An NMR study of the metabolic fate of 2-, 3- and 4-fluorobenzyl alcohols in the rat: Detection of N-acetylcysteinyl conjugates as minor metabolites in urine

Journal of Pharmaceutical and Biomedical Analysis

Volumn 32, Issue 1, 2003, Pages 133-140

  Blackledge, C A ^a   Nicholson, J K ^a   Wilson, I D ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

19F NMR spectroscopy; Glycine conjugation; Mercapturate formation; Metabolism; Reactive metabolites

Indexed keywords

ACETYLCYSTEINE DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZYL ALCOHOL DERIVATIVE; DRUG METABOLITE; GLYCINE DERIVATIVE; SULFATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG METABOLISM; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; URINALYSIS;

EID: 0037464406     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00049-9     Document Type: Article

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