Compartmentation of glycolysis and glycogenolysis in the perfused rat heart

NMR in Biomedicine

Volumn 17, Issue 2, 2004, Pages 51-59

  Anousis, Nick ^a   Carvalho, Rui A ^a,b,c   Zhao, Piyu ^a   Malloy, Craig R ^c   Sherry, A Dean ^a,c  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Glycogenolysis; Glycolysis; Metabolic compartmentation; NMR isotopomer analysis

Indexed keywords

BIOCATALYSTS; FRAGRANCES; GLUCOSE; GLYCOLS; HEART VALVE PROSTHESES; INSULIN; METABOLISM; MYOELECTRICALLY CONTROLLED PROSTHETICS; RESONANCE; TISSUE;

ENERGY DEMAND; GLYCOGENOLYSIS; GLYCOLYSIS; PYRUVATE;

BIOMEDICAL ENGINEERING;

ACETYL COENZYME A; CARBON 13; GLUCOSE; GLYCOGEN; GLYCOLYTIC ENZYME; INSULIN; LACTIC ACID; PYRUVIC ACID;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; GLYCOGENOLYSIS; GLYCOLYSIS; HEART PERFUSION; HEART STIMULATION; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; STIMULATION;

ANIMALS; ENERGY METABOLISM; GLUCAGON; GLUCOSE; GLUTAMIC ACID; GLYCOGEN; GLYCOLYSIS; HEART; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MYOCARDIUM; PYRUVIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 1842679313     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/nbm.860     Document Type: Article

References (39)

1. Ovadi J, Orosz F. Channelling in Intermediary Metabolism, Agius L, Sherratt HSA (eds). Portland Press: London, 1996; 237-268.
2. Mowbray J, Ottaway JH. The flux of pyruvate in perfused rat heart. Eur. J. Biochem. 1973; 36: 362-368.
3. Mowbray J, Ottaway JH. The effect of insulin and growth hormone on the flux of tracer from labeled lactate in perfused rat heart. Eur. J Biochem. 1973; 36: 369-379.
4. Ottaway JH, Mowbray J. The computation of parameters in isotopic tracer systems not in a steady-state. Eur. J. Biochem. 1973; 36: 380-384.
5. Macnab R, Moses V, Mowbray J. Evidence for metabolic compartmentation in Escherichia coli. Eur. J. Biochem. 1973; 34: 15-19.
6. Peuhkurinen KJ, Hassinen IE. Pyruvate carboxylation as an anaplerotic mechanism in the isolated perfused rat heart. Biochem. J. 1982; 202: 67-76.
7. Chatham JC, Forder JR. Metabolic compartmentation of lactate in the glucose-perfused rat heart. Am. J. Physiol. 1996; 270: H224-H229.
8. Chatham JC, DesRosiers C, Forder JR. Evidence of separate pathways for lactate uptake and release by the perfused rat heart. Am. J. Physiol. 2001; 281: E794-E802.
9. Peuhkurinen KJ, Hiltunen JK, Hassinen IE. Metabolic compartmentation of pyruvate in the isolated perfused rat heart. Biochem. J. 1983; 210: 193-198.
10. Lewandowski ED, Johnston DL, Roberts R. Effects of inosine on glycolysis and contracture during myocardial ischemia. Circul. Res. 1991; 68: 578-587.
11. Lewandowski ED. Metabolic heterogeneity of carbon substrate utilization in mammalian heart: NMR determinations of mitochondrial versus cytosolic compartmentation. Biochemistry 1992; 31: 8916-8923.
12. 13C] pyruvate. FEBS Lett. 1992; 303: 247-250.
13. 1H NMR detection of lactate and alanine in perfused rat hearts during global and low pressure ischemia. Magn. Reson. Med. 1995; 33: 53-60.
14. Laughlin MR, Taylor J, Chesnick AS, DeGroot M, Balaban RS. Pyruvate and lactate metabolism in the in vivo dog heart. Am. J. Physiol. 1993; 264: H2068-H2079.
15. 13C NMR. J. Mol. Cell. Cardiol. 1994; 26: 1197-1210.
16. Lloyd S, Brocks C, Chatham JC. Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart. Am. J. Physiol. 2003; 285: H163-H172.
17. Henning SL, Wambolt RB, Schonekess BO, Lopashuk GD, Allard MF. Contribution of glycogen to aerobic myocardial glucose utilization. Circulation 1996; 93: 1549-1555.
18. Goodwin GW, Ahmad F, Taegtmeyer H. Preferential oxidation of glycogen in isolated working rat heart. J. Clin. Invest. 1996; 97: 1409-1416.
19. Russel III RR, Cline GW, Guthrie PH, Goodwin GW, Shulman GI, Taegtmeyer H. Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart: a three tracer study of glycolysis, glycogen metabolism, and glucose oxidation. J. Clin. Invest. 1997; 100: 2892-2899.
20. Schönekess BO, Allard MF, Henning SL, Wambolt R, Lopaschuk GD. Contribution of glycogen and exogenous glucose to glucose metabolism during ischemia in the hypertrophied rat heart. Circul. Res. 1997; 81: 540-549.
21. Fraser H, Lopaschuk GD, Clanachan AS. Assessment of glycogen turnover in aerobic, ischemic, and reperfused working hearts. Am. J. Physiol. 1998; 275: H1533-H1541.
22. Wambolt RB, Henning SL, English DR, Dyachkova Y, Lopaschuk GD, Allard MF. Glucose utilization and glycogen turnover are accelerated in hypertrophied rat hearts during severe low-flow ischemia. J. Mol. Cell. Cardiol. 1999; 31: 493-502.
23. Goodwin GW, Ahmad F, Doenst T, Taegtmeyer H. Energy provision from glycogen, glucose, and fatty acids on adrenergic stimulation of isolated working rat hearts. Am. J. Physiol. 1998; 274: H1239-H1247.
24. 13C NMR study on the isolated perfused rat heart. FEBS Lett. 1984; 178: 34-38.
25. 13C visibility of rabbit glycogen in vivo. Magn. Reson. Med. 1991; 20: 327-332.
26. Goodwin GW, Arteaga JR, Taegtmeyer H. Glycogen turnover in the isolated working rat heart. J. Biol. Chem. 1995; 270: 9234-9240.
27. Jeffrey FMH, Reshetov A, Storey CJ, Carvalho RA, Sherry AD, Malloy CR. Use of a single resonance of glutamate to measure oxygen consumption in intact tissues. Am. J. Physiol. 1999; 277: E1103-E1110.
28. Hassid WZ, Abraham S. Determination of total glycogen. Meth. Enzymol. 1957; 3: 34-37.
29. Bergmeyer HU, Bergmeyer J. Enzymatic determination of glycogen content. In Methods of Enzymatic Analysis, Vol. VI. Verlag Chemie: Weinheim, 1984; 1-18.
30. Shaka AJ, Keeler J. Broadband spin decoupling in isotropic-liquids. Prog. NMR Spectrosc. 1983; 19: 47-129.
31. McVeigh JH, Lopaschuk GD. Dichloroacetate stimulation of glucose oxidation improves recovery of ischemic rat hearts. Am. J. Physiol. 1990; 259: H1079-H1085.
32. 13C NMR spectroscopy. J. Biol. Chem. 1988; 263: 6964-6971.
33. 13C isotope isomers. Am. J. Physiol. 1990; 259: H987-H995.
34. 13C NMR. Biochemistry 1992; 31: 4833-4837.
35. Ureta T. The role of isozymes in metabolism: a model of metabolic pathways as the basis for the biological role of isozymes. Curr. Top. Cell. Regul. 1978; 13: 233-266.
36. Horowitz SB, Pearson TW. Intracellular monosaccharide and amino acid concentrations and activities and the mechanism of insulin action. Mol. Cell. Biol. 1981; 1: 769-784.
37. 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc. Natl Acad. Sci. USA 2002; 99: 2708-2713.
38. Brooks GA, Dubouchaud H, Brown M, Sicurello JP, Butz CE. Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle. Proc. Natl Acad. Sci. USA 1999; 96: 1129-1134.
39. Brooks GA. Lactate shuttles in nature. Biochem. Soc. Trans. 2002; 30: 258-264.