Structure-based drug design: From nucleic acid to membrane protein targets

Experimental and Molecular Pathology

Volumn 86, Issue 3, 2009, Pages 141-150

  Dailey, Magdalena M ^a   Hait, Chayanendu ^b   Holt, Patrick A ^a   Maguire, Jon M ^b   Meier, Jason B ^a   Miller, M Clarke ^b   Petraccone, Luigi ^c   Trent, John O ^a,b,d  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d University of Louisville School of Medicine   (United States)

Author keywords

DNA; Drug discovery; G protein coupled receptor; Membrane protein; Quadruplex; Telomere; Virtual screening

Indexed keywords

ANTINEOPLASTIC AGENT; DAUNORUBICIN; DISTAMYCIN A; DOUBLE STRANDED DNA; ELLIPTICINE; G PROTEIN COUPLED RECEPTOR; MEMBRANE PROTEIN; MIGRATORY INHIBITION FACTOR; NUCLEIC ACID; NUCLEOLIN; PENTAMIDINE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

COMPUTER MODEL; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DNA STRUCTURE; DRUG DESIGN; DRUG TARGETING; EXPERIMENTAL MODEL; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; TELOMERE; VIRTUAL REALITY;

ANIMALS; ANTINEOPLASTIC AGENTS; COMPUTER SIMULATION; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEIC ACIDS; PHOSPHOFRUCTOKINASE-2; PHOSPHOPROTEINS; RECEPTORS, CXCR4; RNA-BINDING PROTEINS; TELOMERASE; USER-COMPUTER INTERFACE;

EID: 67349140440     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.01.011     Document Type: Review

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