Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Molecular and Cellular Biology

Volumn 27, Issue 21, 2007, Pages 7381-7393

  Kim, Jung Whan ^a,d   Gao, Ping ^a   Liu, Yen Chun ^a   Semenza, Gregg L ^a,b   Dang, Chi V ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c HSW 1301 ^*  (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GLUCOSE; HEXOKINASE; HEXOKINASE 2; HYPOXIA INDUCIBLE FACTOR 1; LACTIC ACID; MYC PROTEIN; PHOSPHOTRANSFERASE; PYRUVATE DEHYDROGENASE KINASE 1; UNCLASSIFIED DRUG; VASCULOTROPIN;

AEROBIC METABOLISM; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURKITT LYMPHOMA; CANCER MODEL; CELL GROWTH; CELL HYPOXIA; CELL PROLIFERATION; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; ENZYME INACTIVATION; ENZYME MECHANISM; GENE ACTIVATION; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DNA; ENZYME INDUCTION; GLUCOSE; GLYCOLYSIS; HEXOKINASE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; NEOPLASMS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MYC; REGULATORY SEQUENCES, NUCLEIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 35649014840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00440-07     Document Type: Article

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