Stable isotope resolved metabolomics of primary human hepatocytes reveals a stressed phenotype

Metabolomics

Volumn 8, Issue 1, 2012, Pages 34-49

  Winnike, Jason H ^a   Pediaditakis, Peter ^a   Wolak, Justyna E ^a   McClelland, Randall E ^c   Watkins, Paul B ^b,d   Macdonald, Jeffrey M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c SciKon Corporation   (United States)

^d Hamner UNC Center for Drug Safety Sciences   (United States)

Author keywords

13C metabolites; 1H NMR spectroscopy; Human hepatocytes; Metabolomics; Stable isotopes

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CARBON 13; CYTOCHROME P450; GLUCOKINASE; GLUCURONIC ACID; GLUTAMINE; INSULIN; KETONE BODY; OCTANOIC ACID C 13; PARACETAMOL;

ADULT; AGED; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CELL VIABILITY; CELLULAR STRESS RESPONSE; CHILD; CITRIC ACID CYCLE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYOPRESERVATION; DOWN REGULATION; ENZYME INHIBITION; FATTY ACID OXIDATION; FEMALE; GLUCONEOGENESIS; GLUCOSE UTILIZATION; GLUCURONIDATION; GLUTAMINE UTILIZATION; GLYCOLYSIS; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER METABOLISM; MALE; METABOLOMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHENOTYPE; PRESCHOOL CHILD; RAT; STABLE ISOTOPE RESOLVED METABOLOMICS; STEADY STATE;

MAMMALIA; RATTUS;

EID: 84855875833     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0284-5     Document Type: Article

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