-
1
-
-
0033233243
-
Regulation of mammalian O2 homeostasis by hypoxia inducible factor 1
-
10611972
-
Semenza GL Regulation of mammalian O2 homeostasis by hypoxia inducible factor 1 Annu Rev Cell Dev Biol 1999, 15:551-78 10611972
-
(1999)
Annu Rev Cell Dev Biol
, vol.15
, pp. 551-578
-
-
Semenza, G.L.1
-
2
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
13130303
-
Semenza GL Targeting HIF-1 for cancer therapy Nat Rev Cancer 2003, 3:721-32 13130303
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
13130303
-
Semenza GL Targeting HIF-1 for cancer therapy Nat Rev Cancer 2003, 3:721-32 13130303
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
4
-
-
33749362031
-
Inhibiting hypoxia-inducible factor 1 for cancer therapy
-
16940159
-
Melillo G Inhibiting hypoxia-inducible factor 1 for cancer therapy Mol Cancer Res 2006, 4:601-5 16940159
-
(2006)
Mol Cancer Res
, vol.4
, pp. 601-605
-
-
Melillo, G.1
-
5
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
10582706
-
Zhong H De Marzo AM Laughner E Lim M Hilton DA Zagzag D Buechler P Isaacs WB Semenza GL Simons JW Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases Cancer Res 1999, 59:5830-5835 10582706
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
6
-
-
0034896068
-
Expression of hypoxia-inducible factor 1 alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
11410504
-
Birner P M Schindle A Obermair G Breitenecker G Oberhuber G Expression of hypoxia-inducible factor 1 alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy Clin Cancer Res 2001, 7:1661-1668 11410504
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1661-1668
-
-
Birner, P.M.1
Schindle, A.2
Obermair, G.3
Breitenecker, G.4
Oberhuber, G.5
-
7
-
-
1642341137
-
VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancer
-
14675669
-
Wong C Wellman TL Lounsbury KM VEGF and HIF-1alpha expression are increased in advanced stages of epithelial ovarian cancer Gynecol Oncol 2003, 91:513-517 14675669
-
(2003)
Gynecol Oncol
, vol.91
, pp. 513-517
-
-
Wong, C.1
Wellman, T.L.2
Lounsbury, K.M.3
-
8
-
-
0037169870
-
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma
-
11804750
-
Nakayama K A Kanzaki K Hata H Katabuchi H Okamura K Miyazaki M Fukumoto Y Takebayashi Hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression in human ovarian carcinoma Cancer Lett 2002, 176:215-223 11804750
-
(2002)
Cancer Lett
, vol.176
, pp. 215-223
-
-
Nakayama, K.1
Kanzaki, A.2
Hata, K.3
Katabuchi, H.4
Okamura, H.5
Miyazaki, K.6
Fukumoto, M.7
Takebayashi, Y.8
-
9
-
-
34247155290
-
Hypoxia inducible factor 1-alpha expression as a factor predictive of efficacy of taxane/platinum chemotherapy in advanced primary epithelial ovarian cancer
-
17215078
-
Nakai H Watanabe Y Ueda H Hoshiai H Hypoxia inducible factor 1-alpha expression as a factor predictive of efficacy of taxane/platinum chemotherapy in advanced primary epithelial ovarian cancer Cancer Lett 2007, 251(1):164-7 17215078
-
(2007)
Cancer Lett
, vol.251
, Issue.1
, pp. 164-167
-
-
Nakai, H.1
Watanabe, Y.2
Ueda, H.3
Hoshiai, H.4
-
10
-
-
34547838192
-
Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: Nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma
-
17555795
-
Osada R Horiuchi A Kikuchi N Yoshida J Hayashi A Ota M Katsuyama Y Mellilo G Konishi I Expression of hypoxia-inducible factor 1alpha, hypoxia-inducible factor 2alpha, and von Hippel-Lindau protein in epithelial ovarian neoplasms and allelic loss of von Hippel-Lindau gene: nuclear expression of hypoxia-inducible factor 1alpha is an independent prognostic factor in ovarian carcinoma Hum Pathol 2007, 38(9):1310-20 17555795
-
(2007)
Hum Pathol
, vol.38
, Issue.9
, pp. 1310-1320
-
-
Osada, R.1
Horiuchi, A.2
Kikuchi, N.3
Yoshida, J.4
Hayashi, A.5
Ota, M.6
Katsuyama, Y.7
Mellilo, G.8
Konishi, I.9
-
11
-
-
35848959085
-
MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity
-
17982282
-
Lyberopoulou A Venieris E Mylonis I Chachami G Pappas I Simos G Bonanou S Georgatsou E MgcRacGAP interacts with HIF-1alpha and regulates its transcriptional activity Cell Physiol Biochem 2007, 20:995-1006 17982282
-
(2007)
Cell Physiol Biochem
, vol.20
, pp. 995-1006
-
-
Lyberopoulou, A.1
Venieris, E.2
Mylonis, I.3
Chachami, G.4
Pappas, I.5
Simos, G.6
Bonanou, S.7
Georgatsou, E.8
-
13
-
-
0036569941
-
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients
-
11980639
-
Beasley NJ Leek R Alam M Turley H Cox GJ Gatter K Millard P Fuggle S Harris AL Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: Relationship to tumor biology and treatment outcome in surgically resected patients Cancer Res 2002, 62:2493-7 11980639
-
(2002)
Cancer Res
, vol.62
, pp. 2493-2497
-
-
Beasley, N.J.1
Leek, R.2
Alam, M.3
Turley, H.4
Cox, G.J.5
Gatter, K.6
Millard, P.7
Fuggle, S.8
Harris, A.L.9
-
14
-
-
33644849887
-
Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
-
16418497
-
Koukourakis MI Bentzen SM Giatromanolaki A Wilson GD Daley FM Saunders MI Dische S Sivridis E Harris AL Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial J Clin Oncol 2006, 24:727-35 16418497
-
(2006)
J Clin Oncol
, vol.24
, pp. 727-735
-
-
Koukourakis, M.I.1
Bentzen, S.M.2
Giatromanolaki, A.3
Wilson, G.D.4
Daley, F.M.5
Saunders, M.I.6
Dische, S.7
Sivridis, E.8
Harris, A.L.9
-
15
-
-
33748037026
-
Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
-
16899602
-
Generali D Berruti A Brizzi MP Campo L Bonardi S Wigfield S Bersiga A Allevi G Milani M Aguggini S Gandolfi V Dogliotti L Bottini A Harris AL Fox SB Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer Clin Cancer Res 2006, 12:4562-8 16899602
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4562-4568
-
-
Generali, D.1
Berruti, A.2
Brizzi, M.P.3
Campo, L.4
Bonardi, S.5
Wigfield, S.6
Bersiga, A.7
Allevi, G.8
Milani, M.9
Aguggini, S.10
Gandolfi, V.11
Dogliotti, L.12
Bottini, A.13
Harris, A.L.14
Fox, S.B.15
-
17
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
2005 Oct 18 16234508
-
Wenger RH Stiehl DP Camenisch G Integration of oxygen signaling at the consensus HRE Sci STKE 2005, 306:rE12 2005 Oct 18 16234508
-
(2005)
Sci STKE
, vol.306
-
-
Wenger, R.H.1
Stiehl, D.P.2
Camenisch, G.3
-
18
-
-
28844433666
-
Mitochondria: Oxygen sinks rather than sensors?
-
16229963
-
Wenger RH Mitochondria: Oxygen sinks rather than sensors? Med Hypotheses 2006, 66:380-383 16229963
-
(2006)
Med Hypotheses
, vol.66
, pp. 380-383
-
-
Wenger, R.H.1
-
19
-
-
25444465116
-
Both microtubulestabilizing and micro tubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
-
16204076
-
Escuin D Kline ER Giannakakou P Both microtubulestabilizing and micro tubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function Cancer Res 2005, 65:9021-9028 16204076
-
(2005)
Cancer Res
, vol.65
, pp. 9021-9028
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
20
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
-
1171004 9822602
-
Kallio PJ Okamoto K O'Brien S Carrero P Makino Y Tanaka H Poellinger L Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha EMBO J 1998, 17:6573-6586 1171004 9822602
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
Carrero, P.4
Makino, Y.5
Tanaka, H.6
Poellinger, L.7
-
21
-
-
0037083845
-
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene
-
1222361 11829741
-
Y Chun YS Choi E Kim TY Kim MS Park JW A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene Biochem J 2002, 362:71-79 1222361 11829741
-
(2002)
Biochem J
, vol.362
, pp. 71-79
-
-
Y Chun, Y.S.1
Choi, E.2
Kim, T.Y.3
Kim, M.S.4
Park, J.W.5
-
22
-
-
0035266307
-
Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
-
11280732
-
Koukourakis MI Giatromanolaki A Skarlatos J Corti L Blandamura S Piazza M Gatter KC Harris AL Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy Cancer Res 2001, 61:1830-1832 11280732
-
(2001)
Cancer Res
, vol.61
, pp. 1830-1832
-
-
Koukourakis, M.I.1
Giatromanolaki, A.2
Skarlatos, J.3
Corti, L.4
Blandamura, S.5
Piazza, M.6
Gatter, K.C.7
Harris, A.L.8
-
23
-
-
0033870281
-
The expression and distribution of the hypoxia inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
-
1850121 10934146
-
Talks KL Turley H Gatter KC Maxwell PH Pugh CW Ratcliffe PJ Harris AL The expression and distribution of the hypoxia inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages Am J Pathol 2000, 157:411-421 1850121 10934146
-
(2000)
Am J Pathol
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
24
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
10861440
-
Zagzag D Zhong H Scalzitti JM Laughner E Simons JW Semenza GL Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression Cancer 2000, 88:2606-2618 10861440
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
25
-
-
33845403070
-
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha
-
16954218
-
Mylonis I Chachami G Samiotaki M Panayotou G Paraskeva E Kalousi A Georgatsou E Bonanou S Simos G Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1alpha J Biol Chem 2006, 281:33095-106 16954218
-
(2006)
J Biol Chem
, vol.281
, pp. 33095-33106
-
-
Mylonis, I.1
Chachami, G.2
Samiotaki, M.3
Panayotou, G.4
Paraskeva, E.5
Kalousi, A.6
Georgatsou, E.7
Bonanou, S.8
Simos, G.9
-
26
-
-
3843078830
-
Targeting topoisomerase I to inhibit hypoxia inducible factor 1
-
Review 14712084
-
Rapisarda A Shoemaker RH Melillo G Targeting topoisomerase I to inhibit hypoxia inducible factor 1 Cell Cycle 2004, 3(2):172-5 Review 14712084
-
(2004)
Cell Cycle
, vol.3
, Issue.2
, pp. 172-175
-
-
Rapisarda, A.1
Shoemaker, R.H.2
Melillo, G.3
-
27
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
12726862
-
Mabjeesh NJ Escuin D LaVallee TM Pribluda VS Swartz GM Johnson MS Willard MT Zhong H Simons JW Giannakakou P 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF Cancer Cell 2003, 3(4):363-75 12726862
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
Pribluda, V.S.4
Swartz, G.M.5
Johnson, M.S.6
Willard, M.T.7
Zhong, H.8
Simons, J.W.9
Giannakakou, P.10
-
28
-
-
11144239579
-
2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma
-
2004 Dec 15 15623651
-
Ricker JL Chen Z Yang XP Pribluda VS Swartz GM Van Waes C 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma Clin Cancer Res 10(24):8665-73 2004 Dec 15 15623651
-
Clin Cancer Res
, vol.10
, Issue.24
, pp. 8665-8673
-
-
Ricker, J.L.1
Chen, Z.2
Yang, X.P.3
Pribluda, V.S.4
Swartz, G.M.5
Van Waes, C.6
-
29
-
-
33645975518
-
Chaperoning oncogenes: Hsp90 as a target of geldanamycin
-
16610363
-
Neckers L Chaperoning oncogenes: Hsp90 as a target of geldanamycin Handb Exp Pharmacol 2006, 172:259-77 16610363
-
(2006)
Handb Exp Pharmacol
, vol.172
, pp. 259-277
-
-
Neckers, L.1
-
30
-
-
33746379315
-
Using natural product inhibitors to validate Hsp90 as a molecular target in cancer
-
16842153
-
Neckers L Using natural product inhibitors to validate Hsp90 as a molecular target in cancer Curr Top Med Chem 2006, 6(11):1163-71 16842153
-
(2006)
Curr Top Med Chem
, vol.6
, Issue.11
, pp. 1163-1171
-
-
Neckers, L.1
-
31
-
-
33645376457
-
Hypoxia-inducible factor 1alpha (HIF-1alpha) correlated with tumor growth and apoptosis in ovarian cancer
-
16515634
-
Jiang H Feng Y Hypoxia-inducible factor 1alpha (HIF-1alpha) correlated with tumor growth and apoptosis in ovarian cancer Int J Gynecol Cancer 2006, 1:405-412 16515634
-
(2006)
Int J Gynecol Cancer
, vol.1
, pp. 405-412
-
-
Jiang, H.1
Feng, Y.2
-
32
-
-
34047253075
-
RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer
-
17363557
-
Mabuchi S Altomare DA Connolly DC Klein-Szanto A Litwin S Hoelzle MK Hensley HH Hamilton TC Testa JR RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer Cancer Res 2007, 67:2408-2413 17363557
-
(2007)
Cancer Res
, vol.67
, pp. 2408-2413
-
-
Mabuchi, S.1
Altomare, D.A.2
Connolly, D.C.3
Klein-Szanto, A.4
Litwin, S.5
Hoelzle, M.K.6
Hensley, H.H.7
Hamilton, T.C.8
Testa, J.R.9
-
33
-
-
33745903146
-
Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells
-
16443261
-
Treek O Wackwitz B Haus U Ortmann O Effects of a combined treatment with mTOR inhibitor RAD001 and tamoxifen in vitro on growth and apoptosis of human cancer cells Gynecol Oncol 2006, 102:292-299 16443261
-
(2006)
Gynecol Oncol
, vol.102
, pp. 292-299
-
-
Treek, O.1
Wackwitz, B.2
Haus, U.3
Ortmann, O.4
|