Close coupling between astrocytic and neuronal metabolisms to fulfill anaplerotic and energy needs in the rat brain

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 4, 2008, Pages 712-724

  Serres, Sébastien ^a,b   Raffard, Gérard ^a   Franconi, Jean Michel ^a   Merle, Michel ^a  

^a CNRS University Bordeaux Segalen   (France)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Astrocyte; Brain energy; Brain metabolism; Neuron; NMR spectroscopy

Indexed keywords

ACETIC ACID; ACETYL COENZYME A; GLUCOSE; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN METABOLISM; BRAIN NERVE CELL; CARBON METABOLISM; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; FEMALE; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 41149085081     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600568     Document Type: Article

References (37)

1. Attwell D, Iadecola C (2002) The neural basis of functional brain imaging signals. Trends Neurosci 25:621-5
2. Attwell D, Laughlin SB (2001) An energy budget for signaling in the grey matter of the brain. J Cereb Blood Flow Metab 21:1133-45
3. 13C-NMR spectroscopy. A technique for investigating metabolic compartmentation in the brain. Biochem J 266:133-9
4. Berl S, Lajtha A, Waelsch H (1961) Amino acid and protein metabolism-VI Cerebral compartments of glutamic acid metabolism. J Neurochem 7:186-97
5. +-mediated metabolic waves. Proc Nat Acad Sci 101:14937-42
6. 13C]lactate in the rat brain is specific of a pyruvate carboxylase-deprived compartment. J Neurochem 75:480-6
7. 13C NMR. J Biol Chem 265:12916-26
8. Choi IY, Lei H, Gruetter R (2002) Effect of deep pentobarbital anesthesia on neurotransmitter metabolism in vivo: on the correlation of total glucose consumption with glutamatergic action. J Cereb Blood Flow Metab 22:1343-51
9. 13C NMR studies of metabolic compartmentation in the adult mammalian brain. NMR Biomed 12:454-62
10. Cruz NF, Lasater A, Zielke HR, Dienel A (2005) Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain. J Neurochem 92:934-47
11. Dienel GA, Wang RY, Cruz NF (2002) Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises. J Cereb Blood Flow Metab 22:1490-502
12. 13C nuclear magnetic resonance spectroscopy. J Neurosci 23:5928-35
13. Eriksson G, Peterson A, Iverfeldt K, Walum E (1995) Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat. Glia 15:152-6
14. 13C NMR. NMR Biomed 16:440-9
15. Hertz L, Peng L, Dienel GA (2007) Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab 27:219-49
16. 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism. J Neurosci 22:1523-31
17. Magistretti PJ, Pellerin L, Rothman DL, Shulman RG (1999) Energy on demand. Science 283:496-7
18. 13C NMR under non-steady state conditions. Biochemistry 29:6756-61
19. Martinez-Hernandez A, Bell KP, Norenberg MD (1977) Glutamine synthetase: glial localization in brain. Science 195:1356-8
20. 13C]glucose metabolism. J Neurochem 82:47-57
21. 13C]glucose. Eur J Biochem 239:742-51
22. 14C-trajectography combined with immunohistochemistry. J Cereb Blood Flow Metab 24:1004-14
23. O'Neal RM, Koeppe RE (1966) Precursors in vivo of glutamate, aspartate and their derivatives of rat brain. J Neurochem 13:835-47
24. 2 fixation increases with brain activity. J Neurosci 24:11273-9
25. Patel AB, de Graaf RA, Mason GF, Kanamatsu T, Rothman DL, Shulman RG, Behar KL (2004) Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation. J Cereb Blood Flow Metab 24:972-85
26. Pellerin L (2003) Lactate as a pivotal element in neuron-glia metabolic cooperation. Neurochem Int 43:331-8
27. Pellerin L, Magistretti P (1994) Glutamate uptake into astrocytes stimulates aerobic glycolysis : a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci USA 91:10625-9
28. Serres S, Bezançon E, Franconi JM, Merle M(2004) Ex vivo analysis of lactate and glucose metabolism in the rat brain under different states of depressed activity. J Biol Chem 279:47881-9
29. Serres S, Bezançon E, Franconi JM, Merle M(2005) Ex vivo NMR study of lactate metabolism in rat brain under various depressed states. J Neurosci Res 79:19-25
30. Serres S, Bezançon E, Franconi JM, Merle M (2007) Brain pyruvate recycling and peripheral metabolism: a NMR analysis ex vivo of acetate and glucose metabolism in the rat. J Neurochem 101:1428-40
31. 13C]glucose metabolism. J Neurochem 61:315-23
32. Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci USA 95:316-21
33. 13C]glucose infusion. J Neurochem 76:975-89
34. Van den Berg CJ, Garfinkel D (1971) A simulation study of brain compartments. Metabolism of glutamate and related substances in mouse brain. Biochem J 123:211-8
35. Walz W (2000) Role of astrocytes in the clearance of excess extracellular potassium. Neurochem Int 36:291-300
36. Yu ACH, Drejer J, Hertz L, Schousboe A (1983) Pyruvate carboxylase activity in primary cultures of astrocytes and neurons. J Neurochem 41:1484-7
37. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6:43-50