Artificial tumor model suitable for monitoring 31P and 13C NMR spectroscopic changes during chemotherapy-induced apoptosis in human glioma cells

Magnetic Resonance in Medicine

Volumn 54, Issue 1, 2005, Pages 67-78

  Mancuso, Anthony ^a   Zhu, Aizhi ^a   Beardsley, Nancy J ^a   Glickson, Jerry D ^a   Wehrli, Suzanne ^b   Pickup, Stephen ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

13C; 31P T1; Apoptosis; Glioma; Temozolomide

Indexed keywords

CELL DEATH; CHEMOTHERAPY; COLLAGEN; MICROSPHERES; PACKED BEDS; POLYSTYRENES; SPECTROMETERS;

GLIOMA; GLYCEROPHOSPHOCHOLINE; POLYSTYRENE MICRO-SPHERE; SPECTROSCOPIC CHANGES; STRUCTURAL SUPPORT; TEMOZOLOMIDE; ^13C; ^31P T1;

TUMORS;

COLLAGEN; DIPHOSPHODIESTER; ESTER DERIVATIVE; GLYCEROPHOSPHORYLCHOLINE; MICROSPHERE; PHOSPHORYLCHOLINE; POLYSTYRENE; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST TUMOR; CARBON NUCLEAR MAGNETIC RESONANCE; CELL LINE; CHEMOTHERAPY; CONTROLLED STUDY; GLIOMA CELL; GLYCOLYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PERFUSION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; TUMOR MODEL;

EID: 21244442653     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.20545     Document Type: Article

References (39)

1. Glickson JD. Clinical NMR spectroscopy of tumors. Current status and future directions. Invest Radiol 1989;24:1011-1016.
2. Evelhoch JL, Gillies RJ, Karczmar GS, Koutcher JA, Maxwell RJ, Nalcioglu O, Raghunand N, Ronen SM, Ross BD, Swartz HM. Applications of magnetic resonance in model systems: cancer therapeutics. Neoplasia 2000;2:152-165.
3. Nelson SJ. Multivoxel magnetic resonance spectroscopy of brain tumors. Mol Cancer Ther 2003;2:497-507.
4. Maintz D, Heindel W, Kugel H, Jaeger R, Lackner KJ. Phosphorus-31 MR spectroscopy of normal adult human brain and brain tumours. NMR Biomed 2002;15:18-27.
5. Podo F. Tumour phospholipid metabolism. NMR Biomed 1999;12:413-439.
6. 13C magnetic resonance spectroscopy, Eppendorf electrode, and redox scanning. Cancer Res 2003;63:8813-8820.
7. Mancuso A, Glickson JD. Applications of NMR spectroscopy and imaging to the study of immobilised cell physiology. In: Nedovic V, Willaert R, editors. Fundamentals of cell immobilisation biotechnology. Dordrecht, The Netherlands: Kluwer Academic Publishers; 2004.
8. Hickman JA. Apoptosis induced by anticancer drugs. Cancer Metast Rev 1992;11:121-139.
9. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
10. Kaplan O, Cohen JS. Metabolism of breast cancer cells as revealed by non-invasive magnetic resonance spectroscopy studies. Breast Cancer Res Treat 1994;31:285-299.
11. 31P-NMR spectroscopy of human cancer cells proliferating in a basement membrane gel. FASEB J 1988;2:2596-2604.
12. Alves PM, Flogel U, Brand A, Leibfritz D, Carrondo MJ, Santos H, Sonnewald U. Immobilization of primary astrocytes and neurons for online monitoring of biochemical processes by NMR. Dev Neurosci 1996;18:478-483.
13. 31P NMR of mammalian cells encapsulated in alginate gels utilizing a new phosphate-free perfusion medium. NMR Biomed 1990;3:23-26.
14. 31P NMR spectroscopic study of the effects of gamma-irradiation on RIF-1 tumor cells perfused in vitro. Magn Reson Med 1992;27:296-309.
15. Sambanis A, Papas KK, Flanders PC, Long Jr RC, Kang H, Constantinidis I. Towards the development of a bioartificial pancreas: immunoisolation and NMR monitoring of mouse insulinomas. Cytotechnology 1994;15:351-363.
16. 31P NMR spectroscopic studies of the effects of cyclophosphamide on perfused RIF-1 tumor cells. Magn Reson Med 1994;31:241-247.
17. 31P NMR studies of RIF-1 fibrosarcoma cells perfused in vitro. NMR Biomed 1996;9:173-178.
18. Gillies RJ, Galons JP, McGovern KA, Scherer PG, Lien YH, Job C, Ratcliff R, Chapa F, Cerdan S, Dale BE. Design and application of NMR-compatible bioreactor circuits for extended perfusion of high-density mammalian cell cultures. NMR Biomed 1993;6:95-104.
19. Callies R, Jackson ME, Brindle KM. Measurements of the growth and distribution of mammalian cells in a hollow-fiber bioreactor using nuclear magnetic resonance imaging. Biotechnology (NY) 1994;12:75-78.
20. 31P MRS. Magn Reson Med 1998;40:411-420.
21. Mancuso A, Beardsley NJ, Wehrli S, Pickup S, Matschinsky FM, Glickson JD. Real time detection of 13C NMR labeling kinetics in perfused EMT6 mouse mammary tumor cells and BHC9 mouse insulinomas. Biotechnol Bioeng 2004;87:835-848.
22. Mancuso A, Fernandez EJ, Blanch HW, Clark DS. A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors. Biotechnology (NY) 1990;8:1282-1285.
23. Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnol Bioeng 1994;44:563-585.
24. Zhu A, Beardsley NJ, Yang K, Milkevitch M, Pickup S, Delikatny EJ, Mancuso A. Repeated doses of temozolomide cause repeated increases in nucleoside triphosphates in cultured human glioma cells. In: Proceedings of the 12th Annual Meeting of ISMRM, Kyoto, Japan, 2004. p 2019.
25. Roslin M, Henriksson R, Bergstrom P, Ungerstedt U, Bergenheim AT. Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis. J Neurooncol 2003;61:151-160.
26. Ronen SM, DiStefano F, McCoy CL, Robertson D, Smith TA, Al Saffar NM, Titley J, Cunningham DC, Griffiths JR, Leach MO, Clarke PA. Magnetic resonance detects metabolic changes associated with chemotherapy-induced apoptosis. Br J Cancer 1999;80:1035-1041.
27. Bernsen HJ, Rijken PF, Hagemeier NE, van der Kogel AJ. A quantitative analysis of vascularization and perfusion of human glioma xenografts at different implantation sites. Microvasc Res 1999;57:244-257.
28. Fernandez EJ, Mancuso A, Murphy MK, Blanch HW, Clark DS. Nuclear magnetic resonance methods for observing the intracellular environment of mammalian cells. Ann NY Acad Sci 1990;589:458-475.
29. 31P NMR. Magn Reson Med 1991;18:181-192.
30. Maurer BJ, Ihnat MA, Morgan C, Pullman J, O'Brien C, Johnson SW, Rasey JS, Cornwell MM. Growth of human tumor cells in macroporous microcarriers results in p53-independent, decreased cisplatin sensitivity relative to monolayers. Mol Pharmacol 1999;55:938-947.
31. Pilatus U, Shim H, Artemov D, Davis D, van Zijl PC, Glickson JD. Intracellular volume and apparent diffusion constants of perfused cancer cell cultures, as measured by NMR. Magn Reson Med 1997;37:825-832.
32. Ruiz-Cabello J, Cohen JS. Phospholipid metabolites as indicators of cancer cell function. NMR Biomed 1992;5:226-233.
33. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-1312.
34. Neeman M, Eldar H, Rushkin E, Degani H. Chemotherapy-induced changes in the energetics of human breast cancer cells: 31P- and 13C-NMR studies. Biochim Biophys Acta 1990;1052:255-263.
35. 31P NMR spectroscopy. Biochem Biophys Res Commun 1992;183:114-120.
36. Lodi R, Setola E, Tonon C, Ambrosetto P, Franceschi E, Crino L, Barbiroli B, Cortelli P. Gliomatosis cerebri: clinical, neurochemical and neuroradiological response to temozolomide administration. Magn Reson Imaging 2003;21:1003-1007.
37. 13C] magnetic resonance spectroscopy at 4.1T. J Cereb Blood Flow Metab 1999;19:1179-1188.
38. Tyler JL, Diksic M, Villemure JG, Evans AC, Meyer E, Yamamoto YL, Feindel W. Metabolic and hemodynamic evaluation of gliomas using positron emission tomography. J Nucl Med 1987;28:1123-1133.
39. Chang GH, Barbaro NM, Pieper RO. Phosphatidylserine-dependent phagocytosis of apoptotic glioma cells by normal human microglia, astrocytes, and glioma cells. Neuro-oncol 2000;2:174-183.