Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1α, leading to its oxygen-independent degradation

Molecular and Cellular Biology

Volumn 28, Issue 23, 2008, Pages 7081-7095

  Mei, Yee Koh ^a   Darnay, Bryant G ^a   Powis, Garth ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; HYPOXIA ASSOCIATED FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL STRAIN HT29; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; TUMOR GROWTH; TUMOR XENOGRAFT; UBIQUITINATION;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OXYGEN; PROTEIN BINDING; TRANSPLANTATION, HETEROLOGOUS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 57349136768     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00773-08     Document Type: Article

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