메뉴 건너뛰기




Volumn 96, Issue 8, 2007, Pages 1284-1292

Target gene selectivity of hypoxia-inducible factor-α in renal cancer cells is conveyed by post-DNA-binding mechanisms

Author keywords

Chromatin immunoprecipitation; Hypoxia inducible factor; Renal carcinoma; Transcription; Von Hippel Lindau

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA;

EID: 34247219188     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603675     Document Type: Article
Times cited : (93)

References (37)
  • 1
    • 4644318828 scopus 로고    scopus 로고
    • Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
    • doi:10.1074/jbc.m406026200
    • Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM (2004) Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J Biol Chem 279: 38458-38465, doi:10.1074/jbc.m406026200
    • (2004) J Biol Chem , vol.279 , pp. 38458-38465
    • Appelhoff, R.J.1    Tian, Y.M.2    Raval, R.R.3    Turley, H.4    Harris, A.L.5    Pugh, C.W.6    Ratcliffe, P.J.7    Gleadle, J.M.8
  • 3
    • 17144420466 scopus 로고    scopus 로고
    • Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator
    • doi:10.1074/jbc. m409987200
    • Bracken CP, Whitelaw ML, Peet DJ (2005) Activity of hypoxia-inducible factor 2alpha is regulated by association with the NF-kappaB essential modulator. J Biol Chem 280: 14240-14251, doi:10.1074/jbc. m409987200
    • (2005) J Biol Chem , vol.280 , pp. 14240-14251
    • Bracken, C.P.1    Whitelaw, M.L.2    Peet, D.J.3
  • 5
    • 16844386959 scopus 로고    scopus 로고
    • Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumour growth
    • Covello KL, Simon MC, Keith B (2005) Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumour growth. Cancer Res 65: 2277-2286
    • (2005) Cancer Res , vol.65 , pp. 2277-2286
    • Covello, K.L.1    Simon, M.C.2    Keith, B.3
  • 6
    • 3342967945 scopus 로고    scopus 로고
    • Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma
    • doi:10.1038/sj.onc.1207764
    • Grabmaier K, MC AdW, Verhaegh GW, Schalken JA, Oosterwijk E (2004) Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene 23: 5624-5631, doi:10.1038/sj.onc.1207764
    • (2004) Oncogene , vol.23 , pp. 5624-5631
    • Grabmaier, K.1    AdW, M.C.2    Verhaegh, G.W.3    Schalken, J.A.4    Oosterwijk, E.5
  • 7
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - a key regulatory factor in tumour growth
    • doi:10.1038/nrc704
    • Harris AL (2002) Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, doi:10.1038/nrc704
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 8
    • 27544504817 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
    • doi:10.1016/j.bbrc.2005.08.193
    • Hirota K, Semenza GL (2005) Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun 338: 610-616, doi:10.1016/j.bbrc.2005.08.193
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 610-616
    • Hirota, K.1    Semenza, G.L.2
  • 9
    • 33646248422 scopus 로고    scopus 로고
    • Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in stem cells
    • Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC (2006) Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1 alpha) and HIF-2 alpha in stem cells. Mol Cell Biol 26: 3514-3526
    • (2006) Mol Cell Biol , vol.26 , pp. 3514-3526
    • Hu, C.J.1    Iyer, S.2    Sataur, A.3    Covello, K.L.4    Chodosh, L.A.5    Simon, M.C.6
  • 10
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • doi:10.1128/mcb.23.24. 9361-9374.2003
    • Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC (2003) Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol 23: 9361-9374, doi:10.1128/mcb.23.24. 9361-9374.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 11
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • doi:10.1038/16476
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M (1999) The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 397: 164-168, doi:10.1038/16476
    • (1999) Nature , vol.397 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    van Lohuizen, M.5
  • 12
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang BH, Rue E, Wang GL, Roe R, Semenza GL (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 271: 17771-17778
    • (1996) J Biol Chem , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 13
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • doi:10.1038/nrc885
    • Kaelin Jr WG (2002) Molecular basis of the VHL hereditary cancer syndrome. Nat Rev Cancer 2: 673-682, doi:10.1038/nrc885
    • (2002) Nat Rev Cancer , vol.2 , pp. 673-682
    • Kaelin Jr, W.G.1
  • 14
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha Is Sufficient to Suppress pVHL-Defective Tumour Growth
    • doi:10.1371/journal.pbio.0000083
    • Kondo K, Kim WY, Lechpammer M, Kaelin Jr WG (2003) Inhibition of HIF2alpha Is Sufficient to Suppress pVHL-Defective Tumour Growth. PLoS Biol 1: E83, doi:10.1371/journal.pbio.0000083
    • (2003) PLoS Biol , vol.1
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin Jr, W.G.4
  • 15
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumour suppression by the von Hippel-Lindau protein
    • doi:10.1016/s1535-6108(02)00043-0
    • Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin Jr WG (2002) Inhibition of HIF is necessary for tumour suppression by the von Hippel-Lindau protein. Cancer Cell 1: 237-246, doi:10.1016/s1535-6108(02)00043-0
    • (2002) Cancer Cell , vol.1 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin Jr, W.G.5
  • 16
    • 0034676331 scopus 로고    scopus 로고
    • Upregulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumour suppressor gene loss of function
    • Krieg M, Haas R, Brauch H, Acker T, Flamme I, Plate KH (2000) Upregulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumour suppressor gene loss of function. Oncogene 19: 5435-5443
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3    Acker, T.4    Flamme, I.5    Plate, K.H.6
  • 17
    • 0034681378 scopus 로고    scopus 로고
    • A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor
    • Lando D, Pongratz I, Poellinger L, Whitelaw ML (2000) A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor. J Biol Chem 275: 4618-4627
    • (2000) J Biol Chem , vol.275 , pp. 4618-4627
    • Lando, D.1    Pongratz, I.2    Poellinger, L.3    Whitelaw, M.L.4
  • 18
    • 11244315697 scopus 로고    scopus 로고
    • Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
    • doi:10.1182/blood-2004-07-2958
    • Manalo DJ, Rowan A, Lavoie T, Natarajan L, Kelly BD, Ye SQ, Garcia JGN, Semenza GL (2005) Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1. Blood 105: 659-669, doi:10.1182/blood-2004-07-2958
    • (2005) Blood , vol.105 , pp. 659-669
    • Manalo, D.J.1    Rowan, A.2    Lavoie, T.3    Natarajan, L.4    Kelly, B.D.5    Ye, S.Q.6    Garcia, J.G.N.7    Semenza, G.L.8
  • 20
    • 0036527785 scopus 로고    scopus 로고
    • The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
    • doi:10.1016/s1535-6108(02)00044-2
    • Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD (2002) The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 1: 247-255, doi:10.1016/s1535-6108(02)00044-2
    • (2002) Cancer Cell , vol.1 , pp. 247-255
    • Maranchie, J.K.1    Vasselli, J.R.2    Riss, J.3    Bonifacino, J.S.4    Linehan, W.M.5    Klausner, R.D.6
  • 22
    • 0033593219 scopus 로고    scopus 로고
    • Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1alpha
    • O'Rourke JF, Tian YM, Ratcliffe PJ, Pugh CW (1999) Oxygen-regulated and transactivating domains in endothelial PAS protein 1: comparison with hypoxia-inducible factor-1alpha. J Biol Chem 274: 2060-2071
    • (1999) J Biol Chem , vol.274 , pp. 2060-2071
    • O'Rourke, J.F.1    Tian, Y.M.2    Ratcliffe, P.J.3    Pugh, C.W.4
  • 23
    • 0038788826 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): Role of cytoplasmic trapping of HIF-2alpha
    • doi:10.1128/mcb.23.14. 4959-4971.2003
    • Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS (2003) Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol 23: 4959-4971, doi:10.1128/mcb.23.14. 4959-4971.2003
    • (2003) Mol Cell Biol , vol.23 , pp. 4959-4971
    • Park, S.K.1    Dadak, A.M.2    Haase, V.H.3    Fontana, L.4    Giaccia, A.J.5    Johnson, R.S.6
  • 25
    • 23944454868 scopus 로고    scopus 로고
    • Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
    • doi:10.1042/bj20042121
    • Pescador N, Cuevas Y, Naranjo S, Alcaide M, Villar D, Landazuri MD, Del Peso L (2005) Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem J 390: 189-197, doi:10.1042/bj20042121
    • (2005) Biochem J , vol.390 , pp. 189-197
    • Pescador, N.1    Cuevas, Y.2    Naranjo, S.3    Alcaide, M.4    Villar, D.5    Landazuri, M.D.6    Del Peso, L.7
  • 26
    • 20744445650 scopus 로고    scopus 로고
    • Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma
    • doi:10.1128/mcb.25.13.5675-5686.2005
    • Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ (2005) Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 25: 5675-5686, doi:10.1128/mcb.25.13.5675-5686.2005
    • (2005) Mol Cell Biol , vol.25 , pp. 5675-5686
    • Raval, R.R.1    Lau, K.W.2    Tran, M.G.3    Sowter, H.M.4    Mandriota, S.J.5    Li, J.L.6    Pugh, C.W.7    Maxwell, P.H.8    Harris, A.L.9    Ratcliffe, P.J.10
  • 27
    • 27544434803 scopus 로고    scopus 로고
    • Signalling hypoxia by HIF hydroxylases
    • doi:10.1016/j.bbrc.2005. 08.111
    • Schofield CJ, Ratcliffe PJ (2005) Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun 338: 617-626, doi:10.1016/j.bbrc.2005. 08.111
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 617-626
    • Schofield, C.J.1    Ratcliffe, P.J.2
  • 28
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • doi:10.1038/nrc1187
    • Semenza GL (2003) Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3: 721-732, doi:10.1038/nrc1187
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 29
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
    • Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 63: 6130-6134
    • (2003) Cancer Res , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 32
    • 17144416530 scopus 로고    scopus 로고
    • Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells
    • Wang V, Davis DA, Haque M, Huang LE, Yarchoan R (2005) Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells. Cancer Res 65: 3299-3306
    • (2005) Cancer Res , vol.65 , pp. 3299-3306
    • Wang, V.1    Davis, D.A.2    Haque, M.3    Huang, L.E.4    Yarchoan, R.5
  • 33
    • 9444283176 scopus 로고    scopus 로고
    • Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: Erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells
    • doi: 10.1096/fj.04-1640 fje
    • Warnecke C, Zaborowska Z, Kurreck J, Erdmann VA, Frei U, Wiesener M, Eckardt KU (2004) Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J. 18: 1462-1464, doi: 10.1096/fj.04-1640 fje
    • (2004) FASEB J , vol.18 , pp. 1462-1464
    • Warnecke, C.1    Zaborowska, Z.2    Kurreck, J.3    Erdmann, V.A.4    Frei, U.5    Wiesener, M.6    Eckardt, K.U.7
  • 34
    • 0036024955 scopus 로고    scopus 로고
    • Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation
    • Weinmann AS, Farnham PJ (2002) Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation. Methods 26: 37-47
    • (2002) Methods , vol.26 , pp. 37-47
    • Weinmann, A.S.1    Farnham, P.J.2
  • 35
    • 0036024957 scopus 로고    scopus 로고
    • Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation
    • Wells J, Farnham PJ (2002) Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods 26: 48-56
    • (2002) Methods , vol.26 , pp. 48-56
    • Wells, J.1    Farnham, P.J.2
  • 37
    • 1342280515 scopus 로고    scopus 로고
    • Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/-tumours
    • Zimmer M, Doucette D, Siddiqui N, Iliopoulos O (2004) Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/-tumours. Mol Cancer Res 2: 89-95
    • (2004) Mol Cancer Res , vol.2 , pp. 89-95
    • Zimmer, M.1    Doucette, D.2    Siddiqui, N.3    Iliopoulos, O.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.