Highly sensitive matrix-assisted laser desorption lonization-mass spectrometry for high-throughput metabolic profiling

Analytical Chemistry

Volumn 82, Issue 2, 2010, Pages 498-504

  Miura, Daisuke ^a   Fujimura, Yoshinori ^a   Tachibana, Hirofumi ^a   Wariishi, Hiroyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTICANCER DRUG; CELLULAR METABOLITES; DETECTION LIMITS; DRUG EFFICACY; DRUG SCREENING; HIGH LINEARITY; HIGH-THROUGHPUT; HIGHLY SENSITIVE; INDEPENDENT CLUSTERS; JURKAT CELL; LOW CONCENTRATIONS; MALDI-MS; MATRIX; MATRIX ASSISTED LASER DESORPTION; MATRIX-ASSISTED LASER DESORPTION IONIZATION MASS SPECTROMETRY; METABOLIC PROFILING; METABOLOMICS; MULTI VARIATE ANALYSIS; NON-TARGETED; NUCLEOTIDE SYNTHESIS; PEAK INTENSITY; RAPID ANALYSIS;

BIOMOLECULES; DECISION MAKING; DESORPTION; INDEPENDENT COMPONENT ANALYSIS; LINEARIZATION; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; MULTIVARIANT ANALYSIS;

PRINCIPAL COMPONENT ANALYSIS;

ANTINEOPLASTIC AGENT; METHOTREXATE;

ARTICLE; HUMAN; LEUKEMIA CELL LINE; MASS SPECTROMETRY; METABOLOME; METHODOLOGY; PRINCIPAL COMPONENT ANALYSIS; TIME;

ANTINEOPLASTIC AGENTS; HUMANS; JURKAT CELLS; METABOLOME; METHOTREXATE; PRINCIPAL COMPONENT ANALYSIS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TIME FACTORS;

EID: 75649147055     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901083a     Document Type: Article

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