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Volumn 5, Issue 4, 2009, Pages 435-458

Mass-spectrometry-based metabolomics: Limitations and recommendations for future progress with particular focus on nutrition research

Author keywords

Mass spectrometry; Metabolomics; Method development; Nutrition

Indexed keywords


EID: 74449085466     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-009-0168-0     Document Type: Review
Times cited : (457)

References (156)
  • 1
    • 52949129488 scopus 로고    scopus 로고
    • A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects
    • doi:10.1017/S000711450789547X
    • Abdel-Sayed, A., Binnert, C., Lê, K.-A., Bortolotti, M., Schneiter, P., & Tappy, L. (2008). A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects. The British Journal of Nutrition, 100, 393-399. doi: 10. 1017/S000711450789547X.
    • (2008) The British Journal of Nutrition , vol.100 , pp. 393-399
    • Abdel-Sayed, A.1    Binnert, C.2    Lê, K.-A.3    Bortolotti, M.4    Schneiter, P.5    Tappy, L.6
  • 2
    • 33645376731 scopus 로고    scopus 로고
    • Nutrigenomics: From molecular nutrition to prevention of disease
    • doi:10.1016/j.jada.2006.01.001
    • Afman, L., & Muller, M. (2006). Nutrigenomics: From molecular nutrition to prevention of disease. Journal of the American Dietetic Association, 106, 569-576. doi: 10. 1016/j. jada. 2006. 01. 001.
    • (2006) Journal of the American Dietetic Association , vol.106 , pp. 569-576
    • Afman, L.1    Muller, M.2
  • 3
    • 46349084465 scopus 로고    scopus 로고
    • Bioinformatics analysis of targeted metabolomics-Uncovering old and new tales of diabetic mice under medication
    • doi:10.1210/en.2007-1747
    • Altmaier, E., Ramsay, S. L., Graber, A., Mewes, H. W., Weinberger, K. M., & Suhre, K. (2008). Bioinformatics analysis of targeted metabolomics-Uncovering old and new tales of diabetic mice under medication. Endocrinology, 149, 3478-3489. doi: 10. 1210/en. 2007-1747.
    • (2008) Endocrinology , vol.149 , pp. 3478-3489
    • Altmaier, E.1    Ramsay, S.L.2    Graber, A.3    Mewes, H.W.4    Weinberger, K.M.5    Suhre, K.6
  • 5
    • 33746606019 scopus 로고    scopus 로고
    • Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry
    • doi:10.1016/j.chroma.2006.05.019
    • Bajad, S. U., Lu, W. Y., Kimball, E. H., Yuan, J., Peterson, C., & Rabinowitz, J. D. (2006). Separation and quantitation of water soluble cellular metabolites by hydrophilic interaction chromatography-tandem mass spectrometry. Journal of Chromatography A, 1125, 76-88. doi: 10. 1016/j. chroma. 2006. 05. 019.
    • (2006) Journal of Chromatography A , vol.1125 , pp. 76-88
    • Bajad, S.U.1    Lu, W.Y.2    Kimball, E.H.3    Yuan, J.4    Peterson, C.5    Rabinowitz, J.D.6
  • 7
    • 33645233956 scopus 로고    scopus 로고
    • Determination of strongly overlapping signaling activity from microarray data
    • Bidaut, G., Suhre, K., Claverie, J. M., & Ochs, M. F. (2006). Determination of strongly overlapping signaling activity from microarray data. BMC Bioinformatics, 7, 99.
    • (2006) BMC Bioinformatics , vol.7 , pp. 99
    • Bidaut, G.1    Suhre, K.2    Claverie, J.M.3    Ochs, M.F.4
  • 8
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • doi:10.1001/jama.297.8.842
    • Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007). Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. Journal of the American Medical Association, 297, 842-857. doi: 10. 1001/jama. 297. 8. 842.
    • (2007) Journal of the American Medical Association , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 10
    • 27944492417 scopus 로고    scopus 로고
    • Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma
    • doi:10.1021/ac0508604
    • Boernsen, K. O., Gatzek, S., & Imbert, G. (2005). Controlled protein precipitation in combination with chip-based nanospray infusion mass spectrometry. An approach for metabolomics profiling of plasma. Analytical Chemistry, 77, 7255-7264. doi: 10. 1021/ac0508604.
    • (2005) Analytical Chemistry , vol.77 , pp. 7255-7264
    • Boernsen, K.O.1    Gatzek, S.2    Imbert, G.3
  • 12
    • 33846240326 scopus 로고    scopus 로고
    • Statistical strategies for avoiding false discoveries in metabolomics and related experiments
    • doi:10.1007/s11306-006-0037-z
    • Broadhurst, D., & Kell, D. (2006). Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics, 2, 171-196. doi: 10. 1007/s11306-006-0037-z.
    • (2006) Metabolomics , vol.2 , pp. 171-196
    • Broadhurst, D.1    Kell, D.2
  • 14
    • 36148968834 scopus 로고    scopus 로고
    • Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis
    • Bruce, S. J., Jonsson, P., Antti, H., Cloarec, O., Trygg, J., Marklund, S. L., et al. (2007). Evaluation of a protocol for metabolic profiling studies on human blood plasma by combined ultra-performance liquid chromatography/mass spectrometry: From extraction to data analysis. Analytical Biochemistry, 372, 237-249.
    • (2007) Analytical Biochemistry , vol.372 , pp. 237-249
    • Bruce, S.J.1    Jonsson, P.2    Antti, H.3    Cloarec, O.4    Sugnet, C.W.5    Trygg, J.6    Marklund, S.L.7
  • 15
    • 38949118922 scopus 로고    scopus 로고
    • HORA suite: A database and software for human metabolomics
    • doi:10.1007/s11306-007-0095-x
    • Bruschi, S., Calzolari, D., Coquin, L., & Paternostro, G. (2008). HORA suite: A database and software for human metabolomics. Metabolomics, 4, 90-93. doi: 10. 1007/s11306-007-0095-x.
    • (2008) Metabolomics , vol.4 , pp. 90-93
    • Bruschi, S.1    Calzolari, D.2    Coquin, L.3    Paternostro, G.4
  • 16
    • 37549027670 scopus 로고    scopus 로고
    • Enrichment tags for enhanced-resolution profiling of the polar metabolome
    • doi:10.1021/ja0779506
    • Carlson, E. E., & Cravatt, B. F. (2007a). Enrichment tags for enhanced-resolution profiling of the polar metabolome. Journal of the American Chemical Society, 129, 15780. doi: 10. 1021/ja0779506.
    • (2007) Journal of the American Chemical Society , vol.129 , pp. 15780
    • Carlson, E.E.1    Cravatt, B.F.2
  • 17
    • 34250164588 scopus 로고    scopus 로고
    • Chemoselective probes for metabolite enrichment and profiling
    • Carlson, E. E., & Cravatt, B. F. (2007b). Chemoselective probes for metabolite enrichment and profiling. Nature Methods, 4, 429-435.
    • (2007) Nature Methods , vol.4 , pp. 429-435
    • Carlson, E.E.1    Cravatt, B.F.2
  • 18
    • 0141851085 scopus 로고    scopus 로고
    • Nutrigenomics in public health nutrition: Short-term perspectives
    • doi:10.1038/sj.ejcn.1601809
    • Chavez, A., & de Chavez, M. M. (2003). Nutrigenomics in public health nutrition: Short-term perspectives. European Journal of Clinical Nutrition, 57, S97-S100. doi: 10. 1038/sj. ejcn. 1601809.
    • (2003) European Journal of Clinical Nutrition , vol.57
    • Chavez, A.1    de Chavez, M.M.2
  • 22
    • 28644449917 scopus 로고    scopus 로고
    • How does gene expression clustering work?
    • doi:10.1038/nbt1205-1499
    • D'Haeseleer, P. (2005). How does gene expression clustering work? Nature Biotechnology, 23, 1499-1501. doi: 10. 1038/nbt1205-1499.
    • (2005) Nature Biotechnology , vol.23 , pp. 1499-1501
    • D'Haeseleer, P.1
  • 23
    • 0037092975 scopus 로고    scopus 로고
    • The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by H-1 nuclear magnetic resonance spectroscopy
    • doi:10.1006/abio.2002.5637
    • Daykin, C. A., Foxall, P. J. D., Connor, S. C., Lindon, J. C., & Nicholson, J. K. (2002). The comparison of plasma deproteinization methods for the detection of low-molecular-weight metabolites by H-1 nuclear magnetic resonance spectroscopy. Analytical Biochemistry, 304, 220-230. doi: 10. 1006/abio. 2002. 5637.
    • (2002) Analytical Biochemistry , vol.304 , pp. 220-230
    • Daykin, C.A.1    Foxall, P.J.D.2    Connor, S.C.3    Lindon, J.C.4    Nicholson, J.K.5
  • 25
    • 33846000626 scopus 로고    scopus 로고
    • Mass spectrometry-based metabolomics
    • doi:10.1002/mas.20108
    • Dettmer, K., Aronov, P. A., & Hammock, B. D. (2007). Mass spectrometry-based metabolomics. Mass Spectrometry Reviews, 26, 51-78. doi: 10. 1002/mas. 20108.
    • (2007) Mass Spectrometry Reviews , vol.26 , pp. 51-78
    • Dettmer, K.1    Aronov, P.A.2    Hammock, B.D.3
  • 27
    • 9244227101 scopus 로고    scopus 로고
    • Potential interferences from blood collection tubes in mass spectrometric analyses of serum polypeptides
    • doi:10.1373/clinchem.2004.040303
    • Drake, S. K., Bowen, R. A. R., Remaley, A. T., & Hortin, G. L. (2004). Potential interferences from blood collection tubes in mass spectrometric analyses of serum polypeptides. Clinical Chemistry, 50, 2398-2401. doi: 10. 1373/clinchem. 2004. 040303.
    • (2004) Clinical Chemistry , vol.50 , pp. 2398-2401
    • Drake, S.K.1    Bowen, R.A.R.2    Remaley, A.T.3    Hortin, G.L.4
  • 29
    • 38949210993 scopus 로고    scopus 로고
    • Metabolic profiling by ion mobility mass spectrometry (IMMS)
    • doi:10.1007/s11306-007-0093-z
    • Dwivedi, P., Wu, P., Klopsch, S. J., Puzon, G. J., Xun, L., & Hill, H. H. (2008). Metabolic profiling by ion mobility mass spectrometry (IMMS). Metabolomics, 4, 63-80. doi: 10. 1007/s11306-007-0093-z.
    • (2008) Metabolomics , vol.4 , pp. 63-80
    • Dwivedi, P.1    Wu, P.2    Klopsch, S.J.3    Puzon, G.J.4    Xun, L.5    Hill, H.H.6
  • 30
    • 0036269481 scopus 로고    scopus 로고
    • Rapid and quantitative detection of the microbial spoilage of meat by Fourier transform infrared spectroscopy and machine learning
    • doi:10.1128/AEM.68.6.2822-2828.2002
    • Ellis, D. I., Broadhurst, D., Kell, D. B., Rowland, J. J., & Goodacre, R. (2002). Rapid and quantitative detection of the microbial spoilage of meat by Fourier transform infrared spectroscopy and machine learning. Applied and Environmental Microbiology, 68, 2822-2828. doi: 10. 1128/AEM. 68. 6. 2822-2828. 2002.
    • (2002) Applied and Environmental Microbiology , vol.68 , pp. 2822-2828
    • Ellis, D.I.1    Broadhurst, D.2    Kell, D.B.3    Rowland, J.J.4    Goodacre, R.5
  • 33
    • 49849083087 scopus 로고    scopus 로고
    • A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets
    • doi:10.1021/pr800034h
    • Fardet, A., Llorach, R., Martin, J.-F., Besson, C., Lyan, B., Pujos, E., et al. (2008a). A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets. Journal of Proteome Research, 7, 2388-2398. doi: 10. 1021/pr800034h.
    • (2008) Journal of Proteome Research , vol.7 , pp. 2388-2398
    • Fardet, A.1    Llorach, R.2    Martin, J.-F.3    Besson, C.4    Lyan, B.5    Pujos, E.6    Scalbert, A.7
  • 37
    • 26444491700 scopus 로고    scopus 로고
    • Setup and annotation of metabolomic experiments by integrating biological and mass spectrometric metadata
    • Fiehn, O., Wohlgemuth, G., & Scholz, M. (2005). Setup and annotation of metabolomic experiments by integrating biological and mass spectrometric metadata. Data Integration in the Life Sciences. Proceedings, 3615, 224-239.
    • (2005) Data Integration in the Life Sciences. Proceedings , vol.3615 , pp. 224-239
    • Fiehn, O.1    Wohlgemuth, G.2    Scholz, M.3
  • 42
    • 41949086183 scopus 로고    scopus 로고
    • Liquid chromatography and ultra-performance liquid chromatography-mass spectrometry fingerprinting of human urine-Sample stability under different handling and storage conditions for metabonomics studies
    • doi:10.1016/j.chroma.2007.10.066
    • Gika, H. G., Theodoridis, G. A., & Wilson, I. D. (2008). Liquid chromatography and ultra-performance liquid chromatography-mass spectrometry fingerprinting of human urine-Sample stability under different handling and storage conditions for metabonomics studies. Journal of Chromatography A, 1189, 314-322. doi: 10. 1016/j. chroma. 2007. 10. 066.
    • (2008) Journal of Chromatography A , vol.1189 , pp. 314-322
    • Gika, H.G.1    Theodoridis, G.A.2    Wilson, I.D.3
  • 43
    • 34548146614 scopus 로고    scopus 로고
    • Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine
    • doi:10.1021/pr070183p
    • Gika, H. G., Theodoridis, G. A., Wingate, J. E., & Wilson, I. D. (2007). Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine. Journal of Proteome Research, 6, 3291-3303. doi: 10. 1021/pr070183p.
    • (2007) Journal of Proteome Research , vol.6 , pp. 3291-3303
    • Gika, H.G.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4
  • 44
    • 33846055395 scopus 로고    scopus 로고
    • Metabolomics of a superorganism
    • Goodacre, R. (2007). Metabolomics of a superorganism. The Journal of Nutrition, 137, 259S-266S.
    • (2007) The Journal of Nutrition , vol.137
    • Goodacre, R.1
  • 46
    • 0030058833 scopus 로고    scopus 로고
    • Identification and discrimination of oral asaccharolytic Eubacterium spp by pyrolysis mass spectrometry and artificial neural networks
    • doi:10.1007/s002849900014
    • Goodacre, R., Hiom, S. J., Cheeseman, S. L., Murdoch, D., Weightman, A. J., & Wade, W. G. (1996). Identification and discrimination of oral asaccharolytic Eubacterium spp by pyrolysis mass spectrometry and artificial neural networks. Current Microbiology, 32, 77-84. doi: 10. 1007/s002849900014.
    • (1996) Current Microbiology , vol.32 , pp. 77-84
    • Goodacre, R.1    Hiom, S.J.2    Cheeseman, S.L.3    Murdoch, D.4    Weightman, A.J.5    Wade, W.G.6
  • 48
    • 36448966459 scopus 로고    scopus 로고
    • Stable-isotope dimethylation labeling combined with LC-ESI MS for quantification of amine-containing metabolites in biological samples
    • doi:10.1021/ac0704356
    • Guo, K., Ji, C. J., & Li, L. (2007). Stable-isotope dimethylation labeling combined with LC-ESI MS for quantification of amine-containing metabolites in biological samples. Analytical Chemistry, 79, 8631-8638. doi: 10. 1021/ac0704356.
    • (2007) Analytical Chemistry , vol.79 , pp. 8631-8638
    • Guo, K.1    Ji, C.J.2    Li, L.3
  • 49
    • 33846233853 scopus 로고    scopus 로고
    • Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics
    • doi:10.1021/ac061443+
    • Hagan, S. O., Dunn, W. B., Knowles, J. D., Broadhurst, D., Williams, R., Ashworth, J. J., et al. (2007). Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics. Analytical Chemistry, 79, 464-476. doi: 10. 1021/ac061443+.
    • (2007) Analytical Chemistry , vol.79 , pp. 464-476
    • Hagan, S.O.1    Dunn, W.B.2    Knowles, J.D.3    Broadhurst, D.4    Williams, R.5    Ashworth, J.J.6    Cameron, M.7    Kell, D.B.8
  • 51
    • 18344393519 scopus 로고    scopus 로고
    • Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples
    • doi:10.1002/mas.20023
    • Han, X. L., & Gross, R. W. (2005). Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrometry Reviews, 24, 367-412. doi: 10. 1002/mas. 20023.
    • (2005) Mass Spectrometry Reviews , vol.24 , pp. 367-412
    • Han, X.L.1    Gross, R.W.2
  • 52
  • 53
    • 12344252950 scopus 로고    scopus 로고
    • Medicinal chemistry, metabolic profiling and drug target discovery: A role for metabolic profiling in reverse pharmacology and chemical genetics
    • Harrigan, G. G., Brackett, D. J., & Boros, L. G. (2005). Medicinal chemistry, metabolic profiling and drug target discovery: A role for metabolic profiling in reverse pharmacology and chemical genetics. Mini Reviews in Medicinal Chemistry, 5, 13-20.
    • (2005) Mini Reviews in Medicinal Chemistry , vol.5 , pp. 13-20
    • Harrigan, G.G.1    Brackett, D.J.2    Boros, L.G.3
  • 54
    • 58149375914 scopus 로고    scopus 로고
    • RPLC-FTMS method for lipid profiling of plasma: Method validation and application to p53 mutant mouse model
    • Hu, C., van Dommelen, J., van der Heijden, R., Spijksma, G., Rejmers, T., Wang, M., et al. (2009). RPLC-FTMS method for lipid profiling of plasma: Method validation and application to p53 mutant mouse model. Journal of Proteome Research, 7, 4982-4991.
    • (2009) Ournal of Proteome Research , vol.7 , pp. 4982-4991
    • Hu, C.1    van Dommelen, J.2    van der Heijden, R.3    Spijksma, G.4    Rejmers, T.5    Wang, M.6
  • 61
    • 33644867564 scopus 로고    scopus 로고
    • MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data
    • doi:10.1093/bioinformatics/btk039
    • Katajamaa, M., Miettinen, J., & Oresic, M. (2006). MZmine: Toolbox for processing and visualization of mass spectrometry based molecular profile data. Bioinformatics (Oxford, England), 22, 634-636. doi: 10. 1093/bioinformatics/btk039.
    • (2006) Bioinformatics (Oxford, England) , vol.22 , pp. 634-636
    • Katajamaa, M.1    Miettinen, J.2    Oresic, M.3
  • 62
    • 34347405493 scopus 로고    scopus 로고
    • Data processing for mass spectrometry-based metabolomics
    • doi:10.1016/j.chroma.2007.04.021
    • Katajamaa, M., & Oresic, M. (2007). Data processing for mass spectrometry-based metabolomics. Journal of Chromatography A, 1158, 318-328. doi: 10. 1016/j. chroma. 2007. 04. 021.
    • (2007) Journal of Chromatography A , vol.1158 , pp. 318-328
    • Katajamaa, M.1    Oresic, M.2
  • 64
    • 34247163207 scopus 로고    scopus 로고
    • Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry
    • Kind, T., & Fiehn, O. (2007). Seven Golden Rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics, 8, 105.
    • (2007) BMC Bioinformatics , vol.8 , pp. 105
    • Kind, T.1    Fiehn, O.2
  • 66
    • 33144485880 scopus 로고    scopus 로고
    • Microbial metabolomics with gas chromatography/mass spectrometry
    • doi:10.1021/ac051683+
    • Koek, M. M., Muilwijk, B., van der Werf, M. J., & Hankemeier, T. (2006). Microbial metabolomics with gas chromatography/mass spectrometry. Analytical Chemistry, 78, 1272-1281. doi: 10. 1021/ac051683+.
    • (2006) Analytical Chemistry , vol.78 , pp. 1272-1281
    • Koek, M.M.1    Muilwijk, B.2    van der Werf, M.J.3    Hankemeier, T.4
  • 67
    • 40649088623 scopus 로고    scopus 로고
    • Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis
    • doi:10.1016/j.chroma.2007.11.107
    • Koek, M. M., Muilwijk, B., van Stee, L. L. P., & Hankemeier, T. (2008). Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis. Journal of Chromatography A, 1186, 420-429. doi: 10. 1016/j. chroma. 2007. 11. 107.
    • (2008) Journal of Chromatography A , vol.1186 , pp. 420-429
    • Koek, M.M.1    Muilwijk, B.2    van Stee, L.L.P.3    Hankemeier, T.4
  • 68
    • 33744525340 scopus 로고    scopus 로고
    • Current challenges and developments in GC-MS based metabolite profiling technology
    • doi:10.1016/j.jbiotec.2005.12.012
    • Kopka, J. (2006). Current challenges and developments in GC-MS based metabolite profiling technology. Journal of Biotechnology, 124, 312-322. doi: 10. 1016/j. jbiotec. 2005. 12. 012.
    • (2006) Journal of Biotechnology , vol.124 , pp. 312-322
    • Kopka, J.1
  • 70
    • 36549022447 scopus 로고    scopus 로고
    • Methodological issues and experimental design considerations to facilitate development of robust, metabolic profile-based classification
    • G. Harrigan, R. Goodacre, and S. Vaidyanathan (Eds.), New York: Kluwer Academic Publishing
    • Kristal, B., Shurubor, Y., Paolucci, U., & Matson, W. R. (2005). Methodological issues and experimental design considerations to facilitate development of robust, metabolic profile-based classification. In G. Harrigan, R. Goodacre, & S. Vaidyanathan (Eds.), Metabolic profiling: Its role in drug discovery and integration with genomics and proteomics. New York: Kluwer Academic Publishing.
    • (2005) Metabolic Profiling: Its Role in Drug Discovery and Integration with Genomics and Proteomics
    • Kristal, B.1    Shurubor, Y.2    Paolucci, U.3    Matson, W.R.4
  • 74
    • 42249106391 scopus 로고    scopus 로고
    • Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: Plasma concentration and intake estimated from dietary records
    • Landberg, R., Kamal-Eldin, A., Andersson, A., Vessby, B., & Aman, P. (2008). Alkylresorcinols as biomarkers of whole-grain wheat and rye intake: Plasma concentration and intake estimated from dietary records. The American Journal of Clinical Nutrition, 87, 832-838.
    • (2008) The American Journal of Clinical Nutrition , vol.87 , pp. 832-838
    • Landberg, R.1    Kamal-Eldin, A.2    Andersson, A.3    Vessby, B.4    Aman, P.5
  • 75
    • 33846986484 scopus 로고    scopus 로고
    • Human urine as test material in H-1 NMR-based metabonomics: Recommendations for sample preparation and storage
    • doi:10.1021/ac061354x
    • Lauridsen, M., Hansen, S. H., Jaroszewski, J. W., & Cornett, C. (2007). Human urine as test material in H-1 NMR-based metabonomics: Recommendations for sample preparation and storage. Analytical Chemistry, 79, 1181-1186. doi: 10. 1021/ac061354x.
    • (2007) Analytical Chemistry , vol.79 , pp. 1181-1186
    • Lauridsen, M.1    Hansen, S.H.2    Jaroszewski, J.W.3    Cornett, C.4
  • 77
    • 0035796127 scopus 로고    scopus 로고
    • Pattern recognition methods and applications in biomedical magnetic resonance
    • doi:10.1016/S0079-6565(00)00036-4
    • Lindon, J., Holmes, E., & Nicholson, J. (2001). Pattern recognition methods and applications in biomedical magnetic resonance. Progress in Nuclear Magnetic Resonance Spectroscopy, 39, 1-40. doi: 10. 1016/S0079-6565(00)00036-4.
    • (2001) Progress in Nuclear Magnetic Resonance Spectroscopy , vol.39 , pp. 1-40
    • Lindon, J.1    Holmes, E.2    Nicholson, J.3
  • 78
    • 34547190179 scopus 로고    scopus 로고
    • Experimental and analytical variation in human urine in H-1 NMR spectroscopy-based metabolic phenotyping studies
    • doi:10.1021/ac070212f
    • Maher, A. D., Zirah, S. F. M., Holmes, E., & Nicholson, J. K. (2007). Experimental and analytical variation in human urine in H-1 NMR spectroscopy-based metabolic phenotyping studies. Analytical Chemistry, 79, 5204-5211. doi: 10. 1021/ac070212f.
    • (2007) Analytical Chemistry , vol.79 , pp. 5204-5211
    • Maher, A.D.1    Zirah, S.F.M.2    Holmes, E.3    Nicholson, J.K.4
  • 79
    • 70350008025 scopus 로고    scopus 로고
    • The complex links between dietary phytochemicals and human health deciphered by metabolomics
    • (in press)
    • Manach, C., Hubert, J., Llorach, R., & Scalbert, A. (2009). The complex links between dietary phytochemicals and human health deciphered by metabolomics. Molecular Nutrition & Food Research (in press).
    • (2009) Molecular Nutrition & Food Research
    • Manach, C.1    Hubert, J.2    Llorach, R.3    Scalbert, A.4
  • 81
    • 33746689714 scopus 로고    scopus 로고
    • Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
    • doi:10.1079/BJN20061808
    • Mennen, L., Sapinho, D., Ito, H., Galan, P., Hercberg, S., & Scalbert, A. (2006). Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods. The British Journal of Nutrition, 96, 191-198. doi: 10. 1079/BJN20061808.
    • (2006) The British Journal of Nutrition , vol.96 , pp. 191-198
    • Mennen, L.1    Sapinho, D.2    Ito, H.3    Galan, P.4    Hercberg, S.5    Scalbert, A.6
  • 82
    • 47949116376 scopus 로고    scopus 로고
    • Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects-Variability and possible use as biomarkers of polyphenol intake
    • doi:10.1038/sj.ejcn.1602744
    • Mennen, L. I., Sapinho, D., Ito, H., Galan, P., Hercberg, S., & Scalbert, A. (2008). Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects-Variability and possible use as biomarkers of polyphenol intake. European Journal of Clinical Nutrition, 62, 519-525. doi: 10. 1038/sj. ejcn. 1602744.
    • (2008) European Journal of Clinical Nutrition , vol.62 , pp. 519-525
    • Mennen, L.I.1    Sapinho, D.2    Ito, H.3    Galan, P.4    Hercberg, S.5    Scalbert, A.6
  • 83
    • 14944347637 scopus 로고    scopus 로고
    • Vitamin E modulation of cardiovascular disease
    • doi:10.1196/annals.1331.027
    • Meydani, M. (2004). Vitamin E modulation of cardiovascular disease. Annals of the New York Academy of Sciences, 1031, 271-279. doi: 10. 1196/annals. 1331. 027.
    • (2004) Annals of the New York Academy of Sciences , vol.1031 , pp. 271-279
    • Meydani, M.1
  • 84
    • 0000507872 scopus 로고    scopus 로고
    • CEAS generation of large multiparameter databases for determining categorical process involvement of biomolecules
    • VSP International Science Publication
    • Milbury, P. E. (1997). CEAS generation of large multiparameter databases for determining categorical process involvement of biomolecules. In Coulometric array detectors for HPLC (pp. 125-141). VSP International Science Publication.
    • (1997) Coulometric array detectors for HPLC , pp. 125-141
    • Milbury, P.E.1
  • 87
    • 0037380812 scopus 로고    scopus 로고
    • Nutrigenomics: Goals and strategies
    • doi:10.1038/nrg1047
    • Müller, M., & Kersten, S. (2003). Nutrigenomics: Goals and strategies. Nature Reviews. Genetics, 4, 315-322. doi: 10. 1038/nrg1047.
    • (2003) Nature Reviews. Genetics , vol.4 , pp. 315-322
    • Müller, M.1    Kersten, S.2
  • 88
    • 34548173536 scopus 로고    scopus 로고
    • Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat
    • doi:10.1194/jlr.M700146-JLR200
    • Newman, J. W., Kaysen, G. A., Hammock, B. D., & Shearer, G. C. (2007). Proteinuria increases oxylipid concentrations in VLDL and HDL but not LDL particles in the rat. Journal of Lipid Research, 48, 1792-1800. doi: 10. 1194/jlr. M700146-JLR200.
    • (2007) Journal of Lipid Research , vol.48 , pp. 1792-1800
    • Newman, J.W.1    Kaysen, G.A.2    Hammock, B.D.3    Shearer, G.C.4
  • 90
    • 7044222525 scopus 로고    scopus 로고
    • Development of biomarkers based on diet-dependent metabolic serotypes: Characteristics of component-based models of metabolic serotypes
    • doi:10.1089/omi.2004.8.221
    • Paolucci, U., Vigneau-Callahan, K. E., Shi, H., Matson, W. R., & Kristal, B. S. (2004a). Development of biomarkers based on diet-dependent metabolic serotypes: Characteristics of component-based models of metabolic serotypes. Omics, 8, 221-238. doi: 10. 1089/omi. 2004. 8. 221.
    • (2004) Omics , vol.8 , pp. 221-238
    • Paolucci, U.1    Vigneau-Callahan, K.E.2    Shi, H.3    Matson, W.R.4    Kristal, B.S.5
  • 91
    • 7044249739 scopus 로고    scopus 로고
    • Development of biomarkers based on diet-dependent metabolic serotypes: Concerns and approaches for cohort and gender issues in serum metabolome studies
    • doi:10.1089/omi.2004.8.209
    • Paolucci, U., Vigneau-Callahan, K. E., Shi, H. L., Matson, W. R., & Kristal, B. S. (2004b). Development of biomarkers based on diet-dependent metabolic serotypes: Concerns and approaches for cohort and gender issues in serum metabolome studies. Omics: A Journal of Integrative Biology, 8, 209-220. doi: 10. 1089/omi. 2004. 8. 209.
    • (2004) Omics: A Journal of Integrative Biology , vol.8 , pp. 209-220
    • Paolucci, U.1    Vigneau-Callahan, K.E.2    Shi, H.L.3    Matson, W.R.4    Kristal, B.S.5
  • 92
    • 48349105261 scopus 로고    scopus 로고
    • WikiPathways: Pathway editing for the people
    • doi:10.1371/journal.pbio.0060184
    • Pico, A. R., Kelder, T., van Iersel, M. P., Hanspers, K., Conklin, B. R., & Evelo, C. (2008). WikiPathways: Pathway editing for the people. PLoS Biology, 6, 1403-1407. doi: 10. 1371/journal. pbio. 0060184.
    • (2008) PLoS Biology , vol.6 , pp. 1403-1407
    • Pico, A.R.1    Kelder, T.2    van Iersel, M.P.3    Hanspers, K.4    Conklin, B.R.5    Evelo, C.6
  • 93
    • 33750259677 scopus 로고    scopus 로고
    • Generation of Ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities
    • doi:10.1021/ac060935j
    • Plumb, R. S., Rainville, P., Smith, B. W., Johnson, K. A., Castro-Perez, J., Wilson, I. D., et al. (2006). Generation of Ultrahigh peak capacity LC separations via elevated temperatures and high linear mobile-phase velocities. Analytical Chemistry, 78, 7278-7283. doi: 10. 1021/ac060935j.
    • (2006) Analytical Chemistry , vol.78 , pp. 7278-7283
    • Plumb, R.S.1    Rainville, P.2    Smith, B.W.3    Johnson, K.A.4    Castro-Perez, J.5    Wilson, I.D.6    Nicholson, J.K.7
  • 95
    • 33847368152 scopus 로고    scopus 로고
    • Nutritional metabonomics: Applications and perspectives
    • doi:10.1021/pr060522z
    • Rezzi, S., Ramadan, Z., Fay, L. B., & Kochhar, S. (2007). Nutritional metabonomics: Applications and perspectives. Journal of Proteome Research, 6, 513-525. doi: 10. 1021/pr060522z.
    • (2007) Journal of Proteome Research , vol.6 , pp. 513-525
    • Rezzi, S.1    Ramadan, Z.2    Fay, L.B.3    Kochhar, S.4
  • 97
    • 33746909835 scopus 로고    scopus 로고
    • Assessing the performance of statistical validation tools for megavariate metabolomics data
    • doi:10.1007/s11306-006-0022-6
    • Rubingh, C., Bijlsma, S., Derks, E., Bobeldijk, I., Verheij, E., Kochhar, S., et al. (2006). Assessing the performance of statistical validation tools for megavariate metabolomics data. Metabolomics, 2, 53-61. doi: 10. 1007/s11306-006-0022-6.
    • (2006) Metabolomics , vol.2 , pp. 53-61
    • Rubingh, C.1    Bijlsma, S.2    Derks, E.3    Bobeldijk, I.4    Verheij, E.5    Kochhar, S.6    Smilde, A.7
  • 99
    • 33748078772 scopus 로고    scopus 로고
    • A strategy capitalizing on synergies: The Reporting Structure for Biological Investigation (RSBI) working group
    • doi:10.1089/omi.2006.10.164
    • Sansone, S. A., Rocca-Serra, P., Tong, W. D., Fostel, J., Morrison, N., & Jones, A. R. (2006). A strategy capitalizing on synergies: The Reporting Structure for Biological Investigation (RSBI) working group. Omics: A Journal of Integrative Biology, 10, 164-171. doi: 10. 1089/omi. 2006. 10. 164.
    • (2006) Omics: A Journal of Integrative Biology , vol.10 , pp. 164-171
    • Sansone, S.A.1    Rocca-Serra, P.2    Tong, W.D.3    Fostel, J.4    Morrison, N.5    Jones, A.R.6
  • 102
  • 103
    • 33947392610 scopus 로고    scopus 로고
    • Urine stability for metabolomic studies: Effects of preparation and storage
    • doi:10.1007/s11306-006-0042-2
    • Saude, E. J., & Sykes, B. D. (2007). Urine stability for metabolomic studies: Effects of preparation and storage. Metabolomics, 3, 19-27. doi: 10. 1007/s11306-006-0042-2.
    • (2007) Metabolomics , vol.3 , pp. 19-27
    • Saude, E.J.1    Sykes, B.D.2
  • 104
    • 36348979386 scopus 로고    scopus 로고
    • SetupX-A public study design database for metabolomic projects
    • Scholz, M., & Fiehn, O. (2007). SetupX-A public study design database for metabolomic projects. Pacific Symposium on Biocomputing, 169-180.
    • (2007) Pacific Symposium on Biocomputing , pp. 169-180
    • Scholz, M.1    Fiehn, O.2
  • 107
    • 7044229934 scopus 로고    scopus 로고
    • Development of biomarkers based on diet-dependent metabolic serotypes: Practical issues in development of expert system-based classification models in metabolomic studies
    • doi:10.1089/omi.2004.8.197
    • Shi, H. L., Paolucci, U., Vigneau-Callahan, K. E., Milbury, P. E., Matson, W. R., & Kristal, B. S. (2004). Development of biomarkers based on diet-dependent metabolic serotypes: Practical issues in development of expert system-based classification models in metabolomic studies. Omics: A Journal of Integrative Biology, 8, 197-208. doi: 10. 1089/omi. 2004. 8. 197.
    • (2004) Omics: A Journal of Integrative Biology , vol.8 , pp. 197-208
    • Shi, H.L.1    Paolucci, U.2    Vigneau-Callahan, K.E.3    Milbury, P.E.4    Matson, W.R.5    Kristal, B.S.6
  • 108
    • 0036246743 scopus 로고    scopus 로고
    • Characterization of diet-dependent metabolic serotypes: Primary validation of male and female serotypes in independent cohorts of rats
    • Shi, H., Vigneau-Callahan, K. E., Shestopalov, A. I., Milbury, P. E., Matson, W. R., & Kristal, B. S. (2002). Characterization of diet-dependent metabolic serotypes: Primary validation of male and female serotypes in independent cohorts of rats. The Journal of Nutrition, 132, 1039-1046.
    • (2002) The Journal of Nutrition , vol.132 , pp. 1039-1046
    • Shi, H.1    Vigneau-Callahan, K.E.2    Shestopalov, A.I.3    Milbury, P.E.4    Matson, W.R.5    Kristal, B.S.6
  • 109
    • 38349048408 scopus 로고    scopus 로고
    • Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome
    • doi:10.1186/1472-6890-7-9
    • Shurubor, Y., Matson, W., Willett, W., Hankinson, S., & Kristal, B. (2007). Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome. BMC Clinical Pathology, 7, 9. doi: 10. 1186/1472-6890-7-9.
    • (2007) BMC Clinical Pathology , vol.7 , pp. 9
    • Shurubor, Y.1    Matson, W.2    Willett, W.3    Hankinson, S.4    Kristal, B.5
  • 111
    • 32444446805 scopus 로고    scopus 로고
    • XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification
    • doi:10.1021/ac051437y
    • Smith, C. A., Want, E. J., O'Maille, G., Abagyan, R., & Siuzdak, G. (2006). XCMS: Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Analytical Chemistry, 78, 779-787. doi: 10. 1021/ac051437y.
    • (2006) Analytical Chemistry , vol.78 , pp. 779-787
    • Smith, C.A.1    Want, E.J.2    O'Maille, G.3    Abagyan, R.4    Siuzdak, G.5
  • 112
    • 0242569355 scopus 로고    scopus 로고
    • Quantitative metabolome analysis using capillary electrophoresis mass spectrometry
    • doi:10.1021/pr034020m
    • Soga, T., Ohashi, Y., Ueno, Y., Naraoka, H., Tomita, M., & Nishioka, T. (2003). Quantitative metabolome analysis using capillary electrophoresis mass spectrometry. Journal of Proteome Research, 2, 488-494. doi: 10. 1021/pr034020m.
    • (2003) Journal of Proteome Research , vol.2 , pp. 488-494
    • Soga, T.1    Ohashi, Y.2    Ueno, Y.3    Naraoka, H.4    Tomita, M.5    Nishioka, T.6
  • 113
    • 34347229424 scopus 로고    scopus 로고
    • Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method
    • doi:10.1021/ac062446p
    • Southam, A. D., Payne, T. G., Cooper, H. J., Arvanitis, T. N., & Viant, M. R. (2007). Dynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method. Analytical Chemistry, 79, 4595-4602. doi: 10. 1021/ac062446p.
    • (2007) Analytical Chemistry , vol.79 , pp. 4595-4602
    • Southam, A.D.1    Payne, T.G.2    Cooper, H.J.3    Arvanitis, T.N.4    Viant, M.R.5
  • 114
    • 34748886039 scopus 로고    scopus 로고
    • Fast, comprehensive two-dimensional liquid chromatography
    • doi:10.1016/j.chroma.2007.08.054
    • Stoll, D. R., Li, X. P., Wang, X. O., Carr, P. W., Porter, S. E. G., & Rutan, S. C. (2007). Fast, comprehensive two-dimensional liquid chromatography. Journal of Chromatography A, 1168, 3-43. doi: 10. 1016/j. chroma. 2007. 08. 054.
    • (2007) Journal of Chromatography A , vol.1168 , pp. 3-43
    • Stoll, D.R.1    Li, X.P.2    Wang, X.O.3    Carr, P.W.4    Porter, S.E.G.5    Rutan, S.C.6
  • 117
    • 34447274030 scopus 로고    scopus 로고
    • Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women
    • Sun, Q., Ma, J., Campos, H., Hankinson, S. E., & Hu, F. B. (2007a). Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women. The American Journal of Clinical Nutrition, 86, 74-81.
    • (2007) The American Journal of Clinical Nutrition , vol.86 , pp. 74-81
    • Sun, Q.1    Ma, J.2    Campos, H.3    Hankinson, S.E.4    Hu, F.B.5
  • 118
    • 35148898711 scopus 로고    scopus 로고
    • Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart diseased
    • Sun, Q., Ma, J., Campos, H., & Hu, F. B. (2007b). Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart diseased. The American Journal of Clinical Nutrition, 86, 929-937.
    • (2007) The American Journal of Clinical Nutrition , vol.86 , pp. 929-937
    • Sun, Q.1    Ma, J.2    Campos, H.3    Hu, F.B.4
  • 121
    • 0037731046 scopus 로고    scopus 로고
    • Application of metabolomics to plant genotype discrimination using statistics and machine learning
    • (Oxford, England)
    • Taylor, J., King, R. D., Altmann, T., & Fiehn, O. (2002). Application of metabolomics to plant genotype discrimination using statistics and machine learning. Bioinformatics (Oxford, England), 18, S241-S248.
    • (2002) Bioinformatics , vol.18
    • Taylor, J.1    King, R.D.2    Altmann, T.3    Fiehn, O.4
  • 122
    • 33745700684 scopus 로고    scopus 로고
    • Impact of analytical bias in metabonomic studies of human blood serum and plasma
    • doi:10.1021/ac051972y
    • Teahan, O., Gamble, S., Holmes, E., Waxman, J., Nicholson, J. K., Bevan, C., et al. (2006). Impact of analytical bias in metabonomic studies of human blood serum and plasma. Analytical Chemistry, 78, 4307-4318. doi: 10. 1021/ac051972y.
    • (2006) Analytical Chemistry , vol.78 , pp. 4307-4318
    • Teahan, O.1    Gamble, S.2    Holmes, E.3    Waxman, J.4    Nicholson, J.K.5    Bevan, C.6    Keun, H.C.7
  • 123
    • 33344469496 scopus 로고    scopus 로고
    • A novel approach for nontargeted data analysis for metabolomics Large-scale profiling of tomato fruit volatiles
    • doi:10.1104/pp.105.068130
    • Tikunov, Y., Lommen, A., de Vos, C. H. R., Verhoeven, H. A., Bino, R. J., Hall, R. D., et al. (2005). A novel approach for nontargeted data analysis for metabolomics Large-scale profiling of tomato fruit volatiles. Plant Physiology, 139, 1125-1137. doi: 10. 1104/pp. 105. 068130.
    • (2005) Plant Physiology , vol.139 , pp. 1125-1137
    • Tikunov, Y.1    Lommen, A.2    de Vos, C.H.R.3    Verhoeven, H.A.4    Bino, R.J.5    Hall, R.D.6    Bovy, A.G.7
  • 124
    • 43049140446 scopus 로고    scopus 로고
    • Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy
    • doi:10.1016/j.ab.2008.01.037
    • Tiziani, S., Einwas, A. H., Lodi, A., Ludwig, C., Bunce, C. M., Viant, M. R., et al. (2008). Optimized metabolite extraction from blood serum for H-1 nuclear magnetic resonance spectroscopy. Analytical Biochemistry, 377, 16-23. doi: 10. 1016/j. ab. 2008. 01. 037.
    • (2008) Analytical Biochemistry , vol.377 , pp. 16-23
    • Tiziani, S.1    Einwas, A.H.2    Lodi, A.3    Ludwig, C.4    Bunce, C.M.5    Viant, M.R.6    Gunther, U.L.7
  • 125
    • 0037083636 scopus 로고    scopus 로고
    • Analysis of highly polar compounds of plant origin: Combination of hydrophilic interaction chromatography and electrospray ion trap mass spectrometry
    • doi:10.1006/abio.2001.5513
    • Tolstikov, V. V., & Fiehn, O. (2002). Analysis of highly polar compounds of plant origin: Combination of hydrophilic interaction chromatography and electrospray ion trap mass spectrometry. Analytical Biochemistry, 301, 298-307. doi: 10. 1006/abio. 2001. 5513.
    • (2002) Analytical Biochemistry , vol.301 , pp. 298-307
    • Tolstikov, V.V.1    Fiehn, O.2
  • 126
    • 0345168159 scopus 로고    scopus 로고
    • Monolithic silica-based capillary reversed-phase liquid chromatography/electrospray mass spectrometry for plant metabolomics
    • doi:10.1021/ac034716z
    • Tolstikov, V. V., Lommen, A., Nakanishi, K., Tanaka, N., & Fiehn, O. (2003). Monolithic silica-based capillary reversed-phase liquid chromatography/electrospray mass spectrometry for plant metabolomics. Analytical Chemistry, 75, 6737-6740. doi: 10. 1021/ac034716z.
    • (2003) Analytical Chemistry , vol.75 , pp. 6737-6740
    • Tolstikov, V.V.1    Lommen, A.2    Nakanishi, K.3    Tanaka, N.4    Fiehn, O.5
  • 127
    • 0032781888 scopus 로고    scopus 로고
    • Comparative study of class data analysis with PCA-LDA, SIMCA, PLS, ANNs, and k-NN
    • doi:10.1016/S0169-7439(99)00034-9
    • Tominaga, Y. (1999). Comparative study of class data analysis with PCA-LDA, SIMCA, PLS, ANNs, and k-NN. Chemometrics and Intelligent Laboratory Systems, 49, 105-115. doi: 10. 1016/S0169-7439(99)00034-9.
    • (1999) Chemometrics and Intelligent Laboratory Systems , vol.49 , pp. 105-115
    • Tominaga, Y.1
  • 128
    • 41649090385 scopus 로고    scopus 로고
    • Deep phenotyping': Characterizing populations in the era of genomics and systems biology
    • doi:10.1097/MOL.0b013e3282f73893
    • Tracy, R. P. (2008). 'Deep phenotyping': Characterizing populations in the era of genomics and systems biology. Current Opinion in Lipidology, 19, 151-157. doi: 10. 1097/MOL. 0b013e3282f73893.
    • (2008) Current Opinion in Lipidology , vol.19 , pp. 151-157
    • Tracy, R.P.1
  • 129
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • doi:10.1002/cem.695
    • Trygg, J., & Wold, S. (2002). Orthogonal projections to latent structures (O-PLS). Journal of Chemometrics, 16, 119-128. doi: 10. 1002/cem. 695.
    • (2002) Journal of Chemometrics , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 131
    • 33747019547 scopus 로고    scopus 로고
    • Centering, scaling, and transformations: Improving the biological information content of metabolomics data
    • doi:10.1186/1471-2164-7-142
    • van den Berg, R. A., Hoefsloot, H. C. J., Westerhuis, J. A., Smilde, A. K., & van der Werf, M. J. (2006). Centering, scaling, and transformations: Improving the biological information content of metabolomics data. BMC Genomics, 7, 142. doi: 10. 1186/1471-2164-7-142.
    • (2006) BMC Genomics , vol.7 , pp. 142
    • van den Berg, R.A.1    Hoefsloot, H.C.J.2    Westerhuis, J.A.3    Smilde, A.K.4    van der Werf, M.J.5
  • 133
    • 32444433438 scopus 로고    scopus 로고
    • Symbiosis of chemometrics and metabolomics: Past, present, and future
    • doi:10.1002/cem.941
    • van der Greef, J., & Smilde, A. K. (2005). Symbiosis of chemometrics and metabolomics: Past, present, and future. Journal of Chemometrics, 19, 376-386. doi: 10. 1002/cem. 941.
    • (2005) Journal of Chemometrics , vol.19 , pp. 376-386
    • van der Greef, J.1    Smilde, A.K.2
  • 135
    • 49749135740 scopus 로고    scopus 로고
    • The challenges for molecular nutrition research 2: Quantification of the nutritional phenotype
    • doi:10.1007/s12263-008-0084-3
    • van Ommen, B., Keijer, J., Kleemann, R., Elliott, R., Drevon, C. A., mcardle, H., et al. (2008b). The challenges for molecular nutrition research 2: Quantification of the nutritional phenotype. Genes & Nutrition, 3, 51-59. doi: 10. 1007/s12263-008-0084-3.
    • (2008) Genes & Nutrition , vol.3 , pp. 51-59
    • van Ommen, B.1    Keijer, J.2    Kleemann, R.3    Elliott, R.4    Drevon, C.A.5    McArdle, H.6    Gibney, M.7    Müller, M.8
  • 136
    • 0036812118 scopus 로고    scopus 로고
    • Nutrigenomics: Exploiting systems biology in the nutrition and health arena
    • doi:10.1016/S0958-1669(02)00349-X
    • van Ommen, B., & Stierum, R. (2002). Nutrigenomics: Exploiting systems biology in the nutrition and health arena. Current Opinion in Biotechnology, 13, 517-521. doi: 10. 1016/S0958-1669(02)00349-X.
    • (2002) Current Opinion in Biotechnology , vol.13 , pp. 517-521
    • van Ommen, B.1    Stierum, R.2
  • 137
    • 4444363957 scopus 로고    scopus 로고
    • Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis
    • doi:10.1016/j.intimp.2004.07.008
    • Verhoeckx, K. C. M., Bijlsma, S., Jespersen, S., Ramaker, R., Verheij, E. R., Witkamp, R. F., et al. (2004). Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis. International Immunopharmacology, 4, 1499-1514. doi: 10. 1016/j. intimp. 2004. 07. 008.
    • (2004) International Immunopharmacology , vol.4 , pp. 1499-1514
    • Verhoeckx, K.C.M.1    Bijlsma, S.2    Jespersen, S.3    Ramaker, R.4    Verheij, E.R.5    Witkamp, R.F.6    van der Greef, J.7    Rodenburg, R.J.T.8
  • 139
    • 0001173405 scopus 로고    scopus 로고
    • Partial linear fit: A new NMR spectroscopy preprocessing tool for pattern recognition applications
    • doi:10.1002/(SICI)1099-128X(199609)10:5/6<425::AID-CEM442>3.0.CO;2-S
    • Vogels, J., Tas, A. C., Venekamp, J., & VanderGreef, J. (1996). Partial linear fit: A new NMR spectroscopy preprocessing tool for pattern recognition applications. Journal of Chemometrics, 10, 425-438. doi: 10. 1002/(SICI)1099-128X(199609)10: 5/6< 425:: AID-CEM442> 3. 0. CO; 2-S.
    • (1996) Journal of Chemometrics , vol.10 , pp. 425-438
    • Vogels, J.1    Tas, A.C.2    Venekamp, J.3    Vandergreef, J.4
  • 140
    • 33750095958 scopus 로고    scopus 로고
    • Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans
    • Walsh, M. C., Brennan, L., Malthouse, J. P. G., Roche, H. M., & Gibney, M. J. (2006). Effect of acute dietary standardization on the urinary, plasma, and salivary metabolomic profiles of healthy humans. The American Journal of Clinical Nutrition, 84, 531-539.
    • (2006) The American Journal of Clinical Nutrition , vol.84 , pp. 531-539
    • Walsh, M.C.1    Brennan, L.2    Malthouse, J.P.G.3    Roche, H.M.4    Gibney, M.J.5
  • 142
    • 34548364227 scopus 로고    scopus 로고
    • Identification of pathways for atherosclerosis in mice-Integration of quantitative trait locus analysis and global gene expression data
    • doi:10.1161/CIRCRESAHA.107.152975
    • Wang, S. S., Schadt, E. E., Wang, H., Wang, X. P., Ingram-Drake, L., Shi, W., et al. (2007). Identification of pathways for atherosclerosis in mice-Integration of quantitative trait locus analysis and global gene expression data. Circulation Research, 101, E11-E30. doi: 10. 1161/CIRCRESAHA. 107. 152975.
    • (2007) Circulation Research , vol.101
    • Wang, S.S.1    Schadt, E.E.2    Wang, H.3    Wang, X.P.4    Ingram-Drake, L.5    Shi, W.6    Drake, T.A.7    Lusis, A.J.8
  • 143
    • 60349120185 scopus 로고    scopus 로고
    • Alkaloids profiling of the Chinese herbal medicine Fuzi by Matrix-assisted laser desorption ionization mass spectrometry and its validation by Liquid chromatography-mass spectrometry
    • Wang, J., van der Heijden, R., Spijksma, G., Reijmers, T., Wang, M., Xu, G., et al. (2009). Alkaloids profiling of the Chinese herbal medicine Fuzi by Matrix-assisted laser desorption ionization mass spectrometry and its validation by Liquid chromatography-mass spectrometry. Journal of Chromatography A, 1216, 2169-2178.
    • (2009) Ournal of Chromatography A , vol.1216 , pp. 2169-2178
    • Wang, J.1    van der Heijden, R.2    Spijksma, G.3    Reijmers, T.4    Wang, M.5    Xu, G.6
  • 144
    • 32444451016 scopus 로고    scopus 로고
    • Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry
    • doi:10.1021/ac051312t
    • Want, E. J., O'Maille, G., Smith, C. A., Brandon, T. R., Uritboonthai, W., Qin, C., et al. (2006). Solvent-dependent metabolite distribution, clustering, and protein extraction for serum profiling with mass spectrometry. Analytical Chemistry, 78, 743-752. doi: 10. 1021/ac051312t.
    • (2006) Analytical Chemistry , vol.78 , pp. 743-752
    • Want, E.J.1    O'Maille, G.2    Smith, C.A.3    Brandon, T.R.4    Uritboonthai, W.5    Qin, C.6    Trauger, S.A.7    Siuzdak, G.8
  • 145
    • 0036846241 scopus 로고    scopus 로고
    • Lipid metabolome-wide effects of the PPAR{gamma} agonist rosiglitazone
    • doi:10.1194/jlr.M200169-JLR200
    • Watkins, S. M., Reifsnyder, P. R., Pan, H.-j., German, J. B., & Leiter, E. H. (2002). Lipid metabolome-wide effects of the PPAR{gamma} agonist rosiglitazone. Journal of Lipid Research, 43, 1809-1817. doi: 10. 1194/jlr. M200169-JLR200.
    • (2002) Journal of Lipid Research , vol.43 , pp. 1809-1817
    • Watkins, S.M.1    Reifsnyder, P.R.2    Pan, H.-J.3    German, J.B.4    Leiter, E.H.5
  • 146
    • 33745700438 scopus 로고    scopus 로고
    • Targeted profiling: Quantitative analysis of H-1 NMR metabolomics data
    • doi:10.1021/ac060209g
    • Weljie, A. M., Newton, J., Mercier, P., Carlson, E., & Slupsky, C. M. (2006). Targeted profiling: Quantitative analysis of H-1 NMR metabolomics data. Analytical Chemistry, 78, 4430-4442. doi: 10. 1021/ac060209g.
    • (2006) Analytical Chemistry , vol.78 , pp. 4430-4442
    • Weljie, A.M.1    Newton, J.2    Mercier, P.3    Carlson, E.4    Slupsky, C.M.5
  • 148
    • 0030260340 scopus 로고    scopus 로고
    • A noise and background reduction method for component detection in liquid chromatography mass spectrometry
    • doi:10.1021/ac960435y
    • Windig, W., Phalp, J. M., & Payne, A. W. (1996). A noise and background reduction method for component detection in liquid chromatography mass spectrometry. Analytical Chemistry, 68, 3602-3606. doi: 10. 1021/ac960435y.
    • (1996) Analytical Chemistry , vol.68 , pp. 3602-3606
    • Windig, W.1    Phalp, J.M.2    Payne, A.W.3
  • 149
    • 48949118698 scopus 로고    scopus 로고
    • Metabolomics: Applications to food science and nutrition research
    • doi:10.1016/j.tifs.2008.03.003
    • Wishart, D. S. (2008). Metabolomics: Applications to food science and nutrition research. Trends in Food Science & Technology, 19, 482-493. doi: 10. 1016/j. tifs. 2008. 03. 003.
    • (2008) Trends in Food Science & Technology , vol.19 , pp. 482-493
    • Wishart, D.S.1


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