Sumoylation increases HIF-1α stability and its transcriptional activity

Biochemical and Biophysical Research Communications

Volumn 324, Issue 1, 2004, Pages 394-400

  Bae, Seong Hui ^a   Jeong, Joo Won ^a,b   Park, Jeong Ae ^a   Kim, Se Hee ^a   Bae, Moon Kyoung ^c   Choi, Soo Joon ^d   Kim, Kyu Won ^a  

^a Department of Anthropology   (United States)

^b MCLEAN HOSPITAL   (United States)

^c Pusan National University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Acetylation; HIF; Hypoxia; SUMO; Ubiquitination

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; LYSINE; OXYGEN; SUMO 1 PROTEIN;

ACETYLATION; ANGIOGENESIS; ARTICLE; CELL SURVIVAL; COVALENT BOND; EMBRYO; ENERGY METABOLISM; FEMALE; HUMAN; HUMAN CELL; HYDROXYLATION; IMMUNOPRECIPITATION; KIDNEY CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; UBIQUITINATION; UPREGULATION; UTERINE CERVIX CARCINOMA;

AMINO ACID SEQUENCE; ANIMALS; ENZYME STABILITY; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYSINE; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUMO-1 PROTEIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 4744353220     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.068     Document Type: Article

References (26)

1. 2 homeostasis by hypoxia-inducible factor 1 Annu. Rev. Cell Dev. Biol. 15 1999 551 578
2. C.W. Pugh, and P.J. Ratcliffe Regulation of angiogenesis by hypoxia: role of the HIF system Nat. Med. 9 2003 677 684
3. 2 tension Proc. Natl. Acad. Sci. USA 92 1995 5510 5514
4. E. Berra, D.E. Richard, E. Gothie, and J. Pouyssegur HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation FEBS Lett. 491 2001 85 90
5. 2-dependent degradation domain via the ubiquitin-proteasome pathway Proc. Natl. Acad. Sci. USA 95 1998 7987 7992
6. P.H. Maxwell, M.S. Wiesener, G.W. Chang, S.C. Clifford, E.C. Vaux, M.E. Cockman, C.C. Wykoff, C.W. Pugh, E.R. Maher, and P.J. Ratcliffe The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 399 1999 271 275
7. 2 sensing Science 292 2001 464 468
8. 2-regulated prolyl hydroxylation Science 292 2001 468 472
9. N. Masson, C. Willam, P.H. Maxwell, C.W. Pugh, and P.J. Ratcliffe Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation EMBO J. 20 2001 5197 5206
10. R.K. Bruick, and S.L. McKnight A conserved family of prolyl-4- hydroxylases that modify HIF Science 294 2001 1337 1340
11. A.C. Epstein, J.M. Gleadle, L.A. McNeill, K.S. Hewitson, J. O'Rourke, D.R. Mole, M. Mukherji, E. Metzen, M.I. Wilson, A. Dhanda, Y.M. Tian, N. Masson, D.L. Hamilton, P. Jaakkola, R. Barstead, J. Hodgkin, P.H. Maxwell, C.W. Pugh, C.J. Schofield, and P.J. Ratcliffe C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 107 2001 43 54
12. K.S. Hewitson, L.A. McNeill, M.V. Riordan, Y.M. Tian, A.N. Bullock, R.W. Welford, J.M. Elkins, N.J. Oldham, S. Bhattacharya, J.M. Gleadle, P.J. Ratcliffe, C.W. Pugh, and C.J. Schofield Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J. Biol. Chem. 277 2002 26351 26355
13. D. Lando, D.J. Peet, J.J. Gorman, D.A. Whelan, M.L. Whitelaw, and R.K. Bruick FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev. 16 2002 1466 1471
14. D. Lando, D.J. Peet, D.A. Whelan, J.J. Gorman, and M.L. Whitelaw Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 295 2002 858 861
15. J.W. Jeong, M.K. Bae, M.Y. Ahn, S.H. Kim, T.K. Sohn, M.H. Bae, M.A. Yoo, E.J. Song, K.J. Lee, and K.W. Kim Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation Cell 111 2002 709 720
16. S. Muller, C. Hoege, G. Pyrowolakis, and S. Jentsch SUMO, ubiquitin's mysterious cousin Nat. Rev. Mol. Cell Biol. 2 2001 202 210
17. F. Melchior SUMO - nonclassical ubiquitin Annu. Rev. Cell Dev. Biol. 16 2000 591 626
18. M.S. Rodriguez, C. Dargemont, and R.T. Hay SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting J. Biol. Chem. 276 2001 12654 12659
19. T. Kamitani, H.P. Nguyen, K. Kito, T. Fukuda-Kamitani, and E.T. Yeh Covalent modification of PML by the sentrin family of ubiquitin-like proteins J. Biol. Chem. 273 1998 3117 3120
20. R. Mahajan, C. Delphin, T. Guan, L. Gerace, and F. Melchior A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2 Cell 88 1997 97 107
21. M.J. Matunis, J. Wu, and G. Blobel SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex J. Cell Biol. 140 1998 499 509
22. S. Muller, M.J. Matunis, and A. Dejean Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus EMBO J. 17 1998 61 70
23. M. Gostissa, A. Hengstermann, V. Fogal, P. Sandy, S.E. Schwarz, M. Scheffner, and G. Del Sal Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1 EMBO J. 18 1999 6462 6471
24. H. Poukka, U. Karvonen, O.A. Janne, and J.J. Palvimo Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1) Proc. Natl. Acad. Sci. USA 97 2000 14145 14150
25. J.M. Desterro, M.S. Rodriguez, and R.T. Hay SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation Mol. Cell 2 1998 233 239
26. R. Shao, F.P. Zhang, F. Tian, F.P. Anders, X. Wang, H. Sjoland, and H. Billig Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo FEBS Lett. 569 2004 293 300