Lessons from basic research in selenium and cancer prevention

Journal of Nutrition

Volumn 128, Issue 11, 1998, Pages 1845-1854

  Ip, Clement ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Animal models; Cancer prevention; Cell growth regulation; Selenium biochemistry

Indexed keywords

AROMATIC COMPOUND; CARCINOGEN; METHYL GROUP; SELENITE; SELENIUM; SELENIUM DERIVATIVE; SELENOAMINO ACID;

ANTINEOPLASTIC ACTIVITY; CANCER PREVENTION; CANCER RESEARCH; CELL GROWTH; FOOD COMPOSITION; GARLIC; HUMAN; NONHUMAN; REVIEW;

EID: 0031794470     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.11.1845     Document Type: Review

References (85)

1. Bird, S. M., Uden, P. C., Tyson, J. F., Block, E. & Denoyer, E. (1997) Speciation of selenoamino acids and organoselenium compounds in selenium-enriched yeast using high-performance liquid chromatography-inductively coupled plasma mass spectrometry. J. Anal. Atom. Spectrom. 12: 785-788.
2. Cai, X. J., Block, E., Uden, P. C., Zhang, Z., Quimby, B. D. & Sullivan, J. J. (1995) Allium chemistry: identification of selenoamino acids in ordinary and selenium-enriched garlic, onion, and broccoli using gas chromatography with atomic emission detection. J. Agric. Food Chem. 43: 1754-1757.
3. Clark, L. C., Cantor, K. & Allaway, W. H. (1991) Selenium in forage crops and cancer mortality in U.S. counties. Arch. Environ. Health 46: 37-42.
4. Clark, L. C., Combs, G. F., Turnbull, B. W., Slate, E. H., Chalker, D. K., Chow, J., Davis, L. S., Glover, R. A., Graham, G. F., Gross, E. G., Krongrad, A., Lesher, J. L., Park, K., Sanders, B. B., Smith, C. L. & Taylor, R. (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. J. Am. Med. Assoc. 276: 1957-1985.
5. Clark, L. C., Graham, G. F., Crounse, R. G., Grimson, R., Hulka, B. & Shy, C. M. (1984) Plasma selenium and skin neoplasms: a case control study. Nutr. Cancer 6: 13-21.
6. Clark, L. C., Hixson, L. J., Combs, G. F., Jr. , Reid, M. E., Turnbull, B. W. & Sampliner, R. E. (1993) Plasma selenium concentration predicts the prevalence of colorectal adenomatous polyps. Cancer Epidemiol. Biomark. Prev. 2: 41-46.
7. Coates, R. J., Weiss, N. S., Daling, J. R., Morris, J. S. & Labbe, R. F. (1988) Serum levels of selenium and retinol and the subsequent risk of cancer. Am. J. Epidemiol. 128: 515-523.
8. Combs, G. F., Jr. (1997) Selenium and cancer. In: Antioxidants and Disease Prevention (Garewal, H. S., ed.), pp. 97-113. CRC Press, New York, NY.
9. Comstock, G. W., Bush, T. L. & Helzlsouer, K. (1992) Serum retinol, betacarotene, vitamin E and selenium as related to subsequent cancer of specific sites. Am. J. Epidemiol. 135: 115-121.
10. Conaway, C. C., Upadhyaya, P., Meschter, C. L., Kurtzke, C., Marcus, L. A. & El-Bayoumy, K. (1992) Subchronic toxicity of benzyl selenocyanate and 1,4-phenylenebis(methylene)selenocyanate in F344 rats. Fund. Appl. Toxicol. 19: 563-574.
11. Dipple, A., Pigott, M., Moschel, R. D. & Costantino, N. (1983) Evidence that binding of 7,12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues. Cancer Res. 43: 4132-4135.
12. El-Bayoumy, K. (1985) Effects of organoselenium compounds on induction of mouse forestomach tumors by benzo(a)pyrene. Cancer Res, 45: 3631-3635.
13. El-Bayoumy, K. (1991) The role of selenium in cancer prevention. In: Cancer Principles and Practice of Oncology (DeVita, V. T., Hellman, S. & Rosenberg, S. S., eds.), 4th ed., pp. 1-15. J. B. Lippincott, Philadelphia, PA.
14. El-Bayoumy, K., Chae, Y.-H., Upadhyaya, P., Meschter, C., Cohen, L. A. & Reddy, B. S. (1992) Inhibition of 7,12-dimethylbenz(a)anthracene-induced tumors and DNA adduct formation in the mammary glands of female Sprague-Dawley rats by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Cancer Res. 52: 2402-2407.
15. El-Bayoumy, K., Upadhyaya, P., Desai, D. H., Amin, S. & Hecht, S. S. (1993) Inhibition of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone tumorigenicity in mouse lung by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Carcinogenesis 14: 1111-1113.
16. Fiala, E. S., Joseph, C., Sohn, O.-S., El-Bayoumy, K. & Reddy, B. S. (1991) Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats. Cancer Res. 51: 2826-2830.
17. Foster, S. J., Kraus, R. J. & Ganther, H. E. (1986a) Formation of dimethyl selenide and trimethylselenonium from selenobetaine in the rat. Arch. Biochem. Biophys. 247: 12-19.
18. Foster, S. J., Kraus, R. J. & Ganther, H. E. (1986b) The metabolism of selenomethionine, Se-methylselenocysteine, their selenonium derivatives, and trimethylselenonium in the rat. Arch. Biochem. Biophys. 251: 77-86.
19. Ganther, H. E. (1986) Pathways of selenium metabolism including respiratory excretory products. J. Am. Coll. Toxicol. 5: 1-5.
20. Ganther, H. E. & Lawrence, J. R. (1997) Chemical transformations of selenium in living organisms. Improved forms of selenium for cancer prevention. Tetrahedron 53: 12299-12310.
21. Greenblatt, M. S., Bennett, W. P., Hollstein, M. & Harris, C. C. (1994) Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54: 4855-4878.
22. Hecht, S.S. (1994) Metabolic activation and detoxification of tobacco-specific nitrosoamines - a model for cancer prevention strategies. Drug. Metab. Rev. 26: 373-390.
23. Hecht, S. S. & Hoffmann, D. (1988) Tobacco-specific nitrosoamines: an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis 9: 875-884.
24. Ip, C. (1986) The chemopreventive role of selenium in carcinogenesis. J. Am. Coll. Toxicol. 5: 7-20.
25. Ip, C. (1988) Differential effect of dietary methionine on the biopotency of selenomethionine and selenite in cancer chemoprevention. J. Natl. Cancer Inst. 80: 258-262.
26. Ip, C., El-Bayoumy, K., Upadhyaya, P., Ganther, H., Vadhanavikit, S. & Thompson, H. (1994a) Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention. Carcinogenesis 15: 187-192.
27. Ip, C. & Ganther, H. E. (1988) Efficacy of trimethylselenonium versus selenite in cancer chemoprevention and its modulation by arsenite. Carcinogenesis 9: 1481-1484.
28. Ip, C. & Ganther, H. E. (1990) Activity of methylated forms of selenium in cancer prevention. Cancer Res. 50: 1206-1211.
29. Ip, C. & Ganther, H. E. (1992) Relationship between the chemical form of selenium and anticarcinogenic activity. In: Cancer Chemoprevention (Wattenberg, L., Lipkin, M., Boone, C. W. & Kelloff, G. J., eds.), pp. 479-488. CRC Press, Boca Raton, FL.
30. Ip, C. & Hayes, C. (1989) Tissue selenium levels in selenium-supplemented rats and their relevance in mammary cancer protection. Carcinogenesis 10: 921-925.
31. Ip, C., Hayes, C., Budnick, R. M. & Ganther, H. E. (1991) Chemical form of selenium, critical metabolites, and cancer prevention. Cancer Res. 51: 595-600.
32. Ip, C. & Lisk, D. J. (1993) Bioavailability of selenium from selenium-enriched garlic. Nutr. Cancer 20: 129-137.
33. Ip, C. & Lisk, D. J. (1994a) Characterization of tissue selenium profiles and anticarcinogenic responses in rats fed natural sources of selenium-rich products. Carcinogenesis 15: 573-576.
34. Ip, C. & Lisk, D. J. (1994b) Enrichment of selenium in allium vegetables for cancer prevention. Carcinogenesis 15: 1881-1885.
35. Ip, C. & Lisk, D. J. (1995) Efficacy of cancer prevention by high selenium-garlic is primarily dependent on the action of selenium. Carcinogenesis 16: 2649-2652
36. Ip, C. & Lisk, D. J. (1996) The attributes of selenium-enriched garlic in cancer prevention. Adv. Exp. Med. Biol. 401: 179-187.
37. Ip, C. & Lisk, D. J. (1997) Modulation of phase I and phase II xenobiotic metabolizing enzymes by selenium-enriched garlic in rats. Nutr. Cancer 28: 184-188.
38. Ip, C., Lisk, D. J., Ganther, H. & Thompson, H. J. (1997) Triphenylselenonium and diphenylselenide in cancer chemoprevention: comparative studies of anticarcinogenic efficacy, tissue selenium levels and excretion profile. Anticancer Res. 17: 3195-3200.
39. Ip, C., Lisk, D. J. & Stoewsand, G. S. (1992) Mammary cancer prevention by regular garlic and selenium-enriched garlic. Nutr. Cancer 17: 279-286.
40. Ip, C., Lisk, D. J. & Thompson, H. (1996) Selenium-enriched garlic inhibits the early stage but not the late stage of mammary carcinogenesis. Carcinogenesis 17: 1979-1982.
41. Ip, C. & Medina, D. (1987) Current concept of selenium and mammary tumor-igenesis. In: Cellular and Molecular Biology of Breast Cancer (Medina, D., Kidwell, W., Heppner, G. & Anderson, E. P., eds.), pp. 479-494. Plenum Press, New York, NY.
42. Ip, C., Thompson, H. & Ganther, H. (1994b) Activity of triphenylselenonium chloride in mammary cancer prevention. Carcinogenesis 15: 2879-2882.
43. Ip, C., Thompson, H. & Ganther, H. E. (1998) Cytostasis and cancer chemoprevention: investigating the action of triphenylselenonium chloride in in vivo models of mammary carcinogenesis. Anticancer Res. 18: 9-12.
44. Ip, C., Vadhanavikit, S. & Ganther, H. (1995) Cancer chemoprevention by aliphatic selenocyanates: Effect of chain length on inhibition of mammary tumors and DMBA adducts. Carcinogenesis 16: 35-38.
45. Jacobs, M. & Frost, C. (1981) Toxicological effects of sodium selenite in Sprague-Dawley rats. J. Toxicol. Environ. Health 8: 575-585.
46. Jiang, C., Lu, J., Garcia, G. & Thompson, H. J. (1993) Spontaneous nucleosomal DNA fragmentation in murine leukemic L1210 cells. Biochem. Biophys. Res. Commun. 194: 836-841.
47. Kaeck, M., Lu, J., Strange, R., Ip, C., Ganther, H. E. & Thompson, H. J. (1997) Differential induction of growth arrest inducible genes by selenium compounds. Biochem. Pharmacol. 53: 921-926.
48. Knekt, P., Aromaa, A., Maatela, J., Alfthan, G., Aaran, R.-K., Teppo, L. & Hakama, M. (1988) Serum vitamin E, serum selenium and the risk of gastrointestinal cancer. Int. J. Cancer 42: 846-850.
49. Lanfear, J., Fleming, J., Wu, L., Webster, G. & Harrison, P. R. (1994) The selenium metabolite selenodigluthionine induces p53 and apoptosis: relevance to the chemopreventive effects of selenium? Carcinogenesis 15: 1387-1392.
50. Liu, J.-Z. & Milner, J. A. (1992) Age, dietary selenium and quantity of 7,12-dimethylbenz(a)anthracene influence the in vivo occurrence of rat mammary DNA adducts. J. Nutr. 122: 1361-1368.
51. Lu, J., Jiang, C., Kaeck, M., Ganther, H., Ip, C. & Thompson, H. (1995a) Cellular and metabolic effects of triphenylselenonium chloride in a mammary cell culture model. Carcinogenesis 16: 513-517.
52. Lu, J., Jiang, C., Kaeck, M., Ganther, H., Vadhanavikit, S., Ip, C. & Thompson, H. (1995b) Dissociation of the genotoxic and growth inhibitory effects of selenium. Biochem. Pharmacol. 50: 213-219.
53. Lu, J., Kaeck, M., Jiang, C., Wilson, A. C. & Thompson, H. J. (1994) Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells. Biochem. Pharmacol. 49: 1531-1535.
54. Lu, J., Pei, H., Ip, C., Lisk, D. J., Ganther, H. & Thompson, H. J. (1996) Effect of an aqueous extract of selenium-enriched garlic on in vitro markers and in vivo efficacy in cancer prevention. Carcinogenesis 17: 1903-1907.
55. Medina, D. & Morrison, D. G. (1988) Current ideas on selenium as a chemoprevent agent. Pathol. Immunopathol. Res. 7: 187-199.
56. Menkes, M. S., Comstock, G. W., Vuilleumier, J. P., Helsing, K. J., Rider, A. A. & Brookmeyer, R. P. (1986) Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N. Engl. J. Med. 315: 1250-1254.
57. Morris, V. C. & Levander, O. A. (1970) Selenium content of foods. J. Nutr. 100: 1383-1388.
58. Morrison, V. M., Burnett, A. K. & Craft, J. A. (1991) Metabolism of 7,12-dimethylbenz(a)anthracene in hepatic microsomal membranes from rats treated with isoenzyme-selective inducers of cytochromes P450. Biochem. Pharmacol. 41: 1505-1512.
59. Nayini, J., El-Bayoumy, K., Sugie, S., Cohen, L. A. & Reddy, B. S. (1989) Chemoprevention of experimental mammary carcinogenesis by the synthetic organoselenium compound, benzylselenocyanate, in rats. Carcinogenesis 10: 509-512.
60. Nayini, J. R., Sugie, S., El-Bayoumy, K., Rao, C. V., Rigotty, J., Sohn, O.-S. & Reddy, B. S. (1991) Effect of dietary benzylselenocyanate on azoxymethane-induced colon carcinogenesis in male F344 rats. Nutr. Cancer 15: 129-139.
61. Nomura, A., Heilbrun, L. K., Morris, J. S. & Stemmermann, G. N. (1987) Serum selenium and the risk of cancer by specific sites. J. Natl. Cancer Inst. 79: 103-108.
62. Prokopczyk, B., Cox, J. E., Upadhyaya, P., Amin, S., Desai, D., Hoffmann, D. & El-Bayoumy, K. (1996) Effects of dietary 1,4-phenylenebis(methylene)selenocyanate on 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation in lung and liver of A/J mice and F344 rats. Carcinogenesis 17: 749-753.
63. Reddy, B. S., Rivenson, A., Kulkami, N., Upadhyaya, P. & El-Bayoumy, K. (1992) Chemoprevention of colon carcinogenesis by the synthetic organoselenium compound, 1,4-phenylenebis(methylene)selenocyanate. Cancer Res. 52: 5635-5640.
64. Reddy, B. S., Tanaka, T. & El-Bayoumy, K. (1985) Inhibitory effect of dietary p-methoxybenzeneselenol on azoxymethane-induced colon and kidney carcinogenesis in female F344 rats. J. Natl. Cancer Inst. 74: 1325-1328.
65. Reddy, B. S., Upadhyaya, P., Simi, B. & Rao, C. V. (1994) Evaluation of organoselenium compounds for potential chemopreventive properties in colon carcinogenesis. Anticancer Res. 14: 2509-2514.
66. Redman, C., Xu, M. J., Peng, Y.-M., Scott, J. A., Payne, C., Clark, L C. & Nelson, M. A. (1997) Involvement of polyamines in selenomethionine induced apoptosis and mitotic alterations in human tumor cells. Carcinogenesis 18: 1195-1202.
67. Ringstad, J., Jacobsen, B. K., Tretli, S. & Thomassen Y. (1988) Serum selenium concentration associated with risk of cancer. J. Clin. Pathol. 41: 454-457.
68. Russo, J., Tay, L. K. & Russo, I. H. (1982) Differentiation of the mammary gland and susceptibility to carcinogenesis. Breast Cancer Res. Treat. 2: 5-73.
69. Salonen, J. T., Alfthan, G., Huttunen, J. K. & Puska, P. (1984) Association between serum selenium and the risk of cancer. Am. J. Epidemiol. 120: 342-349.
70. Salonen, J. T., Salonen, R., Lappetelainen, R., Maenpaa, P. H., Alfthan, G. & Puska, P. (1985) Risk of cancer in relation to serum concentrations of selenium and vitamins A and E: matched case-control analysis of prosective data. Br. Med. J. 290: 417-420.
71. Schrauzer, G. N., White, D. A. & Schneider, C. J. (1977) Cancer mortality correlation studies. III. Statistical associations with dietary selenium intakes. Bioinorg. Chem. 7: 23-24.
72. Shamberger, R. J., Tytko, S. A. & Willis, C. E. (1976) Antioxidants and cancer. Part VI. Selenium and age-adjusted human cancer mortality. Arch. Environ. Health 31: 231-235.
73. Sherr, C. J. (1996) Cancer cell cycles. Science (Washington, DC) 274: 1672-1677.
74. Shrift, A. (1973) Metabolism of selenium by plants and microorganisms. In: Organic Selenium Compounds: Their Chemistry and Biology (Klayman, D. K. & Gunther, W. H. H., eds.), pp. 763-814. Wiley-Interscience, New York, NY.
75. Sinha, R. & Medina, D. (1997) Inhibition of cdk2 kinase activity by methylselenocysteine in synchronized mouse mammary epithelial tumor cells. Carcinogenesis 18: 1541-1547.
76. Sinha, R., Said, T. K, & Medina, D. (1996) Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Lett. 107: 277-284.
77. Sohn, O. S., Li, H., Surace, A., El-Bayoumy, K., Upadhyaya, P. & Fiala, E. S. (1995) Contrasting patterns of selenium excretion by female CD rats treated with chemically related chemopreventive organic selenocyanate compounds. Anticancer Res. 15: 1849-1856.
78. Stewart, M. J., Davis, R. L., Walsh, L. P. & Pence, B. C. (1997) Induction of differentiation and apoptosis by sodium selenite in human colonic carcinoma cells (HT29). Cancer Lett. 117: 35-40.
79. Talalay, P. (1992) The role of enzyme induction in protection against carcinogenesis. In: Cancer Chemoprevention (Wattenberg, L., Lipkin, M., Boone, C. W. & Kelloff, G. J., eds.), pp. 469-478. CRC Press, Boca Raton, FL.
80. Tanaka, T., Reddy, B. S. & El-Bayoumy, K. (1985) Inhibition by dietary organoselenium, p-methoxybenzene-selenol, of hepatocarcinogenesis induced by azoxymethane in rats. Jpn. J. Cancer Res. 76: 462-467.
81. Vadhanavikit, S., Ip, C. & Ganther, H. E. (1993) Metabolites of sodium selenite and methylated selenium compounds administered at cancer chemoprevention levels in the rat. Xenobiotica 23: 731-745.
82. Weinberg, R. A. (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
83. Willett, W. C., Polk, B. F., Morris, J. S., Stampfer, M. J., Pressel, S., Rosner, B., Taylor, J. O., Schneider, K. & Hames, C. G. (1983) Prediagnostic serum selenium and risk of cancer. Lancet ii: 130-134.
84. Wilson, A. C., Thompson, H. J., Schedin, P. J., Gibson, N. W. & Ganther, H. E. (1992) Effect of methylated forms of selenium on cell viability and the induction of DNA strand breakage. Biochem. Pharmacol. 43: 1137-1141.
85. Yu, S. Y., Chu, Y. J., Gong, X. L. & Hou, C. (1985) Regional variation of cancer mortality and its relation to selenium levels in China. Biol. Trace Elem. Res. 7: 21-29.