HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 34, 2009, Pages 14391-14396

  Bertout, Jessica A ^a,b   Majmundar, Amar J ^a,b   Gordan, John D ^a,b   Lam, Jennifer C ^a,b   Ditsworth, Dara ^a,b   Keith, Brian ^a,b   Brown, Eric J ^a,b   Nathanson, Katherine L ^a,b   Simon, M Celeste ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cancer; DNA damage; Hypoxia; IR; ROS

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; APOPTOSIS REGULATORY PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BBC3 PROTEIN, HUMAN; CASPASE 3; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; ONCOPROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL DEATH; CLONOGENESIS; DNA DAMAGE; GENE EXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RADIATION; CELL CYCLE; CELL HYPOXIA; DNA MICROARRAY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; IONIZING RADIATION; METABOLISM; NEOPLASM; PATHOLOGY; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS REGULATORY PROTEINS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CASPASE 3; CELL CYCLE; CELL DEATH; CELL HYPOXIA; CELL LINE, TUMOR; DNA DAMAGE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS; RADIATION, IONIZING; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 70149106164     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907357106     Document Type: Article

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