-
1
-
-
23644435597
-
Genetic evidence for a tumor suppressor role of HIF-2alpha
-
Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P (2005) Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell 8: 131-141
-
(2005)
Cancer Cell
, vol.8
, pp. 131-141
-
-
Acker, T.1
Diez-Juan, A.2
Aragones, J.3
Tjwa, M.4
Brusselmans, K.5
Moons, L.6
Fukumura, D.7
Moreno-Murciano, M.P.8
Herbert, J.M.9
Burger, A.10
Riedel, J.11
Elvert, G.12
Flamme, I.13
Maxwell, P.H.14
Collen, D.15
Dewerchin, M.16
Jain, R.K.17
Plate, K.H.18
Carmeliet, P.19
-
2
-
-
38649143118
-
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
-
Aragones J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40: 170-180
-
(2008)
Nat Genet
, vol.40
, pp. 170-180
-
-
Aragones, J.1
Schneider, M.2
Van Geyte, K.3
Fraisl, P.4
Dresselaers, T.5
Mazzone, M.6
Dirkx, R.7
Zacchigna, S.8
Lemieux, H.9
Jeoung, N.H.10
Lambrechts, D.11
Bishop, T.12
Lafuste, P.13
Diez-Juan, A.14
Harten, S.K.15
Van Noten, P.16
De Bock, K.17
Willam, C.18
Tjwa, M.19
Grosfeld, A.20
Navet, R.21
Moons, L.22
Vandendriessche, T.23
Deroose, C.24
Wijeyekoon, B.25
Nuyts, J.26
Jordan, B.27
Silasi-Mansat, R.28
Lupu, F.29
Dewerchin, M.30
Pugh, C.31
Salmon, P.32
Mortelmans, L.33
Gallez, B.34
Gorus, F.35
Buyse, J.36
Sluse, F.37
Harris, R.A.38
Gnaiger, E.39
Hespel, P.40
Van Hecke, P.41
Schuit, F.42
Van Veldhoven, P.43
Ratcliffe, P.44
Baes, M.45
Maxwell, P.46
Carmeliet, P.47
more..
-
3
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22: 4082-4090
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
4
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angio-genesis
-
Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshert E, Keshet E (1998) Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angio-genesis. Nature 394: 485-490
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
Koch, C.J.11
Ratcliffe, P.12
Moons, L.13
Jain, R.K.14
Collen, D.15
Keshert, E.16
Keshet, E.17
-
5
-
-
65649138377
-
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
-
Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ (2009) Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 15: 527-538
-
(2009)
Cancer Cell
, vol.15
, pp. 527-538
-
-
Chan, D.A.1
Kawahara, T.L.2
Sutphin, P.D.3
Chang, H.Y.4
Chi, J.T.5
Giaccia, A.J.6
-
6
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity
-
Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, Godson C, Nielsen JE, Moynagh P, Pouyssegur J, Taylor CT (2006) Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci USA 103: 18154-18159
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 18154-18159
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
Ginouves, A.4
Fitzgerald, K.T.5
Seeballuck, F.6
Godson, C.7
Nielsen, J.E.8
Moynagh, P.9
Pouyssegur, J.10
Taylor, C.T.11
-
7
-
-
32944477859
-
Hypoxia-inducible factor-1alpha promotes non-hypoxia-mediated proliferation in colon cancer cells and xenografts
-
Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH (2006) Hypoxia-inducible factor-1alpha promotes non-hypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res 66: 1684-1936
-
(2006)
Cancer Res
, vol.66
, pp. 1684-1936
-
-
Dang, D.T.1
Chen, F.2
Gardner, L.B.3
Cummins, J.M.4
Rago, C.5
Bunz, F.6
Kantsevoy, S.V.7
Dang, L.H.8
-
8
-
-
39849102836
-
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
-
Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegue E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G (2008) HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13: 206-220
-
(2008)
Cancer Cell
, vol.13
, pp. 206-220
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
Liu, P.4
Ganss, R.5
Passegue, E.6
Song, H.7
Vandenberg, S.8
Johnson, R.S.9
Werb, Z.10
Bergers, G.11
-
9
-
-
0346059600
-
Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth
-
Erez N, Milyavsky M, Eilam R, Shats I, Goldfinger N, Rotter V (2003) Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res 63: 8777-8783
-
(2003)
Cancer Res
, vol.63
, pp. 8777-8783
-
-
Erez, N.1
Milyavsky, M.2
Eilam, R.3
Shats, I.4
Goldfinger, N.5
Rotter, V.6
-
10
-
-
0027238288
-
Molecular genetic studies of sporadic and familial renal cell carcinoma
-
Gnarra JR, Glenn GM, Latif F, Anglard P, Lerman MI, Zbar B, Linehan WM (1993)Molecular genetic studies of sporadic and familial renal cell carcinoma. Urol Clin North Am 20: 207-216
-
(1993)
Urol Clin North Am
, vol.20
, pp. 207-216
-
-
Gnarra, J.R.1
Glenn, G.M.2
Latif, F.3
Anglard, P.4
Lerman, M.I.5
Zbar, B.6
Linehan, W.M.7
-
11
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh FM, Lubensky I, Duan DR, Florence C, Pozzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman MI, Zbar B, Linehan WM (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 7: 85-90
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
Schmidt, L.4
Wei, M.H.5
Li, H.6
Latif, F.7
Liu, S.8
Chen, F.9
Duh, F.M.10
Lubensky, I.11
Duan, D.R.12
Florence, C.13
Pozzatti, R.14
Walther, M.M.15
Bander, N.H.16
Grossman, H.B.17
Brauch, H.18
Pomer, S.19
Brooks, J.D.20
Isaacs, W.B.21
Lerman, M.I.22
Zbar, B.23
Linehan, W.M.24
more..
-
12
-
-
56849096837
-
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
-
Gordan JD, Lal P, Dondeti VR, Letrero R, Parekh KN, Oquendo CE, Greenberg RA, Flaherty KT, Rathmell WK, Keith B, Simon MC, Nathanson KL (2008) HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma. Cancer Cell 14: 435-446
-
(2008)
Cancer Cell
, vol.14
, pp. 435-446
-
-
Gordan, J.D.1
Lal, P.2
Dondeti, V.R.3
Letrero, R.4
Parekh, K.N.5
Oquendo, C.E.6
Greenberg, R.A.7
Flaherty, K.T.8
Rathmell, W.K.9
Keith, B.10
Simon, M.C.11
Nathanson, K.L.12
-
13
-
-
75149165633
-
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
-
Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T (2010) Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 70: 357-366
-
(2010)
Cancer Res
, vol.70
, pp. 357-366
-
-
Henze, A.T.1
Riedel, J.2
Diem, T.3
Wenner, J.4
Flamme, I.5
Pouyseggur, J.6
Plate, K.H.7
Acker, T.8
-
14
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L (2005) HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 8: 143-153
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
Merino, M.7
Trepel, J.8
Zbar, B.9
Toro, J.10
Ratcliffe, P.J.11
Linehan, W.M.12
Neckers, L.13
-
15
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin Jr WG (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292: 464-468
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
16
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
17
-
-
33947528891
-
Von Hippel-Lindau disease
-
Kaelin WG (2007) Von Hippel-Lindau disease. Annu Rev Pathol 2: 145-173
-
(2007)
Annu Rev Pathol
, vol.2
, pp. 145-173
-
-
Kaelin, W.G.1
-
18
-
-
31444442758
-
Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1
-
Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N (2006) Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer 118: 1144-1153
-
(2006)
Int J Cancer
, vol.118
, pp. 1144-1153
-
-
Kato, H.1
Inoue, T.2
Asanoma, K.3
Nishimura, C.4
Matsuda, T.5
Wake, N.6
-
19
-
-
58049215232
-
PHD2 mutation and congenital erythrocytosis with paraganglioma
-
Ladroue C, Carcenac R, Leporrier M, Gad S, Le Hello C, Galateau-Salle F, Feunteun J, Pouyssegur J, Richard S, Gardie B (2008) PHD2 mutation and congenital erythrocytosis with paraganglioma. N Engl J Med 359: 2685-2692
-
(2008)
N Engl J Med
, vol.359
, pp. 2685-2692
-
-
Ladroue, C.1
Carcenac, R.2
Leporrier, M.3
Gad, S.4
Le Hello, C.5
Galateau-Salle, F.6
Feunteun, J.7
Pouyssegur, J.8
Richard, S.9
Gardie, B.10
-
20
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcrip-tional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002a) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcrip-tional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
21
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002b) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
22
-
-
51049097730
-
The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential
-
Lee KA, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ (2008) The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 6: 829-842
-
(2008)
Mol Cancer Res
, vol.6
, pp. 829-842
-
-
Lee, K.A.1
Lynd, J.D.2
O'Reilly, S.3
Kiupel, M.4
McCormick, J.J.5
Lapres, J.J.6
-
23
-
-
33846652552
-
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
-
Liao D, Corle C, Seagroves TN, Johnson RS (2007) Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572
-
(2007)
Cancer Res
, vol.67
, pp. 563-572
-
-
Liao, D.1
Corle, C.2
Seagroves, T.N.3
Johnson, R.S.4
-
24
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
25
-
-
33749259102
-
2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis
-
Matsumoto K, Imagawa S, Obara N, Suzuki N, Takahashi S, Nagasawa T, Yamamoto M (2006) 2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis. J Cell Physiol 209: 333-340
-
(2006)
J Cell Physiol
, vol.209
, pp. 333-340
-
-
Matsumoto, K.1
Imagawa, S.2
Obara, N.3
Suzuki, N.4
Takahashi, S.5
Nagasawa, T.6
Yamamoto, M.7
-
26
-
-
70149097074
-
Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model
-
Matsumoto K, Obara N, Ema M, Horie M, Naka A, Takahashi S, Imagawa S (2009) Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model. Cancer Sci 100: 1639-1647
-
(2009)
Cancer Sci
, vol.100
, pp. 1639-1647
-
-
Matsumoto, K.1
Obara, N.2
Ema, M.3
Horie, M.4
Naka, A.5
Takahashi, S.6
Imagawa, S.7
-
27
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399: 271-275
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
28
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone M, Dettori D, Leite de Oliveira R, Loges S, Schmidt T, Jonckx B, Tian YM, Lanahan AA, Pollard P, Ruiz de Almodovar C, De Smet F, Vinckier S, Aragones J, Debackere K, Luttun A, Wyns S, Jordan B, Pisacane A, Gallez B, Lampugnani MG, Dejana E, Simons M, Ratcliffe P, Maxwell P, Carmeliet P (2009) Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136(5): 839-851
-
(2009)
Cell
, vol.136
, Issue.5
, pp. 839-851
-
-
Mazzone, M.1
Dettori, D.2
Leite De Oliveira, R.3
Loges, S.4
Schmidt, T.5
Jonckx, B.6
Tian, Y.M.7
Lanahan, A.A.8
Pollard, P.9
Ruiz De Almodovar, C.10
De Smet, F.11
Vinckier, S.12
Aragones, J.13
Debackere, K.14
Luttun, A.15
Wyns, S.16
Jordan, B.17
Pisacane, A.18
Gallez, B.19
Lampugnani, M.G.20
Dejana, E.21
Simons, M.22
Ratcliffe, P.23
Maxwell, P.24
Carmeliet, P.25
more..
-
29
-
-
42449163874
-
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
-
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin Jr WG (2008) Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111: 3236-3244
-
(2008)
Blood
, vol.111
, pp. 3236-3244
-
-
Minamishima, Y.A.1
Moslehi, J.2
Bardeesy, N.3
Cullen, D.4
Bronson, R.T.5
Kaelin Jr., W.G.6
-
30
-
-
51049084870
-
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
-
Nickerson ML, Jaeger E, Shi Y, Durocher JA, Mahurkar S, Zaridze D, Matveev V, Janout V, Kollarova H, Bencko V, Navratilova M, Szeszenia-Dabrowska N, Mates D, Mukeria A, Holcatova I, Schmidt LS, Toro JR, Karami S, Hung R, Gerard GF, Linehan WM, Merino M, Zbar B, Boffetta P, Brennan P, Rothman N, Chow WH, Waldman FM, Moore LE (2008) Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 14: 4726-4734
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4726-4734
-
-
Nickerson, M.L.1
Jaeger, E.2
Shi, Y.3
Durocher, J.A.4
Mahurkar, S.5
Zaridze, D.6
Matveev, V.7
Janout, V.8
Kollarova, H.9
Bencko, V.10
Navratilova, M.11
Szeszenia-Dabrowska, N.12
Mates, D.13
Mukeria, A.14
Holcatova, I.15
Schmidt, L.S.16
Toro, J.R.17
Karami, S.18
Hung, R.19
Gerard, G.F.20
Linehan, W.M.21
Merino, M.22
Zbar, B.23
Boffetta, P.24
Brennan, P.25
Rothman, N.26
Chow, W.H.27
Waldman, F.M.28
Moore, L.E.29
more..
-
31
-
-
77954175274
-
-
Ricketts CJ, Forman JR, Rattenberry E, Bradshaw N, Lalloo F, Izatt L, Cole TR, Armstrong R, Kumar VK, Morrison PJ, Atkinson AB, Douglas F
-
-
-
Ricketts, C.J.1
Forman, J.R.2
Rattenberry, E.3
Bradshaw, N.4
Lalloo, F.5
Izatt, L.6
Cole, T.R.7
Armstrong, R.8
Kumar, V.K.9
Morrison, P.J.10
Atkinson, A.B.11
Douglas, F.12
-
32
-
-
74049144943
-
Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD
-
Ball SG, Cook J, Srirangalingam U, Killick P, Kirby G, Aylwin S, Woodward ER, Evans DG, Hodgson SV, Murday V, Chew SL, Connell JM, Blundell TL, Macdonald F, Maher ER (2009) Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD. Hum Mutat 31: 41-51
-
(2009)
Hum Mutat
, vol.31
, pp. 41-51
-
-
Ball, S.G.1
Cook, J.2
Srirangalingam, U.3
Killick, P.4
Kirby, G.5
Aylwin, S.6
Woodward, E.R.7
Evans, D.G.8
Hodgson, S.V.9
Murday, V.10
Chew, S.L.11
Connell, J.M.12
Blundell, T.L.13
MacDonald, F.14
Maher, E.R.15
-
33
-
-
0032100732
-
HIF-1 alpha is required for solid tumor formation and embryonic vascularization
-
Ryan HE, Lo J, Johnson RS (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-3015
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
34
-
-
0033870727
-
Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth
-
Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS (2000) Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth. Cancer Res 60: 4010-4015
-
(2000)
Cancer Res
, vol.60
, pp. 4010-4015
-
-
Ryan, H.E.1
Poloni, M.2
McNulty, W.3
Elson, D.4
Gassmann, M.5
Arbeit, J.M.6
Johnson, R.S.7
-
35
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza GL (2002) HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-S67
-
(2002)
Trends Mol Med
, vol.8
-
-
Semenza, G.L.1
-
36
-
-
34547905406
-
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
-
Takeda K, Cowan A, Fong GH (2007) Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116: 774-781
-
(2007)
Circulation
, vol.116
, pp. 774-781
-
-
Takeda, K.1
Cowan, A.2
Fong, G.H.3
-
37
-
-
33847615147
-
Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation
-
Takeda K, Fong GH (2007) Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation. Hypertension 49: 178-184
-
(2007)
Hypertension
, vol.49
, pp. 178-184
-
-
Takeda, K.1
Fong, G.H.2
-
38
-
-
33750976389
-
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
-
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH (2006) Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26: 8336-8346
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8336-8346
-
-
Takeda, K.1
Ho, V.C.2
Takeda, H.3
Duan, L.J.4
Nagy, A.5
Fong, G.H.6
-
39
-
-
7944224442
-
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS (2004) Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6: 485-495
-
(2004)
Cancer Cell
, vol.6
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.P.6
Ferrara, N.7
Johnson, R.S.8
-
40
-
-
75149150805
-
Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
-
Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J (2009) Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. Gastroenterology 138: 606-615
-
(2009)
Gastroenterology
, vol.138
, pp. 606-615
-
-
Xue, J.1
Li, X.2
Jiao, S.3
Wei, Y.4
Wu, G.5
Fang, J.6
-
41
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
Yu F, White SB, Zhao Q, Lee FS (2001) HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.B.2
Zhao, Q.3
Lee, F.S.4
-
42
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW (1999) Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 59: 5830-5835
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
|