Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 49, 2007, Pages 19345-19350

  DeBerardinis, Ralph J ^a,b   Mancuso, Anthony ^a   Daikhin, Evgueni ^b   Nissim, Ilana ^b   Yudkoff, Marc ^b   Wehrli, Suzanne ^b   Thompson, Craig B ^a,c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c 1600 Penn Tower ^*  (United States)

Author keywords

Anaplerosis; Cancer; Glioblastoma; Glutaminolysis; Warburg effect

Indexed keywords

ALANINE; AMMONIA; GLUTAMINE; LACTIC ACID; OXALOACETIC ACID; PYRUVATE CARBOXYLASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AEROBIC METABOLISM; ARTICLE; CARBOXYLATION; CATABOLISM; CELL METABOLISM; CELL PROLIFERATION; CELL TRANSFORMATION; CITRIC ACID CYCLE; CONTROLLED STUDY; FATTY ACID SYNTHESIS; GLIOBLASTOMA; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; LIPOGENESIS; MITOCHONDRIAL RESPIRATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

AEROBIOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CITRIC ACID CYCLE; GLIOBLASTOMA; GLUCOSE; GLUTAMINE; GLYCOLYSIS; HUMANS; NUCLEOTIDES; PROTEIN BIOSYNTHESIS;

EID: 37449034854     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0709747104     Document Type: Article

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