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Volumn 103, Issue 1, 2010, Pages 1-5

PHD2 in tumour angiogenesis

Author keywords

HIF; PHD2; tumour angiogenesis

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PHD2 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; EGLN1 PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

EID: 77954175077     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605682     Document Type: Short Survey
Times cited : (61)

References (42)
  • 3
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
    • Berra E, Benizri E, Ginouves A, Volmat V, Roux D, Pouyssegur J (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 22: 4082-4090
    • (2003) EMBO J , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 5
    • 65649138377 scopus 로고    scopus 로고
    • Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment
    • Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ (2009) Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell 15: 527-538
    • (2009) Cancer Cell , vol.15 , pp. 527-538
    • Chan, D.A.1    Kawahara, T.L.2    Sutphin, P.D.3    Chang, H.Y.4    Chi, J.T.5    Giaccia, A.J.6
  • 7
    • 32944477859 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha promotes non-hypoxia-mediated proliferation in colon cancer cells and xenografts
    • Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH (2006) Hypoxia-inducible factor-1alpha promotes non-hypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res 66: 1684-1936
    • (2006) Cancer Res , vol.66 , pp. 1684-1936
    • Dang, D.T.1    Chen, F.2    Gardner, L.B.3    Cummins, J.M.4    Rago, C.5    Bunz, F.6    Kantsevoy, S.V.7    Dang, L.H.8
  • 9
    • 0346059600 scopus 로고    scopus 로고
    • Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth
    • Erez N, Milyavsky M, Eilam R, Shats I, Goldfinger N, Rotter V (2003) Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth. Cancer Res 63: 8777-8783
    • (2003) Cancer Res , vol.63 , pp. 8777-8783
    • Erez, N.1    Milyavsky, M.2    Eilam, R.3    Shats, I.4    Goldfinger, N.5    Rotter, V.6
  • 13
    • 75149165633 scopus 로고    scopus 로고
    • Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors
    • Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T (2010) Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Cancer Res 70: 357-366
    • (2010) Cancer Res , vol.70 , pp. 357-366
    • Henze, A.T.1    Riedel, J.2    Diem, T.3    Wenner, J.4    Flamme, I.5    Pouyseggur, J.6    Plate, K.H.7    Acker, T.8
  • 17
    • 33947528891 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease
    • Kaelin WG (2007) Von Hippel-Lindau disease. Annu Rev Pathol 2: 145-173
    • (2007) Annu Rev Pathol , vol.2 , pp. 145-173
    • Kaelin, W.G.1
  • 18
    • 31444442758 scopus 로고    scopus 로고
    • Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1
    • Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N (2006) Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer 118: 1144-1153
    • (2006) Int J Cancer , vol.118 , pp. 1144-1153
    • Kato, H.1    Inoue, T.2    Asanoma, K.3    Nishimura, C.4    Matsuda, T.5    Wake, N.6
  • 20
    • 0037097861 scopus 로고    scopus 로고
    • FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcrip-tional activity of hypoxia-inducible factor
    • Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK (2002a) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcrip-tional activity of hypoxia-inducible factor. Genes Dev 16: 1466-1471
    • (2002) Genes Dev , vol.16 , pp. 1466-1471
    • Lando, D.1    Peet, D.J.2    Gorman, J.J.3    Whelan, D.A.4    Whitelaw, M.L.5    Bruick, R.K.6
  • 21
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (2002b) Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science 295: 858-861
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 22
    • 51049097730 scopus 로고    scopus 로고
    • The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential
    • Lee KA, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ (2008) The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential. Mol Cancer Res 6: 829-842
    • (2008) Mol Cancer Res , vol.6 , pp. 829-842
    • Lee, K.A.1    Lynd, J.D.2    O'Reilly, S.3    Kiupel, M.4    McCormick, J.J.5    Lapres, J.J.6
  • 23
    • 33846652552 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression
    • Liao D, Corle C, Seagroves TN, Johnson RS (2007) Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression. Cancer Res 67: 563-572
    • (2007) Cancer Res , vol.67 , pp. 563-572
    • Liao, D.1    Corle, C.2    Seagroves, T.N.3    Johnson, R.S.4
  • 24
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev 15: 2675-2686
    • (2001) Genes Dev , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 25
    • 33749259102 scopus 로고    scopus 로고
    • 2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis
    • Matsumoto K, Imagawa S, Obara N, Suzuki N, Takahashi S, Nagasawa T, Yamamoto M (2006) 2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis. J Cell Physiol 209: 333-340
    • (2006) J Cell Physiol , vol.209 , pp. 333-340
    • Matsumoto, K.1    Imagawa, S.2    Obara, N.3    Suzuki, N.4    Takahashi, S.5    Nagasawa, T.6    Yamamoto, M.7
  • 26
    • 70149097074 scopus 로고    scopus 로고
    • Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model
    • Matsumoto K, Obara N, Ema M, Horie M, Naka A, Takahashi S, Imagawa S (2009) Antitumor effects of 2-oxoglutarate through inhibition of angiogenesis in a murine tumor model. Cancer Sci 100: 1639-1647
    • (2009) Cancer Sci , vol.100 , pp. 1639-1647
    • Matsumoto, K.1    Obara, N.2    Ema, M.3    Horie, M.4    Naka, A.5    Takahashi, S.6    Imagawa, S.7
  • 29
    • 42449163874 scopus 로고    scopus 로고
    • Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
    • Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin Jr WG (2008) Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111: 3236-3244
    • (2008) Blood , vol.111 , pp. 3236-3244
    • Minamishima, Y.A.1    Moslehi, J.2    Bardeesy, N.3    Cullen, D.4    Bronson, R.T.5    Kaelin Jr., W.G.6
  • 33
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS (1998) HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 17: 3005-3015
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 35
    • 0036216692 scopus 로고    scopus 로고
    • HIF-1 and tumor progression: Pathophysiology and therapeutics
    • Semenza GL (2002) HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med 8: S62-S67
    • (2002) Trends Mol Med , vol.8
    • Semenza, G.L.1
  • 36
    • 34547905406 scopus 로고    scopus 로고
    • Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
    • Takeda K, Cowan A, Fong GH (2007) Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Circulation 116: 774-781
    • (2007) Circulation , vol.116 , pp. 774-781
    • Takeda, K.1    Cowan, A.2    Fong, G.H.3
  • 37
    • 33847615147 scopus 로고    scopus 로고
    • Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation
    • Takeda K, Fong GH (2007) Prolyl hydroxylase domain 2 protein suppresses hypoxia-induced endothelial cell proliferation. Hypertension 49: 178-184
    • (2007) Hypertension , vol.49 , pp. 178-184
    • Takeda, K.1    Fong, G.H.2
  • 38
    • 33750976389 scopus 로고    scopus 로고
    • Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
    • Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH (2006) Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol Cell Biol 26: 8336-8346
    • (2006) Mol Cell Biol , vol.26 , pp. 8336-8346
    • Takeda, K.1    Ho, V.C.2    Takeda, H.3    Duan, L.J.4    Nagy, A.5    Fong, G.H.6
  • 39
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS (2004) Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6: 485-495
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1    Wang, L.2    Esko, J.3    Giordano, F.J.4    Huang, Y.5    Gerber, H.P.6    Ferrara, N.7    Johnson, R.S.8
  • 40
    • 75149150805 scopus 로고    scopus 로고
    • Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity
    • Xue J, Li X, Jiao S, Wei Y, Wu G, Fang J (2009) Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity. Gastroenterology 138: 606-615
    • (2009) Gastroenterology , vol.138 , pp. 606-615
    • Xue, J.1    Li, X.2    Jiao, S.3    Wei, Y.4    Wu, G.5    Fang, J.6
  • 41
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu F, White SB, Zhao Q, Lee FS (2001) HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 98: 9630-9635
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.