Metabolomic and mass isotopomer analysis of liver gluconeogenesis and citric acid cycle: I. Interrelation between gluconeogenesis and cataplerosis; formation of methoxamates from aminooxyacetate and ketoacids

Journal of Biological Chemistry

Volumn 283, Issue 32, 2008, Pages 21978-21987

  Yang, Lili ^a   Kombu, Rajan S ^a   Kasumov, Takhar ^a   Zhu, Shu Han ^a   Cendrowski, Andrea V ^a   David, France ^a   Anderson, Vernon E ^a   Kelleher, Joanne K ^b   Brunengraber, Henri ^a,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; CITRIC ACID; ISOMERS; ISOTOPES; LIVER;

GLUCONEOGENESIS; GLUCONEOGENIC; IN-VIVO; ISOTOPOMER; KETO ACIDS; KETOGLUTARATE; METABOLIC EFFECTS; METABOLOMIC; METABOLOMICS; MULTIPLE CROSSOVERS; PYRUVATE; RAT LIVERS; REDOX MEASUREMENTS;

METABOLISM;

2 OXOGLUTARIC ACID; AMINOOXYACETIC ACID; BICARBONATE; CARBON 13; CITRIC ACID; GLUCOSE; GLYCEROPHOSPHATE; LACTIC ACID; MERCAPTOPICOLINIC ACID; OXALOACETIC ACID; OXOACID; PHOSPHOENOLPYRUVATE; PICOLINIC ACID; PYRUVIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG; CARBON; SUCCINIC ACID DERIVATIVE; SUCCINIC ACID DIMETHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; GAS CHROMATOGRAPHY; GLUCONEOGENESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; LIVER; LIVER METABOLISM; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; MALE; METABOLISM; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

RATTUS;

AMINOOXYACETIC ACID; ANIMALS; CARBON ISOTOPES; CITRIC ACID CYCLE; GLUCONEOGENESIS; KETO ACIDS; LACTIC ACID; LIVER; MALE; OXIDATION-REDUCTION; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SUCCINATES;

EID: 52049125995     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803454200     Document Type: Article

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