-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721-732 (2003). (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
2
-
-
57149142495
-
The impact of O2 availability on human cancer
-
Bertout, J. A., Patel, S. A. & Simon, M. C. The impact of O2 availability on human cancer. Nature Rev. Cancer 8, 967-975 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 967-975
-
-
Bertout, J.A.1
Patel, S.A.2
Simon, M.C.3
-
3
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
DOI 10.1038/cdd.2008.21, PII CDD200821, The biology of Hypoxia-inducible factors
-
Rankin, E. B. & Giaccia, A. J. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 15, 678-685 (2008). (Pubitemid 351405072)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.4
, pp. 678-685
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
4
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
DOI 10.1016/j.molcel.2008.04.009, PII S109727650800292X
-
Kaelin, W. G. Jr & Ratcliffe, P. J. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol. Cell 30, 393-402 (2008). (Pubitemid 351681994)
-
(2008)
Molecular Cell
, vol.30
, Issue.4
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
5
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar, A. J., Wong, W. J. & Simon, M. C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 40, 294-309 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
6
-
-
33745303045
-
Hypoxia signalling in cancer and approaches to enforce tumour regression
-
DOI 10.1038/nature04871, PII NATURE04871
-
Pouyssegur, J., Dayan, F. & Mazure, N. M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443 (2006). (Pubitemid 44050138)
-
(2006)
Nature
, vol.441
, Issue.7092
, pp. 437-443
-
-
Pouyssegur, J.1
Dayan, F.2
Mazure, N.M.3
-
7
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang, G. L., Jiang, B.-H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 5510-5514 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.-H.2
Rue, E.A.3
Semenza, G.L.4
-
8
-
-
0031020884
-
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
-
Tian, H., McKnight, S. L. & Russell, D. W. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev. 11, 72-82 (1997). (Pubitemid 27043825)
-
(1997)
Genes and Development
, vol.11
, Issue.1
, pp. 72-82
-
-
Tian, H.1
McKnight, S.L.2
Russell, D.W.3
-
9
-
-
0343683375
-
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-lot and developmentally expressed in blood vessels
-
DOI 10.1016/S0925-4773(97)00674-6, PII S0925477397006746
-
Flamme, I. et al. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels. Mech. Dev. 63, 51-60 (1997). (Pubitemid 27214502)
-
(1997)
Mechanisms of Development
, vol.63
, Issue.1
, pp. 51-60
-
-
Flamme, I.1
Frohlich, T.2
Von Reutern, M.3
Kappel, A.4
Damert, A.5
Risau, W.6
-
10
-
-
0031000736
-
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
-
Ema, M. et al. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development. Proc. Natl Acad. Sci. USA 94, 4273-4278 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4273-4278
-
-
Ema, M.1
-
11
-
-
0030887045
-
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
-
DOI 10.1074/jbc.272.13.8581
-
Hogenesch, J. B. et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272, 8581-8593 (1997). (Pubitemid 27147824)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.13
, pp. 8581-8593
-
-
Hogenesch, J.B.1
Chan, W.K.2
Jackiw, V.H.3
Brown, R.C.4
Gu, Y.-Z.5
Pray-Grant, M.6
Perdew, G.H.7
Bradfield, C.A.8
-
12
-
-
0037315337
-
Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
-
Wiesener, M. S. et al. Widespread hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs. FASEB J. 17, 271-273 (2003).
-
(2003)
FASEB J.
, vol.17
, pp. 271-273
-
-
Wiesener, M.S.1
-
13
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus
-
DOI 10.1074/jbc.C200328200
-
Makino, Y., Kanopka, A., Wilson, W. J., Tanaka, H. & Poellinger, L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3α locus. J. Biol. Chem. 277, 32405-32408 (2002). (Pubitemid 34984738)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.36
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
14
-
-
82255186546
-
Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response
-
Heikkila, M., Pasanen, A., Kivirikko, K. I. & Myllyharju, J. Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response. Cell. Mol. Life Sci. 68, 3885-3901 (2011).
-
(2011)
Cell. Mol. Life Sci.
, vol.68
, pp. 3885-3901
-
-
Heikkila, M.1
Pasanen, A.2
Kivirikko, K.I.3
Myllyharju, J.4
-
15
-
-
70350692093
-
The human HIF (hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction
-
Tanaka, T., Wiesener, M., Bernhardt, W., Eckardt, K. U. & Warnecke, C. The human HIF (hypoxia-inducible factor)-3α gene is a HIF-1 target gene and may modulate hypoxic gene induction. Biochem. J. 424, 143-151 (2009).
-
(2009)
Biochem. J.
, vol.424
, pp. 143-151
-
-
Tanaka, T.1
Wiesener, M.2
Bernhardt, W.3
Eckardt, K.U.4
Warnecke, C.5
-
16
-
-
0037837724
-
Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
-
DOI 10.1074/jbc.M208681200
-
Maynard, M. A. et al. Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. J. Biol. Chem. 278, 11032-11040 (2003). (Pubitemid 36792653)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.13
, pp. 11032-11040
-
-
Maynard, M.A.1
Qi, H.2
Chung, J.3
Lee, E.H.L.4
Kondo, Y.5
Hara, S.6
Conaway, R.C.7
Conaway, J.W.8
Ohh, M.9
-
17
-
-
37249001223
-
Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression
-
Maynard, M. A. et al. Dominant-negative HIF-3α4 suppresses VHL-null renal cell carcinoma progression. Cell Cycle 6, 2810-2816 (2007). (Pubitemid 350277174)
-
(2007)
Cell Cycle
, vol.6
, Issue.22
, pp. 2810-2816
-
-
Maynard, M.A.1
Evans, A.J.2
Shi, W.3
Kim, W.Y.4
Liu, F.-F.5
Ohh, M.6
-
18
-
-
0029928689
-
CDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the Aryl hydrocarbon receptor nuclear translocator (Arnt)
-
Hirose, K. et al. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the Aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16, 1706-1713 (1996).
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1706-1713
-
-
Hirose, K.1
-
19
-
-
0033989154
-
ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus
-
DOI 10.1016/S0925-4773(99)00328-7, PII S0925477399003287
-
Michaud, J. L., DeRossi, C., May, N. R., Holdener, B. C. & Fan, C. ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mech. Dev. 90, 253-261 (2000). (Pubitemid 30042930)
-
(2000)
Mechanisms of Development
, vol.90
, Issue.2
, pp. 253-261
-
-
Michaud, J.L.1
Derossi, C.2
May, N.R.3
Holdener, B.C.4
Fan, C.-M.5
-
20
-
-
0035810987
-
Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
-
DOI 10.1073/pnas.121494298
-
Keith, B., Adelman, D. M. & Simon, M. C. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl Acad. Sci. USA 98, 6692-6697 (2001). (Pubitemid 32538278)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.12
, pp. 6692-6697
-
-
Keith, B.1
Adelman, D.M.2
Simon, M.C.3
-
21
-
-
80054072674
-
SiRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells
-
Qin, X. Y. et al. siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. FEBS Lett. 585, 3310-3315 (2011).
-
(2011)
FEBS Lett.
, vol.585
, pp. 3310-3315
-
-
Qin, X.Y.1
-
22
-
-
54549113030
-
The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
-
Kaelin, W. G. Jr. The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nature Rev. Cancer 8, 865-873 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 865-873
-
-
Kaelin Jr., W.G.1
-
23
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
-
DOI 10.1016/S1535-6108(02)00044-2
-
Maranchie, J. K. et al. The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1, 247-255 (2002). (Pubitemid 41039149)
-
(2002)
Cancer Cell
, vol.1
, Issue.3
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
24
-
-
2342597973
-
Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth
-
Kondo, K., Kim, W. Y., Lechpammer, M. & Kaelin, W. G. Jr. Inhibition of HIF2α is sufficient to suppress pVHL-defective tumor growth. PLoS Biol. 1, e83 (2003).
-
(2003)
PLoS Biol.
, vol.1
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin Jr., W.G.4
-
25
-
-
23644435597
-
Genetic evidence for a tumor suppressor role of HIF-2α
-
DOI 10.1016/j.ccr.2005.07.003, PII S1535610805002278
-
Acker, T. et al. Genetic evidence for a tumor suppressor role of HIF-2α. Cancer Cell 8, 131-141 (2005). (Pubitemid 41132742)
-
(2005)
Cancer Cell
, vol.8
, Issue.2
, pp. 131-141
-
-
Acker, T.1
Diez-Juan, A.2
Aragones, J.3
Tjwa, M.4
Brusselmans, K.5
Moons, L.6
Fukumura, D.7
Moreno-Murciano, M.P.8
Herbert, J.-M.9
Burger, A.10
Riedel, J.11
Elvert, G.12
Flamme, I.13
Maxwell, P.H.14
Collen, D.15
Dewerchin, M.16
Jain, R.K.17
Plate, K.H.18
Carmeliet, P.19
-
26
-
-
77955982276
-
HIF-2α deletion promotes Kras-driven lung tumor development
-
Mazumdar, J. et al. HIF-2α deletion promotes Kras-driven lung tumor development. Proc. Natl Acad. Sci. USA 107, 14182-14187 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 14182-14187
-
-
Mazumdar, J.1
-
27
-
-
0345491599
-
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
-
DOI 10.1128/MCB.23.24.9361-9374.2003
-
Hu, C.J., Wang, L.Y., Chodosh, L. A., Keith, B. & Simon, M. C. Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation. Mol. Biol. Cell 23, 9361-9374 (2003). (Pubitemid 37499822)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.24
, pp. 9361-9374
-
-
Hu, C.-J.1
Wang, L.-Y.2
Chodosh, L.A.3
Keith, B.4
Simon, M.C.5
-
28
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
-
DOI 10.1128/MCB.25.13.5675-5686.2005
-
Raval, R. R. et al. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol. Cell. Biol. 25, 5675-5686 (2005). (Pubitemid 40853601)
-
(2005)
Molecular and Cellular Biology
, vol.25
, Issue.13
, pp. 5675-5686
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.B.3
Sowter, H.M.4
Mandriota, S.J.5
Li, J.-L.6
Pugh, C.W.7
Maxwell, P.H.8
Harris, A.L.9
Ratcliffe, P.J.10
-
29
-
-
35848938945
-
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α
-
DOI 10.1091/mbc.E06-05-0419
-
Hu, C. J., Sataur, A., Wang, L., Chen, H. & Simon, M. C. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1α and HIF-2α. Mol. Biol. Cell 18, 4528-4542 (2007). (Pubitemid 350060179)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.11
, pp. 4528-4542
-
-
Hu, C.-J.1
Sataur, A.2
Wang, L.3
Chen, H.4
Simon, M.C.5
-
30
-
-
34247219188
-
Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms
-
DOI 10.1038/sj.bjc.6603675, PII 6603675
-
Lau, K. W., Tian, Y. M., Raval, R. R., Ratcliffe, P. J. & Pugh, C. W. Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms. Br. J. Cancer 96, 1284-1292 (2007). (Pubitemid 46625064)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.8
, pp. 1284-1292
-
-
Lau, K.W.1
Tian, Y.-M.2
Raval, R.R.3
Ratcliffe, P.J.4
Pugh, C.W.5
-
31
-
-
63449103705
-
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
-
Xia, X. et al. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc. Natl Acad. Sci. USA 106, 4260-4265 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4260-4265
-
-
Xia, X.1
-
32
-
-
75349114759
-
Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia
-
Xia, X. & Kung, A. L. Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia. Genome Biol. 10, R113 (2009).
-
(2009)
Genome Biol.
, vol.10
-
-
Xia, X.1
Kung, A.L.2
-
33
-
-
67650531089
-
Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α. DNA binding with expression profiling of hypoxia-inducible transcripts
-
Mole, D. R. et al. Genome-wide association of hypoxia-inducible factor (HIF)-1α and HIF-2α DNA binding with expression profiling of hypoxia-inducible transcripts. J. Biol. Chem. 284, 16767-16775 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 16767-16775
-
-
Mole, D.R.1
-
34
-
-
73549088729
-
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1α enhances hypoxic gene expression and tumor growth
-
Krieg, A. J. et al. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1α enhances hypoxic gene expression and tumor growth. Mol. Cell. Biol. 30, 344-353 (2010).
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 344-353
-
-
Krieg, A.J.1
-
35
-
-
79959450883
-
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
-
Schodel, J. et al. High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood 117, e207-e217 (2011).
-
(2011)
Blood
, vol.117
-
-
Schodel, J.1
-
36
-
-
15444342958
-
2 homeostasis by hypoxia- inducible factor 1α
-
Iyer, N. V. et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12, 149-162 (1998). (Pubitemid 28060446)
-
(1998)
Genes and Development
, vol.12
, Issue.2
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
37
-
-
0032100732
-
HIF-1α is required for solid tumor formation and embryonic vascularization
-
DOI 10.1093/emboj/17.11.3005
-
Ryan, H. E., Lo, J. & Johnson, R. S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015 (1998). (Pubitemid 28254373)
-
(1998)
EMBO Journal
, vol.17
, Issue.11
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
38
-
-
0032213236
-
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
-
Tian, H., Hammer, R. E., Matsumoto, A. M., Russell, D. W. & McKnight, S. L. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 12, 3320-3324 (1998). (Pubitemid 28520979)
-
(1998)
Genes and Development
, vol.12
, Issue.21
, pp. 3320-3324
-
-
Tian, H.1
Hammer, R.E.2
Matsumoto, A.M.3
Russell, D.W.4
McKnight, S.L.5
-
39
-
-
0035983324
-
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
-
DOI 10.1038/nm721
-
Compernolle, V. et al. Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nature Med. 8, 702-710 (2002). (Pubitemid 34778723)
-
(2002)
Nature Medicine
, vol.8
, Issue.7
, pp. 702-710
-
-
Compernolle, V.1
Brusselmans, K.2
Acker, T.3
Hoet, P.4
Tjwa, M.5
Beck, H.6
Plaisance, S.7
Dor, Y.8
Keshet, E.9
Lupu, F.10
Nemery, B.11
Dewerchin, M.12
Van Veldhoven, P.13
Plate, K.14
Moons, L.15
Collen, D.16
Carmeliet, P.17
-
40
-
-
0034682513
-
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
-
DOI 10.1073/pnas.140087397
-
Peng, J., Zhang, L., Drysdale, L. & Fong, G. H. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling. Proc. Natl Acad. Sci. USA 97, 8386-8391 (2000). (Pubitemid 30639682)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.15
, pp. 8386-8391
-
-
Peng, J.1
Zhang, L.2
Drysdale, L.3
Fong, G.-H.4
-
41
-
-
0344826529
-
-/- mice
-
DOI 10.1038/ng1266
-
Scortegagna, M. et al. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/-mice. Nature Genet. 35, 331-340 (2003). (Pubitemid 37486916)
-
(2003)
Nature Genetics
, vol.35
, Issue.4
, pp. 331-340
-
-
Scortegagna, M.1
Ding, K.2
Oktay, Y.3
Gaur, A.4
Thurmond, F.5
Yan, L.-J.6
Marck, B.T.7
Matsumoto, A.M.8
Shelton, J.M.9
Richardson, J.A.10
Bennet, M.J.11
Garcia, J.A.12
-
42
-
-
33847796951
-
Acute postnatal ablation of Hif-2α results in anemia
-
DOI 10.1073/pnas.0608382104
-
Gruber, M. et al. Acute postnatal ablation of Hif-2α results in anemia. Proc. Natl Acad. Sci. USA 104, 2301-2306 (2007). (Pubitemid 46391392)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.7
, pp. 2301-2306
-
-
Gruber, M.1
Hu, C.-J.2
Johnson, R.S.3
Brown, E.J.4
Keith, B.5
Simon, M.C.6
-
43
-
-
33846652552
-
Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
DOI 10.1158/0008-5472.CAN-06-2701
-
Liao, D., Corle, C., Seagroves, T. N. & Johnson, R. S. Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res. 67, 563-572 (2007). (Pubitemid 46192193)
-
(2007)
Cancer Research
, vol.67
, Issue.2
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
Johnson, R.S.4
-
44
-
-
27544469796
-
HIN-1, an inhibitor of cell growth, invasion, and AKT activation
-
DOI 10.1158/0008-5472.CAN-05-1663
-
Krop, I. et al. HIN-1, an inhibitor of cell growth, invasion, and AKT activation. Cancer Res. 65, 9659-9669 (2005). (Pubitemid 41541441)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9659-9669
-
-
Krop, I.1
Parker, M.T.2
Bloushtain-Qimron, N.3
Porter, D.4
Gelman, R.5
Sasaki, H.6
Maurer, M.7
Terry, M.B.8
Parsons, R.9
Polyak, K.10
-
45
-
-
68849102685
-
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
-
Kim, W. Y. et al. HIF2α cooperates with RAS to promote lung tumorigenesis in mice. J. Clin. Invest. 119, 2160-2170 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 2160-2170
-
-
Kim, W.Y.1
-
46
-
-
51649090078
-
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
-
Rankin, E. B. et al. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 27, 5354-5358 (2008).
-
(2008)
Oncogene
, vol.27
, pp. 5354-5358
-
-
Rankin, E.B.1
-
47
-
-
68249140395
-
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
-
Fang, H. Y. et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114, 844-859 (2009).
-
(2009)
Blood
, vol.114
, pp. 844-859
-
-
Fang, H.Y.1
-
48
-
-
77957350018
-
Macrophage expression of hypoxia-inducible factor-1α suppresses T-cell function and promotes tumor progression
-
Doedens, A. L. et al. Macrophage expression of hypoxia-inducible factor-1α suppresses T-cell function and promotes tumor progression. Cancer Res. 70, 7465-7475 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 7465-7475
-
-
Doedens, A.L.1
-
49
-
-
77649177217
-
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
-
Takeda, N. et al. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis. Genes Dev. 24, 491-501 (2010).
-
(2010)
Genes Dev.
, vol.24
, pp. 491-501
-
-
Takeda, N.1
-
50
-
-
77955295091
-
Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
-
Imtiyaz, H. Z. et al. Hypoxia-inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest. 120, 2699-2714 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2699-2714
-
-
Imtiyaz, H.Z.1
-
51
-
-
7944224442
-
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
DOI 10.1016/j.ccr.2004.09.026, PII S1535610804003022
-
Tang, N. et al. Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6, 485-495 (2004). (Pubitemid 39469984)
-
(2004)
Cancer Cell
, vol.6
, Issue.5
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.-P.6
Ferrara, N.7
Johnson, R.S.8
-
52
-
-
49649115935
-
Hypoxia-inducible transcription factor-2α in endothelial cells regulates tumor neovascularization through activation of ephrin A1
-
Yamashita, T. et al. Hypoxia-inducible transcription factor-2α in endothelial cells regulates tumor neovascularization through activation of ephrin A1. J. Biol. Chem. 283, 18926-18936 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 18926-18936
-
-
Yamashita, T.1
-
53
-
-
67651098992
-
Endothelial deletion of hypoxia-inducible factor-2α (HIF-2α) alters vascular function and tumor angiogenesis
-
Skuli, N. et al. Endothelial deletion of hypoxia-inducible factor-2α (HIF-2α) alters vascular function and tumor angiogenesis. Blood 114, 469-477 (2009).
-
(2009)
Blood
, vol.114
, pp. 469-477
-
-
Skuli, N.1
-
54
-
-
37049002653
-
Hypoxia up-regulates hypoxia-inducible factor-1αtranscription by involving phosphatidylinositol 3-kinase and nuclear factor κb in pulmonary artery smooth muscle cells
-
Belaiba, R. S. et al. Hypoxia up-regulates hypoxia-inducible factor-1αtranscription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells. Mol. Biol. Cell 18, 4691-4697 (2007).
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 4691-4697
-
-
Belaiba, R.S.1
-
55
-
-
33745003285
-
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB
-
DOI 10.1042/BJ20051839
-
Frede, S., Stockmann, C., Freitag, P. & Fandrey, J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB. Biochem. J. 396, 517-527 (2006). (Pubitemid 44228166)
-
(2006)
Biochemical Journal
, vol.396
, Issue.3
, pp. 517-527
-
-
Frede, S.1
Stockmann, C.2
Freitag, P.3
Fandrey, J.4
-
56
-
-
70249099576
-
Interdependence of hypoxic and innate immune responses
-
Nizet, V. & Johnson, R. S. Interdependence of hypoxic and innate immune responses. Nature Rev. Immunol. 9, 609-617 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 609-617
-
-
Nizet, V.1
Johnson, R.S.2
-
57
-
-
44849100198
-
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
-
DOI 10.1038/nature06905, PII NATURE06905
-
Rius, J. et al. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453, 807-811 (2008). (Pubitemid 351793778)
-
(2008)
Nature
, vol.453
, Issue.7196
, pp. 807-811
-
-
Rius, J.1
Guma, M.2
Schachtrup, C.3
Akassoglou, K.4
Zinkernagel, A.S.5
Nizet, V.6
Johnson, R.S.7
Haddad, G.G.8
Karin, M.9
-
58
-
-
63249087504
-
SWI/SNF regulates the cellular response to hypoxia
-
Kenneth, N. S., Mudie, S., van Uden, P. & Rocha, S. SWI/SNF regulates the cellular response to hypoxia. J. Biol. Chem. 284, 4123-4131 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 4123-4131
-
-
Kenneth, N.S.1
Mudie, S.2
Van Uden, P.3
Rocha, S.4
-
59
-
-
58049216350
-
Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2
-
Toschi, A., Lee, E., Gadir, N., Ohh, M. & Foster, D. A. Differential dependence of hypoxia-inducible factors 1α and 2α on mTORC1 and mTORC2. J. Biol. Chem. 283, 34495-34499 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 34495-34499
-
-
Toschi, A.1
Lee, E.2
Gadir, N.3
Ohh, M.4
Foster, D.A.5
-
60
-
-
2442544693
-
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: Implication of natural antisense HIF-1α
-
Uchida, T. et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1α and HIF-2α expression in lung epithelial cells: implication of natural antisense HIF-1α. J. Biol. Chem. 279, 14871-14878 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14871-14878
-
-
Uchida, T.1
-
61
-
-
34247628002
-
Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency
-
DOI 10.1038/nsmb1222, PII NSMB1222
-
Sanchez, M., Galy, B., Muckenthaler, M. U. & Hentze, M. W. Iron-regulatory proteins limit hypoxia-inducible factor-2α expression in iron deficiency. Nature Struct. Mol. Biol. 14, 420-426 (2007). (Pubitemid 46685876)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.5
, pp. 420-426
-
-
Sanchez, M.1
Galy, B.2
Muckenthaler, M.U.3
Hentze, M.W.4
-
62
-
-
57849147670
-
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing
-
Zimmer, M. et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing. Mol. Cell 32, 838-848 (2008).
-
(2008)
Mol. Cell
, vol.32
, pp. 838-848
-
-
Zimmer, M.1
-
63
-
-
79751479288
-
The HIF pathway and erythrocytosis
-
Lee, F. S. & Percy, M. J. The HIF pathway and erythrocytosis. Annu. Rev. Pathol. 6, 165-192 (2011).
-
(2011)
Annu. Rev. Pathol.
, vol.6
, pp. 165-192
-
-
Lee, F.S.1
Percy, M.J.2
-
64
-
-
66449124596
-
HIF-2α, but not HIF-1α, promotes iron absorption in mice
-
Mastrogiannaki, M. et al. HIF-2α, but not HIF-1α, promotes iron absorption in mice. J. Clin. Invest. 119, 1159-1166 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1159-1166
-
-
Mastrogiannaki, M.1
-
65
-
-
34147124264
-
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
-
DOI 10.1172/JCI30117
-
Rankin, E. B. et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J. Clin. Invest. 117, 1068-1077 (2007). (Pubitemid 46556763)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.4
, pp. 1068-1077
-
-
Rankin, E.B.1
Biju, M.P.2
Liu, Q.3
Unger, T.L.4
Rha, J.5
Johnson, R.S.6
Simon, M.C.7
Keith, B.8
Haase, V.H.9
-
66
-
-
0037416792
-
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
-
DOI 10.1093/emboj/cdg117
-
Morita, M. et al. HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 22, 1134-1146 (2003). (Pubitemid 36313597)
-
(2003)
EMBO Journal
, vol.22
, Issue.5
, pp. 1134-1146
-
-
Morita, M.1
Ohneda, O.2
Yamashita, T.3
Takahashi, S.4
Suzuki, N.5
Nakajima, O.6
Kawauchi, S.7
Ema, M.8
Shibahara, S.9
Udono, T.10
Tomita, K.11
Tamai, M.12
Sogawa, K.13
Yamamoto, M.14
Fujii-Kuriyama, Y.15
-
67
-
-
12344331744
-
HIF-2α expression in human fetal paraganglia and neuroblastoma: Relation to sympathetic differentiation, glucose deficiency, and hypoxia
-
DOI 10.1016/j.yexcr.2004.10.003, PII S0014482704005865
-
Nilsson, H. et al. HIF-2α expression in human fetal paraganglia and neuroblastoma: relation to sympathetic differentiation, glucose deficiency, and hypoxia. Exp. Cell Res. 303, 447-456 (2005). (Pubitemid 40126276)
-
(2005)
Experimental Cell Research
, vol.303
, Issue.2
, pp. 447-456
-
-
Nilsson, H.1
Jogi, A.2
Beckman, S.3
Harris, A.L.4
Poellinger, L.5
Pahlman, S.6
-
68
-
-
33750630119
-
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
-
DOI 10.1016/j.ccr.2006.08.026, PII S153561080600290X
-
Holmquist-Mengelbier, L. et al. Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype. Cancer Cell 10, 413-423 (2006). (Pubitemid 44693470)
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Lofstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
Pietras, A.7
Vallon-Christersson, J.8
Borg, A.9
Gradin, K.10
Poellinger, L.11
Pahlman, S.12
-
69
-
-
65749106405
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
-
Li, Z. et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15, 501-513 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 501-513
-
-
Li, Z.1
-
70
-
-
57349136768
-
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation
-
Koh, M. Y., Darnay, B. G. & Powis, G. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation. Mol. Cell. Biol. 28, 7081-7095 (2008).
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 7081-7095
-
-
Koh, M.Y.1
Darnay, B.G.2
Powis, G.3
-
71
-
-
79957440998
-
The hypoxia-associated factor switches cells from HIF-1α-to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
-
Koh, M. Y., Lemos, R. Jr, Liu, X. & Powis, G. The hypoxia-associated factor switches cells from HIF-1α-to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res. 71, 4015-4027 (2011).
-
(2011)
Cancer Res.
, vol.71
, pp. 4015-4027
-
-
Koh, M.Y.1
Lemos Jr., R.2
Liu, X.3
Powis, G.4
-
72
-
-
77950473770
-
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but Not HIF-2α
-
Luo, W. et al. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1α but Not HIF-2α. J. Biol. Chem. 285, 3651-3663 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 3651-3663
-
-
Luo, W.1
-
73
-
-
77953954331
-
The role of HIF prolyl hydroxylases in tumour growth
-
Jokilehto, T. & Jaakkola, P. M. The role of HIF prolyl hydroxylases in tumour growth. J. Cell. Mol. Med. 14, 758-770 (2010).
-
(2010)
J. Cell. Mol. Med.
, vol.14
, pp. 758-770
-
-
Jokilehto, T.1
Jaakkola, P.M.2
-
74
-
-
77954175077
-
PHD2 in tumour angiogenesis
-
Chan, D. A. & Giaccia, A. J. PHD2 in tumour angiogenesis. Br. J. Cancer 103, 1-5 (2010).
-
(2010)
Br. J. Cancer
, vol.103
, pp. 1-5
-
-
Chan, D.A.1
Giaccia, A.J.2
-
75
-
-
70350389957
-
FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins
-
Cockman, M. E., Webb, J. D. & Ratcliffe, P. J. FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Ann. NY Acad. Sci. 1177, 9-18 (2009).
-
(2009)
Ann. NY Acad. Sci.
, vol.1177
, pp. 9-18
-
-
Cockman, M.E.1
Webb, J.D.2
Ratcliffe, P.J.3
-
76
-
-
4644318828
-
Differential function of the prolyl hydroxylases, PHD1, PHD2 and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff, R. J. et al. Differential function of the prolyl hydroxylases, PHD1, PHD2 and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 279, 38458-38465 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38458-38465
-
-
Appelhoff, R.J.1
-
77
-
-
33747366672
-
Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment
-
Bracken, C. P. et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment. J. Biol. Chem. 281, 22575-22585 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 22575-22585
-
-
Bracken, C.P.1
-
78
-
-
77955284188
-
The asparaginyl hydroxylase factor inhibiting HIF-1α is an essential regulator of metabolism
-
Zhang, N. et al. The asparaginyl hydroxylase factor inhibiting HIF-1α is an essential regulator of metabolism. Cell Metab. 11, 364-378 (2010).
-
(2010)
Cell Metab.
, vol.11
, pp. 364-378
-
-
Zhang, N.1
-
79
-
-
0032725554
-
P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
-
Richard, D. E., Berra, E., Gothie, E., Roux., D. & Pouyssegur, J. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J. Biol. Chem. 274, 32631-32637 (1999). (Pubitemid 129535289)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.46
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
Roux, D.4
Pouyssegur, J.5
-
80
-
-
0033584965
-
EPAS1 trans-activation during hypoxia requires p42/p44 MARK
-
Conrad, P. W., Freeman, T. L., Beitner-Johnson, D. & Millhorn, D. E. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. J. Biol. Chem. 274, 33709-33713 (1999). (Pubitemid 129511686)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.47
, pp. 33709-33713
-
-
Conrad, P.W.1
Freeman, T.L.2
Beitner-Johnson, D.3
Millhorn, D.E.4
-
81
-
-
33750202279
-
The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression
-
DOI 10.1038/sj.emboj.7601369, PII 7601369
-
To, K. K., Sedelnikova, O. A., Samons, M., Bonner, W. M. & Huang, L. E. The phosphorylation status of PAS-B distinguishes HIF-1α from HIF-2α in NBS1 repression. EMBO J. 25, 4784-4794 (2006). (Pubitemid 44607024)
-
(2006)
EMBO Journal
, vol.25
, Issue.20
, pp. 4784-4794
-
-
To, K.K.-W.1
Sedelnikova, O.A.2
Samons, M.3
Bonner, W.M.4
Huang, L.E.5
-
82
-
-
33845403070
-
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
-
DOI 10.1074/jbc.M605058200
-
Mylonis, I. et al. Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α. J. Biol. Chem. 281, 33095-33106 (2006). (Pubitemid 46043259)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.44
, pp. 33095-33106
-
-
Mylonis, I.1
Chachami, G.2
Samiotaki, M.3
Panayotou, G.4
Paraskeva, E.5
Kalousi, A.6
Georgatsou, E.7
Bonanou, S.8
Simos, G.9
-
83
-
-
77956912534
-
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
-
Kalousi, A. et al. Casein kinase 1 regulates human hypoxia-inducible factor HIF-1. J. Cell Sci. 123, 2976-2986 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 2976-2986
-
-
Kalousi, A.1
-
84
-
-
78649231611
-
MTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
-
Cam, H., Easton, J. B., High, A. & Houghton, P. J. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol. Cell 40, 509-520 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 509-520
-
-
Cam, H.1
Easton, J.B.2
High, A.3
Houghton, P.J.4
-
85
-
-
67949102053
-
Recent progress in the biology and physiology of sirtuins
-
Finkel, T., Deng, C. X. & Mostoslavsky, R. Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591 (2009).
-
(2009)
Nature
, vol.460
, pp. 587-591
-
-
Finkel, T.1
Deng, C.X.2
Mostoslavsky, R.3
-
86
-
-
66749129781
-
Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1
-
Dioum, E. M. et al. Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1. Science 324, 1289-1293 (2009).
-
(2009)
Science
, vol.324
, pp. 1289-1293
-
-
Dioum, E.M.1
-
87
-
-
77955499804
-
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α
-
Lim, J. H. et al. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α. Mol. Cell 38, 864-878 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 864-878
-
-
Lim, J.H.1
-
88
-
-
79954609893
-
Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
-
Chen, R., Dioum, E. M., Hogg, R. T., Gerard, R. D. & Garcia, J. A. Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner. J. Biol. Chem. 286, 13869-13878 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13869-13878
-
-
Chen, R.1
Dioum, E.M.2
Hogg, R.T.3
Gerard, R.D.4
Garcia, J.A.5
-
89
-
-
77955727321
-
AKT-ing via microRNA
-
Sayed, D. & Abdellatif, M. AKT-ing via microRNA. Cell Cycle 9, 3213-3217 (2010).
-
(2010)
Cell Cycle
, vol.9
, pp. 3213-3217
-
-
Sayed, D.1
Abdellatif, M.2
-
90
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α
-
Zhong, L. et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α. Cell 140, 280-293 (2010).
-
(2010)
Cell
, vol.140
, pp. 280-293
-
-
Zhong, L.1
-
91
-
-
79958041601
-
The SirT3 divining rod points to oxidative stress
-
Bell, E. L. & Guarente, L. The SirT3 divining rod points to oxidative stress. Mol. Cell 42, 561-568 (2011).
-
(2011)
Mol. Cell
, vol.42
, pp. 561-568
-
-
Bell, E.L.1
Guarente, L.2
-
92
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
-
DOI 10.1016/j.cmet.2005.05.001, PII S1550413105001397
-
Guzy, R. D. et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1, 401-408 (2005). (Pubitemid 43960623)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 401-408
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
Chen, H.4
Liu, L.5
Mansfield, K.D.6
Simon, M.C.7
Hammerling, U.8
Schumacker, P.T.9
-
93
-
-
24144447915
-
Cytochrome C is required for cellular oxygen sensing and hypoxic HIF activation
-
Mansfield, K. D. et al. Cytochrome C is required for cellular oxygen sensing and hypoxic HIF activation. Cell Metab. 1, 393-399 (2005).
-
(2005)
Cell Metab.
, vol.1
, pp. 393-399
-
-
Mansfield, K.D.1
-
94
-
-
24144444133
-
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
-
DOI 10.1016/j.cmet.2005.05.002, PII S1550413105001403
-
Brunelle, J. K. et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 1, 409-414 (2005). (Pubitemid 43960624)
-
(2005)
Cell Metabolism
, vol.1
, Issue.6
, pp. 409-414
-
-
Brunelle, J.K.1
Bell, E.L.2
Quesada, N.M.3
Vercauteren, K.4
Tiranti, V.5
Zeviani, M.6
Scarpulla, R.C.7
Chandel, N.S.8
-
95
-
-
79959819034
-
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
-
Bell, E. L., Emerling, B. M., Ricoult, S. J. & Guarente, L. SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30, 2986-2996 (2011).
-
(2011)
Oncogene
, vol.30
, pp. 2986-2996
-
-
Bell, E.L.1
Emerling, B.M.2
Ricoult, S.J.3
Guarente, L.4
-
96
-
-
79952501323
-
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization
-
Finley, L. W. et al. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell 19, 416-428 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 416-428
-
-
Finley, L.W.1
-
97
-
-
18744375998
-
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
-
Jeong, J. W. et al. Regulation and destabilization of HIF-1α by ARD1-mediated acetylation. Cell 111, 709-720 (2002).
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
-
98
-
-
33645322383
-
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1α protein by recruiting histone deacetylase 1
-
Yoo, Y. G., Kong, G. & Lee, M. O. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1α protein by recruiting histone deacetylase 1. EMBO J. 25, 1231-1241 (2006).
-
(2006)
EMBO J.
, vol.25
, pp. 1231-1241
-
-
Yoo, Y.G.1
Kong, G.2
Lee, M.O.3
-
99
-
-
24744460523
-
Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF
-
DOI 10.1074/jbc.M504482200
-
Bilton, R. et al. Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1α and is not induced by hypoxia or HIF. J. Biol. Chem. 280, 31132-31140 (2005). (Pubitemid 41291849)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.35
, pp. 31132-31140
-
-
Bilton, R.1
Mazure, N.2
Trottier, E.3
Hattab, M.4
Dery, M.-A.5
Richard, D.E.6
Pouyssegur, J.7
Brahimi-Horn, M.C.8
-
100
-
-
35548935098
-
SUMO-Specific protease 1 is essential for stabilization of HIF1α during hypoxia
-
DOI 10.1016/j.cell.2007.08.045, PII S0092867407011439
-
Cheng, J., Kang, X., Zhang, S. & Yeh, E. T. SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia. Cell 131, 584-595 (2007). (Pubitemid 350007694)
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 584-595
-
-
Cheng, J.1
Kang, X.2
Zhang, S.3
Yeh, E.T.H.4
-
101
-
-
77951211689
-
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
-
van Hagen, M., Overmeer, R. M., Abolvardi, S. S. & Vertegaal, A. C. RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α. Nucleic Acids Res. 38, 1922-1931 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 1922-1931
-
-
Van Hagen, M.1
Overmeer, R.M.2
Abolvardi, S.S.3
Vertegaal, A.C.4
-
102
-
-
4744353220
-
Sumoylation increases HIF-1α stability and its transcriptional activity
-
Bae, S. H. et al. Sumoylation increases HIF-1α stability and its transcriptional activity. Biochem. Biophys. Res. Commun. 324, 394-400 (2004).
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 394-400
-
-
Bae, S.H.1
-
103
-
-
35348904953
-
RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia
-
DOI 10.1016/j.cell.2007.07.044, PII S0092867407010240
-
Carbia-Nagashima, A. et al. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia. Cell 131, 309-323 (2007). (Pubitemid 47592916)
-
(2007)
Cell
, vol.131
, Issue.2
, pp. 309-323
-
-
Carbia-Nagashima, A.1
Gerez, J.2
Perez-Castro, C.3
Paez-Pereda, M.4
Silberstein, S.5
Stalla, G.K.6
Holsboer, F.7
Arzt, E.8
-
104
-
-
70349213234
-
SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation
-
Huang, C. et al. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 28, 2748-2762 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 2748-2762
-
-
Huang, C.1
-
105
-
-
34047272690
-
Regulation of HIF-1α Stability through S-Nitrosylation
-
DOI 10.1016/j.molcel.2007.02.024, PII S1097276507001244
-
Li, F. et al. Regulation of HIF-1α stability through S-nitrosylation. Mol. Cell 26, 63-74 (2007). (Pubitemid 46550936)
-
(2007)
Molecular Cell
, vol.26
, Issue.1
, pp. 63-74
-
-
Li, F.1
Sonveaux, P.2
Rabbani, Z.N.3
Liu, S.4
Yan, B.5
Huang, Q.6
Vujaskovic, Z.7
Dewhirst, MarkW.8
Li, C.-Y.9
-
106
-
-
79953170581
-
Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent
-
Ryu, J. H. et al. Hypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent. J. Biol. Chem. 286, 6963-6970 (2011).
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 6963-6970
-
-
Ryu, J.H.1
-
107
-
-
3142631736
-
HIF-1α induces cell cycle arrest by functionally counteracting Myc
-
DOI 10.1038/sj.emboj.7600196
-
Koshiji, M. et al. HIF-1α induces cell cycle arrest by functionally counteracting Myc. EMBO J. 23, 1949-1956 (2004). (Pubitemid 38902073)
-
(2004)
EMBO Journal
, vol.23
, Issue.9
, pp. 1949-1956
-
-
Koshiji, M.1
Kageyama, Y.2
Pete, E.A.3
Horikawa, I.4
Barrett, J.C.5
Huang, L.E.6
-
108
-
-
37549032776
-
The interplay between MYC and HIF in cancer
-
Dang, C. V., Kim, J. W., Gao, P. & Yustein, J. The interplay between MYC and HIF in cancer. Nature Rev. Cancer 8, 51-56 (2008).
-
(2008)
Nature Rev. Cancer
, vol.8
, pp. 51-56
-
-
Dang, C.V.1
Kim, J.W.2
Gao, P.3
Yustein, J.4
-
109
-
-
15244344206
-
HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression
-
DOI 10.1016/j.molcel.2005.02.015
-
Koshiji, M. et al. HIF-1α induces genetic instability by transcriptionally downregulating MutSα expression. Mol. Cell 17, 793-803 (2005). (Pubitemid 40386941)
-
(2005)
Molecular Cell
, vol.17
, Issue.6
, pp. 793-803
-
-
Koshiji, M.1
To, K.K.-W.2
Hammer, S.3
Kumamoto, K.4
Harris, A.L.5
Modrich, P.6
Huang, L.E.7
-
110
-
-
34047156190
-
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
-
DOI 10.1016/j.ccr.2007.02.006, PII S1535610807000591
-
Gordan, J. D., Bertout, J. A., Hu, C. J., Diehl, J. A. & Simon, M. C. HIF-2α promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity. Cancer Cell 11, 335-347 (2007). (Pubitemid 46518312)
-
(2007)
Cancer Cell
, vol.11
, Issue.4
, pp. 335-347
-
-
Gordan, J.D.1
Bertout, J.A.2
Hu, C.-J.3
Diehl, J.A.4
Simon, M.C.5
-
111
-
-
31144478127
-
Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis
-
Corn, P. G. et al. Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis. Cancer Biol. Ther. 4, 1285-1294 (2005).
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 1285-1294
-
-
Corn, P.G.1
-
112
-
-
34247614521
-
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-Deficient renal cell carcinoma by repression of C-MYC activity
-
DOI 10.1016/j.ccr.2007.04.001, PII S1535610807001158
-
Zhang, H. et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell 11, 407-420 (2007). (Pubitemid 46670080)
-
(2007)
Cancer Cell
, vol.11
, Issue.5
, pp. 407-420
-
-
Zhang, H.1
Gao, P.2
Fukuda, R.3
Kumar, G.4
Krishnamachary, B.5
Zeller, K.I.6
Dang, ChiV.7
Semenza, G.L.8
-
113
-
-
56849096837
-
HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan, J. D. et al. HIF-α effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14, 435-446 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
-
114
-
-
35649014840
-
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
-
DOI 10.1128/MCB.00440-07
-
Kim, J. W., Gao, P., Liu, Y. C., Semenza, G. L. & Dang, C. V. Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1. Mol. Cell. Biol. 27, 7381-7393 (2007). (Pubitemid 350033646)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.21
, pp. 7381-7393
-
-
Kim, J.-W.1
Gao, P.2
Liu, Y.-C.3
Semenza, G.L.4
Dang, C.V.5
-
115
-
-
78650403118
-
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α
-
Qing, G. et al. Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α. Cancer Res. 70, 10351-10361 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 10351-10361
-
-
Qing, G.1
-
116
-
-
57049177125
-
Kidney cancer: Now available in a new flavor
-
Kaelin, W. G. Jr. Kidney cancer: now available in a new flavor. Cancer Cell 14, 423-424 (2008).
-
(2008)
Cancer Cell
, vol.14
, pp. 423-424
-
-
Kaelin Jr., W.G.1
-
117
-
-
65349103899
-
Blinded by the light: The growing complexity of p53
-
Vousden, K. H. & Prives, C. Blinded by the light: the growing complexity of p53. Cell 137, 413-431 (2009).
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
118
-
-
33646757232
-
The complexity of p53 stabilization and activation
-
Lavin, M. F. & Gueven, N. The complexity of p53 stabilization and activation. Cell Death Differ. 13, 941-950 (2006).
-
(2006)
Cell Death Differ.
, vol.13
, pp. 941-950
-
-
Lavin, M.F.1
Gueven, N.2
-
119
-
-
3042779529
-
P53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
-
DOI 10.1038/sj.onc.1207657
-
Pan, Y., Oprysko, P. R., Asham, A. M., Koch, C. J. & Simon, M. C. p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene 23, 4975-4983 (2004). (Pubitemid 38938730)
-
(2004)
Oncogene
, vol.23
, Issue.29
, pp. 4975-4983
-
-
Pan, Y.1
Oprysko, P.R.2
Asham, A.M.3
Koch, C.J.4
Simon, M.C.5
-
120
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
-
An, W. G. et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1α. Nature 392, 405-408 (1998).
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
-
121
-
-
11344292626
-
Binding of natively unfolded HIF-1α ODD domain to p53
-
DOI 10.1016/j.molcel.2004.11.019, PII S1097276504007105
-
Sanchez-Puig, N., Veprintsev, D. B. & Fersht, A. R. Binding of natively unfolded HIF-1α ODD domain to p53. Mol. Cell 17, 11-21 (2005). (Pubitemid 40075361)
-
(2005)
Molecular Cell
, vol.17
, Issue.1
, pp. 11-21
-
-
Sanchez-Puig, N.1
Veprintsev, D.B.2
Fersht, A.R.3
-
122
-
-
0038529602
-
Direct interactions between HIF-1α and Mdm2 modulate p53 function
-
DOI 10.1074/jbc.C200694200
-
Chen, D., Li, M., Luo, J. & Gu, W. Direct interactions between HIF-1α and Mdm2 modulate p53 function. J. Biol. Chem. 278, 13595-13598 (2003). (Pubitemid 36799889)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.16
, pp. 13595-13598
-
-
Chen, D.1
Li, M.2
Luo, J.3
Gu, W.4
-
123
-
-
23644453277
-
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
-
DOI 10.1016/j.ccr.2005.06.016, PII S1535610805002254
-
Moeller, B. J. et al. Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. Cancer Cell 8, 99-110 (2005). (Pubitemid 41132739)
-
(2005)
Cancer Cell
, vol.8
, Issue.2
, pp. 99-110
-
-
Moeller, B.J.1
Dreher, M.R.2
Rabbani, Z.N.3
Schroeder, T.4
Cao, Y.5
Li, C.Y.6
Dewhirst, M.W.7
-
124
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia- inducible factor 1α
-
Ravi, R. et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev. 14, 34-44 (2000). (Pubitemid 30051577)
-
(2000)
Genes and Development
, vol.14
, Issue.1
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
Sutter, C.H.4
Artemov, D.5
Zeng, Q.6
Dillehay, L.E.7
Madan, A.8
Semenza, G.L.9
Bedi, A.10
-
125
-
-
70149106164
-
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
-
Bertout, J. A. et al. HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses. Proc. Natl Acad. Sci. USA 106, 14391-14396 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14391-14396
-
-
Bertout, J.A.1
-
126
-
-
71549151624
-
Suppression of hypoxia-inducible factor 2α restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells
-
Roberts, A. M. et al. Suppression of hypoxia-inducible factor 2α restores p53 activity via Hdm2 and reverses chemoresistance of renal carcinoma cells. Cancer Res. 69, 9056-9064 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 9056-9064
-
-
Roberts, A.M.1
-
127
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta, S., Peterson, T. R. & Sabatini, D. M. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 40, 310-322 (2010).
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
128
-
-
72949083368
-
Common corruption of the mTOR signaling network in human tumors
-
Menon, S. & Manning, B. D. Common corruption of the mTOR signaling network in human tumors. Oncogene 27 (Suppl. 2), S43-S51 (2008).
-
(2008)
Oncogene
, vol.27
, Issue.SUPPL. 2
-
-
Menon, S.1
Manning, B.D.2
-
129
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
DOI 10.1016/j.molcel.2006.01.010, PII S1097276506000116
-
Liu, L. et al. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol. Cell 21, 521-531 (2006). (Pubitemid 43228007)
-
(2006)
Molecular Cell
, vol.21
, Issue.4
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
130
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
DOI 10.1101/gad.1256804
-
Brugarolas, J. et al. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904 (2004). (Pubitemid 39602308)
-
(2004)
Genes and Development
, vol.18
, Issue.23
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin Jr., W.G.9
-
131
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung, M. P., Horak, P., Sofer, A., Sgroi, D. & Ellisen, L. W. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 22, 239-251 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 239-251
-
-
Deyoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
132
-
-
37248999267
-
Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb
-
DOI 10.1074/jbc.M705231200
-
Li, Y. et al. Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb. J. Biol. Chem. 282, 35803-35813 (2007). (Pubitemid 350277153)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.49
, pp. 35803-35813
-
-
Li, Y.1
Wang, Y.2
Kim, E.3
Beemiller, P.4
Wang, C.-Y.5
Swanson, J.6
You, M.7
Guan, K.-L.8
-
133
-
-
23744454765
-
Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
-
DOI 10.1083/jcb.200411106
-
Gan, B., Melkoumian, Z. K., Wu, X., Guan, K. L. & Guan, J. L. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J. Cell Biol. 170, 379-389 (2005). (Pubitemid 41126938)
-
(2005)
Journal of Cell Biology
, vol.170
, Issue.3
, pp. 379-389
-
-
Gan, B.1
Melkoumian, Z.K.2
Wu, X.3
Guan, K.-L.4
Guan, J.-L.5
-
134
-
-
33750592447
-
Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
-
Chano, T. et al. Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation. Int. J. Mol. Med. 18, 425-432 (2006).
-
(2006)
Int. J. Mol. Med.
, vol.18
, pp. 425-432
-
-
Chano, T.1
-
135
-
-
75149174239
-
Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma
-
Morris, M. R. et al. Mutation analysis of hypoxia-inducible factors HIF1A and HIF2A in renal cell carcinoma. Anticancer Res. 29, 4337-4343 (2009).
-
(2009)
Anticancer Res.
, vol.29
, pp. 4337-4343
-
-
Morris, M.R.1
-
136
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh, G. L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
-
137
-
-
66349100709
-
Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney
-
Beroukhim, R. et al. Patterns of gene expression and copy-number alterations in von-hippel lindau disease-associated and sporadic clear cell carcinoma of the kidney. Cancer Res. 69, 4674-4681 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 4674-4681
-
-
Beroukhim, R.1
-
138
-
-
78651257523
-
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
-
Purdue, M. P. et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nature Genet. 43, 60-65 (2010).
-
(2010)
Nature Genet.
, vol.43
, pp. 60-65
-
-
Purdue, M.P.1
-
139
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza, G. L. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29, 625-634 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
140
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda, A. et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 62, 4316-4324 (2002). (Pubitemid 34827288)
-
(2002)
Cancer Research
, vol.62
, Issue.15
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
Melillo, G.7
-
141
-
-
70449580319
-
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
-
Lee, K. et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl Acad. Sci. USA 106, 17910-17915 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 17910-17915
-
-
Lee, K.1
-
142
-
-
2942724235
-
MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
DOI 10.1038/nm1052
-
Majumder, P. K. et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nature Med. 10, 594-601 (2004). (Pubitemid 38796850)
-
(2004)
Nature Medicine
, vol.10
, Issue.6
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
Manolal, J.7
Brugarolas, J.8
J McDonnell, T.9
Golub, T.R.10
Loda, M.11
Lane, H.A.12
Sellers, W.R.13
-
143
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
DOI 10.1038/nm1337
-
Thomas, G. V. et al. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nature Med. 12, 122-127 (2006). (Pubitemid 43050086)
-
(2006)
Nature Medicine
, vol.12
, Issue.1
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
Czernin, J.7
Sawyers, C.L.8
-
144
-
-
33644780111
-
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1α
-
DOI 10.1128/MCB.26.6.2019-2028.2006
-
Kong, X. et al. Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1α. Mol. Cell. Biol. 26, 2019-2028 (2006). (Pubitemid 43346906)
-
(2006)
Molecular and Cellular Biology
, vol.26
, Issue.6
, pp. 2019-2028
-
-
Kong, X.1
Lin, Z.2
Liang, D.3
Fath, D.4
Sang, N.5
Caro, J.6
-
145
-
-
33749006252
-
Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α
-
DOI 10.1158/0008-5472.CAN-05-4598
-
Qian, D. Z. et al. Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1α. Cancer Res. 66, 8814-8821 (2006). (Pubitemid 44449199)
-
(2006)
Cancer Research
, vol.66
, Issue.17
, pp. 8814-8821
-
-
Qian, D.Z.1
Kachhap, S.K.2
Collis, S.J.3
Verheul, H.M.W.4
Carducci, M.A.5
Atadja, P.6
Pili, R.7
-
146
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway
-
Isaacs, J. S. et al. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1α-degradative pathway. J. Biol. Chem. 277, 29936-29944 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
-
147
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh, N. J. et al. Geldanamycin induces degradation of hypoxia-inducible factor 1α protein via the proteosome pathway in prostate cancer cells. Cancer Res. 62, 2478-2482 (2002). (Pubitemid 34462721)
-
(2002)
Cancer Research
, vol.62
, Issue.9
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
Kaur, B.4
Van Meir, E.G.5
Simons, J.W.6
Zhong, H.7
-
148
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
DOI 10.1016/S1535-6108(04)00115-1, PII S1535610804001151
-
Moeller, B. J., Cao, Y., Li, C. Y. & Dewhirst, M. W. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 5, 429-441 (2004). (Pubitemid 38610245)
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
Dewhirst, M.W.4
-
149
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
DOI 10.1101/gad.991402
-
Lando, D. et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471 (2002). (Pubitemid 34686328)
-
(2002)
Genes and Development
, vol.16
, Issue.12
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
150
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
-
DOI 10.1101/gad.924501
-
Mahon, P. C., Hirota, K. & Semenza, G. L. FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 2675-2686 (2001). (Pubitemid 32988878)
-
(2001)
Genes and Development
, vol.15
, Issue.20
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
151
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
DOI 10.1074/jbc.C200273200
-
Hewitson, K. S. et al. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 26351-26355 (2002). (Pubitemid 34967127)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.29
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
Tian, Y.-M.4
Bullock, A.N.5
Welford, R.W.6
Elkins, J.M.7
Oldham, N.J.8
Bhattacharya, S.9
Gleadle, J.M.10
Ratcliffe, P.J.11
Pugh, C.W.12
Schofield, C.J.13
-
152
-
-
41149115123
-
The role of oxygen availability in embryonic development and stem cell function
-
DOI 10.1038/nrm2354, PII NRM2354
-
Simon, M. C. & Keith, B. The role of oxygen availability in embryonic development and stem cell function. Nature Rev. Mol. Cell Biol. 9, 285-296 (2008). (Pubitemid 351430845)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.4
, pp. 285-296
-
-
Simon, M.C.1
Keith, B.2
-
153
-
-
77957584397
-
O2 regulates stem cells through Wnt/β-catenin signalling
-
Mazumdar, J. et al. O2 regulates stem cells through Wnt/β-catenin signalling. Nature Cell Biol. 12, 1007-1013 (2010).
-
(2010)
Nature Cell Biol.
, vol.12
, pp. 1007-1013
-
-
Mazumdar, J.1
-
154
-
-
33947217823
-
Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia
-
DOI 10.1038/ncb1534, PII NCB1534
-
Kaidi, A., Williams, A. C. & Paraskeva, C. Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nature Cell Biol. 9, 210-217 (2007). (Pubitemid 46420864)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.2
, pp. 210-217
-
-
Kaidi, A.1
Williams, A.C.2
Paraskeva, C.3
-
155
-
-
27644561755
-
Hypoxia requires Notch signaling to maintain the undifferentiated cell state
-
DOI 10.1016/j.devcel.2005.09.010, PII S1534580705003722
-
Gustafsson, M. V. et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev. Cell 9, 617-628 (2005). (Pubitemid 41555144)
-
(2005)
Developmental Cell
, vol.9
, Issue.5
, pp. 617-628
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
Gradin, K.4
Jin, S.5
Lundkvist, J.6
Ruas, J.L.7
Poellinger, L.8
Lendahl, U.9
Bondesson, M.10
-
156
-
-
66149108432
-
Heterozygosity for hypoxia inducible factor 1α decreases the incidence of thymic lymphomas in a p53 mutant mouse model
-
Bertout, J. A. et al. Heterozygosity for hypoxia inducible factor 1α decreases the incidence of thymic lymphomas in a p53 mutant mouse model. Cancer Res. 69, 3213-3220 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 3213-3220
-
-
Bertout, J.A.1
-
157
-
-
70349753257
-
HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells
-
Pietras, A. et al. HIF-2α maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. Proc. Natl Acad. Sci. USA 106, 16805-16810 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 16805-16810
-
-
Pietras, A.1
-
158
-
-
33644747418
-
HIF-2α regulates Oct-4: Effects of hypoxia on stem cell function, embryonic development, and tumor growth
-
DOI 10.1101/gad.1399906
-
Covello, K. L. et al. HIF-2α regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 20, 557-570 (2006). (Pubitemid 43345322)
-
(2006)
Genes and Development
, vol.20
, Issue.5
, pp. 557-570
-
-
Covello, K.L.1
Kehler, J.2
Yu, H.3
Gordan, J.D.4
Arsham, A.M.5
Hu, C.-J.6
Labosky, P.A.7
Simon, M.C.8
Keith, B.9
-
159
-
-
34648821254
-
Making a tumour's bed: Glioblastoma stem cells and the vascular niche
-
DOI 10.1038/nrc2246, PII NRC2246
-
Gilbertson, R. J. & Rich, J. N. Making a tumour's bed: glioblastoma stem cells and the vascular niche. Nature Rev. Cancer 7, 733-736 (2007). (Pubitemid 47463683)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.10
, pp. 733-736
-
-
Gilbertson, R.J.1
Rich, J.N.2
-
160
-
-
76049100577
-
HIF-1: Upstream and downstream of cancer metabolism
-
Semenza, G. L. HIF-1: upstream and downstream of cancer metabolism. Curr. Opin. Genet. Dev. 20, 51-56 (2010).
-
(2010)
Curr. Opin. Genet. Dev.
, vol.20
, pp. 51-56
-
-
Semenza, G.L.1
-
161
-
-
2942707871
-
Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis
-
DOI 10.1111/j.1365-2990.2003.00535.x
-
Korkolopoulou, P. et al. Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas. Associations with microvessel morphometry, proliferation and prognosis. Neuropathol. Appl. Neurobiol. 30, 267-278 (2004). (Pubitemid 38789248)
-
(2004)
Neuropathology and Applied Neurobiology
, vol.30
, Issue.3
, pp. 267-278
-
-
Korkolopoulou, P.1
Patsouris, E.2
Konstantinidou, A.E.3
Pavlopoulos, P.M.4
Kavantzas, N.5
Boviatsis, E.6
Thymara, I.7
Perdiki, M.8
Thomas-Tsagli, E.9
Angelidakis, D.10
Rologis, D.11
Sakkas, D.12
-
162
-
-
34250781164
-
Prognostic significance of co-overexpression of the EGFR/IGFBP-2/HIF-2A genes in astrocytomas
-
DOI 10.1007/s11060-007-9328-0
-
Scrideli, C. A. et al. Prognostic significance of co-overexpression of the EGFR/IGFBP-2/HIF-2A genes in astrocytomas. J. Neurooncol. 83, 233-239 (2007). (Pubitemid 46952233)
-
(2007)
Journal of Neuro-Oncology
, vol.83
, Issue.3
, pp. 233-239
-
-
Scrideli, C.A.1
Carlotti Jr., C.G.2
Mata, J.F.3
Neder, L.4
Machado, H.R.5
Oba-Sinjo, S.M.6
Rosemberg, S.7
Marie, S.K.N.8
Tone, L.G.9
-
163
-
-
3142534607
-
Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
DOI 10.1016/j.eururo.2004.04.008, PII S0302283804001769
-
Theodoropoulos, V. E. et al. Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur. Urol. 46, 200-208 (2004). (Pubitemid 38902737)
-
(2004)
European Urology
, vol.46
, Issue.2
, pp. 200-208
-
-
Theodoropoulos, V.E.1
Lazaris, A.Ch.2
Sofras, F.3
Gerzelis, I.4
Tsoukala, V.5
Ghikonti, I.6
Manikas, K.7
Kastriotis, I.8
-
164
-
-
46949094778
-
Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer
-
DOI 10.1007/s10549-007-9742-1
-
Yamamoto, Y. et al. Hypoxia-inducible factor 1α is closely linked to an aggressive phenotype in breast cancer. Breast Cancer Res. Treat. 110, 465-475 (2008). (Pubitemid 351962589)
-
(2008)
Breast Cancer Research and Treatment
, vol.110
, Issue.3
, pp. 465-475
-
-
Yamamoto, Y.1
Ibusuki, M.2
Okumura, Y.3
Kawasoe, T.4
Kai, K.5
Iyama, K.6
Iwase, H.7
-
165
-
-
56449095636
-
Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer
-
Helczynska, K. et al. Hypoxia-inducible factor-2α correlates to distant recurrence and poor outcome in invasive breast cancer. Cancer Res. 68, 9212-9220 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 9212-9220
-
-
Helczynska, K.1
-
166
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner, P. et al. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60, 4693-4696 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
-
167
-
-
43149084780
-
Prognostic significance of HIF-2α expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy
-
DOI 10.2152/jmi.55.78
-
Kawanaka, T. et al. Prognostic significance of HIF-2α expression on tumor infiltrating macrophages in patients with uterine cervical cancer undergoing radiotherapy. J. Med. Invest. 55, 78-86 (2008). (Pubitemid 351643597)
-
(2008)
Journal of Medical Investigation
, vol.55
, Issue.1-2
, pp. 78-86
-
-
Kawanaka, T.1
Kubo, A.2
Ikushima, H.3
Sano, T.4
Takegawa, Y.5
Nishitani, H.6
-
168
-
-
11144222884
-
Prognostic impact of hypoxia-inducible factors 1α and 2α in colorectal cancer patients: Correlation with tumor angiogenesis and cyclooxygenase-2 expression
-
DOI 10.1158/1078-0432.CCR-0946-03
-
Yoshimura, H. et al. Prognostic impact of hypoxia-inducible factors 1α and 2α in colorectal cancer patients: correlation with tumor angiogenesis and cyclooxygenase-2 expression. Clin. Cancer Res. 10, 8554-8560 (2004). (Pubitemid 40053424)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.24
, pp. 8554-8560
-
-
Yoshimura, H.1
Dhar, D.K.2
Kohno, H.3
Kubota, H.4
Fujii, T.5
Ueda, S.6
Kinugasa, S.7
Tachibana, M.8
Nagasue, N.9
-
169
-
-
33846189403
-
Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas
-
DOI 10.1038/sj.bjc.6603524, PII 6603524
-
Griffiths, E. A. et al. Hypoxia-inducible factor-1α expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas. Br. J. Cancer 96, 95-103 (2007). (Pubitemid 46094645)
-
(2007)
British Journal of Cancer
, vol.96
, Issue.1
, pp. 95-103
-
-
Griffiths, E.A.1
Pritchard, S.A.2
Valentine, H.R.3
Whitchelo, N.4
Bishop, P.W.5
Ebert, M.P.6
Price, P.M.7
Welch, I.M.8
West, C.M.L.9
-
170
-
-
40349093149
-
Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis
-
DOI 10.1038/sj.bjc.6604210, PII 6604210
-
Griffiths, E. A. et al. Hypoxia-associated markers in gastric carcinogenesis and HIF-2α in gastric and gastro-oesophageal cancer prognosis. Br. J. Cancer 98, 965-973 (2008). (Pubitemid 351341598)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.5
, pp. 965-973
-
-
Griffiths, E.A.1
Pritchard, S.A.2
McGrath, S.M.3
Valentine, H.R.4
Price, P.M.5
Welch, I.M.6
West, C.M.L.7
-
171
-
-
33846001692
-
Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer
-
Mizokami, K., Kakeji, Y., Oda, S. & Maehara, Y. Relationship of hypoxia-inducible factor 1α and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer. World J. Surg. Oncol. 4, 94 (2006).
-
(2006)
World J. Surg. Oncol.
, vol.4
, pp. 94
-
-
Mizokami, K.1
Kakeji, Y.2
Oda, S.3
Maehara, Y.4
-
172
-
-
0142175222
-
Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach
-
Takahashi, R. et al. Hypoxia-inducible factor-1α expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol. Rep. 10, 797-802 (2003).
-
(2003)
Oncol. Rep.
, vol.10
, pp. 797-802
-
-
Takahashi, R.1
-
173
-
-
0036680153
-
Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer
-
DOI 10.1016/S0360-3016(02)02848-1, PII S0360301602028481
-
Koukourakis, M. I. et al. Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 53, 1192-1202 (2002). (Pubitemid 34787855)
-
(2002)
International Journal of Radiation Oncology Biology Physics
, vol.53
, Issue.5
, pp. 1192-1202
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Sivridis, E.3
Simopoulos, C.4
Turley, H.5
Talks, K.6
Gatter, K.C.7
Harris, A.L.8
-
174
-
-
33747176556
-
The relation between hypoxia-inducible factor (HIF)=1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer
-
DOI 10.1002/cncr.21983
-
Winter, S. C. et al. The relation between hypoxia-inducible factor (HIF)-1α and HIF-2α expression with anemia and outcome in surgically treated head and neck cancer. Cancer 107, 757-766 (2006). (Pubitemid 44232668)
-
(2006)
Cancer
, vol.107
, Issue.4
, pp. 757-766
-
-
Winter, S.C.1
Shah, K.A.2
Han, C.3
Campo, L.4
Turley, H.5
Leek, R.6
Corbridge, R.J.7
Cox, G.J.8
Harris, A.L.9
-
175
-
-
34447537888
-
Prognostic significance of HIF-2α/EPAS1 expression in hepatocellular carcinoma
-
Bangoura, G. et al. Prognostic significance of HIF-2α/EPAS1 expression in hepatocellular carcinoma. World J. Gastroenterol. 13, 3176-3182 (2007). (Pubitemid 47064579)
-
(2007)
World Journal of Gastroenterology
, vol.13
, Issue.23
, pp. 3176-3182
-
-
Bangoura, G.1
Liu, Z.-S.2
Qian, Q.3
Jiang, C.-Q.4
Yang, G.-F.5
Jing, S.6
-
176
-
-
0035860147
-
Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
-
DOI 10.1054/bjoc.2001.2018
-
Giatromanolaki, A. et al. Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br. J. Cancer 85, 881-890 (2001). (Pubitemid 33010557)
-
(2001)
British Journal of Cancer
, vol.85
, Issue.6
, pp. 881-890
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Sivridis, E.3
Turley, H.4
Talks, K.5
Pezzella, F.6
Gatter, K.C.7
Harris, A.L.8
-
177
-
-
23744479831
-
Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer
-
DOI 10.1016/j.lungcan.2005.03.036, PII S0169500205001765
-
Kim, S. J. et al. Expression of HIF-1α, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer 49, 325-335 (2005). (Pubitemid 41139145)
-
(2005)
Lung Cancer
, vol.49
, Issue.3
, pp. 325-335
-
-
Kim, S.J.1
Rabbani, Z.N.2
Dewhirst, M.W.3
Vujaskovic, Z.4
Vollmer, R.T.5
Schreiber, E.-G.6
Oosterwijk, E.7
Kelley, M.J.8
-
178
-
-
78651231169
-
Correlations of hypoxia-inducible factor-1α/hypoxia-inducible factor-2α expression with angiogenesis factors expression and prognosis in non-small cell lung cancer
-
Wu, X. H., Qian, C. & Yuan, K. Correlations of hypoxia-inducible factor-1α/hypoxia-inducible factor-2α expression with angiogenesis factors expression and prognosis in non-small cell lung cancer. Chin. Med. J. 124, 11-18 (2011).
-
(2011)
Chin. Med. J.
, vol.124
, pp. 11-18
-
-
Wu, X.H.1
Qian, C.2
Yuan, K.3
-
179
-
-
0142120661
-
Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
-
DOI 10.1097/00008390-200310000-00008
-
Giatromanolaki, A. et al. Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res. 13, 493-501 (2003). (Pubitemid 37266952)
-
(2003)
Melanoma Research
, vol.13
, Issue.5
, pp. 493-501
-
-
Giatromanolaki, A.1
Sivridis, E.2
Kouskoukis, C.3
Gatter, K.C.4
Harris, A.L.5
Koukourakis, M.I.6
-
180
-
-
73149112785
-
HIF-1α and HIF-2α are differentially regulated in vivo in neuroblastoma: High HIF-1α correlates negatively to advanced clinical stage and tumor vascularization
-
Noguera, R. et al. HIF-1α and HIF-2α are differentially regulated in vivo in neuroblastoma: high HIF-1α correlates negatively to advanced clinical stage and tumor vascularization. Clin. Cancer Res. 15, 7130-7136 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 7130-7136
-
-
Noguera, R.1
-
181
-
-
62349084794
-
Prognostic significance of Hypoxia-Inducible Factor 1α (HIF-1α) expression in serous ovarian cancer: An immunohistochemical study
-
Daponte, A. et al. Prognostic significance of Hypoxia-Inducible Factor 1α (HIF-1α) expression in serous ovarian cancer: an immunohistochemical study. BMC Cancer 8, 335 (2008).
-
(2008)
BMC Cancer
, vol.8
, pp. 335
-
-
Daponte, A.1
-
182
-
-
34547838192
-
Expression of hypoxia-inducible factor 1α, hypoxia-inducible factor 2α, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1α is an independent prognostic factor in ovarian carcinoma
-
DOI 10.1016/j.humpath.2007.02.010, PII S0046817707000998
-
Osada, R. et al. Expression of hypoxia-inducible factor 1α, hypoxia-inducible factor 2α, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1α is an independent prognostic factor in ovarian carcinoma. Hum. Pathol. 38, 1310-1320 (2007). (Pubitemid 47247486)
-
(2007)
Human Pathology
, vol.38
, Issue.9
, pp. 1310-1320
-
-
Osada, R.1
Horiuchi, A.2
Kikuchi, N.3
Yoshida, J.4
Hayashi, A.5
Ota, M.6
Katsuyama, Y.7
Mellilo, G.8
Konishi, I.9
-
183
-
-
34447266708
-
Expression of hypoxia-inducible factor-1α and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis
-
Sun, H. C. et al. Expression of hypoxia-inducible factor-1α and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int. J. Oncol. 30, 1359-1367 (2007).
-
(2007)
Int. J. Oncol.
, vol.30
, pp. 1359-1367
-
-
Sun, H.C.1
-
184
-
-
0842333201
-
Prognostic significance of HIF-1α overexpression in human pancreatic cancer
-
Shibaji, T. et al. Prognostic significance of HIF-1α overexpression in human pancreatic cancer. Anticancer Res. 23, 4721-4727 (2003). (Pubitemid 38173890)
-
(2003)
Anticancer Research
, vol.23
, Issue.6
, pp. 4721-4727
-
-
Shibaji, T.1
Nagao, M.2
Ikeda, N.3
Kanehiro, H.4
Hisanaga, M.5
Ko, S.6
Fukumoto, A.7
Nakajima, Y.8
-
185
-
-
66449130218
-
Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
-
Nanni, S. et al. Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer. J. Clin. Invest. 119, 1093-1108 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1093-1108
-
-
Nanni, S.1
-
186
-
-
12944266844
-
The expression of hypoxia-inducible factor 1α is a favorable independent prognostic factor in renal cell carcinoma
-
Lidgren, A. et al. The expression of hypoxia-inducible factor 1α is a favorable independent prognostic factor in renal cell carcinoma. Clin. Cancer Res. 11, 1129-1135 (2005). (Pubitemid 40175762)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.3
, pp. 1129-1135
-
-
Lidgren, A.1
Hedberg, Y.2
Grankvist, K.3
Rasmuson, T.4
Vasko, J.5
Ljungberg, B.6
-
187
-
-
37549043546
-
Hypoxia-inducible factor 1α in clear cell renal cell carcinoma
-
Klatte, T. et al. Hypoxia-inducible factor 1α in clear cell renal cell carcinoma. Clin. Cancer Res. 13, 7388-7393 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7388-7393
-
-
Klatte, T.1
-
188
-
-
77958177671
-
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
-
Kapitsinou, P. P. et al. Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia. Blood 116, 3039-3048 (2010).
-
(2010)
Blood
, vol.116
, pp. 3039-3048
-
-
Kapitsinou, P.P.1
-
189
-
-
0242581718
-
-/- renal cell carcinoma cells
-
DOI 10.1074/jbc.M305502200
-
Gunaratnam, L. et al. Hypoxia inducible factor activates the transforming growth factor-α/epidermal growth factor receptor growth stimulatory pathway in VHL-/-renal cell carcinoma cells. J. Biol. Chem. 278, 44966-44974 (2003). (Pubitemid 37377256)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.45
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
De Paulsen, N.4
Mekhail, K.5
Parolin, D.A.E.6
Nakamura, E.7
Lorimer, I.A.J.8
Lee, S.9
-
190
-
-
0032581277
-
Role of HIF-1α in hypoxiamediated apoptosis, cell proliferation and tumour angiogenesis
-
DOI 10.1038/28867
-
Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485-490 (1998). (Pubitemid 28373960)
-
(1998)
Nature
, vol.394
, Issue.6692
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herber, J.-M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshet, E.16
-
191
-
-
0033870727
-
Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
-
Ryan, H. E. et al. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth. Cancer Res. 60, 4010-4015 (2000). (Pubitemid 30636574)
-
(2000)
Cancer Research
, vol.60
, Issue.15
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
192
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
DOI 10.1016/S1535-6108(02)00043-0
-
Kondo, K., Klco, J., Nakamura, E., Lechpammer, M. & Kaelin, W. G. Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1, 237-246 (2002). (Pubitemid 41039148)
-
(2002)
Cancer Cell
, vol.1
, Issue.3
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin Jr., W.G.5
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