Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer

European Urology

Volumn 46, Issue 2, 2004, Pages 200-208

  Theodoropoulos, Vasilios E ^a   Lazaris, Andreas Ch ^b   Sofras, Fragiskos ^c   Gerzelis, Ioannis ^a   Tsoukala, Vasiliki ^b   Ghikonti, Ioanna ^a   Manikas, Konstantinos ^a   Kastriotis, Ioannis ^c  

^a AGIA OLGA HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Angiogenesis; Bladder; Hypoxia; Hypoxia inducible factor; Urothelial carcinoma

Indexed keywords

CD31 ANTIGEN; CELL ADHESION MOLECULE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCLONAL ANTIBODY; PARAFFIN; REGULATOR PROTEIN; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BLADDER CARCINOMA; CANCER GRADING; CANCER STAGING; CELL DENSITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC VALUE; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; TRANSITIONAL CELL CARCINOMA; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANDROLOGY; CARCINOMA, TRANSITIONAL CELL; DNA-BINDING PROTEINS; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; PROGNOSIS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TRANSCRIPTION FACTORS; URINARY BLADDER NEOPLASMS;

EID: 3142534607     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2004.04.008     Document Type: Article

References (21)

1. Ellis L.M., Fidler I.J. Angiogenesis and metastasis. Eur. J. Cancer. 32A:1996;2451-2460
2. Campbell S.C. Advances in angiogenesis research: relevance to urological oncology. J. Urol. 58:1997;1663-1674
3. Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 59:1999;5830-5835
4. Brizel D.M., Scully S.P., Harrelson J.M., Layfield L.J., Bean J.M., Prosnitz L.R., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943
5. Brown J.M., Giaccia A.J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 58:1998;1408-1416
6. Aebersold D.M., Burri P., Beer K.T., Laissue J., Djonov V., Greiner R.H., et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61:2001;2911-2916
7. Forsythe J.A., Jiang B.H., Iyer N.V., Agani F., Leung S.W., Koos R.D., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell Biol. 16:1996;4604-4613
8. Ryan H.E., Lo J., Johnson R.S. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015
9. Talks K.L., Turley H., Gatter K.C., Maxwell P.H., Pugh C.W., Ratcliffe P.J., et al. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157:2000;411-421
10. Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., et al. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 394:1998;485-490
11. 2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 12:1998;149-162
12. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc. Natl. Acad. Sci. USA. 95:1998;7987-7992
13. Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275
14. Sivridis E., Giatromanolaki A., Gatter K.C., Harris A.L., Koukourakis M.I. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer. 95:2002;1055-1063
15. Crew J.P., O'Brien T., Bradburn M., Fuggle S., Bicknell R., Cranston D., et al. Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer. Cancer Res. 57:1997;5281-5285
16. Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60:2000;4693-4696
17. Giatromanolaki A., Koukourakis M.I., Sivridis E., Turley H., Talks K., Pezzella F., et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br. J. Cancer. 85:2001;881-890
18. Koukourakis M.I., Giatromanolaki A., Skarlatos J., Corti L., Blandamura S., Piazza M., et al. Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy. Cancer Res. 61:2001;1830-1832
19. Jones A., Fujiyama C., Blanche C., Moore J.W., Fuggle S., Cranston D., et al. Relation of vascular endothelial growth factor production to expression and regulation of hypoxia-inducible factor-1 alpha and hypoxia-inducible factor-2 alpha in human bladder tumors and cell lines. Clin. Cancer Res. 7:2001;1263-1272
20. Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev. 14:2000;34-44
21. Chaudhary R., Bromley M., Clarke N.W., Betts C.D., Barnard R.J., Ryder W.D., et al. Prognostic relevance of micro-vessel density in cancer of the urinary bladder. Anticancer Res. 19:1999;3479-3484