. Real-time monitoring of ubiquitination in living cells by BRET. Nature Methods 1, 203-208 (2004).
-
(2004)
Nature Methods
, vol.1
, pp. 203-208
-
-
Perroy, J.1
Pontier, S.2
Charest, P.G.3
Aubry, M.4
Bouvier, M.5
-
33
-
-
1542615075
-
Molecular imaging of drug-modulated protein-protein interactions in living subjects
-
Paulmurugan, R., Massoud, T. F., Huang, J. & Gambhir, S. S. Molecular imaging of drug-modulated protein-protein interactions in living subjects. Cancer Res. 64, 2113-2119 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 2113-2119
-
-
Paulmurugan, R.1
Massoud, T.F.2
Huang, J.3
Gambhir, S.S.4
-
34
-
-
84945499865
-
Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma
-
in the press
-
Kelly, K. et al. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med. (in the press).
-
PLoS Med
-
-
Kelly, K.1
-
35
-
-
27944496941
-
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
-
This study used libraries of nanoparticles to identify cell-specific targeting agents that can be used for in vivo labelling
-
Weissleder, R., Kelly, K., Sun, E. Y., Shtatland, T. & Josephson, L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nature Biotechnol. 23, 1418-1423 (2005). This study used libraries of nanoparticles to identify cell-specific targeting agents that can be used for in vivo labelling.
-
(2005)
Nature Biotechnol
, vol.23
, pp. 1418-1423
-
-
Weissleder, R.1
Kelly, K.2
Sun, E.Y.3
Shtatland, T.4
Josephson, L.5
-
36
-
-
33845564339
-
In vivo imaging of molecularly targeted phage
-
Kelly, K. A., Waterman, P. & Weissleder, R. In vivo imaging of molecularly targeted phage. Neoplasia 8, 1011-1018 (2006).
-
(2006)
Neoplasia
, vol.8
, pp. 1011-1018
-
-
Kelly, K.A.1
Waterman, P.2
Weissleder, R.3
-
37
-
-
34547636355
-
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
-
Pittet, M. J. et al. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc. Natl Acad. Sci. USA 104, 12457-12461 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 12457-12461
-
-
Pittet, M.J.1
-
38
-
-
33645232205
-
Intracellular endosomal magnetic labeling of cells
-
Bulte, J. W. Intracellular endosomal magnetic labeling of cells. Methods Mol. Med. 124, 419-439 (2006).
-
(2006)
Methods Mol. Med
, vol.124
, pp. 419-439
-
-
Bulte, J.W.1
-
39
-
-
33746658566
-
Cellular magnetic resonance imaging: Current status and future prospects
-
Arbab, A. S., Liu, W. & Frank, J. A. Cellular magnetic resonance imaging: current status and future prospects. Expert Rev. Med. Devices 3, 427-439 (2006).
-
(2006)
Expert Rev. Med. Devices
, vol.3
, pp. 427-439
-
-
Arbab, A.S.1
Liu, W.2
Frank, J.A.3
-
40
-
-
34250665090
-
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
-
doi:10.1038/nprot. 2006.11
-
Pittet, M. J., Swirski, F. K., Reynolds, F., Josephson, L. & Weissleder, R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nature Protocols doi:10.1038/nprot. 2006.11 (2006).
-
(2006)
Nature Protocols
-
-
Pittet, M.J.1
Swirski, F.K.2
Reynolds, F.3
Josephson, L.4
Weissleder, R.5
-
41
-
-
41649093964
-
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses
-
Swirski, F. K. et al. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS ONE 2, e1075 (2007).
-
(2007)
PLoS ONE
, vol.2
-
-
Swirski, F.K.1
-
42
-
-
33646179699
-
-
Boon, T., Coulie, P. G., Van den Eynde, B. J. & van der Bruggen, P. Human T cell responses against melanoma. Annu. Rev. Immunol. 24, 175-208 (2006).
-
Boon, T., Coulie, P. G., Van den Eynde, B. J. & van der Bruggen, P. Human T cell responses against melanoma. Annu. Rev. Immunol. 24, 175-208 (2006).
-
-
-
-
43
-
-
0032476616
-
Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes
-
Romero, P. et al. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J. Exp. Med. 188, 1641-1650 (1998).
-
(1998)
J. Exp. Med
, vol.188
, pp. 1641-1650
-
-
Romero, P.1
-
44
-
-
4644237613
-
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
-
Curiel, T. J. et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Med. 10, 942-949 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 942-949
-
-
Curiel, T.J.1
-
45
-
-
12244285937
-
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
-
Chen, M. L. et al. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo. Proc. Natl Acad. Sci. USA 102, 419-424 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 419-424
-
-
Chen, M.L.1
-
46
-
-
34447118098
-
+ T cell tolerance in cancer
-
+ T cell tolerance in cancer. Nature Med. 13, 828-835 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 828-835
-
-
Nagaraj, S.1
-
47
-
-
37349100945
-
+ myeloid cells that promote metastasis
-
+ myeloid cells that promote metastasis. Cancer Cell 13, 23-35 (2008).
-
(2008)
Cancer Cell
, vol.13
, pp. 23-35
-
-
Yang, L.1
-
48
-
-
33847137354
-
In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor
-
Boissonnas, A., Fetler, L., Zeelenberg, I. S., Hugues, S. & Amigorena, S. In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor. J. Exp. Med. 204, 345-356 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 345-356
-
-
Boissonnas, A.1
Fetler, L.2
Zeelenberg, I.S.3
Hugues, S.4
Amigorena, S.5
-
49
-
-
33751501463
-
Random migration precedes stable target cell interactions of tumor-infiltrating T cells
-
References 48 and 49 were the first in vivo studies of T-cell infiltration and motility in tumour stroma and T-cell formation of cognate-antigen-dependent contacts with tumour cells
-
Mrass, P. et al. Random migration precedes stable target cell interactions of tumor-infiltrating T cells. J. Exp. Med. 203, 2749-2761 (2006). References 48 and 49 were the first in vivo studies of T-cell infiltration and motility in tumour stroma and T-cell formation of cognate-antigen-dependent contacts with tumour cells.
-
(2006)
J. Exp. Med
, vol.203
, pp. 2749-2761
-
-
Mrass, P.1
-
51
-
-
33745978399
-
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
-
reg cells reversibly suppress CTL-mediated antitumour immunity by allowing CTLs to acquire full effector potential but withholding their 'license to kill
-
reg cells reversibly suppress CTL-mediated antitumour immunity by allowing CTLs to acquire full effector potential but withholding their 'license to kill'.
-
(2006)
Immunity
, vol.25
, pp. 129-141
-
-
Mempel, T.R.1
-
52
-
-
4344671644
-
Effector function of human tumor-specific CD8 T cells in melanoma lesions: A state of local functional tolerance
-
Zippelius, A. et al. Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance. Cancer Res. 64, 2865-2873 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 2865-2873
-
-
Zippelius, A.1
-
53
-
-
34249281332
-
The cofilin pathway in breast cancer invasion and metastasis
-
Wang, W., Eddy, R. & Condeelis, J. The cofilin pathway in breast cancer invasion and metastasis. Nature Rev. Cancer 7, 429-440 (2007).
-
(2007)
Nature Rev. Cancer
, vol.7
, pp. 429-440
-
-
Wang, W.1
Eddy, R.2
Condeelis, J.3
-
54
-
-
34047246527
-
-
Wyckoff, J. B. et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67, 2649-2656 (2007). This paper reports that the intravasation of breast tumour cells in vivo occurs in association with perivascular TAMs.
-
Wyckoff, J. B. et al. Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res. 67, 2649-2656 (2007). This paper reports that the intravasation of breast tumour cells in vivo occurs in association with perivascular TAMs.
-
-
-
-
55
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
Orimo, A. et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121, 335-348 (2005).
-
(2005)
Cell
, vol.121
, pp. 335-348
-
-
Orimo, A.1
-
56
-
-
35148873112
-
In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors
-
Granot, D. et al. In vivo imaging of the systemic recruitment of fibroblasts to the angiogenic rim of ovarian carcinoma tumors. Cancer Res. 67, 9180-9189 (2007).
-
(2007)
Cancer Res
, vol.67
, pp. 9180-9189
-
-
Granot, D.1
-
57
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-56 (2001).
-
(2001)
Nature
, vol.410
, pp. 50-56
-
-
Muller, A.1
-
58
-
-
34948852371
-
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
-
Soucek, L. et al. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nature Med. 13, 1211-1218 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 1211-1218
-
-
Soucek, L.1
-
59
-
-
36849013036
-
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
-
Shojaei, F. et al. Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450, 825-831 (2007).
-
(2007)
Nature
, vol.450
, pp. 825-831
-
-
Shojaei, F.1
-
60
-
-
34948896045
-
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
-
Karnoub, A. E. et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449, 557-563 (2007).
-
(2007)
Nature
, vol.449
, pp. 557-563
-
-
Karnoub, A.E.1
-
61
-
-
0032951071
-
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
-
Weissleder, R., Tung, C. H., Mahmood, U. & Bogdanov, A. Jr. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nature Biotechnol. 17, 375-378 (1999).
-
(1999)
Nature Biotechnol
, vol.17
, pp. 375-378
-
-
Weissleder, R.1
Tung, C.H.2
Mahmood, U.3
Bogdanov Jr., A.4
-
62
-
-
0036066218
-
Fluorescence molecular tomography resolves protease activity in vivo
-
Ntziachristos, V., Tung, C. H., Bremer, C. & Weissleder, R. Fluorescence molecular tomography resolves protease activity in vivo. Nature Med. 8, 757-760 (2002).
-
(2002)
Nature Med
, vol.8
, pp. 757-760
-
-
Ntziachristos, V.1
Tung, C.H.2
Bremer, C.3
Weissleder, R.4
-
63
-
-
0034648765
-
Angiogenesis in cancer and other diseases
-
Carmeliet, P. & Jain, R. K. Angiogenesis in cancer and other diseases. Nature 407, 249-257 (2000).
-
(2000)
Nature
, vol.407
, pp. 249-257
-
-
Carmeliet, P.1
Jain, R.K.2
-
64
-
-
0038376001
-
Imaging of angiogenesis: From microscope to clinic
-
McDonald, D. M. & Choyke, P. L. Imaging of angiogenesis: from microscope to clinic. Nature Med. 9, 713-725 (2003).
-
(2003)
Nature Med
, vol.9
, pp. 713-725
-
-
McDonald, D.M.1
Choyke, P.L.2
-
65
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005).
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
66
-
-
0034918106
-
-
Brown, E. B. et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Med. 7, 864-868 (2001). This study used intravital microscopy and tumour-window-chamber models to monitor gene expression, cell adhesion, delivery of therapeutics, angiogenesis and blood-vessel permeability in deep regions of tumours.
-
Brown, E. B. et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nature Med. 7, 864-868 (2001). This study used intravital microscopy and tumour-window-chamber models to monitor gene expression, cell adhesion, delivery of therapeutics, angiogenesis and blood-vessel permeability in deep regions of tumours.
-
-
-
-
67
-
-
11144354392
-
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
-
Willett, C. G. et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature Med. 10, 145-147 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 145-147
-
-
Willett, C.G.1
-
68
-
-
22244458589
-
Tomographic fluorescence mapping of tumor targets
-
Montet, X., Ntziachristos, V., Grimm, J. & Weissleder, R. Tomographic fluorescence mapping of tumor targets. Cancer Res. 65, 6330-6336 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 6330-6336
-
-
Montet, X.1
Ntziachristos, V.2
Grimm, J.3
Weissleder, R.4
-
69
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 307, 58-62 (2005).
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
70
-
-
0034005650
-
Use of reporter genes for optical measurements of neoplastic disease in vivo
-
Contag, C. H., Jenkins, D., Contag, P. R. & Negrin, R. S. Use of reporter genes for optical measurements of neoplastic disease in vivo. Neoplasia 2, 41-52 (2000).
-
(2000)
Neoplasia
, vol.2
, pp. 41-52
-
-
Contag, C.H.1
Jenkins, D.2
Contag, P.R.3
Negrin, R.S.4
-
71
-
-
34250219265
-
Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapy
-
Lee, K. C. et al. Noninvasive molecular imaging sheds light on the synergy between 5-fluorouracil and TRAIL/Apo2L for cancer therapy. Clin. Cancer Res. 13, 1839-1846 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 1839-1846
-
-
Lee, K.C.1
-
72
-
-
0037168582
-
Noninvasive real-time imaging of apoptosis
-
Laxman, B. et al. Noninvasive real-time imaging of apoptosis. Proc. Natl Acad. Sci. USA 99, 16551-16555 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 16551-16555
-
-
Laxman, B.1
-
73
-
-
4344651705
-
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate
-
Ntziachristos, V. et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc. Natl Acad. Sci. USA 101, 12294-12299 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 12294-12299
-
-
Ntziachristos, V.1
-
74
-
-
34250667135
-
Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis
-
doi:10.1038/nprot.2006.17
-
Blankenberg, F. G., Vanderheyden, J. L., Strauss, H. W. & Tait, J. F. Radiolabeling of HYNIC-annexin V with technetium-99m for in vivo imaging of apoptosis. Nature Protocols doi:10.1038/nprot.2006.17 (2006).
-
(2006)
Nature Protocols
-
-
Blankenberg, F.G.1
Vanderheyden, J.L.2
Strauss, H.W.3
Tait, J.F.4
-
75
-
-
32944461277
-
Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer
-
Avril, N. et al. Prediction of response to neoadjuvant chemotherapy by sequential F-18-fluorodeoxyglucose positron emission tomography in patients with advanced-stage ovarian cancer. J. Clin. Oncol. 23, 7445-7453 (2005).
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 7445-7453
-
-
Avril, N.1
-
76
-
-
34548185461
-
PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: The MUNICON phase II trial
-
Lordick, F. et al. PET to assess early metabolic response and to guide treatment of adenocarcinoma of the oesophagogastric junction: the MUNICON phase II trial. Lancet Oncol. 8, 797-805 (2007).
-
(2007)
Lancet Oncol
, vol.8
, pp. 797-805
-
-
Lordick, F.1
-
77
-
-
27644538770
-
New imaging techniques at colonoscopy: Tissue spectroscopy and narrow band imaging
-
Dekker, E. & Fockens, P. New imaging techniques at colonoscopy: tissue spectroscopy and narrow band imaging. Gastrointest. Endosc. Clin. N. Am. 15, 703-714 (2005).
-
(2005)
Gastrointest. Endosc. Clin. N. Am
, vol.15
, pp. 703-714
-
-
Dekker, E.1
Fockens, P.2
-
78
-
-
33745219919
-
The future of bronchoscopy in diagnosing, staging and treatment of lung cancer
-
Herth, F. J., Eberhardt, R. & Ernst, A. The future of bronchoscopy in diagnosing, staging and treatment of lung cancer. Respiration 73, 399-409 (2006).
-
(2006)
Respiration
, vol.73
, pp. 399-409
-
-
Herth, F.J.1
Eberhardt, R.2
Ernst, A.3
-
79
-
-
0036161155
-
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
-
Marten, K. et al. Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice. Gastroenterology 122, 406-414 (2002).
-
(2002)
Gastroenterology
, vol.122
, pp. 406-414
-
-
Marten, K.1
-
80
-
-
2342603891
-
Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis
-
This paper shows that cathepsins promote invasive growth and angiogenesis in pancreatic islet tumours
-
Joyce, J. A. et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5, 443-453 (2004). This paper shows that cathepsins promote invasive growth and angiogenesis in pancreatic islet tumours.
-
(2004)
Cancer Cell
, vol.5
, pp. 443-453
-
-
Joyce, J.A.1
-
81
-
-
33747187479
-
A macrophage-targeted theranostic nanoparticle for biomedical applications
-
McCarthy, J. R., Jaffer, F. A. & Weissleder, R. A macrophage-targeted theranostic nanoparticle for biomedical applications. Small 2, 983-987 (2006).
-
(2006)
Small
, vol.2
, pp. 983-987
-
-
McCarthy, J.R.1
Jaffer, F.A.2
Weissleder, R.3
-
82
-
-
34249821046
-
Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu
-
Koyama, Y. et al. Spectral fluorescence molecular imaging of lung metastases targeting HER2/neu. Clin. Cancer Res. 13, 2936-2945 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2936-2945
-
-
Koyama, Y.1
-
83
-
-
34547660321
-
-
Kirsch, D. G. et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Med. 13, 992-997 (2007). This study combined a new mouse model of soft-tissue sarcoma that mimics human sarcomas with a hand-held imaging device that identifies residual tumour tissue during intra-operative molecular imaging.
-
Kirsch, D. G. et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Med. 13, 992-997 (2007). This study combined a new mouse model of soft-tissue sarcoma that mimics human sarcomas with a hand-held imaging device that identifies residual tumour tissue during intra-operative molecular imaging.
-
-
-
-
84
-
-
0347473808
-
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
-
Kim, S. et al. Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nature Biotechnol. 22, 93-97 (2004).
-
(2004)
Nature Biotechnol
, vol.22
, pp. 93-97
-
-
Kim, S.1
-
85
-
-
0037313516
-
Molecular imaging in drug discovery and development
-
Rudin, M. & Weissleder, R. Molecular imaging in drug discovery and development. Nature Rev. Drug Discov. 2, 123-131 (2003).
-
(2003)
Nature Rev. Drug Discov
, vol.2
, pp. 123-131
-
-
Rudin, M.1
Weissleder, R.2
-
86
-
-
0012701029
-
On a new kind of rays
-
Rontgen, W. C. On a new kind of rays. Nature 53, 274-276 (1896).
-
(1896)
Nature
, vol.53
, pp. 274-276
-
-
Rontgen, W.C.1
-
87
-
-
0022410454
-
Diaphanography in the diagnosis of breast cancer
-
Drexler, B., Davis, J. L. & Schofield, G. Diaphanography in the diagnosis of breast cancer. Radiology 157, 41-44 (1985).
-
(1985)
Radiology
, vol.157
, pp. 41-44
-
-
Drexler, B.1
Davis, J.L.2
Schofield, G.3
-
88
-
-
33646356731
-
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer
-
Figueiredo, J. L., Alencar, H., Weissleder, R. & Mahmood, U. Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer. Int. J. Cancer 118, 2672-2677 (2006).
-
(2006)
Int. J. Cancer
, vol.118
, pp. 2672-2677
-
-
Figueiredo, J.L.1
Alencar, H.2
Weissleder, R.3
Mahmood, U.4
-
89
-
-
0034646351
-
Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement
-
Ntziachristos, V., Yodh, A. G., Schnall, M. & Chance, B. Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement. Proc. Natl Acad. Sci. USA 97, 2767-2772 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2767-2772
-
-
Ntziachristos, V.1
Yodh, A.G.2
Schnall, M.3
Chance, B.4
-
90
-
-
24944450694
-
Protein-reactive natural products
-
Drahl, C., Cravatt, B. F. & Sorensen, E. J. Protein-reactive natural products. Angew. Chem. Int. Ed. Engl. 44, 5788-5809 (2005).
-
(2005)
Angew. Chem. Int. Ed. Engl
, vol.44
, pp. 5788-5809
-
-
Drahl, C.1
Cravatt, B.F.2
Sorensen, E.J.3
-
91
-
-
34247864013
-
Fluorescence imaging of amyloid formation in living cells by a functional, tetracysteine-tagged α-synuclein
-
Roberti, M. J., Bertoncini, C. W., Klement, R., Jares-Erijman, E. A. & Jovin, T. M. Fluorescence imaging of amyloid formation in living cells by a functional, tetracysteine-tagged α-synuclein. Nature Methods 4, 345-351 (2007).
-
(2007)
Nature Methods
, vol.4
, pp. 345-351
-
-
Roberti, M.J.1
Bertoncini, C.W.2
Klement, R.3
Jares-Erijman, E.A.4
Jovin, T.M.5
-
92
-
-
33947308721
-
-
Venkatraman, P. et al. Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nature Chem. Biol. 3, 222-228 (2007).
-
Venkatraman, P. et al. Fluorogenic probes for monitoring peptide binding to class II MHC proteins in living cells. Nature Chem. Biol. 3, 222-228 (2007).
-
-
-
-
93
-
-
0038469746
-
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
-
Harisinghani, M. G. et al. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N. Engl. J. Med. 348, 2491-2499 (2003).
-
(2003)
N. Engl. J. Med
, vol.348
, pp. 2491-2499
-
-
Harisinghani, M.G.1
-
94
-
-
4143094988
-
Circulating tumor cells, disease progression, and survival in metastatic breast cancer
-
Cristofanilli, M. et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351, 781-791 (2004).
-
(2004)
N. Engl. J. Med
, vol.351
, pp. 781-791
-
-
Cristofanilli, M.1
-
95
-
-
3442881617
-
-
Georgakoudi, I. et al. In vivo flow cytometry: a new method for enumerating circulating cancer cells. Cancer Res. 64, 5044-5047 (2004). This paper reports the first in vivo flow-cytometry-based method for quantifying circulating tumour cells.
-
Georgakoudi, I. et al. In vivo flow cytometry: a new method for enumerating circulating cancer cells. Cancer Res. 64, 5044-5047 (2004). This paper reports the first in vivo flow-cytometry-based method for quantifying circulating tumour cells.
-
-
-
-
96
-
-
34250652793
-
Portable two-color in vivo flow cytometer for real-time detection of fluorescently-labeled circulating cells
-
doi:10.1117/1.2722733
-
Boutrus, S. et al. Portable two-color in vivo flow cytometer for real-time detection of fluorescently-labeled circulating cells. J. Biomed. Opt. 12, 020507, doi:10.1117/1.2722733 (2007).
-
(2007)
J. Biomed. Opt
, vol.12
, pp. 020507
-
-
Boutrus, S.1
-
97
-
-
34547487297
-
In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry
-
He, W., Wang, H., Hartmann, L. C., Cheng, J. X. & Low, P. S. In vivo quantitation of rare circulating tumor cells by multiphoton intravital flow cytometry. Proc. Natl Acad. Sci. USA 104, 11760-11765 (2007).
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 11760-11765
-
-
He, W.1
Wang, H.2
Hartmann, L.C.3
Cheng, J.X.4
Low, P.S.5
-
98
-
-
37549002543
-
Isolation of rare circulating epithelial cells in cancer patients by microchip technology
-
Nagrath, S., Haber, D. A. & Toner, M. Isolation of rare circulating epithelial cells in cancer patients by microchip technology. Nature 450, 1235-1239 (2007).
-
(2007)
Nature
, vol.450
, pp. 1235-1239
-
-
Nagrath, S.1
Haber, D.A.2
Toner, M.3
-
99
-
-
84945502054
-
-
Lee, H., Sun, E. Y., Ham, D. & Weissleder, R. Chip-NMR biosensor for detection and molecular analysis of cells. Nature Med. (in the press). This study developed a low-cost diagnostic MRI platform for rapid, quantitative, multichannel detection of biological targets in unprocessed samples.
-
Lee, H., Sun, E. Y., Ham, D. & Weissleder, R. Chip-NMR biosensor for detection and molecular analysis of cells. Nature Med. (in the press). This study developed a low-cost diagnostic MRI platform for rapid, quantitative, multichannel detection of biological targets in unprocessed samples.
-
-
-
-
100
-
-
0036022520
-
Magnetic relaxation switches capable of sensing molecular interactions
-
Perez, J. M., Josephson, L., O'Loughlin, T., Hogemann, D. & Weissleder, R. Magnetic relaxation switches capable of sensing molecular interactions. Nature Biotechnol. 20, 816-820 (2002).
-
(2002)
Nature Biotechnol
, vol.20
, pp. 816-820
-
-
Perez, J.M.1
Josephson, L.2
O'Loughlin, T.3
Hogemann, D.4
Weissleder, R.5
|